Dr Zhongzhao Teng

Zhongzhao Teng

University position

Senior Research Associate

Dr Zhongzhao Teng is pleased to consider applications from prospective PhD students.


Department of Radiology



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Research Theme

Systems and Computational Neuroscience


Atherosclerotic plaques are multi-component structures composed of a lipid core, calcium or haemorrhage enclosed by a fibrous cap, which can be captured by MRI. The rupture of atherosclerotic plaques is responsible for most clinical symptoms of heart attack and stroke. Evidence has shown the correlation between compositional features and plaque vulnerability. Moreover, plaques are subject to mechanical loading due to blood pressure and flow. The rupture possibly occurs if such loading exceeds its material strength. Therefore, critical mechanical conditions should be integrated with compositional features for an accurate vulnerability assessment. We focus on: 1) development of MR sequences 2) mechanical analysis using structure-only, CFD and FSI simulation 3) image processing 4) clinical studies to assess the risk of various compositional features and critical mechanical conditions 5) the pathological impact of stress/stretch concentration at cellular, molecular and genetic levels.

Local big deformation may lead to the rupture of neovessels resulting in the formation and expansion of intraplaque hemorrhage.
Local big deformation may lead to the rupture of neovessels resulting in the formation and expansion of intraplaque hemorrhage.
View image full-size (1474x1045 pixels)

Research Focus





Medical Imaging

Biological Tissue

Clinical conditions

Heart attack



Computational modelling

Magnetic resonance imaging (MRI)



Umar Sadat

United Kingdom

Martin Bennett Web: http://www.med.cam.ac.uk/bennett/

Martin Graves Web: http://www.medschl.cam.ac.uk/radiolo...

Yike Guo Web: https://www.imperial.ac.uk/people/...

Pietro Lio Web: https://www.cl.cam.ac.uk/~pl219/

James Rudd Web: http://www.med.cam.ac.uk/rudd/

Associated News Items



    He J, Yang W, Wu W, Sun X, Li S, Yin G, Zhuang B, Xu J, Zhou D, Zhang Y, Wang Y, Zhu L, Sharma P, Sirajuddin A, Teng Z, Kureshi F, Zhao S, Lu M (2023), “Clinical features, myocardial strain and tissue characteristics of heart failure with preserved ejection fraction in patients with obesity: A prospective cohort study” eClinicalMedicine 55: 1-13


    Huang Y, Wang S, Luo T, Du H, Sun C, Sadat U, Schönlieb C, Gillard JH, Zhang J, Teng Z (2022), “Estimation of the zero-pressure computational start shape of atherosclerotic plaques: improving the backward displacement method with deformation gradient tensor” Journal of Biomechanics 131: 110910

    Li Z, Luo T, Wang S, Jia H, Gong Q, Liu X, Sutcliffe MPF, Zhu H, Liu Q, Chen D, Xiong J, Teng Z (2022), “Mechanical and Histological Characteristics of Aortic Dissection Tissues ” Acta Biomaterialia S1742-7061(22)00179-9

    Qin B, Chen S, Miao P, Teng Z (2022), “Cerebral Vessel Extraction: From Image Acquisition to Machine Learning” Frontiers in Neuroscience 16:972389

    Shi Y, Zheng J, Yang N, Chen Y, Sun J, Zhang Y, Zhou X, Gao Y, Li S, Zhu H, Acosta-Cabronero J, Xia P, Teng Z (2022), “The effect of subbranch for the quantification of local hemodynamic environment in the coronary artery: a CTA-based computational fluid dynamic analysis” Emergency and Critical Care Medicine

    Shi Z, Jiang Y, Weir-McCall J, Wang X, Teng Z (2022), “COVID-19 and Atherosclerosis: looking beyond the acute crisis” Emergency and Critical Care Medicine

    Tokgoz A, Wang S, Sastry P, Sun C, Figg NL, Huang Y, Bennett MR, Sinha S, Gillard JH, Sutcliffe MPF, Teng Z (2022), “Association of collagen, elastin, glycosaminoglycans and macrophages with tissue ultimate material strength and stretch in human thoracic aortic aneurysms: a uniaxial tension study” Journal of Biomechanical Engineering 144(10): 101001

    Yan Y, Lu Z, Ding Y, Pu J, Hu C, Teng Z, Hui P (2022), “Predictors of ischemic events in patients with unilateral extracranial vertebral artery dissection: A single-center exploratory study” Front. Neurol. 13: 939001

    Yang D, Liu J, Yao W, Huang K, Zhou C, Cheng, X, Zhang L, Teng Z, Du J, Liu X (2022), “The MRI enhancement ratio and plaque steepness may be more accurate for predicting recurrent ischemic cerebrovascular events in patients with intracranial atherosclerosis” European Radiology 32(10): 7004-7013

    Zhang R, Zhang Q, Ji A, Lv P, Acosta-Cabronero J, Fu C, Ding J, Guo D, Teng Z, Lin J (2022), “Prediction of new cerebral ischemic lesion after carotid artery stenting: a high-resolution vessel wall MRI-based radiomics analysis” European Radiology

