The hypothalamic arcuate nucleus kisspeptin neurons are responsible for driving the pulsatile release of reproductive hormones such as luteinizing hormone (LH) in the general circulation to control gonadal functions. As PCOS patients have increased pulsatile LH secretion, we hypothesize that over-activity of the arcuate nucleus kisspeptin neurons has a major role in generating the sub-fertility of women with PCOS. Using in vivo fiber photometry, I aim to characterize the properties and activity of the arcuate nucleus kisspeptin neurons in mouse models of PCOS.
