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• Keyword: myelin

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• Muhammad Kaiser Abdul Karim
  My research involves oligodendrocytes and its progenitors which I derive from human pluripotent stem cells through forced expression of key transcription factors, a method called forward programming. My goal is to use these cells to study oligoden...
• Dr Koby Baranes
  I am using forward reprogramming methods to generate oligodendrocytes and other glial cells from human pluripotent stem cells. The main goal of my research is to establish a model system which will allow to study myelination both in normal and in...
• Dr Giulia Bonetto
  Studies of neural circuit plasticity focus almost exclusively on functional and structural changes of neuronal synapses. In recent years, however, myelin plasticity has emerged as a potential modulator of neuronal networks. Indeed, myelination of ...
• Dr Janet Deane
  We study the role of lipid processing pathways in demyelinating neurodegenerative disease. We are interested in how the composition of cellular membranes is maintained and what the effects are when this composition is altered. Lipids and proteins ...
• Professor James Fawcett
  Axon regeneration in the damaged CNS: Regeneration of axons after CNS damage is blocked by several molecules in the environment and by loss of intrinsic regeneration ability, We modify the environment to make it more permissive and modify axonal ...
• Sarah Foerster
  Oligodendrocytes are the myelinating cells of the central nervous system, functioning to accelerate neurotransmission and provide trophic support to the axon. In response to the pathological loss of oligodendrocytes, myelin sheaths can be replaced...
• Professor Robin Franklin
  Robin Franklin is Professor of Stem Cell Medicine at the Wellcome Trust-MRC Cambridge Stem Cell Institute. His lab works on the mechanisms of CNS regeneration with a particular focus on remyelination, an adult stem/precursor cell-mediated process ...
• Jennifer Wanyi Jia
  My research is on myelin plasticity during adulthood and how myelin dynamics may be influenced by neuronal plasticity. Oligodendrocytes in the central nervous system produce myelin, which is essential for ensuring fast signal transmission in neuro...
• Dr Ragnhildur Thora Karadottir
  My lab’s interests are neurotransmitter signalling to oligodendrocytes and their progenitor cells, in both health and disease. Oligodendrocytes produce myelin (in the CNS), which speeds the propagation of the action potential. When the myelin s...
• Dr Mark Kotter
  My group is interested in the biology of adult CNS stem and precursor cells in the context of disease. A particular focus lies on mechanisms of CNS remyelination, a stem/precursor cell-mediated process in which new myelin sheaths are restored to d...
• Dr Crystal McClain
  My current research focus is oligodendrocyte progenitor cell population heterogeneity and dynamics during remyelination using biological statistics. Also, at the single cell level, I’m studying nuclear architecture of stem and progenitor cells, an...
• Alisa Molotova MSci, MRes
  The tissue extracellular matrix (ECM) provides the resident progenitor cells with both biochemical and physical cues, which regulate stem cell fate. During ageing the brain ECM is dynamically altered leading to an imbalance in the tissue homeostas...
• Claudia Pama
  Currently I am based at the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute in the lab of Dr Karadottir, investigating the pattern of developmental cortical myelination as well as the function of myelin in learning - under...
• Dr John Stockley
  I am interested in using in vitro systems to model and understand complex neuron and glial interactions, particularly the interaction between oligodendrocytes, their precursors and neuronal axons for CNS repair as well as understanding memory. I a...
• Dr Chao Zhao
  My research focuses on mechanism of remyelination of central nervous system following demyelination in various conditions. After demyelinating injury, the system activates a repair process, which involves oligodendrocyte progenitor cells turning i...

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