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Post-Doctoral Research Associate (PDRA) position available in Stem Cell Neurobiology

MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine

Applications are invited for a 36 month Post-Doctoral position in neurobiology with the group of Prof. Robin Franklin of the Department of Veterinary Medicine commencing at a mutually agreeable date before fall 2009.

The position is part of an exciting HFSP-funded interdisciplinary project entitled “Mechanotransduction in oligodendrocyte precursor cell differentiation”, which is a joint endeavor with the groups of Dr. Jochen Guck at the Department of Physics, University of Cambridge, and of Prof. Krystyn Van Vliet, Department of Materials Science and Engineerung, MIT, USA. This project aims to establish the importance and physiological relevance of mechanical stimulus in the differentiation of oligodendrocyte precusor cells (OPCs), a population of neural stem cells that are widesrpread in devlopment and adulthood. This differentiation of OPCs is required for the myelination of axons and characteristically fails in multiple sclerosis. The joint labs have a unique set of cell manipulation technologies at their disposal to dissect all potential mechanical mechanisms by which OPCs might be differentiated. The successful applicant will be working closely with PDRAs in Physics and Engineering in the other two groups and provides the biological expertise.

We are seeking a dynamic and motivated candidate with a strong background in neurobiology who is excited to work on this cutting-edge, interdisciplinary project.  Proven competence with relevant experimental techniques is a prerequisite. Especially experience with the preparation, culture and handling of primary glial and stem cell cutures is necessary. The successful applicant will also be familiar with immunohistochemistry, fluorescent protein labelling, qPCR and basic cell and molecular biology. Experience with fluorescence (confocal-)microscopy and other biophysical techniques will be advantageous. Access to state of the art equipment for optical and mechanical measurements and for advanced live cell imaging, as well as to cell culture facilities and techniques will be available.

The post is available from a mutually agreeable date before fall 2009 for a period of up to 36 months.  The salary will be in the range of £24,402 to £28,290 p.a.

Applications including a curriculum vitae, a list of publications and a completed PD18 form (parts I and III available to download from with details of two referees should be sent to Melissa Large (

The closing date for applications is August 31, 2009.

Informal enquiries can be sent to Prof. Robin Franklin ( or Dr. Jochen Guck (

The University is an equal opportunities employer.

Posted on 14/07/2009

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