Dr Zhongzhao Teng University positionSenior Research Associate Dr Zhongzhao Teng is pleased to consider applications from prospective PhD students. DepartmentsHome pagehttp://www.medschl.cam.ac.uk/radiology/ Research ThemeInterestsAtherosclerotic plaques are multi-component structures composed of a lipid core, calcium or haemorrhage enclosed by a fibrous cap, which can be captured by MRI. The rupture of atherosclerotic plaques is responsible for most clinical symptoms of heart attack and stroke. Evidence has shown the correlation between compositional features and plaque vulnerability. Moreover, plaques are subject to mechanical loading due to blood pressure and flow. The rupture possibly occurs if such loading exceeds its material strength. Therefore, critical mechanical conditions should be integrated with compositional features for an accurate vulnerability assessment. We focus on: 1) development of MR sequences 2) mechanical analysis using structure-only, CFD and FSI simulation 3) image processing 4) clinical studies to assess the risk of various compositional features and critical mechanical conditions 5) the pathological impact of stress/stretch concentration at cellular, molecular and genetic levels.  Local big deformation may lead to the rupture of neovessels resulting in the formation and expansion of intraplaque hemorrhage. View image full-size (1474x1045 pixels) Research Focus
EquipmentComputational modelling Magnetic resonance imaging (MRI) Collaborators
Associated News ItemsPublications2023He J, Yang W, Wu W, Sun X, Li S, Yin G, Zhuang B, Xu J, Zhou D, Zhang Y, Wang Y, Zhu L, Sharma P, Sirajuddin A, Teng Z, Kureshi F, Zhao S, Lu M (2023), “Clinical features, myocardial strain and tissue characteristics of heart failure with preserved ejection fraction in patients with obesity: A prospective cohort study” eClinicalMedicine 55: 1-13 2022Huang Y, Wang S, Luo T, Du H, Sun C, Sadat U, Schönlieb C, Gillard JH, Zhang J, Teng Z (2022), “Estimation of the zero-pressure computational start shape of atherosclerotic plaques: improving the backward displacement method with deformation gradient tensor” Journal of Biomechanics 131: 110910 Li Z, Luo T, Wang S, Jia H, Gong Q, Liu X, Sutcliffe MPF, Zhu H, Liu Q, Chen D, Xiong J, Teng Z (2022), “Mechanical and Histological Characteristics of Aortic Dissection Tissues ” Acta Biomaterialia S1742-7061(22)00179-9 Qin B, Chen S, Miao P, Teng Z (2022), “Cerebral Vessel Extraction: From Image Acquisition to Machine Learning” Frontiers in Neuroscience 16:972389 Shi Y, Zheng J, Yang N, Chen Y, Sun J, Zhang Y, Zhou X, Gao Y, Li S, Zhu H, Acosta-Cabronero J, Xia P, Teng Z (2022), “The effect of subbranch for the quantification of local hemodynamic environment in the coronary artery: a CTA-based computational fluid dynamic analysis” Emergency and Critical Care Medicine Shi Z, Jiang Y, Weir-McCall J, Wang X, Teng Z (2022), “COVID-19 and Atherosclerosis: looking beyond the acute crisis” Emergency and Critical Care Medicine Tokgoz A, Wang S, Sastry P, Sun C, Figg NL, Huang Y, Bennett MR, Sinha S, Gillard JH, Sutcliffe MPF, Teng Z (2022), “Association of collagen, elastin, glycosaminoglycans and macrophages with tissue ultimate material strength and stretch in human thoracic aortic aneurysms: a uniaxial tension study” Journal of Biomechanical Engineering 144(10): 101001 Yan Y, Lu Z, Ding Y, Pu J, Hu C, Teng Z, Hui P (2022), “Predictors of ischemic events in patients with unilateral extracranial vertebral artery dissection: A single-center exploratory study” Front. Neurol. 