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  • Keyword: Tau

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  • Jack Brelstaff Dr Jack Brelstaff Ph.D
    Our work focuses on the cellular and molecular consequences of tau pathology in neuronal cultures. Our primary model is derived from the dorsal root ganglia of mice transgenic for P301S mutant human tau. These ganglia are dissociated and grown in ...
  • Dr Eleni Dimou
    Tau is a soluble protein interacting with tubulin to stabilize microtubules. Under pathological conditions, it becomes hyperphosphorylated and adopts a filamentous conformation with a pivotal role in Alzheimer’s Disease pathogenesis. Although tau ...
  • Mr Jacob Dundee
    My project is to understand the role of microglia in development, tauopathy, and ageing. As a person get older, microglia have been found to ‘eat’ synapses of stressed but still functional neurons, possibly driving the disease progression of many ...
  • Dr Claire Durrant (née Harwell)
    My research aims to model aspects of Alzheimer's disease pathology using organotypic hippocampal slice cultures from APP mutant mice. By maintaining slice cultures from TgCRND8 mice for several months in culture, the progressive accumulation of Aβ...
  • Éimear Foley
    My research is primarily focused on the role of inflammation in psychiatric disorders. As a research assistant for the Insight study, I am particularly interested in the relationship between the immune system and depression. This research is curre...
  • Dr Jonathan Gilley
    My principle research area is investigation of the molecular mechanisms involved in axon degeneration after injury and in disease.
  • Michel Goedert Dr Michel Goedert
    Alzheimer's disease and Parkinson's disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in related disorders, including progressive supranuclear palsy, dementia with Le...
  • Dr Taxiarchis Katsinelos
    The progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark and it correlates with the disease progression of tauopathies, such as Alzheimer's disease. My research focuses on employing cellular biology and biochemica...
  • Dr Will McEwan
    The ability to selectively destroy harmful proteins could represent a powerful therapeutic approach in several diseases. Our work focusses on a newly discovered arm of immunity that operates in the intracellular environment. Viruses that import an...
  • Maria Grazia  Spillantini Professor Maria Grazia Spillantini FRS FMedSci
    Our interest is in the identification of the mechanisms leading to neuronal death and clinical phenotype in diseases such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia. In particular we study the role of microtubule-assoc...
  • Miss Patricia Vazquez Rodriguez
    My work focuses on clinicopathological correlations and biomarker evaluation of a tau radioligand in Progressive Supranuclear Palsy (PSP). PSP is at a positive turning point, following decades of hard won progress in understanding the biology of t...
  • Dr Shahid Zaman
    The main theme of our research is to understand the role of amyloid, tau, inflammation and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down's syndrome.

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