    Zhu C, Wang X, Chen S, Teng Z, Bai C, Huang X, Xia M, Shao Z, Gu Z, Sun P (2022), “Complex carotid artery segmentation in multi-contrast MR sequences by improved optimal surface graph cuts based on flow line learning” Medical & Biological Engineering & Computing 60: 2693-2706


    Bai X, Wang H, Ma L, Xu Y, Gan J, Fan Z, Yang F, Ma K, Yang J, Bai S, Shu S, Zou X, Huang R, Zhang C, Liu X, Tu D, Xu C, Zhang W, Wang X, Chen A, Zeng Y, Yang D, Wang M, Holalkere N, Halin NJ, Kamel IR, Wu J, Peng X, Wang X, Shao J, Mongkolwat P, Zhang J, Liu W, Roberts M, Teng Z, Beer L, Sanchez LE, Sala E, Rubin DL, Weller A, Lasenby J, Zheng C, Wang J, Li Z, Schönlieb C, Xia T (2021), “Advancing COVID-19 Diagnosis with Privacy-Preserving Collaboration in Artificial Intelligence” Nature Machine Intelligence

    Gu S, Costopoulos C, Huang Y, Bourantas C, Woolf A, Sun C, Teng Z, Losdat S, Räber L, Samady H, Bennett MR (2021), “High-intensity Statin Treatment Is Associated with Reduced Plaque Structural Stress and Remodelling of Artery Geometry and Plaque Architecture” European Heart Journal - Open

    He J, Yang W, Wu W, Li S, Yin G, Zhuang B, Xu J, Sun X, Zhou D, Wei B, Sirajuddin A, Teng Z, Zhao S, Kureshi F, Lu M (2021), “Early Diastolic Longitudinal Strain Rate by MRI and Outcomes in Heart Failure with Preserved Ejection Fraction” Radiology

    Huang X, Mao L, Wang X, Teng Z, Shao M, Gao J, Xia M, Shao Z (2021), “Multi-Sequence MRI Registration of Atherosclerotic Carotid Arteries Based on Cross-Scale Siamese Network” Front. Cardiovasc. Med. 8:785523

    Li F, Wang S, Gao Q, Chen X, Yin G, Yu C, Wang Y, Wang X, Qiao E , Meddings Z, Wang W, Zhao S, Teng Z (2021), “Vessel structural stress mediates aortic media degeneration in bicuspid aortopathy: new insights based on patient-specific fluid-structure interaction analysis” Journal of Biomechanics

    Li S, Duan X, Feng G, Sirajuddin A, Yin G, Zhuang B, He J, Xu J, Yang W, Wu W, Sun X, Zhao S, Wang H, Teng Z, Lu M (2021), “Multiparametric Cardiovascular Magnetic Resonance in Acute Myocarditis: Comparison of 2009 and 2018 Lake Louise Criteria With Endomyocardial Biopsy Confirmation” Frontiers in Cardiovascular Medicine 8: 739892

    Roberts M, Driggs D, Thorpe M, Gilbey J, Yeung M, Ursprung S, Aviles-Rivero A, Etmann C, McCague C, Beer L, Weir-McCall J, Teng Z, Rudd J, Sala E, Schönlieb C, Gkrania-Klotsas E, AIX-COVNET Collaboration (2021), “Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans” Nature Machine Intelligence 3: 199-217

    Shi Z, Tian X, Tian B, Meddings Z, Zhang X, Li J, Saloner D, Liu Q, Teng Z, Lu J (2021), “Identification of high risk clinical and imaging features for intracranial artery dissection using high-resolution MRI” Journal of Cardiovascular Magnetic Resonance 23: 74

    Shi Z, Zhao M, Li J, Meddings Z, Shi Y, Jiang T, Liu Q, Deng B, Lu J, Teng Z (2021), “Association of hypertension with both occurrence and outcome of symptomatic patients with mild intracranial atherosclerotic stenosis: a prospective higher resolution MRI study” Journal of Magnetic Resonance Imaging 54(1): 76-88

    Teng Z, Wang S, Tokgoz A, Taviani V, Bird J, Sadat U, Huang Y, Patterson AJ, Figg N, Graves MJ, Gillard JH (2021), “Study on the association of wall shear stress and vessel structural stress with atherosclerosis: an experimental animal study” Atherosclerosis 320: 38-46

    Wan S, Liu X, Jiang H, Teng Z, Song B (2021), “Noninvasive imaging assessment of portal hypertension: where are we now and where does the future lie?” Expert Review of Molecular Diagnostics 21(4): 343-345

    Zhang Y, Huang Y, Teng Z, Cui J, Lu Q, Jing Z (2021), “Biomechanical insight of the stent-induced thrombosis following flow-diverting strategy in the management of complicated aortic aneurysms” International Angiology 40(1): 52-59

    Zhu C, Wang X, Teng Z, Chen S, Huang X, Xia M, Mao L, Bai C (2021), “Cascaded Residual U-net for Fully Automatic Segmentation of 3D Carotid Artery in High-Resolution Multi-Contrast MR Images” Physics in Medicine and Biology 66: 045033


    Costopoulos C, Costopoulos A, Huang Y, Brown AJ, Gillard JH, Teng Z, Stone GW, Bennett MR (2020), “Heterogeneity of Plaque Structural Stress Is Increased in Plaques Leading to MACE Insights From the PROSPECT Study” JACC: Cardiovascular Imaging 13(5): 1206-1218