13: 939001 Yang D, Liu J, Yao W, Huang K, Zhou C, Cheng, X, Zhang L, Teng Z, Du J, Liu X (2022), “The MRI enhancement ratio and plaque steepness may be more accurate for predicting recurrent ischemic cerebrovascular events in patients with intracranial atherosclerosis” European Radiology 32(10): 7004-7013 Zhang R, Zhang Q, Ji A, Lv P, Acosta-Cabronero J, Fu C, Ding J, Guo D, Teng Z, Lin J (2022), “Prediction of new cerebral ischemic lesion after carotid artery stenting: a high-resolution vessel wall MRI-based radiomics analysis” European Radiology Zhu C, Wang X, Chen S, Teng Z, Bai C, Huang X, Xia M, Shao Z, Gu Z, Sun P (2022), “Complex carotid artery segmentation in multi-contrast MR sequences by improved optimal surface graph cuts based on flow line learning” Medical & Biological Engineering & Computing 60: 2693-2706 2021Bai X, Wang H, Ma L, Xu Y, Gan J, Fan Z, Yang F, Ma K, Yang J, Bai S, Shu S, Zou X, Huang R, Zhang C, Liu X, Tu D, Xu C, Zhang W, Wang X, Chen A, Zeng Y, Yang D, Wang M, Holalkere N, Halin NJ, Kamel IR, Wu J, Peng X, Wang X, Shao J, Mongkolwat P, Zhang J, Liu W, Roberts M, Teng Z, Beer L, Sanchez LE, Sala E, Rubin DL, Weller A, Lasenby J, Zheng C, Wang J, Li Z, Schönlieb C, Xia T (2021), “Advancing COVID-19 Diagnosis with Privacy-Preserving Collaboration in Artificial Intelligence” Nature Machine Intelligence Gu S, Costopoulos C, Huang Y, Bourantas C, Woolf A, Sun C, Teng Z, Losdat S, Räber L, Samady H, Bennett MR (2021), “High-intensity Statin Treatment Is Associated with Reduced Plaque Structural Stress and Remodelling of Artery Geometry and Plaque Architecture” European Heart Journal - Open He J, Yang W, Wu W, Li S, Yin G, Zhuang B, Xu J, Sun X, Zhou D, Wei B, Sirajuddin A, Teng Z, Zhao S, Kureshi F, Lu M (2021), “Early Diastolic Longitudinal Strain Rate by MRI and Outcomes in Heart Failure with Preserved Ejection Fraction” Radiology Huang X, Mao L, Wang X, Teng Z, Shao M, Gao J, Xia M, Shao Z (2021), “Multi-Sequence MRI Registration of Atherosclerotic Carotid Arteries Based on Cross-Scale Siamese Network” Front. 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Nature Machine Intelligence 3: 199-217 Shi Z, Tian X, Tian B, Meddings Z, Zhang X, Li J, Saloner D, Liu Q, Teng Z, Lu J (2021), “Identification of high risk clinical and imaging features for intracranial artery dissection using high-resolution MRI” Journal of Cardiovascular Magnetic Resonance 23: 74 Shi Z, Zhao M, Li J, Meddings Z, Shi Y, Jiang T, Liu Q, Deng B, Lu J, Teng Z (2021), “Association of hypertension with both occurrence and outcome of symptomatic patients with mild intracranial atherosclerotic stenosis: a prospective higher resolution MRI study” Journal of Magnetic Resonance Imaging 54(1): 76-88 Teng Z, Wang S, Tokgoz A, Taviani V, Bird J, Sadat U, Huang Y, Patterson AJ, Figg N, Graves MJ, Gillard JH (2021), “Study on the association of wall shear stress and vessel structural stress with atherosclerosis: an experimental animal study” Atherosclerosis 320: 38-46 Wan S, Liu X, Jiang H, Teng Z, Song B (2021), “Noninvasive imaging assessment of portal hypertension: where are we 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Brown