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Research Theme Beyond the Neuron

Other Interdiciplinary Incentives

  • Neuroscience
  • Research Focus

    Keywords

  • Drug Discovery
  • Clinical Conditions

  • Alzheimer's disease
  • Parkinson's disease
  • Equipment & Techniques

  • Cell culture
  • Behavioural analysis
  • Confocal microscopy
  • Fluorescence microscopy
  • Other
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    Dr Wei-Li Kuan

    University Position
    Principal Research Associate

    Key Publications

    Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.bbi.2020.01.018
    Journal: Brain Behav Immun
    E-pub date: 1 Jul 2020
    Authors: RS Wijeyekoon, D Kronenberg-Versteeg, KM Scott, S Hayat, W-L Kuan, JR Evans, DP Breen, G Cummins, JL Jones, MR Clatworthy, RA Floto, RA Barker, CH Williams-Gray

    Publications

    Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain.

    DOI: http://doi.org/10.1111/bpa.13128
    Journal: Brain Pathol
    E-pub date: 1 May 2023
    Authors: W-L Kuan, M Alfaidi, CB Horne, B Vallin, S Fox, SV Fazal, CH Williams-Gray, RA Barker

    DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

    DOI: http://doi.org/10.1016/j.nbd.2019.104629
    Journal: Neurobiol Dis
    E-pub date: 1 Feb 2020
    Authors: K Solti, W-L Kuan, B Fórizs, G Kustos, J Mihály, Z Varga, B Herberth, É Moravcsik, R Kiss, M Kárpáti, A Mikes, Y Zhao, T Imre, J-C Rochet, F Aigbirhio, CH Williams-Gray, RA Barker, G Tóth

    α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.

    DOI: http://doi.org/10.1016/j.expneurol.2016.09.003
    Journal: Exp Neurol
    E-pub date: 1 Nov 2016
    Authors: W-L Kuan, N Bennett, X He, JN Skepper, N Martynyuk, R Wijeyekoon, PV Moghe, CH Williams-Gray, RA Barker