    Joshi N, Elkhawad M, Tarkin J, Chowdhury M, Boyle J, Fryer T, Huang Y, Teng Z, Coughlin P, Wilkinson I, Rudd J (2020), “Greater aortic inflammation and calcification in abdominal aortic aneurysms than atherosclerosis” BMJ Open Heart 7(1): e001141

    Shi Z, Li J, Zhao M, Peng W, Meddings Z, Jiang T, Liu Q, Teng Z, Lu J (2020), “Quantitative histogram analysis on intracranial atherosclerotic plaques: a pilot study using high resolution magnetic resonance imaging” Stoke 51: 2161-2169

    Wang S, Yang X, Li Li, Nadler P, Arcucci R, Huang Y, Teng Z, Guo Y (2020), “A Bayesian Updating Scheme for Pandemics: Estimating the Infection Dynamics of COVID-19” IEEE Computational Intelligence Magazine 15(4): 23-33

    Yang W, Sirajuddin A, Zhang X, Liu G, Teng Z, Zhao S, Lu M (2020), “The role of imaging in 2019 novel coronavirus pneumonia (COVID-19)” European Radiology 30(9): 4874-4882


    Clement M, Chen X, Chenoweth H, Teng Z, Thome S, Newland SA, Harrison J, Yu X, Finigan AJ, Mallat Z, Li X (2019), “MARK4-dependent inflammasome activation promotes atherosclerosis” Arteriosclerosis, Thrombosis, and Vascular Biology 39:1645-1651

    Costopoulos C, Timmins LH, Huang Y, Hung OY, Molony DS, Brown AJ, Davis EL, Teng Z, Gillard JH, Samady H, Bennett MR (2019), “Impact of combined plaque structural stress and wall shear stress on coronary plaque progression, regression and changes in composition” European Heart Journal 40: 1411–1422

    Wang S, Tokgoz A, Huang Y, Zhang Y, Feng J, Sastry P, Sun C, Figg N, Lu Q, Sutcliffe MPF, Teng Z, Gillard JH (2019), “ Bayesian inference-based estimation of normal aortic, aneurysmal and atherosclerotic tissue mechanical properties: from material testing, modelling and histology” IEEE Transactions on Biomedical Engineering 66(8): 2269-2278

    Wang S, Zhang Y, Feng J, Huang Y, Hui P, Gillard JH, Lu Q, Teng Z (2019), “The role of porosity and 3D cross-stent configuration of multiple overlapping uncovered stents in the management of complex aortic aneurysms – insights from haemodynamics” Medicine in Novel Technology and Devices


    Wang D, Zhang R, Zhu J, Teng Z, Huang Y, Spiga F, Du M, Gillard JH, Lu Q, Lio P (2018), “Neural network fusion: a novel CT-MR aortic aneurysm image segmentation method” Medical Imaging 2018: Image Processing 10574: 1057424

    Yang J, Pan X, Zhang B, Yan Y, Huang Y, Woolf AK, Gillard JH, Teng Z, Hui P (2018), “Superficial and Multiple Calcifications and Ulceration Associate with Intraplaque Hemorrhage in the Carotid Atherosclerotic Plaque” European Radiology 28: 4968-4977

    Yuan J, Makris G, Patterson A, Usman A, Das T, Priest A, Teng Z, Hilborne S, Prudencio D, Gillard J, Graves M (2018), “Relationship between carotid plaque surface morphology and perfusion: a 3D DCE-MRI study” Magnetic Resonance Materials in Physics, Biology and Medicine 31(1): 191-199

    Zhang J, Teng Z, Guan Q, He J, Abutalebm W, Patterson AJ, Graves MJ, Gillard JH, Chen S (2018), “Automatic segmentation of magnetic resonance depicted carotid arterial boundary based on local priors and constrained global optimization” IET Image Processing

    Zhu C, Tian X, Degnan AJ, Shi Z, Zhang X, Chen L, Teng Z, Saloner D, Lu J, Liu Q (2018), “Clinical Significance of Intraplaque Hemorrhage in Low- and High-Grade Basilar Artery Stenosis on High-Resolution MRI” AJNR Am J Neuroradiol 39(7): 1286-1292


    Costopoulos C, Huang Y, Brown AJ, Calvert PA, Hoole SP, West NE, Gillard JH, Teng Z, Bennett MR (2017), “Plaque rupture in coronary atherosclerosis is associated with increased plaque structural stress” JACC: Cardiovascular Imaging 10(12): 1472-1483

    Douglas GR, Brown AJ, Gillard JH, Bennett MR, Sutcliffe MPF, Teng Z (2017), “Impact of fiber structure on the material stability and rupture mechanisms of coronary atherosclerotic plaques” Annals of Biomedical Engineering 45(6):1462-1474

    Hoffman AH, Teng Z, Zheng J, Wu Z, Woodard P, Billiar K, Wang L, Tang D (2017), “Stiffness Properties of Adventitia, Media and Full Thickness Human Atherosclerotic Carotid Arteries in the Axial and Circumferential Directions” Journal of Biomechanical Engineering 139(12): 124501

