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Postdoctoral Research Associate, Wellcome Trust-MRC Institute of Metabolic Science (Fixed Term)

Department/Location: Department of Clinical Biochemistry

Salary: £28,982-£37,768

Reference: RG09138

Category: Research

Published: 13 May 2016

Closing date: 16 June 2016

The laboratory of Florian T. Merkle is seeking an outstanding postdoctoral applicant to help develop human cellular models of obesity. This position at the Institute of Metabolic Science offers the opportunity to work in world-class environment using cutting-edge techniques.

We have recently developed methods to differentiate human pluripotent stem cells into the hypothalamic neurons regulating appetite. The abnormal behaviour of these neurons is thought to be major contributor to obesity. The ability to access these neurons for the first time provides an opportunity to characterise the responsiveness of these neurons to genetic and environmental perturbations. You will characterise human hypothalamic neurons using a variety of approaches ranging from CRISPR/Cas9-based gene editing, transcriptomics, ELISA, confocal microscopy, and high content imaging. These experiments have the potential to provide new insights into the regulation of feeding behaviour and the molecular and cellular basis of obesity.

You will be expected to collect and analyse data, present the findings within the Institute and at international meetings, and prepare and submit research for publication in peer-reviewed journals. You will also assist in the management of the laboratory, the preparation of research proposals to funding bodies and contribute to the training of other group members.

To be considered for this position, you must: - possess a Ph.D. in neuroscience, cell biology, genetics, or a related field - have at least one first-author publication in a high-profile, internationally recognised journal - possess excellent organisational, communication, and interpersonal skills - be highly self-motivated and have a track record of creative problem solving

You should have experience with: - assay development and optimisation (esp. high throughput assays) - molecular biology (esp. cloning, CRISPR/Cas9 technology, bioinformatics) - neurobiology or cell biology (esp. developmental and cellular neuroscience, signal transduction) - laboratory management (esp. data management)

Fixed-term: The funds for this post are available until 31 May 2018 in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. This appointment also requires a Research Passport application.

To apply online for this vacancy, please click on the 'Apply' button below. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

Informal enquiries can be made to Dr. Florian Merkle, Metabolic Research Laboratories, Level 4, Wellcome Trust-MRC Institute of Metabolic Science, Box 289 Addenbrooke's Hospital, Cambridge CB2 0QQ. Email:

Please quote reference RG09138 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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Posted on 01/06/2016

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