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  • Keyword: aggregation

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  • Edward Avezov
    Through an in-depth investigation of the neuronal cell biophysical properties, our program aims to Identify new targetable pathways, disrupted in dementia. In particular, we seek understanding of the role Endoplasmic Reticulum, and its structure f...
  • Anne Bertolotti Dr Anne Bertolotti
    Diverse neurodegenerative diseases share a common cause: aggregation of a specific protein in selective regions of the brain. The disease-causing proteins are expressed throughout life but neurodegenerative diseases are mostly late-onset. In fac...
  • Dr Eleni Dimou
    Tau is a soluble protein interacting with tubulin to stabilize microtubules. Under pathological conditions, it becomes hyperphosphorylated and adopts a filamentous conformation with a pivotal role in Alzheimer’s Disease pathogenesis. Although tau ...
  • Elizabeth English
    My PhD project will analyse Alzheimer’s Disease (AD) brain samples across the disease stages, compared to equivalent healthy brain samples. I will be looking to characterise amyloid-beta, tau, and alpha-synuclein aggregates, in terms of aggregate ...
  • Katie Hall Dr Katie Hall PhD
    I am principally interested in the field of behavioural neurosciences with a particular focus in understanding how neurodegenerative pathologies cause dementia symptoms and behavioural dysfunction, as well as developing potential neuroprotective t...
  • Maria  Herva Moyano Dr Maria Herva Moyano E
    I have developed a fast and reliable method to form alpha-synuclein aggregates and my aim is to use it as a high content assay to screen for drugs with anti aggregating properties. I am specially interested in the option of repurposing existing dr...
  • Clemens Kaminski Professor Clemens Kaminski
    We develop advanced microscopic imaging techniques that permit us to elucidate molecular mechanisms of neurodegeneration. We use techniques such as lifetime, spectrum and polarisation resolved imaging that inform on protein misfolding, aggregat...
  • Gabriele Kaminski Schierle Dr Gabriele Kaminski Schierle
    Our current research is focused on uncovering the molecular mechanisms that cause proteins to misfold and aggregate in live model systems of Alzheimer’s Disease (AD) and Parkinson’s disease (PD). To enable this work we have developed a range of ad...
  • Dr Taxiarchis Katsinelos
    The progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark and it correlates with the disease progression of tauopathies, such as Alzheimer's disease. My research focuses on employing cellular biology and biochemica...
  • Professor David Klenerman
    Small soluble protein aggregates are thought to play a key role in the initial development of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, but are difficult to study using conventional methods due to their low concent...
  • Michele Vendruscolo Professor Michele Vendruscolo
    Our research at the Centre for Misfolding Diseases (https://www.cmd.ch.cam.ac.uk/) is aimed at understanding the molecular origins of neurodegenerative disorders. We have set up an interdisciplinary programme that brings together methods and conc...
  • Alice White Miss Alice White
    I am investigating the neural correlates of decision-making in patients with Huntington's Disease (HD). HD is a genetic neurodegenerative disease in which mutant forms of the huntingtin protein accumulate in the brain. Patients have three main typ...
  • Zhen Zhong Dr Zhen Zhong
    Mechanism of prion-like propagation of mutant SOD1 misfolding from cell to cell in Amyotrophic lateral sclerosis (ALS).

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