Dr Thomas Cope MA MClinRes MRCP PhD
Dr Thomas Cope MA MClinRes MRCP PhD is pleased to consider applications from prospective PhD students.
I am an Academic Clinical Lecturer in Neurology, and Official Fellow of Murray Edwards College, where I teach neuroscience and direct studies for psychology.
My research has two overarching aims:
1) to employ systems neuroscience as a translational bridge between the molecular biology of dementia and targeted clinical trials.
2) to define perceptual mechanisms, neural codes and brain substrates, and how they go wrong in patients with neurological pathology.
I am particularly interested in how brain mechanisms for prediction, language and learning become abnormal in patients with the aphasic forms of frontotemporal dementia. These are ideal demonstrator conditions, because of their stereotyped patterns of neurodegeneration, the psychophysical precision of language as a probe, and the fragility of human language networks to synaptic disruption.
My research uses a variety of techniques, including psychophysics, PET, magnetoencephalography and ultra-high field (7T) functional MRI.
Magnetic resonance imaging (MRI)
Positron Emission Tomography (PET)
Associated News Items
Bevan-Jones WR, Cope TE (joint first author), Jones PS, Kaalund SS, Passamonti L, Allinson K, Green O, Hong YT, Fryer TD, Arnold R, Coles JP, Aigbirhio FI, Larner AJ, Patterson K, O’Brien JT, Rowe JB (2020), “Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum” Brain 143(4): 1010-1026
Cope TE, Borchert R, Rittman TD, Jones PS, Vatansever D, Allinson KSJ, Passamonti L, Vazquez Rodriguez P, Bevan Jones WR, O’Brien JT, Rowe JB. (2018), “Tau Burden and the Functional Connectome in Alzheimer's Disease and Progressive Supranuclear Palsy” Brain https://doi.org/10.1093/brain/awx347
Cope TE, Sohoglu E, Sedley W, Patterson K, Jones PS, Wiggins J, Dawson C, Grube M, Carlyon RP, Griffiths TD, Davis M, Rowe JB. (2017), “Evidence for causal top-down frontal contributions to predictive processes in speech perception” Nature Communications 2154 http://dx.doi.org/10.1038/s41467-017-01958-7
Adams NE, Hughes LE, Rouse MA, Phillips HN, Shaw AD, Murley AG, Cope TE, Bevan-Jones WR, Passamonti L, Street D, Holland N, Nesbitt D, Friston K, Rowe JB (2021), “GABAergic cortical network physiology in frontotemporal lobar degeneration” Brain
Cope TE, Weil RS, Düzel E, Dickerson BC, Rowe JB (2021), “Advances in neuroimaging to support translational medicine in dementia” Journal of Neurology, Neurosurgery & Psychiatry (JNNP) 92 (3), 263-270
Malpetti M, Rittman T, Jones PS, Cope TE, Passamonti L, Bevan-Jones WR, Patterson K, Fryer TD, Hong YT, Aigbirhio FI, O'Brien JT, Rowe JB (2021), “In vivo PET imaging of neuroinflammation in familial frontotemporal dementia” Journal of Neurology, Neurosurgery & Psychiatry (JNNP) 92 (3), 319-322
Adams NE., Hughes LE, Phillips HN, Shaw AD, Murley AG, Nesbitt D, Cope TE, Bevan-Jones WR, Passamonti L, Rowe JB (2020), “GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco-magnetoencephalography” Journal of Neuroscience 40(8): 1640-1649
Cope TE, Isaacs, J, Kopelman, M (2020), “Memory disorders and Dementias” Oxford Textbook of Neuropsychiatry (chapter 25)
Cope TE, Shtyrov Y, MacGregor LJ, Holland R, Pulvermüller F, Rowe JB, Patterson K (2020), “Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity” Cortex 126:107-118
Bevan Jones RW, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer T, Arnold R, Coles JP, Aigbirhio FA, Patterson K, O'Brien JT, Rowe JB (2019), “In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrier” Annals of Clinical and Translational Neurology 6(2):363-378
Bevan Jones RW, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer T, Arnold R, Coles JP, Aigbirhio FA, Patterson K, O'Brien JT (2018), “[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.” Annals of Clinical and Translational Neurology 5(10):1292-1296
Phillips HN, Cope TE, Hughes LE, Zhang J, Rowe, JB (2018), “Monitoring the past and choosing the future: the prefrontal cortical influences on voluntary action.” Scientific Reports 8(1):7247
