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  • Keyword: axon

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  • Dr Peter Arthur-Farraj
    I am a neurology registrar with an interest in neuromuscular disorders and nerve repair. I have recently been awarded a Wellcome Trust Clinical Career Development Fellowship, to work with Professor Michael Coleman’s group at the John Van Geest Cen...
  • Amanda Barber Dr Amanda Barber
    Retinal ganglion cells (RGCs) convey visual signals from the retina to the brain via their axons that forms the optic nerve and the optic tract. Damage to RGC axons, as a result of injury or diseases such as glaucoma, can result in blindness as ma...
  • Professor Michael Coleman
    We study axon degeneration and its roles in neurodegenerative disease. One focus is proteins regulating the degeneration of injured axons (‘Wallerian degeneration'), which we have linked into a molecular pathway. Disease models involving similar m...
  • Geoffrey Cook Dr Geoffrey Cook
    My research concerns the mechanisms controlling axon growth. In the laboratory we are investigating two axon-repulsive systems, 1) the characterization of somite glycoproteins that repel axons, creating the segmented pattern of spinal nerves durin...
  • Handan Elaman
    The aim of my research is to further our understanding of the mechanisms underlying age-related axon loss using models of accelerated ageing.
  • Richard Eva Dr Richard Eva
    Investigating the neuron-intrinsic mechanisms regulating axon regeneration in the central nervous system, in order to develop treatments for repairing damage caused by disease or injury. As CNS neurons develop, they lose their intrinsic capacity f...
  • James Fawcett Professor James Fawcett
    Axon regeneration in the damaged CNS: Regeneration of axons after CNS damage is blocked by several molecules in the environment and by loss of intrinsic regeneration ability, We modify the environment to make it more permissive and modify axonal ...
  • Dr Jonathan Gilley
    My principle research area is investigation of the molecular mechanisms involved in axon degeneration after injury and in disease.
  • Victoria Hewitt Dr Victoria Hewitt
    I am investigating how interactions between mitochondria and the endoplasmic reticulum contribute to mitochondrial dynamics in neurons. I am using fruit flies as a model system to determine how perturbing these interactions contributes to neurodeg...
  • Christine Holt Professor Christine Holt FMedSci FRS
    My laboratory studies how nerve connections are first established in the brain. We focus on the developing visual system and our main goal is to understand the molecular and cellular mechanisms of axon guidance that enable axons to navigate from t...
  • Roger Keynes Professor Roger Keynes
    Growth cone repulsion is an important mechanism controlling axon growth. During development it guides axons by excluding them from repulsive regions of the embryo. Following injury to the adult brain it may also block axon regeneration, with major...
  • Andras Lakatos Dr Andras Lakatos
    Andras’s MRC funded lab focuses on regulators of signaling/transcriptomic networks underlying astrocyte-neuron-synapse interactions in health and in disease. Our specific questions are what cues trigger or maintain the neuroprotective or detriment...
  • Dr Elise Laperrousaz
    I interest myself in the axonal regeneration, after a spinal cord injury. In this context, I focus on integrins role in the process of axonal regeneration in both in vitro and in vivo models.
  • Dr Julie Qiaojin Lin
    I am a Sir Henry Wellcome Postdoctoral Fellow based at the UK Dementia Research Institute at the University of Cambridge. I am interested in understanding how localised protein synthesis at distal neuronal compartments, particularly axons, contrib...
  • Andrea Loreto
    Axon degeneration is an early feature of several neurodegenerative diseases, including Parkinson's disease, motor neuron disease, multiple sclerosis and glaucoma. I have recently been awarded a Sir Henry Wellcome postdoctoral fellowship to work i...
  • Fiona Love
    Adult CNS neurons have marked differences in axon transport compared to their peripheral or developing counterparts. As a result, adult CNS axons often lack the molecular machinery needed to survive and recover from injury or disease. I'm invest...
  • Keith Martin Professor Keith Martin
    The main goal of our group is to understand better the mechanisms of retinal ganglion cell (RGC) death in glaucoma, the leading cause of irreversible blindness worldwide. We aim to develop methods to protect RGC thus slowing the progression of gla...
  • Dr Leonor Miller-Fleming
    My interest is to understand the basic molecular mechanisms that contribute for neurodegenerative diseases. Currently I am focusing on the RNA metabolism dysregulation associated with motor neuron disease and in parallel I am studying the mechanis...
  • Emad Moeendarbary Dr Emad Moeendarbary
    I am a mechanical engineer with a strong interest in the experimental and ‎theoretical/computational study of biological systems. Presently, I am working at the ‎interface of engineering and neuroscience to explore mechanics of neurons ‎in the cen...
  • Dr Bart Nieuwenhuis
    Injury to the brain and spinal cord has devastating consequences because adult neurons in the central nervous system (CNS) do not regenerate. Gene therapy is a promising tool to promote axon regeneration. My research makes contributions to the fie...
  • Cahir O'Kane Dr Cahir O'Kane
    We are interested in the basic biology of axonal ER, and its relevance to neurodegenerative disease, using Drosophila as a model. Axonal ER forms a continuous tubular network throughout the neuron, comparable to a “neuron within a neuron”, potenti...
  • Dr Juan Jose Perez Moreno
    In neurons, endoplasmic reticulum (ER) is not only found in the cell body, but also extends into dendrites and axonal presynaptic terminals. Axonal ER comprises a tubular network of mainly smooth ER, whose function is still poorly understood. In h...
  • Eva Pillai
    Neurons extend axons across long distances, growing along highly specific 'tracks' to reach their synaptic target in the brain. Most studies of this process have focused on how chemical molecules guide axon navigation accurately. Our lab has shown...
  • Dr Mansoor Raza
    Growth cone repulsion during development and adult CNS failure to regenerate after injury. The use of viral vectors for transgene expression in the nervous system to promote axonal regeneration.
  • Evan Reid Dr Evan Reid
    My group's research is focussed on the hereditary spastic paraplegias, genetic conditions where the corticospinal tract axons degenerate. HSPs selectively involve axons while sparing the neuronal cell bodies, so we study them to understand molecul...
  • Dr Toshiaki Shigeoka
    RNA transport and local translation play key roles in the formation and function of neural network. Recent in vitro studies provide evidence that the local translation in axon is critical for the axon pathfinding during development. However, becau...
  • Patrice Smith Professor Patrice Smith
    Promoting regeneration and repair of the damaged CNS, with a particular focus on understanding the contribution of neuronal intrinsic mechanisms in axon regeneration.
  • Ms Amelia Joy Thompson
    I am interested in how the physical environment of growing neurons shapes the development of the embryonic nervous system. My PhD focusses on the role of tissue stiffness as an in vivo axon guidance cue, using the Xenopus laevis embryo as a model ...
  • Vasja Urbančič Vasja Urbančič
    The growth cones of developing axons are guided on their journey through the developing nervous system by guidance cues that instruct their progression along a precise pathway towards their target area. The responses of growth cones to many of the...
  • Alessio Vagnoni Dr Alessio Vagnoni
    The main goal of my research is to better understand the mechanisms of neuronal ageing in vivo. I am particularly interested in studying how macromolecules, proteins and organelles are trafficked within neuronal axons and how this process is regul...
  • Hovy Wong Dr Hovy Wong
    The role of local translation in axonal branching and synaptogenesis in vivo

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