Dr Adrian Carpenter University positionReader Dr Adrian Carpenter is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Clinical Neurosciences InstitutesHome pageResearch ThemeInterestsOur group develops new techniques for the acquisition and analysis of PET and MR images to improve our understanding of the pathophysiology of disease. We also develop novel instrumentation, for example we are an internationally leading centre developing hybrid PET/MR scanners. Research Focus
EquipmentMagnetic resonance imaging (MRI) Collaborators
Associated News ItemsKey publicationsBuonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2013), “A fast protocol for infarct quantification in mice.” J Magn Reson Imaging Details Sawiak SJ, Wood NI, Carpenter TA, Morton AJ (2012), “Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy.” PLoS One 7(12):e53361 Details Sleigh A, Stears A, Thackray K, Watson L, Gambineri A, Nag S, Campi VI, Schoenmakers N, Brage S, Carpenter TA, Murgatroyd PR, O'Rahilly S, Kemp GJ, Savage DB (2012), “Mitochondrial oxidative phosphorylation is impaired in patients with congenital lipodystrophy.” J Clin Endocrinol Metab 97(3):E438-42 Details Hawkes RC, Fryer TD, Siegel S, Ansorge RE, Carpenter TA (2010), “Preliminary evaluation of a combined microPET-MR system.” Technol Cancer Res Treat 9(1):53-60 Details Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry.” Neurobiol Dis 33(1):20-7 Details Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease.” Neurobiol Dis 33(1):12-9 Details Publications2014Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Trajectory correction for free-breathing radial cine MRI.” Magn Reson Imaging 32(7):961-4 Details Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Functional assessment of the mouse heart by MRI with a 1-min acquisition.” NMR Biomed 27(6):733-7 Details Buonincontri G, Wood NI, Puttick SG, Ward AO, Carpenter TA, Sawiak SJ, Morton AJ (2014), “Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine.” J Huntingtons Dis 3(1):25-32 Details Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2014), “Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior.” Biol Psychiatry 75(2):115-23 Details 2013Alawneh JA, Moustafa RR, Marrapu ST, Jensen-Kondering U, Morris RS, Jones PS, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2013), “Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study.” Eur J Nucl Med Mol Imaging Details Buonincontri G, Methner C, Carpenter TA, Hawkes RC, Sawiak SJ, Krieg T (2013), “MRI and PET in mouse models of myocardial infarction.” J Vis Exp (82):e50806 Details Buonincontri G, Sawiak SJ, Methner C, Krieg T, Hawkes RC, Carpenter TA (2013), “PET/MRI in the infarcted mouse heart with the Cambridge split magnet.” Nucl Instrum Methods Phys Res A 702 Details Carpenter KL, Jalloh I, Gallagher CN, Grice P, Howe DJ, Mason A, Timofeev I, Helmy A, Murphy MP, Menon DK, Kirkpatrick PJ, Carpenter TA, Sutherland GR, Pickard JD, Hutchinson PJ (2013), “13C-labelled microdialysis studies of cerebral metabolism in TBI patients.” Eur J Pharm Sci Details Carrera E, Jones PS, Morris RS, Alawneh J, Hong YT, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC (2013), “Is neural activation within the rescued penumbra impeded by selective neuronal loss?” Brain 136(Pt 6):1816-29 Details Phillips AC, Sleigh A, McAllister CJ, Brage S, Carpenter TA, Kemp GJ, Holland AJ (2013), “Defective mitochondrial function in vivo in skeletal muscle in adults with Down's syndrome: a 31P-MRS study.” PLoS One 8(12):e84031 Details Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2013), “Voxel-based morphometry with templates and validation in a mouse model of Huntington's disease.” Magn Reson Imaging 31(9):1522-31 Details 2012Adapa RM, Axell RG, Mangat JS, Carpenter TA, Absalom AR (2012), “Safety and performance of TCI pumps in a magnetic resonance imaging environment.” Anaesthesia 67(1):33-9 Details