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  • Institute: Metabolic Science

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  • Dr Matthew Banton
    Using molecular and cellular techniques including confocal microscopy I am investigating how certain genes play a role in obesity through changes in appetite and metabolism.
  • Clemence Blouet Dr Clemence Blouet
    Impairments in central pathways regulating energy homeostasis can cause profound metabolic dysfunctions, but current knowledge is insufficient to develop safe and efficient therapies targeting these pathways. Brain metabolic sensing is based on th...
  • Miss Sophie Buller
    Our group studies hypothalamic nutrient sensing and its role in the regulation of energy balance.
  • Dr RATNASEKHAR CH
    Life is a cyclical chemical process from birth to death, which consists of developmental changes from single cell to adult and aging changes from adult to death. There are internal circannual cycles, circadian rhythms with in this birth to death ...
  • Tony Coll Dr Tony Coll
    My current research continues to focus upon the roles of the hypothalamus in the control of energy balance. Our current understanding of the central control of appetite has relied heavily upon mouse models and I continue to utilise the power of b...
  • Tamana Darwish Miss Tamana Darwish
    Feeding behaviour and metabolic state are regulated by many factors- one of the them being nutrient intake. I am interested in how the body responds physiologically the intake of nutrients, in particular to amino acids, which are known to promote ...
  • Mark Evans Dr Mark Evans
    My group are interested in (1) how brain detects changes in blood glucose and how this glucose-sensing interacts with peripheral metabolism; (2) how defences against hypoglycaemia (low blood sugar) may become abnormal in diabetes; (3) the short an...
  • Fiona Gribble Professor Fiona Gribble
    Endocrine communication between the gut and brain, relaying food-related signals that control appetite and metabolism.
  • Mark Gurnell Dr Mark Gurnell
    Current programmes of research: 1. endocrine basis of financial decision-making 2. genetic and acquired disorders of the hypothalamic-pituitary-thyroid axis 3. novel approaches to sparing hypothalamic-pituitary function in patients with sellar/par...
  • Dr Olympia Koulouri
    Olympia is an academic trainee in Endocrinology at the Wellcome Trust-MRC Institute of Metabolic Science. Her PhD studies, under the supervision of Dr Mark Gurnell and Dr Nadia Schoenmakers, focused on central disorders of thyroid function. She ...
  • Dr Brian Lam
    Functional genomics of the brain control of energy metabolism.
  • Florian Merkle Dr Florian Merkle
    My laboratory uses pluripotent stem cells to model human diseases that arise from the loss of aberrant function of neurons in the hypothalamus that regulate essential physiological and behavioural processes. In particular, obesity is thought to re...
  • Stephen O'Rahilly Professor Stephen O'Rahilly FRS FMedSci
    My research has been concerned with the elucidation of the basic causes of obesity and Type 2 diabetes at a molecular level and the translation of those discoveries into improved diagnosis and therapy for patients. My work has uncovered several p...
  • Dr Sofia Papadia
    I am interested in the neuronal control of obesity, investigating the molecular mechanisms and signalling pathways by which genes in the brain are regulating energy homeostasis. I have been a member of Prof. I.S. Farooqi's team from 2010-2014 at ...
  • Naomi Penfold Naomi Penfold
    I am a PhD student on the Wellcome Trust programme in Metabolic and Cardiovascular Disease. I work at the Institute of Metabolic Science in the lab of Professor Sue Ozanne. We are interested in how the early life environment (pre- and postnatal) c...
  • Joseph Polex Wolf Dr Joseph Polex Wolf
    I'm a Postdoctoral Research Associate based in Dr Giles Yeo's group within the Institute of Metabolic Science. Our group investigates the neural control of energy homeostasis, with focus on the genetic influences mediating hypothalamic food intak...
  • Frank Reimann Dr Frank Reimann
    Research in the lab is currently focusing on enteroendocrine cells, especially glucagon-like peptide-1 (GLP-1) secreting cells, which we hope to target in the treatment of diabetes and obesity. GLP-1 secreting cells are electrically excitable and ...
  • Anthony Tsang Dr Anthony Tsang
    Along the major research interest of Dr Blouet's group, my current research focus involves characterising amino acid sensing metabolic neural circuits, both anatomically and functionally. However, during my postgraduate studies, I received solid ...
  • Dr Agatha van der Klaauw
    I am currently working with Professor Sadaf Farooqi at the Institute of Metabolic Science. We use a number of genetic approaches, including whole-exome sequencing, to identify novel genes involved in hypothalamic development in patients with sever...
  • Miss Orla Woodward
    Insulin-like peptide 5 (Insl5), secreted from enteroendocrine L-cells in the distal region of the gastrointestinal tract, has been demonstrated to be an orexigenic hormone, with elevated levels of Insl5 following caloric restriction and Insl5 admi...
  • Giles Yeo Dr Giles Yeo
    I study brain control of body-weight, and currently have two main aims: Identifying new players in the hypothalamic control of energy balance. a. Genetic studies point to the brain as having a crucial role in modulating appetitive behaviour. A col...
  • Hisham  Ziauddeen Dr Hisham Ziauddeen MRCPsych PhD
    I am a Senior Clinical Research Associate working with Prof. Paul Fletcher. I work on brain reward systems using pharmacological fMRI and behavioural measures, to study the role of environmental influences and opioid and dopaminergic systems in co...

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