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2 day symposium - Astrocytes in Health and Neurodegenerative Disease - 28th-29th April 2014
The biochemical mechanisms underlying the development and progression of most neurodegenerative diseases remain unknown. It has become increasingly clear that neuronal death is not cell-autonomous, and that signalling between glia and neurons influences the progression of neurodegenerative diseases. Research in this area has traditionally focused on microglia, considered to be the major immune cell in the brain. In the past few years, deficits in the function of the major support cells of the brain, astrocytes, are increasingly recognized to be associated with neuronal loss in motor neurone disease, Alzheimer’s disease, and some rare lysosomal storage disorders.
In addition, substantial evidence shows that astrocytes regulate neuronal activity and connectivity, playing important roles in basal synaptic transmission and long-term potentiation. Major research efforts are ongoing to understand the signaling pathways by which astrocytes and neurons communicate, and the mechanisms by which astrocyte-neuron interactions are disrupted in neurodegenerative diseases. The purpose of this focused meeting is to bring together researchers that are at the cutting edge of investigations into the role of astrocytes in health and astrocyte dysfunction in neurodegenerative diseases. In addition to focusing on relatively well-studied neurodegenerative diseases such as Alzheimer’s disease and motor neurone disease, we will also provide a forum for researchers working on lysosomal storage disorders, including rare neurodegenerative diseases of childhood, such as neuronal ceroid lipofuscinoses.
When: 28th-29th April 2014
Where: University College London, Institute of Child Health, UK
Proceedings (invited speakers) will be published in Biochemical Society Transactions.
Abstract deadline: 24 February 2014.
Earlybird registration deadline: 31 March 2014.
Oral communication slots are available at this meeting. All attendees, particularly researchers in the early stages of their career, are invited to submit a poster abstract for consideration as an oral communication.
Student Bursaries are available for this meeting.
Monday 28th April 2014
Dr Wendy Noble/Professor Jon Cooper (King’s College London)
Chair: Professor Siddharthan Chandran
Chair: Dr Nicola Allen
Chair: Professor Dmitri Rusakov
Chairs: Professor Pamela Shaw and Professor Dmitri Rusakov
Chair: Professor Jon Cooper
Professor Michael Sofroniew (University of California Los Angeles, USA)
17.30 – 17.35 Round-up and Announcements
Dr Brenda Williams (King’s College London)
Dr Diane Hanger (King’s College London)
Chair: Professor Alex Verkhratsky
Chair: Dr Andrey Abramov
Chair: Professor Milos Pekny
Chair: Professor Vladimir Parpura
Astrocyte-neuron interactions in AD
Professor Alex Verkhratsky (University of Manchester, UK)
Chairs: Professor Alex Verkhratsky and Professor Michael Sofroniew
Click here to register.
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Posted on 08/10/2013
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