Dr Wei-Li Kuan


My primary research interest is on investigating novel therapeutics that are potentially disease-modifying in Parkinson's and Huntington's disease. I am also extremely keen in interdisciplinary research and I am currently working with groups of physicists, engineerings, and economicsts on several interesting projects

Research Focus


Parkinson's disease

Huntington's disease



Clinical conditions

Huntington's disease

Parkinson's disease


Behavioural analysis




John Sinclair

United Kingdom

Sumeet Mahajan Web: http://S.Mahajan@soton.ac.uk


Jorge Goncalves Web: http:// jorge.goncalves@uni.lu

Associated News Items

    Key publications

    Huefner A, Kuan WL, Barker RA, Mahajan S (2013), “Intracellular SERS nanoprobes for distinction of different neuronal cell types.” Nano Lett 13(6):2463-70 Details

    Kuan WL, Poole E, Fletcher M, Karniely S, Tyers P, Wills M, Barker RA, Sinclair JH (2012), “A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity.” J Exp Med 209(1):1-10 Details

    Kuan et al (2008), “The role of anxiety in the development of levodopa-induced dyskinesias in an animal model of Parkinson's disease and the effect of chronic treatment with the selective serotonin reuptake inhibitor citalopram” Psychopharmacology 197 (2):279-93



    Barker RA, Kuan WL (2010), “Graft-induced dyskinesias in Parkinson's disease: what is it all about?” Cell Stem Cell 7(2):148-9 Details


    Kuan et al (2007), “The importance of A9 dopaminergic neurons in mediating the functional benefits of fetal ventral mesencephalon transplants and levodopa-induced dyskinesias” Neurobiol Dis 25(3):594-608

    Laguna Goya R, Kuan WL, Barker RA (2007), “The future of cell therapies in the treatment of Parkinson's disease.” Expert Opin Biol Ther 7(10):1487-98 Details


    Kuan et al (2006), “Increased capacity for axonal outgrowth using xenogenic tissue in vitro and in a rodent model of Parkinson's disease” Xenotransplantation 13(3):233-47


    Kuan WL, Barker RA (2005), “New therapeutic approaches to Parkinson's disease including neural transplants.” Neurorehabil Neural Repair 19(3):155-81 Details