Sami S, Hughes LE, Williams N, Cope TE, Rittman T, Coyle-Gilchrist ITS, Henson RN, Rowe JB (2018), “Neurophysiological signatures of Alzheimer’s disease and Frontotemporal lobar degeneration: pathology versus phenotype” Brain 141(8):2600-2510
Bevan Jones WR, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer TD, Arnold R, Allinson KSJ, Coles J, Aigbirhio F, Patterson K, O’Brien JT, Rowe JB. (2017), “[18F]AV1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.” Journal of Neurology, Neurosurgery & Psychiatry (JNNP) http://dx.doi.org/10.1136/jnnp-2017-316402
Cope TE, Wilson B (joint first authors), Robson H, Drinkall R, Dean L, Grube M, Jones PS, Patterson K, Griffiths TD, Rowe JB, Petkov CI. (2017), “Artificial grammar learning in vascular and progressive non-fluent aphasias.” Neuropsychologia 104:201-213
Kumar S, Tansley-Hancock O, Sedley W, Winston JS, Callaghan MF, Allen M, Cope TE, Gander PE, Bamiou DE, Griffiths TD (2017), “The brain basis for misophonia” Current Biology 27(4):527-533
Passamonti L, Vázquez Rodríguez P, Hong YT, Allinson KSJ, Williamson D, Borchert RJ, Sami S, Cope TE, Bevan-Jones WR, Jones PS, Arnold R, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio F, O’Brien JT, Rowe JB. (2017), “[18F]AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy” Brain 140(3):781-791
Bekuis A, Cope TE, Grube M (2016), “The Beat to Read: A Cross-lingual Link between Rhythmic Regularity Perception and Reading Skill.” Frontiers in Human Neuroscience 10: 425
Bevan-Jones WR, Cope TE (joint first authors), Passamonti L, Fryer TD, Hong YT, Aigbirhio F, Kril JJ, Forrest SL, Allinson K, Coles JP, Jones PS, Spillantini MG, Hodges JR, O’Brien JT, Rowe JB (2016), “[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation” Annals of Clinical and Translational Neurology 3: 940-947
Cope TE, Breen DP, Chawda S, Cifelli A (2016), “Anti-collapsin response mediator protein 5 encephalitis masquerading as a low-grade brain tumour” Practical Neurology 16(5):376-380
Cope TE, Baguley DM, Griffiths TD (2015), “The functional anatomy of central auditory processing” Practical Neurology 15(4):302:308
Cope TE, Grube M, Mandal A, Cooper FE, Brechany U, Burn DJ, Griffiths TD (2014), “Subthalamic deep brain stimulation in Parkinson׳s disease has no significant effect on perceptual timing in the hundreds of milliseconds range.” Neuropsychologia 57:29-37 Details
Cope TE, Grube M, Singh B, Burn DJ, Griffiths TD (2014), “The basal ganglia in perceptual timing: Timing performance in Multiple System Atrophy and Huntington's disease.” Neuropsychologia 52:73-81 Details
Cope TE, Cope W, Beaumont DM (2013), “A case of necrotising fasciitis caused by Serratia marsescens: extreme age as functional immunosuppression?” Age Ageing 42(2):266-8 Details
Cope TE, Samaraweera AP, Burn DJ (2013), “Thyrotoxic periodic paralysis: correct hypokalemia with caution.” J Emerg Med 45(3):338-40 Details
Alcántara JI, Cope TE, Cope W, Weisblatt EJ (2012), “Auditory temporal-envelope processing in high-functioning children with Autism Spectrum Disorder.” Neuropsychologia 50(7):1235-51 Details
Cope TE, Grube M, Griffiths TD (2012), “Temporal predictions based on a gradual change in tempo.” J Acoust Soc Am 131(5):4013-22 Details
Cope TE, Baguley DM, Moore BC (2011), “Tinnitus loudness in quiet and noise after resection of vestibular schwannoma.” Otol Neurotol 32(3):488-96 Details
Cope TE, McFarland R, Schaefer A (2011), “Rapid-onset, linezolid-induced lactic acidosis in MELAS.” Mitochondrion 11(6):992-3 Details
Cope TE, Baguley DM (2009), “Is musical hallucination an otological phenomenon? a review of the literature.” Clin Otolaryngol 34(5):423-30 Details
Cope TE (2008), “Clinical hypnosis for the alleviation of tinnitus.” Int Tinnitus J 14(2):135-8 Details
Moore BC, Glasberg BR, Low KE, Cope T, Cope W (2006), “Effects of level and frequency on the audibility of partials in inharmonic complex tones.” J Acoust Soc Am 120(2):934-44 Details