    Jiang Y, Peng W, Tian B, Zhu C, Chen L, Wang X, Liu Q, Wang Y, Xiang Z, Degnan AJ, Teng Z, Saloner D, Lu J (2017), “Identification and Quantitative Assessment of Different Components of Intracranial Atherosclerotic Plaque by Ex Vivo 3T High-Resolution Multicontrast MRI” American Journal of Neuroradiology 38 (9): 1716-1722

    Tang D, Yang C, Huang S, Mani V, Zheng J, Woodard PK, Robson P, Teng Z, Dweck M, Fayad ZA (2017), “Cap Inflammation Leads to Higher Plaque Cap Strain and Lower Cap Stress: An MRI-PET/CT-Based FSI Modeling Approach” Journal of Biomechanics 50: 121-129

    Teng Z, Brown AJ, Gillard JH (2017), “Carotid Intraplaque Hemorrhage: a Biomarker for Subsequent Ischemic Cerebrovascular Event?” Cerebrovascular Diseases 43: 257-258

    Usman A, Sadat U, Teng Z, Graves MJ, Boyle JR, Varty K, Hayes PD, Gillard JH (2017), “Magnetic Resonance Imaging-Based Assessment of Carotid Atheroma: a Comparative Study of Patients with and without Coronary Artery Disease” Journal of Stroke and Cerebrovascular Diseases 26(2):347-351

    Wang D, Teng Z, Spiga F, Huang Y, Du H, Gillard JH, Lu Q, Lio P (2017), “Cross-Net: Convolutional Network for Biomedical Image Segmentation” SPIE Medical Imaging

    Wang S, Zhang Y, Feng J, Huang Y, Tokgoz A, Sadat U, Gillard JH, Lu Q, Teng Z (2017), “Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: a patient-specific parameter study” Journal of Biomechanics 60: 188-196


    Brown AJ, Teng Z, Calvert PA, Rajani NK, Hennessy O, Obaid DR, Costopoulos C, Huang Y, Hoole SP, Goddard M, West NEJ, Gillard JH, Bennett MR (2016), “Plaque structural stress estimations improve prediction of future major adverse cardiovascular events following intracoronary imaging” Circulation Cardiovascular Imaging 9(6): pii: e004172

    Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR (2016), “The role of biomechanical forces in the natural history of coronary atherosclerosis” Nature Reviews Cardiology 13(4): 210-220

    Costopoulos C, Brown AJ, Teng Z, Hoole SP, West NE, Samady H, Bennett MR (2016), “Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis” International Journal of Cardiovascular Imaging 32(1):189-200

    Eshtehardi P, Teng Z (2016), “Protective or Destructive: High Wall Shear Stress and Atherosclerosis” Atherosclerosis 251: 501-503

    Filipovic N, Radovic M, Isailovic V, Milosevic Z, Nikolic D, Saveljic I, Nikolic M, Dukic T, Cirkovic-Andelkovic B, Exarchos T, Meunier N, Teng Z, Fotiadis D, Bohnke F, Parodi O (2016), “A summary of results in modeling plaque formation and development, cochlea mechanics and vestibular disorders” Journal of Serbian Society for Computational Mechanics 10(1): 20-33

    Gupta A, Baradaran H, Al-Dasuqi K, Knight-Greenfield A, Giambrone AE, Delgado D, Wright D, Teng Z, Min JK, Navi BB, Iadecola C, Kamel H (2016), “Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis” J Am Heart Assoc 5(8): pii: e003816

    Huang Y, Teng Z, Elkhawad M, Tarkin JM, Joshi N, Boyle JR, Buscombe JR, Fryer TD, Zhang Y, Park AY, Wilkinson IB, Newby DE , Gillard JH, Rudd JHF (2016), “High structural stress and presence of intraluminal thrombus predict abdominal aortic aneurysm 18F-FDG uptake: Insights from biomechanics” Circulation Cardiovascular Imaging 9(11): pii: e004656

    Jiang Y, Peng W, Teng Z, Gillard JH, Hong B, Liu Q, Lu J (2016), “Local blood pressure associates with the degree of luminal stenosis in patients with atherosclerotic disease in the middle cerebral artery” BioMedical Engineering OnLine 15(1): 67

    Jiang Y, Zhu C, Peng W, Degnan AJ, Chen L, Wang X, Liu Q, Wang Y, Xiang Z, Teng Z, Saloner D, Lu J (2016), “Ex-vivo Imaging and Plaque Type Classification of Intracranial Atherosclerotic Plaque using High Resolution MRI” Atherosclerosis 249:10-6

    Speelman L, Teng Z, Nederveen AJ, der Lugt AV, Gillard JH (2016), “MRI based biomechanical parameters for carotid artery plaque vulnerability assessment” Thrombosis and Haemostasis 115(3): 493-500

    Teng Z, Brown AJ, Gillard JH (2016), “From ultrasonography to high resolution magnetic resonance imaging: towards an optimal management strategy for vulnerable carotid atherosclerotic plaques” EBioMedicine 3: 2-3

    Teng Z, Peng W, Zhan Q, Zhang X, Liu Q, Chen S, Tian X, Chen L, Brown AJ, Graves MJ, Gillard JH, Lu J (2016), “An assessment on the incremental value of high-resolution magnetic resonance imaging to identify culprit plaques in atherosclerotic disease of the middle cerebral artery” European Radiology 26(7): 2206-14


    Athanasiou LS, Rigas G, Sakellarios A, Bourantas CV, Stefanou K, Fotiou E, Exarchos TP, Siogkas P, Naka KK, Parodi O, Vozzi F, Teng Z, Young VE, Gillard JH, Prati F, Michalis LK, Fotiadis DI (2015), “Error propagation in the characterization of atheromatic plaque types based on imaging.” Comput Methods Programs Biomed 121(3):161-74 Details

    Brown AJ, Obaid DR, Costopoulos C, Parker R, Calvert PA, Teng Z, Hoole SP, West ENJ, Goddard M, Bennett MR (2015), “Identification of advanced atherosclerotic coronary plaques using virtual-histology intravascular ultrasound and optical coherence tomography” Circulation: Cardiovascular Imaging 8(10): e003487

    Lu Q, Feng J, Zhou J, Zhao Z, Li H, Teng Z, Jing Z (2015), “Endovascular Repair By Customized Branched Stent-Graft: A Promising Treatment For Chronic Aortic Dissection Involving The Arch Branches” The Journal of Thoracic and Cardiovascular Surgery 150(6):1631-1638

    Makris GC, Teng Z, Patterson AJ, Lin JM, Young V, Graves MJ, Gillard JH (2015), “Advances in MRI for the evaluation of carotid atherosclerosis.” Br J Radiol 88(1052):20140282 Details

    Peng W, Teng Z, Jiang Y, Chen S, Liu Q, Lu J (2015), “Study on the symptomatic atherosclerosis in the middle cerebral artery based on in vivo magnetic resonance imaging” Radiologic Practice 30(12): 1195-1202

    Teng Z, Feng J, Zhang Y, Huang Y, Sutcliffe MP, Brown AJ, Jing Z, Gillard JH, Lu Q (2015), “Layer- and Direction-Specific Material Properties, Extreme Extensibility and Ultimate Material Strength of Human Abdominal Aorta and Aneurysm: A Uniaxial Extension Study.” Ann Biomed Eng Details

    Teng Z, Feng J, Zhang Y, Sutcliffe MPF, Huang Y, Brown AJ, Jing Z, Lu Q, Gillard JH (2015), “A uni-extension study on the ultimate material strength and extreme extensibility of atherosclerotic tissue in human carotid plaques” Journal of Biomechanics 48(14): 3859-3867

    Teng Z, Yuan J, Feng J, Zhang Y, Brown AJ, Wang S, Lu Q, Gillard JH (2015), “The influence of constitutive law choice used to characterise atherosclerotic tissue material properties on computing stress values in human carotid plaques” Journal of Biomechanics 48(14): 3912-3921

    Yuan J, Teng Z, Feng J, Zhang Y, Brown AJ, Gillard JH, Jing Z, Lu Q (2015), “Influence of material property variability on the mechanical behaviour of carotid atherosclerotic plaques: A 3D fluid-structure interaction analysis.” Int J Numer Method Biomed Eng 31(8) Details

    Zhang X, Zhu C, Peng W, Tian B, Chen L, Teng Z, Lu J, Sadat U, Saloner D, Liu Q (2015), “Scan-Rescan Reproducibility of High Resolution Magnetic Resonance Imaging of Atherosclerotic Plaque in the Middle Cerebral Artery.” PLoS One 10(8):e0134913 Details


    Huang Y, Teng Z, Sadat U, Graves MJ, Bennett MR, Gillard JH (2014), “The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses.” J Biomech 47(6):1465-71 Details

    Teng Z, Brown AJ, Calvert PA, Parker RA, Obaid DR, Huang Y, Hoole SP, West NE, Gillard JH, Bennett MR (2014), “Coronary plaque structural stress is associated with plaque composition and subtype and higher in acute coronary syndrome: the BEACON I (Biomechanical Evaluation of Atheromatous Coronary Arteries) study.” Circ Cardiovasc Imaging 7(3):461-70 Details

    Teng Z, Sadat U, Brown AJ, Gillard JH (2014), “Plaque hemorrhage in carotid artery disease: pathogenesis, clinical and biomechanical considerations.” J Biomech 47(4):847-58 Details

    Teng Z, Zhang Y, Huang Y, Feng J, Yuan J, Lu Q, Sutcliffe MP, Brown AJ, Jing Z, Gillard JH (2014), “Material properties of components in human carotid atherosclerotic plaques: A uniaxial extension study.” Acta Biomater 10(12):5055-63 Details

    Zhang J, Chen L, Wang X, Teng Z, Brown AJ, Gillard JH, Guan Q, Chen S (2014), “Compounding Local Invariant Features and Global Deformable Geometry for Medical Image Registration.” PLoS One 9(8):e105815 Details

    Zhang Y, Lu Q, Feng J, Yu P, Zhang S, Teng Z, Gillard JH, Song R, Jing Z (2014), “A Pilot Study Exploring the Mechanisms Involved in the Longitudinal Propagation of Acute Aortic Dissection through Computational Fluid Dynamic Analysis.” Cardiology 128(2):220-225 Details

