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• Keyword: synapse

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• Dr Philip Buttery
  We work on the role of rho family GTPases and their regulators in the plasticity of CNS synapses, as related to brain disease and recovery from brain injury. We are currently focussing on a regulator of the GTPase Rac1 which is upregulated with n...
• Dr Claire Durrant (née Harwell)
  My research aims to model aspects of Alzheimer's disease pathology using organotypic hippocampal slice cultures from APP mutant mice. By maintaining slice cultures from TgCRND8 mice for several months in culture, the progressive accumulation of Aβ...
• Dr Matthias Landgraf
  We seek to understand how neural networks are specified and how they assemble during development. The locomotor network of the Drosophila embryo and larva serves as a powerful experimental model. Composed of identified neurons whose connections ha...
• Miss Nataly Martynyuk
  The neuron-specific alpha1- and alpha2-chimaerins both contain a C1 domain that recruits chimaerins to DAG-containing membranes, and a GTPase Activating Protein (GAP) domain which acts as a specific inactivator of a Rho family GTPase Rac. Alpha2-c...
• Dr Harvey McMahon FRS
  Molecular mechanisms of vesicle exocytosis, endocytosis and membrane trafficking in neurons. We are interested in understanding basic mechanisms of vesicle trafficking, especially at the synapse, where synaptic vesicle exocytosis and endocytosis ...
• Mr Arkoprovo Paul
  Arko is studying dendritic spine plasticity in neurons derived from induced pluripotent stem cells (iPSC). In the latter he is modelling synaptic development in the autistic brain, with a particular interest in activity dependent dendritic plastic...
• Dr Toshiaki Shigeoka
  RNA transport and local translation play key roles in the formation and function of neural network. Recent in vitro studies provide evidence that the local translation in axon is critical for the axon pathfinding during development. However, becau...

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