AJ, Davis EL, Teng Z, Gillard JH, Samady H, Bennett MR (2019), “Impact of combined plaque structural stress and wall shear stress on coronary plaque progression, regression and changes in composition” European Heart Journal 40: 1411–1422 Wang S, Tokgoz A, Huang Y, Zhang Y, Feng J, Sastry P, Sun C, Figg N, Lu Q, Sutcliffe MPF, Teng Z, Gillard JH (2019), “ Bayesian inference-based estimation of normal aortic, aneurysmal and atherosclerotic tissue mechanical properties: from material testing, modelling and histology” IEEE Transactions on Biomedical Engineering 66(8): 2269-2278 Wang S, Zhang Y, Feng J, Huang Y, Hui P, Gillard JH, Lu Q, Teng Z (2019), “The role of porosity and 3D cross-stent configuration of multiple overlapping uncovered stents in the management of complex aortic aneurysms – insights from haemodynamics” Medicine in Novel Technology and Devices 2018Wang D, Zhang R, Zhu J, Teng Z, Huang Y, Spiga F, Du M, Gillard JH, Lu Q, Lio P (2018), “Neural network fusion: a novel 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AJ, Teng Z, Saloner D, Lu J (2017), “Identification and Quantitative Assessment of Different Components of Intracranial Atherosclerotic Plaque by Ex Vivo 3T High-Resolution Multicontrast MRI” American Journal of Neuroradiology 38 (9): 1716-1722 Tang D, Yang C, Huang S, Mani V, Zheng J, Woodard PK, Robson P, Teng Z, Dweck M, Fayad ZA (2017), “Cap Inflammation Leads to Higher Plaque Cap Strain and Lower Cap Stress: An MRI-PET/CT-Based FSI Modeling Approach” Journal of Biomechanics 50: 121-129 Teng Z, Brown AJ, Gillard JH (2017), “Carotid Intraplaque Hemorrhage: a Biomarker for Subsequent Ischemic Cerebrovascular Event?” Cerebrovascular Diseases 43: 257-258 Usman A, Sadat U, Teng Z, Graves MJ, Boyle JR, Varty K, Hayes PD, Gillard JH (2017), “Magnetic Resonance Imaging-Based Assessment of Carotid Atheroma: a Comparative Study of Patients with and without Coronary Artery Disease” Journal of Stroke and Cerebrovascular Diseases 26(2):347-351 Wang D, Teng Z, Spiga F, Huang Y, Du H, Gillard JH, Lu Q, Lio P (2017), “Cross-Net: Convolutional Network for Biomedical Image Segmentation” SPIE Medical Imaging Wang S, Zhang Y, Feng J, Huang Y, Tokgoz A, Sadat U, Gillard JH, Lu Q, Teng Z (2017), “Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: a patient-specific parameter study” Journal of Biomechanics 60: 188-196 2016Brown AJ, Teng Z, Calvert PA, Rajani NK, Hennessy O, Obaid DR, Costopoulos C, Huang Y, Hoole SP, Goddard M, West NEJ, Gillard JH, Bennett MR (2016), “Plaque structural stress estimations improve prediction of future major adverse cardiovascular events following intracoronary imaging” Circulation Cardiovascular Imaging 9(6): pii: e004172 Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR (2016), “The role of biomechanical forces in the natural history of coronary atherosclerosis” Nature Reviews Cardiology 13(4): 210-220 Costopoulos C, Brown AJ, Teng Z, Hoole SP, West NE, Samady H, Bennett MR (2016), “Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis” International Journal of Cardiovascular Imaging 32(1):189-200 Eshtehardi P, Teng Z (2016), “Protective or Destructive: High Wall Shear Stress and Atherosclerosis” Atherosclerosis 251: 501-503 Filipovic N, Radovic M, Isailovic V, Milosevic Z, Nikolic D, Saveljic I, Nikolic M, Dukic