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  • Keyword: Tau

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  • Dorothea Boeken
    I am interested in using single-molecule techniques to study soluble tau aggregates in tauopathy models, such as iPSC-derived neurons and cerebral organoids. These techniques include TIRF microscopy as well as super-resolution microscopy (dSTORM, ...
  • Jack Brelstaff Dr Jack Brelstaff Ph.D
    Our work focuses on the cellular and molecular consequences of tau pathology in neuronal cultures. Our primary model is derived from the dorsal root ganglia of mice transgenic for P301S mutant human tau. These ganglia are dissociated and grown in ...
  • Dr Eleni Dimou
    Tau is a soluble protein interacting with tubulin to stabilize microtubules. Under pathological conditions, it becomes hyperphosphorylated and adopts a filamentous conformation with a pivotal role in Alzheimer’s Disease pathogenesis. Although tau ...
  • Mr Jacob Dundee
    My project is to understand the role of microglia in development, tauopathy, and ageing. As a person get older, microglia have been found to ‘eat’ synapses of stressed but still functional neurons, possibly driving the disease progression of many ...
  • Elizabeth English
    My PhD project will analyse Alzheimer’s Disease (AD) brain samples across the disease stages, compared to equivalent healthy brain samples. I will be looking to characterise amyloid-beta, tau, and alpha-synuclein aggregates, in terms of aggregate ...
  • Dr Jonathan Gilley
    My principle research area is investigation of the molecular mechanisms involved in axon degeneration after injury and in disease.
  • Michel Goedert Dr Michel Goedert
    Alzheimer's disease and Parkinson's disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in related disorders, including progressive supranuclear palsy, dementia with Le...
  • Dr Sanne Kaalund
    As a neuroscientist I am interested in the microscopic structure of the human brain, in particular how changes in the number of brain cells and cell-to-cell connections relate to altered behaviour and cognitive function in brain illnesses. I study...
  • Dr Taxiarchis Katsinelos
    The progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark and it correlates with the disease progression of tauopathies, such as Alzheimer's disease. My research focuses on employing cellular biology and biochemica...
  • Dr Will McEwan
    The ability to selectively destroy harmful proteins could represent a powerful therapeutic approach in several diseases. Our work focusses on a newly discovered arm of immunity that operates in the intracellular environment. Viruses that import an...
  • Maria Grazia  Spillantini Professor Maria Grazia Spillantini FRS FMedSci
    Our interest is in the identification of the mechanisms leading to neuronal death and clinical phenotype in diseases such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia. In particular we study the role of microtubule-assoc...
  • Dr Shahid Zaman
    The main theme of our research is to understand the role of amyloid, tau, inflammation and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down's syndrome.

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