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  • Keyword: stem cell

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  • Kaiser Karim Muhammad Kaiser Abdul Karim
    My research involves oligodendrocytes and its progenitors which I derive from human pluripotent stem cells through forced expression of key transcription factors, a method called forward programming. My goal is to use these cells to study oligoden...
  • Talal Fael Al-Mayhani Dr Talal Al-Mayhani
    Glioblastoma (GBM) is the most common type of primary brain malignancies. Patients face dismal prognosis with survival rate of less than 5% at tow years post-diagnosis. The fact that this figure has not changed significantly over the last 2-3 deca...
  • Dr Koby Baranes
    I am using forward reprogramming methods to generate oligodendrocytes and other glial cells from human pluripotent stem cells. The main goal of my research is to establish a model system which will allow to study myelination both in normal and in...
  • Andrea Brand Professor Andrea Brand FRS FMedSci
    Uncovering the molecular mechanisms that control neural stem quiescence and reactivation is crucial for understanding tissue regeneration under normal and pathological conditions and in response to ageing. It is critical to learn not only how stem...
  • Alastair Compston Professor Alastair Compston
    My research interests focus on clinical and experimental demyelinating disease with an emphasis on multiple sclerosis - the commonest potentially disabling disease of young adults. The research group has a broad set of interests: we work on the a...
  • Anne Ferguson-Smith Professor Anne Ferguson-Smith
    Genomic imprinting is an epigenetic mechanism causing genes to be expressed depending on their parental origin. Our research investigates the mechanism and evolution of genomic imprinting and the function of imprinted genes in development and dise...
  • Robin Franklin Professor Robin Franklin
    Robin Franklin is Professor of Stem Cell Medicine at the Wellcome Trust-MRC Cambridge Stem Cell Institute. His lab works on the mechanisms of CNS regeneration with a particular focus on remyelination, an adult stem/precursor cell-mediated process ...
  • Dr Alexis Joannides
    We have established a scaleable and clinically compatible system for generating and propagating neural stem cells from human embryonic stem (ES) cells. Using this platform, and building on our work on mouse ES cells demonstrating a correlation of ...
  • Dr Phil Jones
    We are investigating how normal stem cells transform into cancer cells in a range of sytems, both by studying stem and progenitor cell fate and also by investigating the role of a specific cell fate regulators. Our focus has been on Hes6, which r...
  • Ragnhildur Thora Karadottir Dr Ragnhildur Thora Karadottir
    My lab’s interests are neurotransmitter signalling to oligodendrocytes and their progenitor cells, in both health and disease. Oligodendrocytes produce myelin (in the CNS), which speeds the propagation of the action potential. When the myelin s...
  • ILIAS KAZANIS Dr ILIAS KAZANIS
    My research focuses on the regulation of adult brain cytogenesis, especilly on the biology of the subependymal zone neurogenic/gliogenic niche. I am interested in the role of components of the extracellular matrix (ECM/ such as integrins, laminins...
  • Dr Mark Kotter
    My group is interested in the biology of adult CNS stem and precursor cells in the context of disease. A particular focus lies on mechanisms of CNS remyelination, a stem/precursor cell-mediated process in which new myelin sheaths are restored to d...
  • Madeline Lancaster Dr Madeline Lancaster
    Human brain development exhibits a number of unique characteristics, such as dramatic size expansion, unique cell types, and distinct neural stem cell behaviors. These characteristics are difficult to examine in model organisms such as mice and ar...
  • Rick Livesey Dr Rick Livesey
    During embryonic development, all of the neurons in the cerebral cortex, the executive and integrative centre of the mammalian brain, are generated from a complex population of multipotent stem and progenitor cells. We have developed methods for r...
  • Keith Martin Professor Keith Martin
    The main goal of our group is to understand better the mechanisms of retinal ganglion cell (RGC) death in glaucoma, the leading cause of irreversible blindness worldwide. We aim to develop methods to protect RGC thus slowing the progression of gla...
  • Crystal McClain Dr Crystal McClain
    My current research focus is oligodendrocyte progenitor cell population heterogeneity and dynamics during remyelination using biological statistics. Also, at the single cell level, I’m studying nuclear architecture of stem and progenitor cells, an...
  • Florian Merkle Dr Florian Merkle
    My laboratory uses pluripotent stem cells to model human diseases that arise from the loss of aberrant function of neurons in the hypothalamus that regulate essential physiological and behavioural processes. In particular, obesity is thought to re...
  • Andrew Osborne Dr Andrew Osborne
    My research interest lies in how stem cells offer neuroprotection to retinal ganglion cells with particular interest to how secreted factors prevent visual loss. My project focuses on how platelet-derived growth factor (PDGF) can reduce retinal d...
  • Dr Rickie Patani
    The focus of my research is neural lineage restriction from human pluripotent stem cells and the subsequent regional fate specification of derived neural precursors. One key area of study is to investigate temporal responsiveness of human neural p...
  • Stefano Pluchino Dr Stefano Pluchino
    Recent evidence from our own laboratory indicates that the systemic injection of somatic neural stem/precursor cells (NPCs) very efficiently protect the CNS from the chronic degeneration induced by inflammation both in small rodents as well as in ...
  • Miss Amy Rochford
    Peripheral nerve injuries result in a disconnection in the nervous system communication and a consequent loss in neurological function. Currently, there are limited treatments for these conditions. Neuroprosthetics and cell transplantation are pro...
  • Miss Ilkem Sevgili
    I am currently working on Spiral Ganglion Neurons-on-a-chip and Stria Vascularis cells-on-a-chip projects. In Spiral Ganglion Neurons-on-a-chip project, I aim to grow Spiral Ganglion Neurons (SGNs) onto the 3D printed structures with embedded sen...
  • Ben Simons Professor Ben Simons
    I am interested in applying methods of non-equilibrium statistical mechanics and population dynamics to lineage tracing studies to investigate mechanisms of stem cell fate in development and maintenance. As well as neurogenesis in adult mammalian ...
  • Dr Sybil Stacpoole
    I am currently a neurology registrar, having completed a PhD working with neural precursor cells derived from human embryonic stem cells. I studied the pathways involved in directing neural precursor cells into oligodendrocytes, and investigated...
  • John Henry Stockley Dr John Stockley
    I am interested in using in vitro systems to model and understand complex neuron and glial interactions, particularly the interaction between oligodendrocytes, their precursors and neuronal axons for CNS repair as well as understanding memory. I a...
  • Dr Jelle van den Ameele
    I am a neurologist with an interest in developmental neurobiology and mitochondrial genetics. In the lab, we study how cells and tissues respond to mitochondrial dysfunction, focusing on neural stem cells and the brain. Our goal is to identify nov...
  • Chao Zhao Dr Chao Zhao
    My research focuses on mechanism of remyelination of central nervous system following demyelination in various conditions. After demyelinating injury, the system activates a repair process, which involves oligodendrocyte progenitor cells turning i...

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