T, Cirkovic-Andelkovic B, Exarchos T, Meunier N, Teng Z, Fotiadis D, Bohnke F, Parodi O (2016), “A summary of results in modeling plaque formation and development, cochlea mechanics and vestibular disorders” Journal of Serbian Society for Computational Mechanics 10(1): 20-33 Gupta A, Baradaran H, Al-Dasuqi K, Knight-Greenfield A, Giambrone AE, Delgado D, Wright D, Teng Z, Min JK, Navi BB, Iadecola C, Kamel H (2016), “Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis” J Am Heart Assoc 5(8): pii: e003816 Huang Y, Teng Z, Elkhawad M, Tarkin JM, Joshi N, Boyle JR, Buscombe JR, Fryer TD, Zhang Y, Park AY, Wilkinson IB, Newby DE , Gillard JH, Rudd JHF (2016), “High structural stress and presence of intraluminal thrombus predict abdominal aortic aneurysm 18F-FDG uptake: Insights from biomechanics” Circulation Cardiovascular Imaging 9(11): pii: e004656 Jiang Y, Peng W, Teng Z, Gillard JH, Hong B, Liu Q, Lu J (2016), “Local blood pressure associates with the degree of luminal stenosis in patients with atherosclerotic disease in the middle cerebral artery” BioMedical Engineering OnLine 15(1): 67 Jiang Y, Zhu C, Peng W, Degnan AJ, Chen L, Wang X, Liu Q, Wang Y, Xiang Z, Teng Z, Saloner D, Lu J (2016), “Ex-vivo Imaging and Plaque Type Classification of Intracranial Atherosclerotic Plaque using High Resolution MRI” Atherosclerosis 249:10-6 Speelman L, Teng Z, Nederveen AJ, der Lugt AV, Gillard JH (2016), “MRI based biomechanical parameters for carotid artery plaque vulnerability assessment” Thrombosis and Haemostasis 115(3): 493-500 Teng Z, Brown AJ, Gillard JH (2016), “From ultrasonography to high resolution magnetic resonance imaging: towards an optimal management strategy for vulnerable carotid atherosclerotic plaques” EBioMedicine 3: 2-3 Teng Z, Peng W, Zhan Q, Zhang X, Liu Q, Chen S, Tian X, Chen L, Brown AJ, Graves MJ, Gillard JH, Lu J (2016), “An assessment on the incremental value of high-resolution magnetic resonance imaging to identify culprit plaques in atherosclerotic disease of the middle cerebral artery” European Radiology 26(7): 2206-14 2015Athanasiou LS, Rigas G, Sakellarios A, Bourantas CV, Stefanou K, Fotiou E, Exarchos TP, Siogkas P, Naka KK, Parodi O, Vozzi F, Teng Z, Young VE, Gillard JH, Prati F, Michalis LK, Fotiadis DI (2015), “Error propagation in the characterization of atheromatic plaque types based on imaging.” Comput Methods Programs Biomed 121(3):161-74 Details Brown AJ, Obaid DR, Costopoulos C, Parker R, Calvert PA, Teng Z, Hoole SP, West ENJ, Goddard M, Bennett MR (2015), “Identification of advanced atherosclerotic coronary plaques using virtual-histology intravascular ultrasound and optical coherence tomography” Circulation: Cardiovascular Imaging 8(10): e003487 Lu Q, Feng J, Zhou J, Zhao Z, Li H, Teng Z, Jing Z (2015), “Endovascular Repair By Customized Branched Stent-Graft: A Promising Treatment For Chronic Aortic Dissection Involving The Arch Branches” The Journal of Thoracic and Cardiovascular Surgery 150(6):1631-1638 Makris GC, Teng Z, Patterson AJ, Lin JM, Young V, Graves MJ, Gillard JH (2015), “Advances in MRI for the evaluation of carotid atherosclerosis.” Br J Radiol 88(1052):20140282 Details Peng W, Teng Z, Jiang Y, Chen S, Liu Q, Lu J (2015), “Study on the symptomatic atherosclerosis in the middle cerebral artery based on in vivo magnetic resonance imaging” Radiologic