    Zhang Y, Teng Z, Lu Q, Zhao Z, Bao J, Feng X, Feng R, Chen Z, Huang Y, Sadat U, Gillard JH, Jing Z (2014), “Management of complicated aortic aneurysms using multiple overlapping uncovered stents: mid-term outcome from a cohort study.” Medicine (Baltimore) 93(27):e209 Details

    Zhongzhao Teng, Jing He, Sadat U, Mercer JR, Xiaoyan Wang, Bahaei NS, Thomas OM, Gillard JH (2014), “How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study.” IEEE Trans Biomed Eng 61(1):35-40 Details

    Zhu C, Sadat U, Patterson AJ, Teng Z, Gillard JH, Graves MJ (2014), “3D high-resolution contrast enhanced MRI of carotid atheroma - a technical update.” Magn Reson Imaging 32(5):594-7 Details


    Filipovic N, Teng Z, Radovic M, Saveljic I, Fotiadis D, Parodi O (2013), “Computer simulation of three-dimensional plaque formation and progression in the carotid artery.” Med Biol Eng Comput 51(6):607-16 Details

    Huang Y, Teng Z, Sadat U, He J, Graves MJ, Gillard JH (2013), “In vivo MRI-based simulation of fatigue process: a possible trigger for human carotid atherosclerotic plaque rupture.” Biomed Eng Online 12(1):36 Details

    Liu Q, Huang J, Degnan AJ, Chen S, Gillard JH, Teng Z, Lu J (2013), “Comparison of high-resolution MRI with CT angiography and digital subtraction angiography for the evaluation of middle cerebral artery atherosclerotic steno-occlusive disease.” Int J Cardiovasc Imaging 29(7):1491-8 Details

    Teng Z, Sadat U (2013), “Editorial (Hot Topic: Translational Application of In Vivo Imaging and Mechanical Analysis for Atherosclerotic Plaque Vulnerability Assessment)” Recent Patents on Medical Imaging 3(1): 2-2

    Teng Z, Sadat U, Gillard JH (2013), “Translational Application of Combining Magnetic Resonance Imaging and Biomechanical Analysis in Carotid Plaque Vulnerability Assessment” Recent Patent on Medical Imaging 3(1): 3-13

    Teng Z, Sadat U, Wang W, Bahaei NS, Chen S, Young VE, Graves MJ, Gillard JH (2013), “Intraplaque stretch in carotid atherosclerotic plaque - an effective biomechanical predictor for subsequent cerebrovascular ischemic events.” PLoS One 8(4):e61522 Details


    Degnan AJ, Gallagher G, Teng Z, Lu J, Liu Q, Gillard JH (2012), “MR angiography and imaging for the evaluation of middle cerebral artery atherosclerotic disease.” AJNR Am J Neuroradiol 33(8):1427-35 Details

    Huang J, Degnan AJ, Liu Q, Teng Z, Yue CS, Gillard JH, Lu JP (2012), “Comparison of NASCET and WASID criteria for the measurement of intracranial stenosis using digital subtraction and computed tomography angiography of the middle cerebral artery.” J Neuroradiol 39(5):342-5 Details

    Liu H, Canton G, Yuan C, Yang C, Billiar K, Teng Z, Hoffman AH, Tang D (2012), “Using in vivo Cine and 3D multi-contrast MRI to determine human atherosclerotic carotid artery material properties and circumferential shrinkage rate and their impact on stress/strain predictions.” J Biomech Eng 134(1):011008 Details

    Teng Z, He J, Degnan AJ, Chen S, Sadat U, Bahaei NS, Rudd JH, Gillard JH (2012), “Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage.” Atherosclerosis 223(2):321-6 Details

    Teng Z, Trabelsi O, Ochoa I, He J, Gillard JH, Doblare M (2012), “Anisotropic material behaviours of soft tissues in human trachea: An experimental study.” J Biomech 45(9):1717-23 Details


    Huang Y, Teng Z, Sadat U, Hilborne S, Young VE, Graves MJ, Gillard JH (2011), “Non-uniform shrinkage for obtaining computational start shape for in-vivo MRI-based plaque vulnerability assessment.” J Biomech 44(12):2316-9 Details

    Sadat U, Taviani V, Patterson AJ, Young VE, Graves MJ, Teng Z, Tang TY, Gillard JH (2011), “Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms--a feasibility study.” Eur J Vasc Endovasc Surg 41(2):167-74 Details

    Sadat U, Teng Z, Young VE, Graves MJ, Gaunt ME, Gillard JH (2011), “High-resolution magnetic resonance imaging-based biomechanical stress analysis of carotid atheroma: a comparison of single transient ischaemic attack, recurrent transient ischaemic attacks, non-disabling stroke and asymptomatic patient groups.” Eur J Vasc Endovasc Surg 41(1):83-90 Details

    Sadat U, Teng Z, Young VE, Li ZY, Gillard JH (2011), “Utility of magnetic resonance imaging-based finite element analysis for the biomechanical stress analysis of hemorrhagic and non-hemorrhagic carotid plaques.” Circ J 75(4):884-9 Details

    Sadat U, Teng Z, Young VE, Zhu C, Tang TY, Graves MJ, Gillard JH (2011), “Impact of plaque haemorrhage and its age on structural stresses in atherosclerotic plaques of patients with carotid artery disease: an MR imaging-based finite element simulation study.” Int J Cardiovasc Imaging 27(3):397-402 Details

