Mr Yizhou Wan
High-grade glioma is the most common primary brain cancer. Cognitive symptoms are the commonest neurological deficits reported by patients. They have a significant impact on quality of life and reduce survival. Cognition depends on brain network functioning. Gliomas have been shown to integrate into neuronal circuits and disrupt whole-brain connectivity.
I am a Neurosurgery Registrar with an interest in how tumours interact with brain networks to disrupt cognition and promote tumour growth. My PhD studies the impact of surgery on cognition and tumour networks. By using diffusion and resting-state MRI we can identify imaging markers associated with surgical injury and computationally model the effects of surgery on network function. I hope to predict preoperatively the effect of surgery on postoperative cognition. This will facilitate shared-decision making between surgeons and patients to formulate personalised resections which preserve cognition and maximise survival.
Magnetic resonance imaging (MRI)
Associated News Items
Wan Y, Rahmat R, Price SJ (2020), “Deep learning for glioblastoma segmentation using preoperative magnetic resonance imaging identifies volumetric features associated with survival. ” Acta Neurochir (Wien) 162(12): 3067-3080
Ganau M, Wan Y, Lawrence T, Plaha P (2021), “Pitfalls regarding the neurosurgical management of traumatic supra and infratentorial extradural haematomas.” Neurosurg Rev https://doi.org/10.1007/s10143-020-01467-0
Wan Y, Griffiths S, Ganau M (2019), “Neurosurgical Care of Nonpowder Firearm Injuries: A Narrative Review of the Literature” Emerg Med Int doi: 10.1155/2019/4680184.
Wan Y, Marcus HJ, Santarius T (2019), “Uncommon Brain Lesions. In: Kirolos R, Helmy A, Thomson S and Hutchinson PJA, editors” Oxford Textbook of Neurological Surgery. 1st ed
Lee JT, Lawson KD, Wan Y, Majeed A, Morris S, Soljak M, Millett C (2017), “Are cardiovascular disease risk assessment and management programmes cost effective? A systematic review of the evidence” Prev Med 99:49-57. doi: 10.1016/j.ypmed.2017.01.005
Wan Y, Kefaloyannis E (2016), “Penetrating chest injury caused by self-inflicted crossbow arrow traversing the hemithorax” Eur J Cardiothorac Surg 50(3):580. doi: 10.1093/ejcts/ezw084
Marcus HJ, Wan Y, Ulrich NH, Reisch R (2015), “Comparative Effectiveness and safety of 3-D versus 2-D Endoscopy in Skull Base Surgery: A Systematic Review” Innovative Neurosurgery 3(3-4):53-58
Wan YC, Wan YI. (2010), “Achievement of equity and universal access in China's health service: a commentary on the historical reform perspective from the UK National Health Service” Glob Public Health 5(1):15-27
Wan YC, Wan YI (2008), “Delivering surgical training in the People's Republic of China: are current mechanisms adequate?” Int J Surg 6(6):443-5