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  • Institute: Brain Repair van Geest Centre for

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  • Fardad  Afshari Dr Fardad Afshari
    I am interested in studying astrocyte biology in the context of gliosis following CNS injury and tumour cell invasion.
  • Talal Fael Al-Mayhani Dr Talal Al-Mayhani
    Glioblastoma (GBM) is the most common type of primary brain malignancies. Patients face dismal prognosis with survival rate of less than 5% at tow years post-diagnosis. The fact that this figure has not changed significantly over the last 2-3 deca...
  • Joao Nuno Alves Joao Nuno Alves
    Chondroitinase is a promising candidate for the treatment of human spinal cord injury (SCI). It is a bacterial enzyme that cleaves glycosaminoglycan (GAG) chains from chondroitin sulphate proteoglycans, which present a major barrier to nerve regen...
  • Dr Melissa Andrews
    My research focuses on assessing the localization and transport of ectopically expressed integrins in adult CNS, in order to better target integrins to sites of injury for therapeutic treatment. We have shown that enhancing the regeneration of do...
  • Dr Peter Arthur-Farraj
    I am a neurology registrar with an interest in neuromuscular disorders and nerve repair. I have recently been awarded a Wellcome Trust Clinical Career Development Fellowship, to work with Professor Michael Coleman’s group at the John Van Geest Cen...
  • Amanda Barber Dr Amanda Barber
    Retinal ganglion cells (RGCs) convey visual signals from the retina to the brain via their axons that forms the optic nerve and the optic tract. Damage to RGC axons, as a result of injury or diseases such as glaucoma, can result in blindness as ma...
  • Roger Barker Professor Roger Barker
    I work on: Clinical aspects of Parkinson's and Huntington's disease including the study of disease heterogeneity using cognitive testing, functional imaging and genetic biomarkers. Examining the value of different biomarkers to assess disease onse...
  • Damiano G. Barone Dr Damiano G. Barone
    Neurological disability can be secondary to many conditions, including trauma, degenerative disease and cancer and imposes a significant health, economic and social burden. Nowadays rehabilitation medicine is the only therapy available to patients...
  • Faye Begeti Dr Faye Begeti
    Problems in cognition are a part of Huntington’s disease (HD) and have a significant impact on quality of life. My main research interest is to investigate the cognitive aspects of HD with the aim of translating animal research into the clinic in...
  • Joshua Bernstock
    Ischemic stroke continues to be a leading cause of morbidity/mortality throughout the world. The paucity of therapeutic options stands in stark contrast to the intensity of research efforts/number of clinical trials that have been performed. While...
  • Jack Brelstaff Dr Jack Brelstaff Ph.D
    Our work focuses on the cellular and molecular consequences of tau pathology in neuronal cultures. Our primary model is derived from the dorsal root ganglia of mice transgenic for P301S mutant human tau. These ganglia are dissociated and grown in ...
  • Philip Buttery Dr Philip Buttery
    We work on the role of rho family GTPases and their regulators in the plasticity of CNS synapses, as related to brain disease and recovery from brain injury. We are currently focussing on a regulator of the GTPase Rac1 which is upregulated with n...
  • Marta Camacho
    I am involved in cohort studies (PICNICS, ICICLE-PD, Proband) which are observational studies tracking the progression of patients with Parkinson’s disease (PD) over several years so that we can better understand how the disease behaves over time....
  • Alejandro Carnicer-Lombarte
    Neural interfaces allow the establishment of connections between the nervous system and external electronics, and hold great potential in both the clinic and basic research. The peripheral nervous system is a particularly attractive site t...
  • Dr Menghon Cheah
    My research focuses on investigating the extracellular and intracellular mechanisms for axon regeneration in the central nervous system after injury. In addition to a plethora of inhibitory factors present in the injured microenviroment, the absen...
  • Dr Rachel Chong BA(Hons), MBBS, MMed(Ophth)
    My project aims to investigate if promoting microtubule stability in retinal ganglion cells can induce neuroprotection in models of glaucoma.
  • Professor Michael Coleman
    We study axon degeneration and its roles in neurodegenerative disease. One focus is proteins regulating the degeneration of injured axons (‘Wallerian degeneration'), which we have linked into a molecular pathway. Disease models involving similar m...
  • Giuseppe D'Amico
    in vivo and in vitro studies on human induced Neural Stem Cells and their prospective therapeutic use in people with progressive Multiple Sclerosis.
