Professor Tuomas Knowles

Tuomas Knowles

University position


Professor Tuomas Knowles is pleased to consider applications from prospective PhD students.


Department of Chemistry


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Research Theme

Cellular and Molecular Neuroscience


We work on the physico-chemical properties and behaviour of biological molecules and soft materials. The research in the group is highly interdisciplinary. Members of the group have a wide range of backgrounds. We used methods from biochemistry, chemistry, chemical engineering and physics, and work in close collaboration with other groups in Cambridge and overseas.

We apply new physical methods to understand the misfolding and aggregation of proteins molecules into amyloid fibrils of the type encountered in neurodegenerative disorders. The techniques used in our laboratory include biosensors, optical lithography, microfluidic devices and scanning probe microscopy and spectroscopy. We also have an interest in applying theoretical concepts from statistical mechanics and chemical kinetics to protein systems.

Atomic force microscopy image of individual nanoscale amyloid fibrils
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Research Focus


None specified

Clinical conditions

Alzheimer's disease

Parkinson's disease

Prion diseases