Dr Eleni Dimou Tau is a soluble protein interacting with tubulin to stabilize microtubules. Under pathological conditions, it becomes hyperphosphorylated and adopts a filamentous conformation with a pivotal role in Alzheimer’s Disease pathogenesis. Although tau ...
Dr Johnny HABCHI My research is focused on understanding the molecular principles underlying protein aggregation in neurodegenerative disorders. In particular, I am studying the molecular pathways through which the amyloid-beta peptide (Ab) aggregate and form depo...
Dr Maya Hanspal I am interested in the role that protein misfolding plays in neurodegenerative diseases. In recent years, much attention has been drawn to the concept of 'prion-like' aggregation and spatiotemporal spread of misfolding protein in neurodegenerative...
Professor David Klenerman Small soluble protein aggregates are thought to play a key role in the initial development of neurodegenerative diseases, such as Alzheimer’s and Parkinson’s disease, but are difficult to study using conventional methods due to their low concent...
Professor Tuomas Knowles We work on the physico-chemical properties and behaviour of biological molecules and soft materials. The research in the group is highly interdisciplinary. Members of the group have a wide range of backgrounds. We used methods from biochemistry, c...
Dr Janet Kumita Protein misfolding is associated with a wide range of human disorders including Alzheimer’s and Parkinson's diseases, systemic amyloidosis and Motor Neurone Disease. Due to the prevalence of these disorders it is crucial to increase our understand...
Professor Michele Vendruscolo Our research at the Centre for Misfolding Diseases (https://www.cmd.ch.cam.ac.uk/) is aimed at understanding the molecular origins of neurodegenerative disorders.
We have set up an interdisciplinary programme that brings together methods and conc...