Mr Yizhou Wan

Interests

High-grade glioma is the most common primary brain cancer. Cognitive symptoms are the commonest neurological deficits reported by patients. They have a significant impact on quality of life and reduce survival. Cognition depends on brain network functioning. Gliomas have been shown to integrate into neuronal circuits and disrupt whole-brain connectivity.

I am a Neurosurgery Registrar with an interest in how tumours interact with brain networks to disrupt cognition and promote tumour growth. My PhD studies the impact of surgery on cognition and tumour networks. By using diffusion and resting-state MRI we can identify imaging markers associated with surgical injury and computationally model the effects of surgery on network function. I hope to predict preoperatively the effect of surgery on postoperative cognition. This will facilitate shared-decision making between surgeons and patients to formulate personalised resections which preserve cognition and maximise survival.

Research Focus

Keywords

Functional MRI

Diffusion MRI

Cognition

Brain tumours

Surgery

Clinical conditions

Cancers

Cognitive impairment

Equipment

Computational modelling

Magnetic resonance imaging (MRI)

Neuropsychological testing

Collaborators

Cambridge

Matt Lambon-Ralph

Rafael Romero-Garcia

John Suckling

Associated News Items


    Key publications

    Wan Y, Rahmat R, Price SJ (2020), “Deep learning for glioblastoma segmentation using preoperative magnetic resonance imaging identifies volumetric features associated with survival. ” Acta Neurochir (Wien) 162(12): 3067-3080

    Publications

    2021

    Ganau M, Wan Y, Lawrence T, Plaha P (2021), “Pitfalls regarding the neurosurgical management of traumatic supra and infratentorial extradural haematomas.” Neurosurg Rev https://doi.org/10.1007/s10143-020-01467-0

    2019

    Wan Y, Griffiths S, Ganau M (2019), “Neurosurgical Care of Nonpowder Firearm Injuries: A Narrative Review of the Literature” Emerg Med Int doi: 10.1155/2019/4680184.

    Wan Y, Marcus HJ, Santarius T (2019), “Uncommon Brain Lesions. In: Kirolos R, Helmy A, Thomson S and Hutchinson PJA, editors” Oxford Textbook of Neurological Surgery. 1st ed

    2017

    Lee JT, Lawson KD, Wan Y, Majeed A, Morris S, Soljak M, Millett C (2017), “Are cardiovascular disease risk assessment and management programmes cost effective? A systematic review of the evidence” Prev Med 99:49-57. doi: 10.1016/j.ypmed.2017.01.005

    2016

    Wan Y, Kefaloyannis E (2016), “Penetrating chest injury caused by self-inflicted crossbow arrow traversing the hemithorax” Eur J Cardiothorac Surg 50(3):580. doi: 10.1093/ejcts/ezw084

    2015

    Marcus HJ, Wan Y, Ulrich NH, Reisch R (2015), “Comparative Effectiveness and safety of 3-D versus 2-D Endoscopy in Skull Base Surgery: A Systematic Review” Innovative Neurosurgery 3(3-4):53-58

    2010

    Wan YC, Wan YI. (2010), “Achievement of equity and universal access in China's health service: a commentary on the historical reform perspective from the UK National Health Service” Glob Public Health 5(1):15-27

    2008

    Wan YC, Wan YI (2008), “Delivering surgical training in the People's Republic of China: are current mechanisms adequate?” Int J Surg 6(6):443-5