Practice 30(12): 1195-1202 Teng Z, Feng J, Zhang Y, Huang Y, Sutcliffe MP, Brown AJ, Jing Z, Gillard JH, Lu Q (2015), “Layer- and Direction-Specific Material Properties, Extreme Extensibility and Ultimate Material Strength of Human Abdominal Aorta and Aneurysm: A Uniaxial Extension Study.” Ann Biomed Eng Details Teng Z, Feng J, Zhang Y, Sutcliffe MPF, Huang Y, Brown AJ, Jing Z, Lu Q, Gillard JH (2015), “A uni-extension study on the ultimate material strength and extreme extensibility of atherosclerotic tissue in human carotid plaques” Journal of Biomechanics 48(14): 3859-3867 Teng Z, Yuan J, Feng J, Zhang Y, Brown AJ, Wang S, Lu Q, Gillard JH (2015), “The influence of constitutive law choice used to characterise atherosclerotic tissue material properties on computing stress values in human carotid plaques” Journal of Biomechanics 48(14): 3912-3921 Yuan J, Teng Z, Feng J, Zhang Y, Brown AJ, Gillard JH, Jing Z, Lu Q (2015), “Influence of material property variability on the mechanical behaviour of carotid atherosclerotic plaques: A 3D fluid-structure interaction analysis.” Int J Numer Method Biomed Eng 31(8) Details Zhang X, Zhu C, Peng W, Tian B, Chen L, Teng Z, Lu J, Sadat U, Saloner D, Liu Q (2015), “Scan-Rescan Reproducibility of High Resolution Magnetic Resonance Imaging of Atherosclerotic Plaque in the Middle Cerebral Artery.” PLoS One 10(8):e0134913 Details 2014Huang Y, Teng Z, Sadat U, Graves MJ, Bennett MR, Gillard JH (2014), “The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses.” J Biomech 47(6):1465-71 Details Teng Z, Brown AJ, Calvert PA, Parker RA, Obaid DR, Huang Y, Hoole SP, West NE, Gillard JH, Bennett MR (2014), “Coronary plaque structural stress is associated with plaque composition and subtype and higher in acute coronary syndrome: the BEACON I (Biomechanical Evaluation of Atheromatous Coronary Arteries) study.” Circ Cardiovasc Imaging 7(3):461-70 Details Teng Z, Sadat U, Brown AJ, Gillard JH (2014), “Plaque hemorrhage in carotid artery disease: pathogenesis, clinical and biomechanical considerations.” J Biomech 47(4):847-58 Details Teng Z, Zhang Y, Huang Y, Feng J, Yuan J, Lu Q, Sutcliffe MP, Brown AJ, Jing Z, Gillard JH (2014), “Material properties of components in human carotid atherosclerotic plaques: A uniaxial extension study.” Acta Biomater 10(12):5055-63 Details Zhang J, Chen L, Wang X, Teng Z, Brown AJ, Gillard JH, Guan Q, Chen S (2014), “Compounding Local Invariant Features and Global Deformable Geometry for Medical Image Registration.” PLoS One 9(8):e105815 Details Zhang Y, Lu Q, Feng J, Yu P, Zhang S, Teng Z, Gillard JH, Song R, Jing Z (2014), “A Pilot Study Exploring the Mechanisms Involved in the Longitudinal Propagation of Acute Aortic Dissection through Computational Fluid Dynamic Analysis.” Cardiology 128(2):220-225 Details Zhang Y, Teng Z, Lu Q, Zhao Z, Bao J, Feng X, Feng R, Chen Z, Huang Y, Sadat U, Gillard JH, Jing Z (2014), “Management of complicated aortic aneurysms using multiple overlapping uncovered stents: mid-term outcome from a cohort study.” Medicine (Baltimore) 93(27):e209 Details Zhongzhao Teng, Jing He, Sadat U, Mercer JR, Xiaoyan Wang, Bahaei NS, Thomas OM, Gillard JH (2014), “How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study.” IEEE Trans Biomed Eng 61(1):35-40 Details Zhu C, Sadat U, Patterson AJ, Teng Z, Gillard JH, Graves MJ (2014), “3D high-resolution contrast enhanced MRI of carotid atheroma - a technical update.” Magn Reson Imaging 32(5):594-7 Details 2013Filipovic N, Teng Z, Radovic M, Saveljic I, Fotiadis D, Parodi O (2013), “Computer simulation of three-dimensional plaque formation and progression in the carotid artery.” Med Biol Eng Comput 51(6):607-16 Details Huang Y, Teng Z, Sadat U, He J, Graves MJ, Gillard JH (2013), “In vivo MRI-based simulation of fatigue process: a possible trigger for human carotid atherosclerotic plaque rupture.” Biomed Eng Online 12(1):36 Details Liu Q, Huang J, Degnan AJ, Chen S, Gillard JH, Teng Z, Lu J (2013), “Comparison of high-resolution MRI with CT angiography and digital subtraction angiography for the evaluation of middle cerebral artery atherosclerotic steno-occlusive disease.” Int J Cardiovasc Imaging 29(7):1491-8 Details Teng Z, Sadat U (2013), “Editorial (Hot Topic: Translational Application of In Vivo Imaging and Mechanical Analysis for Atherosclerotic Plaque Vulnerability Assessment)” Recent Patents on Medical Imaging 3(1): 2-2 Teng Z, Sadat U, Gillard JH (2013), “Translational Application of Combining Magnetic Resonance Imaging and Biomechanical Analysis in Carotid Plaque Vulnerability Assessment” Recent Patent on Medical Imaging 3(1): 3-13 Teng Z, Sadat U, Wang W, Bahaei NS, Chen S, Young VE, Graves MJ, Gillard JH (2013), “Intraplaque stretch in carotid atherosclerotic plaque - an effective biomechanical predictor for subsequent cerebrovascular ischemic events.” PLoS One 8(4):e61522 Details 2012Degnan AJ, Gallagher G, Teng Z, Lu J, Liu Q, Gillard JH (2012), “MR angiography and imaging for the evaluation of middle cerebral artery atherosclerotic disease.” AJNR Am J Neuroradiol 33(8):1427-35 Details Huang J, Degnan AJ, Liu Q, Teng Z, Yue CS, Gillard JH, Lu JP (2012), “Comparison of NASCET and WASID criteria for the measurement of intracranial stenosis using digital subtraction and computed tomography angiography of the middle cerebral artery.” J Neuroradiol 39(5):342-5 Details Liu H, Canton G, Yuan C, Yang C, Billiar K, Teng Z, Hoffman AH, Tang D (2012), “Using in vivo Cine and 3D multi-contrast MRI to determine human atherosclerotic carotid artery material properties and circumferential shrinkage rate and their impact on stress/strain predictions.” J Biomech Eng 134(1):011008 Details Teng Z, He J, Degnan AJ, Chen S, Sadat U, Bahaei NS, Rudd JH, Gillard JH (2012), “Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage.” Atherosclerosis 223(2):321-6 Details Teng Z, Trabelsi O, Ochoa I, He J, Gillard JH, Doblare M (2012), “Anisotropic material behaviours of soft tissues in human trachea: An experimental study.” J Biomech 45(9):1717-23 Details 2011Huang Y, Teng Z, Sadat U, Hilborne S, Young VE, Graves MJ, Gillard JH (2011), “Non-uniform shrinkage for obtaining computational start shape for in-vivo MRI-based plaque vulnerability assessment.” J Biomech 44(12):2316-9 Details Sadat U, Taviani V, Patterson AJ, Young VE, Graves MJ, Teng Z, Tang TY, Gillard JH (2011), “Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms--a feasibility study.” Eur J Vasc Endovasc Surg 41(2):167-74 Details Sadat U, Teng Z, Young VE, Graves MJ, Gaunt ME, Gillard JH (2011), “High-resolution magnetic resonance imaging-based biomechanical stress analysis of carotid atheroma: a comparison of single