  • Dr Claire Durrant (née Harwell)
    My research aims to model aspects of Alzheimer's disease pathology using organotypic hippocampal slice cultures from APP mutant mice. By maintaining slice cultures from TgCRND8 mice for several months in culture, the progressive accumulation of Aβ...
  • Richard Eva Dr Richard Eva
    Boosting axon regeneration after injury by targeting axon transport of growth receptors I would like to understand the mechanisms regulating the traffic and transport of growth and survival molecules into axons. During development these molecules ...
  • James Fawcett Professor James Fawcett
    Axon regeneration in the damaged CNS: Regeneration of axons after CNS damage is blocked by several molecules in the environment and by loss of intrinsic regeneration ability, We modify the environment to make it more permissive and modify axonal ...
  • Dr Jonathan Gilley
    My principle research area is investigation of the molecular mechanisms involved in axon degeneration after injury and in disease.
  • Katie Hall Dr Katie Hall PhD
    I am principally interested in the field of behavioural neurosciences with a particular focus in understanding how neurodegenerative pathologies cause dementia symptoms and behavioural dysfunction, as well as developing potential neuroprotective t...
  • Maria  Herva Moyano Dr Maria Herva Moyano E
    I have developed a fast and reliable method to form alpha-synuclein aggregates and my aim is to use it as a high content assay to screen for drugs with anti aggregating properties. I am specially interested in the option of repurposing existing dr...
  • Nunzio Iraci Dr Nunzio Iraci
    I am pursuing a more basic (fundamental) approach that focuses at the discovery of the cellular machinery controlling the mobility of small nucleic acid sequences (known to regulate the translation into protein products, and ultimately functions) ...
  • Dr Alexis Joannides
    We have established a scaleable and clinically compatible system for generating and propagating neural stem cells from human embryonic stem (ES) cells. Using this platform, and building on our work on mouse ES cells demonstrating a correlation of ...
  • Antonina Kouli Antonina Kouli
    PD is neuropathologically characterised by alpha-synuclein inclusions in neuronal cell bodies (Lewy bodies). Although it is primarily a movement disorder, almost half of the patients also develop dementia within 10 years from diagnosis. Cortical L...
  • Dr Wei-Li Kuan
    My primary research interest is on investigating novel therapeutics that are potentially disease-modifying in Parkinson's and Huntington's disease. I am also extremely keen in interdisciplinary research and I am currently working with groups of ph...
  • Dr Elise Laperrousaz
    I interest myself in the axonal regeneration, after a spinal cord injury. In this context, I focus on integrins role in the process of axonal regeneration in both in vitro and in vivo models.
  • Andrea Loreto
    Axon degeneration is an early feature of several neurodegenerative diseases, including Parkinson's disease, motor neuron disease, multiple sclerosis and glaucoma. I have recently been awarded a Sir Henry Wellcome postdoctoral fellowship to work i...
  • Keith Martin Professor Keith Martin
    The main goal of our group is to understand better the mechanisms of retinal ganglion cell (RGC) death in glaucoma, the leading cause of irreversible blindness worldwide. We aim to develop methods to protect RGC thus slowing the progression of gla...
  • Nataly Martynyuk Miss Nataly Martynyuk
    The neuron-specific alpha1- and alpha2-chimaerins both contain a C1 domain that recruits chimaerins to DAG-containing membranes, and a GTPase Activating Protein (GAP) domain which acts as a specific inactivator of a Rho family GTPase Rac. Alpha2-c...
  • Sarah Mason Dr Sarah Mason
    My research interests are: 1) Better defining the neuropsychological profile of presymptomatic and early Huntington's disease using fMRI scanning and behavioural testing. With a particular interest in determining the factors which underpin the cog...
  • Mr Bart Nieuwenhuis
    Spinal cord injury can lead to damage of the corticospinal tract and thereby result in paralysis. My PhD project aims to promote regeneration of corticospinal tract because this is the key event to restore motor function. The research strategy i...
  • Andrew Osborne Dr Andrew Osborne
    My research interest lies in how stem cells offer neuroprotection to retinal ganglion cells with particular interest to how secreted factors prevent visual loss. My project focuses on how platelet-derived growth factor (PDGF) can reduce retinal d...
