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New insight into links between obesity and activity in the brain
Cambridge Neuroscientists have revealed that an anti-obesity drug changes the way the brain responds to appetising, high-calorie foods in obese individuals. This insight may aid the development of new anti-obesity drugs which reduce the activity in the regions of the brain stimulated by the sight of tasty foods.
“Currently, there are few drugs that effectively help patients to lose weight. Developing new pharmaceuticals is expensive and risky. However, our findings suggest that we may be able to use brain imaging and psychological tests to make better predictions of which drugs are likely to work.”
“Our results help us to understand more precisely how anti-obesity drugs work in the brain to change eating behaviour and hence, ultimately, to assist people in losing weight.
The paper ‘Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala and ventral striatum’ will be published on 26 October 2010 in The Journal of Neuroscience.
Posted on 27/10/2010
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