Wood NI, Sawiak SJ, Buonincontri G, Niu Y, Kane AD, Carpenter TA, Giussani DA, Morton AJ (2012), “Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease.” J Huntingtons Dis 1(1) Details 2011Carrera E, Jones PS, Alawneh JA, Klærke Mikkelsen I, Cho TH, Siemonsen S, Guadagno JV, Mouridsen K, Ribe L, Hjort N, Fryer TD, Carpenter TA, Aigbirhio FI, Fiehler J, Nighoghossian N, Warburton EA, Ostergaard L, Baron JC (2011), “Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?” Stroke 42(6):1602-7 Details Kasahara M, Menon DK, Salmond CH, Outtrim JG, Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2011), “Traumatic brain injury alters the functional brain network mediating working memory.” Brain Inj 25(12):1170-87 Details Malone IB, Ansorge RE, Williams GB, Nestor PJ, Carpenter TA, Fryer TD (2011), “Attenuation correction methods suitable for brain imaging with a PET/MRI scanner: a comparison of tissue atlas and template attenuation map approaches.” J Nucl Med 52(7):1142-9 Details Newcombe V, Chatfield D, Outtrim J, Vowler S, Manktelow A, Cross J, Scoffings D, Coleman M, Hutchinson P, Coles J, Carpenter TA, Pickard J, Williams G, Menon D (2011), “Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome.” PLoS One 6(5):e19214 Details Sleigh A, Raymond-Barker P, Thackray K, Porter D, Hatunic M, Vottero A, Burren C, Mitchell C, McIntyre M, Brage S, Carpenter TA, Murgatroyd PR, Brindle KM, Kemp GJ, O'Rahilly S, Semple RK, Savage DB (2011), “Mitochondrial dysfunction in patients with primary congenital insulin resistance.” J Clin Invest 121(6):2457-61 Details 2010Calautti C, Jones PS, Guincestre JY, Naccarato M, Sharma N, Day DJ, Carpenter TA, Warburton EA, Baron JC (2010), “The neural substrates of impaired finger tapping regularity after stroke.” Neuroimage 50(1):1-6 Details Dickson JD, Ash TW, Williams GB, Harding SG, Carpenter TA, Menon DK, Ansorge RE (2010), “Quantitative BOLD: the effect of diffusion.” J Magn Reson Imaging 32(4):953-61 Details Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2010), “Altered functional connectivity in the motor network after traumatic brain injury.” Neurology 75(2):168-76 Details Newcombe VF, Williams GB, Scoffings D, Cross J, Carpenter TA, Pickard JD, Menon DK (2010), “Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications.” J Neurol Neurosurg Psychiatry 81(5):552-61 Details 2009Donswijk ML, Jones PS, Guadagno JV, Carpenter TA, Moustafa RR, Fryer TD, Aigbirhio FI, Warburton EA, Baron JC (2009), “T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.” Cerebrovasc Dis 28(3):306-13 Details Salgin B, Sleigh AJ, Williams RM, Jackson SJ, Bluck LJ, Murgatroyd PR, Humphreys SM, Harding S, Carpenter TA, Dunger DB (2009), “Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects.” Clin Sci (Lond) 117(3):111-8 Details Semple RK, Sleigh A, Murgatroyd PR, Adams CA, Bluck L, Jackson S, Vottero A, Kanabar D, Charlton-Menys V, Durrington P, Soos MA, Carpenter TA, Lomas DJ, Cochran EK, Gorden P, O'Rahilly S, Savage DB (2009), “Postreceptor insulin resistance contributes to human dyslipidemia and hepatic steatosis.” J Clin Invest 119(2):315-22 Details Sharma N, Simmons LH, Jones PS, Day DJ, Carpenter TA, Pomeroy VM, Warburton EA, Baron JC (2009), “Motor imagery after subcortical stroke: a functional magnetic resonance imaging study.” Stroke 40(4):1315-24 Details 2008Abate MG, Trivedi M, Fryer TD, Smielewski P, Chatfield DA, Williams GB, Aigbirhio F, Carpenter TA, Pickard JD, Menon DK, Coles JP (2008), “Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.” Neurocrit Care 9(3):319-25 Details Correia MM, Carpenter TA, Williams GB (2008), “Looking for the optimal DTI acquisition scheme given a maximum scan time: are more b-values a waste of time?” Magn Reson Imaging Details Hosey TP, Harding SG, Carpenter TA, Ansorge RE, Williams GB (2008), “Application of a probabilistic double-fibre structure model to diffusion-weighted