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  • Institute: MRC Laboratory of Molecular Biology

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  • Dr Byron Andrews
    I'm a life scientist with a mitochondrial background. At the moment, I am looking at the molecular basis of neurodegeneration using quantitative proteomics and structural analysis.
  • Barry Bentley
    My current research aims to map and understand the extrasynaptic volume transmission networks in the nervous system of C. elegans.
  • Anne Bertolotti Dr Anne Bertolotti
    Diverse neurodegenerative diseases share a common cause: aggregation of a specific protein in selective regions of the brain. The disease-causing proteins are expressed throughout life but neurodegenerative diseases are mostly late-onset. In fac...
  • Dr Marco Brancaccio
    Molecular, cellular and circuit mechanisms of circadian rhythms generation in mammals
  • Simon Bullock Dr Simon Bullock
    Our primary goal is to understand how cellular components are sorted and dispersed by microtubule-based motor complexes, and how these transport processes contribute to the functions of cells in situ (i.e. within organisms). We have long-standing ...
  • Karl Emanuel Busch Dr Karl Emanuel Busch
    I study the response of the nematode C. elegans to a cue related to foraging, the concentration of ambient oxygen, which determines the worm´s locomotory activity on bacterial food lawns. I aim to understand how genes that regulate this particular...
  • Mario de Bono Dr Mario de Bono
    We seek to understand how neural networks are assembled, function and evolve. C. elegans is a powerful system to study neural circuits. The worm has exactly 302 neurons each of which can be identified. EM reconstructions have identified synapti...
  • Dr Benjamin Falcon
    Filamentous protein assemblies in the brain characterize a large number of neurodegenerative diseases, the accumulation and spread of which is believed to underlie nerve cell degeneration. My research focuses on using electron cryo-microscopy (cry...
  • Dr Rene Frank
    I am interested in understanding the native molecular architecture of synapses with a particular focus on postsynaptic membranes that contain N-methyl D-aspartic acid receptors (NMDARs). NMDARs mediate Ca2+-dependent signalling, acting in concer...
  • Dana Galili Dr Dana Galili
    Did you ever wonder what makes males and females respond differently to the same stimulus? Sex differences are basic for reproduction, parenting and other social interactions. I work on Drosophila sexually dimorphic behaviours and their underlying...
  • Michel Goedert Dr Michel Goedert
    Alzheimer's disease and Parkinson's disease are characterized by the presence of abnormal filamentous assemblies within some nerve cells. Similar assemblies are found in related disorders, including progressive supranuclear palsy, dementia with Le...
  • Ingo Greger Dr Ingo Greger
    Information transfer in the brain occurs at synapses where chemical transmitters are released from presynaptic terminals and are received by postsynaptic receptors. Glutamate is a major neurotransmitter and glutamate receptors are key to synaptic ...
  • Ryan Hamnett Dr Ryan Hamnett AMRSB
    Molecular, cellular and circuit-level components of the mammalian circadian system, specifically the contributions of different subpopulations of cells within the suprachiasmatic nucleus (SCN) to overall rhythmicity, such as rhythm generation, mai...
  • Michael Hastings FMedSci Dr Michael Hastings FRS, FMedSci
    Cellular and molecular basis to circadian rhythms in mammals and its relevance to metabolic and neurological disease.
  • Gregory Jefferis Dr Gregory Jefferis
    Our broad goal is to understand how smell turns into behaviour in the fruit fly brain. We use a combination of genetic labelling and manipulation, targeted in vivo whole cell patch clamp recording and high resolution neuroanatomy to study olfactor...
  • Johannes Kohl Dr Johannes Kohl
    Neural circuits underlying social behaviours
  • Madeline Lancaster Dr Madeline Lancaster
    Human brain development exhibits a number of unique characteristics, such as dramatic size expansion, unique cell types, and distinct neural stem cell behaviors. These characteristics are difficult to examine in model organisms such as mice and ar...
  • Harvey McMahon Dr Harvey McMahon FRS
    Molecular mechanisms of vesicle exocytosis, endocytosis and membrane trafficking in neurons. We are interested in understanding basic mechanisms of vesicle trafficking, especially at the synapse, where synaptic vesicle exocytosis and endocytosis ...
  • John O'Neill Dr John O'Neill
    The causes and consequences of cellular circadian timekeeping and its interaction with sleep.
  • Dr Shigekazu Oda
    My long-term goal is to discover a general principle of information process in a neural circuit. The main subject is that 'how biological system behave as a system?' To answer this question, I am using a simple model organism, C. elegans by using ...
  • Birgitta  Olofsson Dr Birgitta Olofsson
    How does an animal evaluate food and how is this information used to modify its feeding behaviour appropriately? In many animals food provides a reinforcing feedback after it is eaten that influences subsequent food-seeking behaviour. Variation ...
  • Dr Andrew Patton
    Study of circadian rhythms in the mammalian suprachiasmatic nucleus (SCN) using genetic and electrophysiological approaches. My primary research focuses on the role of GABAergic synaptic transmission within the SCN and how this contributes to the ...
  • Sabine Rühle Dr Sabine Rühle
    By combining behavioural, genetic, electrophysiological and optical techniques, I aim to investigate how sensory inputs and motivational states are integrated to produce behavioural outputs.
  • William Schafer Dr William Schafer
    The fundamental nature of mental phenomena such as perception, learning and memory is one of the remaining scientific mysteries. Since the neuroanatomy of mammalian nervous systems is exceedingly complex and incompletely characterized, it is diffi...
  • Ben Sutcliffe Dr Ben Sutcliffe
    In the Drosophila olfactory system around 1300 olfactory receptor neurons transmit sensory information to the antennal lobe where neurons of the same class converge on distinct glomeruli. Projection neuron dendrites innervate these glomeruli in a...
  • Adam Tozer Dr Adam Tozer
    I am an electrophysiologist working in the Hypothalamus and projecting areas, interested in the neuronal control of diet, and mechanisms controlling food intake and energy balance. My background is in synaptic physiology and neuronal homeostasis...
  • Marco Tripodi Marco Tripodi
    One of the major tasks that the nervous system faces is that of linking perception to action. We perceive the world around us through our senses and we use this information to select the most appropriate set of actions. My lab studies the organiza...
  • nigel unwin Dr Nigel Unwin
    I am interested in finding out how ion channels work, using electron microscopy to analyse their structures trapped in different physiological states. Current research focuses on the nicotinic acetylcholine receptor, the transmitter-gated ion chan...
  • Alessio Vagnoni Dr Alessio Vagnoni
    The main goal of my research is to better understand the mechanisms of neuronal ageing in vivo. I am particularly interested in studying how macromolecules, proteins and organelles are trafficked within neuronal axons and how this process is regul...
  • Buyun Zhao Buyun Zhao
    The ultimate function of the nervous system is to facilitate survival. To accomplish this task in a dynamically changing environment, the animal's behavioural strategies must alter accordingly given its context. One of the fundamental basis of thi...
  • Zhen Zhong Dr Zhen Zhong
    Mechanism of prion-like propagation of mutant SOD1 misfolding from cell to cell in Amyotrophic lateral sclerosis (ALS).

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