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Brains of overweight people ‘ten years older’ than lean counterparts at middle-age

From middle-age, the brains of obese individuals display differences in white matter similar to those in lean individuals ten years their senior, according to new research led by the University of Cambridge. White matter is the tissue that connects areas of the brain and allows for information to be communicated between regions.

We’re living in an ageing population, with increasing levels of obesity, so it’s essential that we establish how these two factors might interact, since the consequences for health are potentially serious

Paul Fletcher


Our brains naturally shrink with age, but scientists are increasingly recognising that obesity – already linked to conditions such as diabetes, cancer and heart disease – may also affect the onset and progression of brain ageing; however, direct studies to support this link are lacking.

In a cross-sectional study – in other words, a study that looks at data from individuals at one point in time – researchers looked at the impact of obesity on brain structure across the adult lifespan to investigate whether obesity was associated with brain changes characteristic of ageing. The team studied data from 473 individuals between the ages of 20 and 87, recruited by the Cambridge Centre for Aging and Neuroscience. The results are published in the journal Neurobiology of Aging.

The researchers divided the data into two categories based on weight: lean and overweight. They found striking differences in the volume of white matter in the brains of overweight individuals compared with those of their leaner counterparts. Overweight individuals had a widespread reduction in white matter compared to lean people.

Comparison of grey matter (brown) and white matter (yellow) in sex-matched subjects A (56 years, BMI 19.5) and B (50 years, BMI 43.4). Credit: Lisa Ronan

The team then calculated how white matter volume related to age across the two groups. They discovered that an overweight person at, say, 50 years old had a comparable white matter volume to a lean person aged 60 years, implying a difference in brain age of 10 years.

Strikingly, however, the researchers only observed these differences from middle-age onwards, suggesting that our brains may be particularly vulnerable during this period of ageing.

“As our brains age, they naturally shrink in size, but it isn’t clear why people who are overweight have a greater reduction in the amount of white matter,” says first author Dr Lisa Ronan from the Department of Psychiatry at the University of Cambridge, “We can only speculate on whether obesity might in some way cause these changes or whether obesity is a consequence of brain changes.”

Senior author Professor Paul Fletcher, from the Department of Psychiatry, adds: “We’re living in an ageing population, with increasing levels of obesity, so it’s essential that we establish how these two factors might interact, since the consequences for health are potentially serious.

“The fact that we only saw these differences from middle-age onwards raises the possibility that we may be particularly vulnerable at this age. It will also be important to find out whether these changes could be reversible with weight loss, which may well be the case.”

Despite the clear differences in the volume of white matter between lean and overweight individuals, the researchers found no connection between being overweight or obese and an individual’s cognitive abilities, as measured using a standard test similar to an IQ test.

Co-author Professor Sadaf Farooqi, from the Wellcome Trust–Medical Research Council Institute of Metabolic Science at Cambridge, says: “We don’t yet know the implications of these changes in brain structure. Clearly, this must be a starting point for us to explore in more depth the effects of weight, diet and exercise on the brain and memory.”

The research was supported by the Bernard Wolfe Health Neuroscience Fund, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.

Ronan, L et al. Obesity associated with increased brain-age from mid-life. Neurobiology of Aging; e-pub 27 July 2016; DOI: 10.1016/j.neurobiolaging.2016.07.010


National/International Media

·         Brains of overweight people look ten years older than those of lean peers - The Guardian 

·         Obese people's brains age more rapidly, University of Cambridge research finds - Daily Mail 

·         Your brain 'could be aged by a DECADE' if you are middle age and obese – Daily Express

·         Being overweight makes brain '10 years older' than if you are slim – Daily Telegraph

·         Being overweight ages the brain by a decade - The Times

·         Middle-aged obesity linked to brain ageing more quickly - Scotsman

·         THICK HEADS: Scientists discover fat people's brains age ten years faster than thin people’s - The Sun

·         Obese people's brains 'age at a quicker rate those those of slim people’s – Daily Mirror

·         Being overweight 'ages people's brains' – BBC News

·         Obese people's brains 'age faster', Cambridge research finds - ITV News

·         Obesity may affect brain aging: study - Xinhua 

·         Overweight Side Effects Consist Of Aging Brain 10 Years, Study Says - International Business Times 

·         Being obese at middle-age can make your brain ten years older - Hindustan Times 


·         Being fat in middle age may shrink your brain's white matter - New Scientist 

·         Brain aging accelerated by 10 years with midlife overweight, obesity - Medical News Today 

·         Your Brain On Obesity: Overweight People Are '10 Years Older' - American Council on Science and Health 

·         Obesity associated with increased brain-age from mid-life -

Posted on 05/08/2016

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