    Teng Z, Degnan AJ, Sadat U, Wang F, Young VE, Graves MJ, Chen S, Gillard JH (2011), “Characterization of healing following atherosclerotic carotid plaque rupture in acutely symptomatic patients: an exploratory study using in vivo cardiovascular magnetic resonance.” J Cardiovasc Magn Reson 13(1):64 Details

    Teng Z, Sadat U, Huang Y, Young VE, Graves MJ, Lu J, Gillard JH (2011), “In vivo MRI-based 3D Mechanical Stress-Strain Profiles of Carotid Plaques with Juxtaluminal Plaque Haemorrhage: An Exploratory Study for the Mechanism of Subsequent Cerebrovascular Events.” Eur J Vasc Endovasc Surg 42(4):427-33 Details

    Teng Z, Sadat U, Ji G, Zhu C, Young VE, Graves MJ, Gillard JH (2011), “Lumen irregularity dominates the relationship between mechanical stress condition, fibrous-cap thickness, and lumen curvature in carotid atherosclerotic plaque.” J Biomech Eng 133(3):034501 Details


    Huang X, Teng Z, Canton G, Ferguson M, Yuan C, Tang D (2010), “Intraplaque hemorrhage is associated with higher structural stresses in human atherosclerotic plaques: an in vivo MRI-based 3d fluid-structure interaction study.” Biomed Eng Online 9(1):86 Details

    Sadat U, Teng Z, Gillard JH (2010), “Biomechanical structural stresses of atherosclerotic plaques.” Expert Rev Cardiovasc Ther 8(10):1469-81 Details

    Sadat U, Teng Z, Young VE, Graves MJ, Gillard JH (2010), “Three-dimensional volumetric analysis of atherosclerotic plaques: a magnetic resonance imaging-based study of patients with moderate stenosis carotid artery disease.” Int J Cardiovasc Imaging 26(8):897-904 Details

    Sadat U, Teng Z, Young VE, Walsh SR, Li ZY, Graves MJ, Varty K, Gillard JH (2010), “Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events--a longitudinal in vivo magnetic resonance imaging-based finite element study.” Eur J Vasc Endovasc Surg 40(4):485-91 Details

    Teng Z, Canton G, Yuan C, Ferguson M, Yang C, Huang X, Zheng J, Woodard PK, Tang D (2010), “3D critical plaque wall stress is a better predictor of carotid plaque rupture sites than flow shear stress: An in vivo MRI-based 3D FSI study.” J Biomech Eng 132(3):031007 Details

    Teng Z, Sadat U, Li Z, Huang X, Zhu C, Young VE, Graves MJ, Gillard JH (2010), “Arterial Luminal Curvature and Fibrous-Cap Thickness Affect Critical Stress Conditions Within Atherosclerotic Plaque: An In Vivo MRI-Based 2D Finite-Element Study.” Ann Biomed Eng 38(10):3096-101 Details

    Umar Sadat, Zhongzhao Teng, Jonathan H Gillard (2010), “Association Between Biomechanical Stresses of Atherosclerotic Carotid Plaques and Subsequent Ischaemic Cerebrovascular Events” Circulation 122: A10116

    Zhu C, Teng Z, Sadat U, Young VE, Graves MJ, Li ZY, Gillard JH (2010), “Normalized wall index specific and MRI-based stress analysis of atherosclerotic carotid plaques: a study comparing acutely symptomatic and asymptomatic patients.” Circ J 74(11):2360-4 Details


    Tang D, Teng Z, Canton G, Hatsukami TS, Dong L, Huang X, Yuan C (2009), “Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient study.” Biomed Eng Online 8:15 Details

    Tang D, Teng Z, Canton G, Yang C, Ferguson M, Huang X, Zheng J, Woodard PK, Yuan C (2009), “Sites of rupture in human atherosclerotic carotid plaques are associated with high structural stresses: an in vivo MRI-based 3D fluid-structure interaction study.” Stroke 40(10):3258-63 Details

    Tang D, Yang C, Kobayashi S, Zheng J, Woodard PK, Teng Z, Billiar K, Bach R, Ku DN (2009), “3D MRI-based anisotropic FSI models with cyclic bending for human coronary atherosclerotic plaque mechanical analysis.” J Biomech Eng 131(6):061010 Details

    Teng Z, Ochoa I, Li Z, Doblare M (2009), “Study of tracheal collapsibility, compliance and stress by considering its asymmetric geometry.” Med Eng Phys 31(3):328-36 Details

    Teng Z, Ochoa I, Li Z, Liao Z, Lin Y, Doblare M (2009), “Study on tracheal collapsibility, compliance, and stress by considering nonlinear mechanical property of cartilage.” Ann Biomed Eng 37(11):2380-9 Details

    Teng Z, Tang D, Zheng J, Woodard PK, Hoffman AH (2009), “An experimental study on the ultimate strength of the adventitia and media of human atherosclerotic carotid arteries in circumferential and axial directions.” J Biomech 42(15):2535-9 Details

