Dr Taxiarchis Katsinelos

Interests

The progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark and it correlates with the disease progression of tauopathies, such as Alzheimer's disease. My research focuses on employing cellular biology and biochemical methods to elucidate the molecular mechanisms governing the generation of fibrilar tau strains. The characterisation of these biological phenomena will help us understand better the cellular pathways underlying the toxicitiy in tauopathies, where early diagnosis is limited and current therapeutics entirely absent.

Research Focus

Keywords

tau

neurodegeneration

prion-like propagation

protein aggregation

trans-cellular spreading

Clinical conditions

Alzheimer's disease

Dementia

Huntington's disease

Parkinson's disease

Prion diseases

Tauopathies

Equipment

Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy

FPLC/HPLC

Immunohistochemistry

Microscopy

Protein purification

Recombinant protein expression

Collaborators

Cambridge

Dr. Michel Goedert

Prof. David Klenerman

Prof. Maria Grazia Spillantini

United Kingdom

Prof. Nigel Hooper Web: https://www.research.manchester.ac.uk/portal/...

International

Prof. Walter Nickel Web: https://bzh.db-engine.de/default...

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