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Dr Tim Fryer

University Position
Other

Interests

My research concentrates on positron emission tomography (PET) methodology, with particular emphasis on the quantitative accuracy of the physiological parameters derived from the data. Current research themes are: parametric mapping using basis functions spatio-temporal image reconstruction for kinetic analysis direct parameter estimation wavelet-based kinetic analysis 4D motion compensated image reconstruction MRI-based motion correction for PET/MRI scanners image optimisation using automated observers automated region-of-interest definition attenuation correction for PET/MRI scanners.

Key Publications

A synergistic core for human brain evolution and cognition.

DOI: http://doi.org/10.1038/s41593-022-01070-0
Journal: Nat Neurosci
E-pub date: 1 Jun 2022
Authors: AI Luppi, PAM Mediano, FE Rosas, N Holland, TD Fryer, JT O'Brien, JB Rowe, DK Menon, D Bor, EA Stamatakis

Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awab255
Journal: Brain
E-pub date: 16 Dec 2021
Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.

DOI: http://doi.org/10.1002/ana.25911
Journal: Ann Neurol
E-pub date: 1 Dec 2020
Authors: M Malpetti, L Passamonti, T Rittman, PS Jones, P Vázquez Rodríguez, WR Bevan-Jones, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat.

DOI: http://doi.org/10.1038/s41467-020-19167-0
Journal: Nat Commun
E-pub date: 26 Oct 2020
Authors: L Alexander, CM Wood, PLR Gaskin, SJ Sawiak, TD Fryer, YT Hong, L McIver, HF Clarke, AC Roberts

Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2019.3854
Journal: JAMA Neurol
E-pub date: 1 Mar 2020
Authors: Y Launey, TD Fryer, YT Hong, LA Steiner, J Nortje, TV Veenith, PJ Hutchinson, A Ercole, AK Gupta, FI Aigbirhio, JD Pickard, JP Coles, DK Menon

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

DOI: http://doi.org/10.1073/pnas.1902087116
Journal: Proc Natl Acad Sci U S A
E-pub date: 16 Jul 2019
Authors: AM Santangelo, SJ Sawiak, T Fryer, Y Hong, Y Shiba, HF Clarke, PJ Riss, V Ferrari, R Tait, J Suckling, FI Aigbirhio, AC Roberts

Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.

DOI: http://doi.org/10.1016/j.neuron.2018.11.021
Journal: Neuron
E-pub date: 16 Jan 2019
Authors: L Alexander, PLR Gaskin, SJ Sawiak, TD Fryer, YT Hong, GJ Cockcroft, HF Clarke, AC Roberts

Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

DOI: http://doi.org/10.1093/brain/awy265
Journal: Brain
E-pub date: 1 Dec 2018
Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2016.0091
Journal: JAMA Neurol
E-pub date: 1 May 2016
Authors: TV Veenith, EL Carter, T Geeraerts, J Grossac, VFJ Newcombe, J Outtrim, GS Gee, V Lupson, R Smith, FI Aigbirhio, TD Fryer, YT Hong, DK Menon, JP Coles

Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.

DOI: http://doi.org/10.1523/JNEUROSCI.0718-14.2014
Journal: J Neurosci
E-pub date: 28 May 2014
Authors: HF Clarke, RN Cardinal, R Rygula, YT Hong, TD Fryer, SJ Sawiak, V Ferrari, G Cockcroft, FI Aigbirhio, TW Robbins, AC Roberts

Incidence and mechanisms of cerebral ischemia in early clinical head injury.

DOI: http://doi.org/10.1097/01.WCB.0000103022.98348.24
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Feb 2004
Authors: JP Coles, TD Fryer, P Smielewski, DA Chatfield, LA Steiner, AJ Johnston, SPMJ Downey, GB Williams, F Aigbirhio, PJ Hutchinson, K Rice, TA Carpenter, JC Clark, JD Pickard, DK Menon

Publications

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

DOI: http://doi.org/10.1093/brain/awad078
Journal: Brain
E-pub date: 1 Aug 2023
Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study.

