Mr Yizhou Wan MBBS BSc MPhil

High-grade glioma is the most common primary brain cancer. Cognitive symptoms are the commonest neurological deficits reported by patients. They have a significant impact on quality of life and reduce survival. Cognition depends on brain network functioning. Gliomas have been shown to integrate into neuronal circuits and disrupt whole-brain connectivity. I am a Neurosurgery Registrar with an interest in how tumours interact with brain networks to disrupt cognition and promote tumour growth. My PhD studies the impact of surgery on cognition and tumour networks. By using diffusion and resting-state MRI we can identify imaging markers associated with surgical injury and computationally model the effects of surgery on network function. I hope to predict preoperatively the effect of surgery on postoperative cognition. This will facilitate shared-decision making between surgeons and patients to formulate personalised resections which preserve cognition and maximise survival.