    Yang C, Bach RG, Zheng J, Naqa IE, Woodard PK, Teng Z, Billiar K, Tang D (2009), “In vivo IVUS-based 3-D fluid-structure interaction models with cyclic bending and anisotropic vessel properties for human atherosclerotic coronary plaque mechanical analysis.” IEEE Trans Biomed Eng 56(10):2420-8 Details


    Chu H, Yu W, Ji G, Zou L, Xu Z, Teng Z (2008), “Correlating endothelial cell functions and histomorphology to hyperlipemia” JOURNAL OF CLINICAL REHABILITATIVE TISSUE ENGINEERING RESEARCH 12(40) 7987-7991

    Teng Z, Ochoa I, Li Z, Lin Y, Rodriguez JF, Bea JA, Doblare M (2008), “Nonlinear mechanical property of tracheal cartilage: a theoretical and experimental study.” J Biomech 41(9):1995-2002 Details

    Teng Z, Wang Y, Li F, Yan H, Liu Z (2008), “Tracheal compliance and limit flow rate changes in a murine model of asthma.” Sci China C Life Sci 51(10):922-31 Details

    Yang C, Tang D, Kobayashi S, Zheng J, Woodard PK, Teng Z, Bach R, Ku DN (2008), “Cyclic Bending Contributes to High Stress in a Human Coronary Atherosclerotic Plaque and Rupture Risk: In Vitro Experimental Modeling and Ex Vivo MRI-Based Computational Modeling Approach.” Mol Cell Biomech 5(4):259-274 Details


    Chu H, Yu W, Ji G, Zou L, Xu Z, Teng Z (2007), “Prevention of restenosis of autologous vein graft by biodegradable external stent in hyperlipemia rabbits” Chinese Journal of Experimental Surgery 24(02): 147-149

    Chu H, Yu W, Ji G, Zou L, Xu Z, Teng Z (2007), “Effect of hyperlipemia on endothelial function and histomorphology of venous conduit in rabbits before grafting” Academic Journal of Second Military Medical University 28(01): 68-70

    Teng Z, Ochoa I, Bea JA, Doblare M (2007), “Theoretical and experimental studies on the nonlinear mechanical property of tracheal cartilage.” Conf Proc IEEE Eng Med Biol Soc 2007:1058-61 Details

    Teng ZZ, Ji GY, Chu HJ, Li ZY, Zou LJ, Xu ZY, Huang SD (2007), “Does PGA external stenting reduce compliance mismatch in venous grafts?” Biomed Eng Online 6:12 Details


    Chu H, Teng Z, Ji G, Zou L (2006), “Effect of External Stent on Venous Graft Mechanical Property” Chinese Quarterly Mechanics 27: 60-69


    Teng Z, Liu Z, Lin Y, Wang Y, Li F, Gong K (2004), “Study on cartilaginous and muscular strains of rat trachea.” Sci China C Life Sci 47(6):485-93 Details


    Liu Z, Gang X, Chen Y, Teng Z, Qin K (2003), “An analysis model of pulsatile blood flow in arteries” Applied Mathematics and Mechanics 24: 230-240

    Liu Z, Teng Z, Wang Y, Tang W (2003), “The Circumferential Residual Strain and Its Non-uniform Distribution for Rat Trachea” Chinese Journal of Biomedical Engineering 22: 149-153

    Wang Y, Li F, Teng Z, Li B, Zhang P, Zhu L, Liu Z (2003), “Study on remodeling of asthmatic Bronchi” Chin. J. Tuberc Respir. Dis. 26: 728-729


    Liu Z, Gang X, Qin K, Teng Z (2002), “Numerical Simulation of Arterial Remodeling in Response to Acute Hypertension” Acta Mechanics Sinica 34(2): 229-237

    Liu Z, Teng Z, Qin K (2002), “On Determination of Circumferential Stress in Arterial Wall Using p-V Exponential Relationship” Acta Mechanics Sinica 34(1): 87-95

    Liu Z, Teng Z, Qin K (2002), “Stress Distribution on Arterial Wall Under Pulsatile Flow” Acta Mechanics Sinica 34: 696-704

    Liu Z, Wang Y, Teng Z, Xu G, Tang W (2002), “Opening angles and residual strains in normal rat trachea.” Sci China C Life Sci 45(2):138-48 Details


    Jiang Z, Li H, Liu B, Teng Z, Qin K (2001), “Biomechanical Properties of Arteries in Experimental Hypotensive Rats” Journal of Medical Biomechanics 18(3): 381-384

    Teng Z, Liu Z, Wang Y, Tang W, Liu B (2001), “p-V Relationship and Limit Flow for Collapsible Trachea” Chinese Quarterly Mechanics 22(1): 40-46

    Wang Y, Tang W, Li F, Teng Z, Liu B, Liu Z (2001), “The Zero-stress State of Rat Trachea” Journal of Medical Biomechanics 16(1): 40-46


    Chen Y, Qin K, Teng Z, Liu Z (2000), “Effects of Pulsatile Pressure on Stress Distribution in Artery Wall at in Vivo Longitudinal Limit Constraint” Chinese Quarterly Mechanics 21(4): 409-414

    Teng Z, Chen Y, Liu Z (2000), “On Circumferential Stress in Arterial Wall at in Vivo Axial Extension Ratio” Chinese Quarterly Mechanics 21(2): 167-172