DOI: http://doi.org/10.1002/mds.29421
Journal: Mov Disord
E-pub date: 1 Jul 2023
Authors: N Holland, PS Jones, G Savulich, M Naessens, M Malpetti, DJ Whiteside, D Street, P Swann, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?: A Longitudinal Positron Emission Tomography-Magnetic Resonance Imaging Study.

DOI: http://doi.org/10.1161/STROKEAHA.122.039517
Journal: Stroke
E-pub date: 1 Feb 2023
Authors: DJ Tozer, RB Brown, J Walsh, YT Hong, GB Williams, JT O'Brien, FI Aigbirhio, TD Fryer, HS Markus

Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

DOI: http://doi.org/10.1002/ana.26543
Journal: Ann Neurol
E-pub date: 1 Jan 2023
Authors: M Malpetti, PS Jones, TE Cope, N Holland, M Naessens, MA Rouse, T Rittman, G Savulich, DJ Whiteside, D Street, TD Fryer, YT Hong, S Milicevic Sephton, FI Aigbirhio, JT O Brien, JB Rowe

In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

DOI: http://doi.org/10.2967/jnumed.121.262985
Journal: J Nucl Med
E-pub date: 1 Jul 2022
Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

DOI: http://doi.org/10.1093/brain/awab282
Journal: Brain
E-pub date: 29 Mar 2022
Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.

DOI: http://doi.org/10.1093/braincomms/fcab177
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, A Kouli, N Holland, N Nicastro, G Savulich, A Surendranathan, M Malpetti, R Manavaki, YT Hong, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien, CH Williams-Gray

Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

DOI: http://doi.org/10.1093/braincomms/fcaa198
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

DOI: http://doi.org/10.1136/jnnp-2020-325549
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jul 2021
Authors: M Malpetti, L Passamonti, PS Jones, D Street, T Rittman, TD Fryer, YT Hong, P Vàsquez Rodriguez, WR Bevan-Jones, FI Aigbirhio, JT O'Brien, JB Rowe

Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

DOI: http://doi.org/10.1002/acn3.51407
Journal: Ann Clin Transl Neurol
E-pub date: 1 Jul 2021
Authors: M Malpetti, N Holland, PS Jones, R Ye, TE Cope, TD Fryer, YT Hong, G Savulich, T Rittman, L Passamonti, E Mak, FI Aigbirhio, JT O'Brien, JB Rowe

[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.

DOI: http://doi.org/10.1212/WNL.0000000000012033
Journal: Neurology
E-pub date: 31 May 2021
Authors: J van den Ameele, Y Hong, R Manavaki, A Kouli, H Biggs, Z MacIntyre, R Horvath, P Yu-Wai-Man, E Reid, CH Williams-Gray, E Bullmore, F Aigbirhio, T Fryer, P Chinnery

In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
Journal: Neurobiol Aging
E-pub date: 1 May 2021
Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
Journal: Neurobiol Aging
E-pub date: 1 May 2021
Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

DOI: http://doi.org/10.1136/jnnp-2020-323698
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Mar 2021
Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

Multimodal imaging markers of tau, neuroinflammation and atrophy to predict clinical progression in progressive supranuclear palsy

DOI: http://doi.org/10.1002/alz.044724
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: M Malpetti, L Passamonti, PS Jones, T Rittman, TD Fryer, YT Hong, D Street, PV Rodríguez, WR Bevan‐Jones, FI Aigbirhio, JT O'Brien, JB Rowe

The prognostic role of microglia and tau PET in Alzheimer’s disease

DOI: http://doi.org/10.1002/alz.039817
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

Gray matter changes related to microglial activation in Alzheimer’s disease.

DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
Journal: Neurobiol Aging
E-pub date: 1 Oct 2020
Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

A synergistic core for human brain evolution and cognition

DOI: http://doi.org/10.1101/2020.09.22.308981
Journal:
E-pub date: 1 Aug 2020
Authors: A Luppi, PAM Mediano, F Rosas, N Holland, T Fryer, J O’Brien, J Rowe, D Menon, D Bor, E Stamatakis

Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

DOI: http://doi.org/10.1101/2020.01.24.20018697
Journal:
E-pub date: 1 Aug 2020
Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

DOI: http://doi.org/10.1101/2020.05.11.20098046
Journal:
E-pub date: 1 Aug 2020
Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

Neuroinflammation predicts disease progression in progressive supranuclear palsy

DOI: http://doi.org/10.1101/2020.05.19.20106393
Journal:
E-pub date: 1 Aug 2020
Authors: M Malpetti, L Passamonti, S Jones, D Street, T Rittman, T Fryer, Y Hong, P Vasquez-Rodriguez, WR Bevan-Jones, F Aigbirhio, J O'Brien, J Rowe

Greater aortic inflammation and calcification in abdominal aortic aneurysmal disease than atherosclerosis: a prospective matched cohort study.

DOI: http://doi.org/10.1136/openhrt-2019-001141
Journal: Open Heart
E-pub date: 1 Aug 2020
Authors: NV Joshi, M Elkhawad, RO Forsythe, OMB McBride, NK Rajani, JM Tarkin, MM Chowdhury, E Donoghue, JMJ Robson, JR Boyle, TD Fryer, Y Huang, Z Teng, MR Dweck, AA Tawakol, JH Gillard, PA Coughlin, IB Wilkinson, DE Newby, JHF Rudd

Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

DOI: http://doi.org/10.1093/brain/awaa088
Journal: Brain
E-pub date: 1 May 2020
Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

DOI: http://doi.org/10.1093/brain/awaa033
Journal: Brain
E-pub date: 1 Mar 2020
Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

DOI: http://doi.org/10.1101/19011189
Journal:
E-pub date: 8 Nov 2019
Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

PET markers of tau and neuroinflammation are co-localized in progressive supranuclear palsy

DOI: http://doi.org/10.1101/19010702
Journal:
E-pub date: 2 Nov 2019
Authors: M Malpetti, L Passamonti, T Rittman, S Jones, P Vázquez Rodríguez, R Bevan-Jones, Y Hong, T Fryer, F Aigbirhio, J O’Brien, J Rowe

In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

DOI: http://doi.org/10.1002/acn3.683
Journal: Ann Clin Transl Neurol
E-pub date: 1 Feb 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

DOI: http://doi.org/10.1136/jnnp-2017-316402
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Oct 2018
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

DOI: http://doi.org/10.1002/acn3.631
Journal: Ann Clin Transl Neurol
E-pub date: 1 Oct 2018
Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

DOI: http://doi.org/10.1016/j.dadm.2018.08.005
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2018
Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1212/WNL.0000000000005610
Journal: Neurology
E-pub date: 29 May 2018
Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1093/brain/aww340
Journal: Brain
E-pub date: 1 Mar 2017
Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

DOI: http://doi.org/10.1002/acn3.366
Journal: Ann Clin Transl Neurol
E-pub date: 1 Dec 2016
Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

High Structural Stress and Presence of Intraluminal Thrombus Predict Abdominal Aortic Aneurysm 18F-FDG Uptake: Insights From Biomechanics.

DOI: http://doi.org/10.1161/CIRCIMAGING.116.004656
Journal: Circ Cardiovasc Imaging
E-pub date: 1 Nov 2016
Authors: Y Huang, Z Teng, M Elkhawad, JM Tarkin, N Joshi, JR Boyle, JR Buscombe, TD Fryer, Y Zhang, AY Park, IB Wilkinson, DE Newby, JH Gillard, JHF Rudd

Imaging regional variation of cellular proliferation in gliomas using 3′-deoxy-3′-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study.

DOI: http://doi.org/10.1016/j.crad.2008.01.016
Journal: Clin Radiol
E-pub date: 1 Jan 2009
Authors: SJ Price, TD Fryer, MC Cleij, AF Dean, J Joseph, R Salvador, DD Wang, PJ Hutchinson, JC Clark, NG Burnet, JD Pickard, FI Aigbirhio, JH Gillard