Virginia Newcombe University positionHF/AMS Clinician Scientist Fellow Virginia Newcombe is pleased to consider applications from prospective PhD students. DepartmentsInstitutesDivision of Anaesthesia and Wolfson Brain Imaging Centre Home pagehttp://www.medschl.cam.ac.uk/anaesth... Research ThemesInterestsMy research focuses on the use of MR imaging as a biomarker in traumatic brain injury (TBI). I am particularly interested in prediction of outcome after TBI and how acute management influences the long-term outcomes of patients. My projects, which are based in the Emergency Department and Neurosciences Critical Care Unit, encompass the entire spectrum of TBI from mild to severe.  Project page for CENTER-TBI comparing tractography in a control to a patient one year after injury View image full-size (2638x1006 pixels) Research Focus
EquipmentBehavioural analysis Computerised tomography Cross-sectional and cohort studies Diffusion tensor imaging Magnetic resonance imaging (MRI) Neuropsychological testing Positron Emission Tomography (PET) Resting state fMRI Collaborators
Associated News ItemsPublications2014Veenith TV, Carter EL, Grossac J, Newcombe VF, Outtrim JG, Nallapareddy S, Lupson V, Correia MM, Mada MM, Williams GB, Menon DK, Coles JP (2014), “Use of diffusion tensor imaging to assess the impact of normobaric hyperoxia within at-risk pericontusional tissue after traumatic brain injury.” J Cereb Blood Flow Metab Details 2013Carter EL, Newcombe VF, Hawkes RC, Coles JP (2013), “Magnetic resonance imaging and thermal injury.” J Neurosurg 119(4):1082-4 Details Newcombe VF, Das T, Cross JJ (2013), “Diffusion imaging in neurological disease.” J Neurol 260(1):335-42 Details Newcombe VF, Menon DK (2013), “Cognitive deficits and mild traumatic brain injury.” BMJ 346:f1522 Details Newcombe VF, Williams GB, Outtrim JG, Chatfield D, Gulia Abate M, Geeraerts T, Manktelow A, Room H, Mariappen L, Hutchinson PJ, Coles JP, Menon DK (2013), “Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.” J Cereb Blood Flow Metab 33(6):855-62 Details Veenith TV, Carter E, Grossac J, Newcombe VF, Outtrim JG, Lupson V, Williams GB, Menon DK, Coles JP (2013), “Inter subject variability and reproducibility of diffusion tensor imaging within and between different imaging sessions.” PLoS One 8(6):e65941 Details 2012Fernández-Espejo D, Soddu A, Cruse D, Palacios EM, Junque C, Vanhaudenhuyse A, Rivas E, Newcombe V, Menon DK, Pickard JD, Laureys S, Owen AM (2012), “A role for the default mode network in the bases of disorders of consciousness.” Ann Neurol 72(3):335-43 Details 2011Correia MM, Newcombe VF, Williams GB (2011), “Contrast-to-noise ratios for indices of anisotropy obtained from diffusion MRI: a study with standard clinical b-values at 3T.” Neuroimage 57(3):1103-15 Details Newcombe V, Chatfield D, Outtrim J, Vowler S, Manktelow A, Cross J, Scoffings D, Coleman M, Hutchinson P, Coles J, Carpenter TA, Pickard J, Williams G, Menon D (2011), “Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome.” PLoS One 6(5):e19214 Details Newcombe VF, Outtrim JG, Chatfield DA, Manktelow A, Hutchinson PJ, Coles JP, Williams GB, Sahakian BJ, Menon DK (2011), “Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury.” Brain 134(Pt 3):759-68 Details 2010Newcombe VF, Williams GB, Scoffings D, Cross J, Carpenter TA, Pickard JD, Menon DK (2010), “Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications.” J Neurol Neurosurg Psychiatry 81(5):552-61 Details 2008Geeraerts T, Newcombe VF, Coles JP, Abate MG, Perkes IE, Hutchinson PJ, Outtrim JG, Chatfield DA, Menon DK (2008), “Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure.” Crit Care 12(5):R114 Details Maiya B, Newcombe V, Nortje J, Bradley P, Bernard F, Chatfield D, Outtrim J, Hutchinson P, Matta B, Antoun N, Menon D (2008), “Magnetic resonance imaging changes in the pituitary gland following acute traumatic brain injury.” Intensive Care Med 34(3):468-75 Details Newcombe VF, Hawkes RC, Harding SG, Willcox R, Brock S, Hutchinson PJ, Menon DK, Carpenter TA, Coles JP (2008), “Potential heating caused by intraparenchymal intracranial pressure transducers in a 3-tesla magnetic resonance imaging system using a body radiofrequency resonator: assessment of the Codman MicroSensor Transducer.” J Neurosurg 109(1):159-64 Details Newcombe VF, Williams GB, Nortje J, Bradley PG, Chatfield DA, Outtrim JG, Harding SG, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2008), “Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma.” Acta Neurochir Suppl 102:247-51 Details 2007Newcombe VF, Williams GB, Nortje J, Bradley PG, Harding SG, Smielewski P, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2007), “Analysis of acute traumatic axonal injury using diffusion tensor imaging.” Br J Neurosurg 21(4):340-8 Details |