transient ischaemic attack, recurrent transient ischaemic attacks, non-disabling stroke and asymptomatic patient groups.” Eur J Vasc Endovasc Surg 41(1):83-90 Details Sadat U, Teng Z, Young VE, Li ZY, Gillard JH (2011), “Utility of magnetic resonance imaging-based finite element analysis for the biomechanical stress analysis of hemorrhagic and non-hemorrhagic carotid plaques.” Circ J 75(4):884-9 Details Sadat U, Teng Z, Young VE, Zhu C, Tang TY, Graves MJ, Gillard JH (2011), “Impact of plaque haemorrhage and its age on structural stresses in atherosclerotic plaques of patients with carotid artery disease: an MR imaging-based finite element simulation study.” Int J Cardiovasc Imaging 27(3):397-402 Details Teng Z, Degnan AJ, Sadat U, Wang F, Young VE, Graves MJ, Chen S, Gillard JH (2011), “Characterization of healing following atherosclerotic carotid plaque rupture in acutely symptomatic patients: an exploratory study using in vivo cardiovascular magnetic resonance.” J Cardiovasc Magn Reson 13(1):64 Details Teng Z, Sadat U, Huang Y, Young VE, Graves MJ, Lu J, Gillard JH (2011), “In vivo MRI-based 3D Mechanical Stress-Strain Profiles of Carotid Plaques with Juxtaluminal Plaque Haemorrhage: An Exploratory Study for the Mechanism of Subsequent Cerebrovascular Events.” Eur J Vasc Endovasc Surg 42(4):427-33 Details Teng Z, Sadat U, Ji G, Zhu C, Young VE, Graves MJ, Gillard JH (2011), “Lumen irregularity dominates the relationship between mechanical stress condition, fibrous-cap thickness, and lumen curvature in carotid atherosclerotic plaque.” J Biomech Eng 133(3):034501 Details 2010Huang X, Teng Z, Canton G, Ferguson M, Yuan C, Tang D (2010), “Intraplaque hemorrhage is associated with higher structural stresses in human atherosclerotic plaques: an in vivo MRI-based 3d fluid-structure interaction study.” Biomed Eng Online 9(1):86 Details Sadat U, Teng Z, Gillard JH (2010), “Biomechanical structural stresses of atherosclerotic plaques.” Expert Rev Cardiovasc Ther 8(10):1469-81 Details Sadat U, Teng Z, Young VE, Graves MJ, Gillard JH (2010), “Three-dimensional volumetric analysis of atherosclerotic plaques: a magnetic resonance imaging-based study of patients with moderate stenosis carotid artery disease.” Int J Cardiovasc Imaging 26(8):897-904 Details Sadat U, Teng Z, Young VE, Walsh SR, Li ZY, Graves MJ, Varty K, Gillard JH (2010), “Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events--a longitudinal in vivo magnetic resonance imaging-based finite element study.” Eur J Vasc Endovasc Surg 40(4):485-91 Details Teng Z, Canton G, Yuan C, Ferguson M, Yang C, Huang X, Zheng J, Woodard PK, Tang D (2010), “3D critical plaque wall stress is a better predictor of carotid plaque rupture sites than flow shear stress: An in vivo MRI-based 3D FSI study.” J Biomech Eng 132(3):031007 Details Teng Z, Sadat U, Li Z, Huang X, Zhu C, Young VE, Graves MJ, Gillard JH (2010), “Arterial Luminal Curvature and Fibrous-Cap Thickness Affect Critical Stress Conditions Within Atherosclerotic Plaque: An In Vivo MRI-Based 2D Finite-Element Study.” Ann Biomed Eng 38(10):3096-101 Details Umar Sadat, Zhongzhao Teng, Jonathan H Gillard (2010), “Association Between Biomechanical Stresses of Atherosclerotic Carotid Plaques and Subsequent Ischaemic Cerebrovascular Events” Circulation 122: 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