  • Craig Pearson Mr Craig Pearson
    Influence of extracellular matrix proteins on regeneration of retinal ganglion cell axons in the optic nerve.
  • Veselina Petrova Veselina Petrova
    My research focuses on restoring the intrinsic ability of adult CNS neurons to regenerate after spinal cord injury. In particular, I work on advancing the axonal transport of molecules, key to the regenerative process such as integrins.
  • Scarlett Pinnock Dr Scarlett Pinnock
    The rate of neurogenesis in the dentate gyrus of the adult hippocampus is highly labile. Much of this lability is due to the exquisite sensitivity of the progenitor cells to glucocorticoids. Glucocorticoids have two principal roles: absolute level...
  • Stefano Pluchino Dr Stefano Pluchino
    Recent evidence from our own laboratory indicates that the systemic injection of somatic neural stem/precursor cells (NPCs) very efficiently protect the CNS from the chronic degeneration induced by inflammation both in small rodents as well as in ...
  • Ruma Raha-Chowdhury Dr Ruma Raha-Chowdhury
    My main interest is in innate immunity, inflammation and brain iron homeostasis. Inflammation and innate immunity are key players in Alzheimer’s disease (AD) and Down syndrome (DS). Individuals with DS have a spectrum of hematopoietic dysfunction...
  • Barbara Sahakian Professor Barbara Sahakian FMedSci DSc
    My research is aimed at understanding the neural basis of cognitive, emotional and behavioural dysfunction in order to develop more effective pharmacological and psychological treatments. The focus of my lab is on early detection, differential dia...
  • Olivia Sheppard
    The main focus of my research is to use mouse organotypic hippocampal slices as a model of Alzheimer's Disease.
  • Patrice Smith Professor Patrice Smith
    Promoting regeneration and repair of the damaged CNS, with a particular focus on understanding the contribution of neuronal intrinsic mechanisms in axon regeneration.
  • Dr Simon Stott
    I am interested in the development, maintenance and functioning of subsets of midbrain dopamine neurons, with a particular interest in Parkinson's disease. My current lab work involves examining gene expression in dopamine neurons in the human mi...
  • Natalie Valle Guzman Natalie Valle Guzman
    I work at the Brain Repair Centre as a neuropsychologist. I manage the Transeuro trial and assess Parkinson´s and Huntington's diaease patients in clinic with multiple neuropsychological assessments. I am particularly interested in cognitive enha...
  • Ms Heleen van 't Spijker
    The aim of my project is the investigation of the role of the neuronal pentraxins in the communication between the perineuronal nets and the synapse.
  • Jeroen Verheyen Jeroen Verheyen
    Nanomedicine and neuroscience have always been great passions of mine. My drive is towards creating nanotherapeutics that enable brain repair and regeneration. Currently, I am working on establishing a highly modular nanotechnology platform for ne...
  • Romina Vuono Dr Romina Vuono
    My research interests include: 1)Molecular mechanisms involved in the pathogenesis of Huntington's disease 2)Embryonic stem cells as a source for cell therapy in Parkinson's disease 3)Sleep and Circadian rhytm dysruption in Parkinson’s disease
  • Colin Watts Dr Colin Watts
    Lab-based research is focused on the genomics of glioblastoma (GBM) and in the role of glial progenitors in their evolution and development. We are also interested in developing patient-specific models of GBM to evaluate intra-tumour variability i...
  • Alice White Miss Alice White
    I am investigating the neural correlates of decision-making in patients with Huntington's Disease (HD). HD is a genetic neurodegenerative disease in which mutant forms of the huntingtin protein accumulate in the brain. Patients have three main typ...
  • Caroline Williams-Gray Dr Caroline Williams-Gray MRCP PhD
    My research aims to better define the clinical heterogeneity of Parkinson’s disease and to understand the neurobiological basis of this, with the ultimate goal of developing more targeted therapeutic strategies for different PD subtypes. Using epi...
  • Stevan Wing Dr Stevan Wing
    I am working with Roger Barker on Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB). We are finding new ways to model the dementia associated with α-synucleinopathies (PDD and DLB) in the hope that new therapies can be better ...
  • Dr Patrick Yu-Wai-Man PhD, FRCPath, FRCOphth
    I am an academic neuro-ophthalmologist with a major research interest in mitochondrial eye diseases. My research programme is currently focused on dissecting the molecular genetic basis and the disease mechanisms leading to progressive retinal g...

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