Dr Taufiq Rahman University positionLecturer Dr Taufiq Rahman is pleased to consider applications from prospective PhD students. DepartmentsHome pagehttp://www.phar.cam.ac.uk/researc... Research ThemesInterestsMy research interests broadly lie in two categories - structure-function studies of intracellular calcium channels and rational design and development of selective modulators of signalling proteins including ion channels Research Focus
EquipmentComputational modelling Electrophysiological recording techniques Fluorescence microscopy Collaborators
Associated News ItemsPublications2014Ohene-Agyei T, Mowla R, Rahman T, Venter H (2014), “Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump.” Microbiologyopen 3(6):885-96 Details Rahman T, Cai X, Brailoiu GC, Abood ME, Brailoiu E, Patel S (2014), “Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels.” Sci Signal 7(352):ra109 Details Rahman T, Smith ES (2014), “In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing ion channel 3.” Biochem Biophys Res Commun 450(1):384-9 Details Taylor CW, Tovey SC, Rossi AM, Lopez Sanjurjo CI, Prole DL, Rahman T (2014), “Structural organization of signalling to and from IP3 receptors.” Biochem Soc Trans 42(1):63-70 Details 2013Churamani D, Hooper R, Rahman T, Brailoiu E, Patel S (2013), “The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.” Biochem J Details Li C, Enomoto M, Rossi AM, Seo MD, Rahman T, Stathopulos PB, Taylor CW, Ikura M, Ames JB (2013), “CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.” Proc Natl Acad Sci U S A 110(21):8507-12 Details Saleem H, Tovey SC, Rahman T, Riley AM, Potter BV, Taylor CW (2013), “Stimulation of Inositol 1,4,5-Trisphosphate (IP(3)) Receptor Subtypes by Analogues of IP(3).” PLoS One 8(1):e54877 Details Sun Y, Rossi AM, Rahman T, Taylor CW (2013), “Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif.” Biochem J 449(1):39-49 Details 2012Rahman T (2012), “Dynamic clustering of IP3 receptors by IP3.” Biochem Soc Trans 40(2):325-30 Details Rossi AM, Tovey SC, Rahman T, Prole DL, Taylor CW (2012), “Analysis of IP3 receptors in and out of cells.” Biochim Biophys Acta 1820(8):1214-27 Details 2011Musa MA, Cooperwood JS, Khan MO, Rahman T (2011), “In-vitro antiproliferative activity of benzopyranone derivatives in comparison with standard chemotherapeutic drugs.” Arch Pharm (Weinheim) 344(2):102-10 Details Patel S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E (2011), “The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels.” Cell Calcium 50(2):157-67 Details 2010Brailoiu E, Rahman T, Churamani D, Prole DL, Brailoiu GC, Hooper R, Taylor CW, Patel S (2010), “An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals.” J Biol Chem 285(49):38511-6 Details Ding Z, Rossi AM, Riley AM, Rahman T, Potter BV, Taylor CW (2010), “Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.” Mol Pharmacol 77(6):995-1004 Details Rahman T, Rahmatullah M (2010), “Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.” Bioorg Med Chem Lett 20(2):537-40 Details Rahman T, Taylor CW (2010), “Nuclear patch-clamp recording from inositol 1,4,5-trisphosphate receptors.” Methods Cell Biol 99:199-224 Details Tovey SC, Dedos SG, Rahman T, Taylor EJ, Pantazaka E, Taylor CW (2010), “Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase.” J Biol Chem 285(17):12979-89 Details 2009Rahman T, Taylor CW (2009), “Dynamic regulation of IP3 receptor clustering and activity by IP3.” Channels (Austin) 3(4):226-32 Details Rossi AM, Riley AM, Tovey SC, Rahman T, Dellis O, Taylor EJ, Veresov VG, Potter BV, Taylor CW (2009), “Synthetic partial agonists reveal key steps in IP3 receptor activation.” Nat Chem Biol 5(9):631-9 Details Taufiq-Ur-Rahman, Skupin A, Falcke M, Taylor CW (2009), “Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.” Nature 458(7238):655-9 Details Taylor CW, Prole DL, Rahman T (2009), “Ca(2+) channels on the move.” Biochemistry 48(51):12062-80 Details Taylor CW, Rahman T, Tovey SC, Dedos SG, Taylor EJ, Velamakanni S (2009), “IP3 receptors: some lessons from DT40 cells.” Immunol Rev 231(1):23-44 Details Taylor CW, Taufiq-Ur-Rahman, Pantazaka E (2009), “Targeting and clustering of IP3 receptors: key determinants of spatially organized Ca2+ signals.” Chaos 19(3):037102 Details 2006Dellis O, Dedos SG, Tovey SC, Taufiq-Ur-Rahman, Dubel SJ, Taylor CW (2006), “Ca2+ entry through plasma membrane IP3 receptors.” Science 313(5784):229-33 Details |