MR images of the human brain.” Magn Reson Imaging 26(2):236-45 Details Newcombe VF, Hawkes RC, Harding SG, Willcox R, Brock S, Hutchinson PJ, Menon DK, Carpenter TA, Coles JP (2008), “Potential heating caused by intraparenchymal intracranial pressure transducers in a 3-tesla magnetic resonance imaging system using a body radiofrequency resonator: assessment of the Codman MicroSensor Transducer.” J Neurosurg 109(1):159-64 Details Newcombe VF, Williams GB, Nortje J, Bradley PG, Chatfield DA, Outtrim JG, Harding SG, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2008), “Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma.” Acta Neurochir Suppl 102:247-51 Details Sharma N, Jones PS, Carpenter TA, Baron JC (2008), “Mapping the involvement of BA 4a and 4p during Motor Imagery.” Neuroimage 41(1):92-9 Details Stevick JW, Harding SG, Paquet U, Ansorge RE, Carpenter TA, Williams GB (2008), “Gaussian process modeling for image distortion correction in echo planar imaging.” Magn Reson Med 59(3):598-606 Details 2007Coles JP, Fryer TD, Coleman MR, Smielewski P, Gupta AK, Minhas PS, Aigbirhio F, Chatfield DA, Williams GB, Boniface S, Carpenter TA, Clark JC, Pickard JD, Menon DK (2007), “Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.” Crit Care Med 35(2):568-78 Details Newcombe VF, Williams GB, Nortje J, Bradley PG, Harding SG, Smielewski P, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2007), “Analysis of acute traumatic axonal injury using diffusion tensor imaging.” Br J Neurosurg 21(4):340-8 Details Price SJ, Jena R, Burnet NG, Carpenter TA, Pickard JD, Gillard JH (2007), “Predicting patterns of glioma recurrence using diffusion tensor imaging.” Eur Radiol 17(7):1675-84 Details 2006Guadagno JV, Jones PS, Fryer TD, Barret O, Aigbirhio FI, Carpenter TA, Price CJ, Gillard JH, Warburton EA, Baron JC (2006), “Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.” Stroke 37(7):1741-8 Details Lucas AJ, Hawkes RC, Ansorge RE, Williams GB, Nutt RE, Clark JC, Fryer TD, Carpenter TA (2006), “Development of a combined microPET-MR system.” Technol Cancer Res Treat 5(4):337-41 Details Naccarato M, Calautti C, Jones PS, Day DJ, Carpenter TA, Baron JC (2006), “Does healthy aging affect the hemispheric activation balance during paced index-to-thumb opposition task? An fMRI study.” Neuroimage 32(3):1250-6 Details Owler BK, Higgins JN, Péna A, Carpenter TA, Pickard JD (2006), “Diffusion tensor imaging of benign intracranial hypertension: absence of cerebral oedema.” Br J Neurosurg 20(2):79-81 Details Peña A, Green HA, Carpenter TA, Price SJ, Pickard JD, Gillard JH (2006), “Enhanced visualization and quantification of magnetic resonance diffusion tensor imaging using the p:q tensor decomposition.” Br J Radiol 79(938):101-9 Details Pickard J, Chir M, Coleman M, Aigbirhio F, Carpenter TA, Owen A (2006), “Head injury: from the Glasgow Coma Scale to quo vadis.” Clin Neurosurg 53:53-7 Details 2005Barret O, Carpenter TA, Clark JC, Ansorge RE, Fryer TD (2005), “Monte Carlo simulation and scatter correction of the GE advance PET scanner with SimSET and Geant4.” Phys Med Biol 50(20):4823-40 Details Cunningham AS, Harding S, Chatfield DA, Hutchinson P, Carpenter TA, Pickard JD, Menon DK (2005), “Metallic neurosurgical implants for cranial reconstruction and fixation: assessment of magnetic field interactions, heating and artefacts at 3.0 Tesla.” Br J Neurosurg 19(2):167-72 Details Cunningham AS, Salvador R, Coles JP, Chatfield DA, Bradley PG, Johnston AJ, Steiner LA, Fryer TD, Aigbirhio FI, Smielewski P, Williams GB, Carpenter TA, Gillard JH, Pickard JD, Menon DK (2005), “Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.” Brain 128(Pt 8):1931-42 Details Guadagno JV, Warburton EA, Jones PS, Fryer TD, Day DJ, Gillard JH, Carpenter TA, Aigbirhio FI, Price CJ, Baron JC (2005), “The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography.” Cerebrovasc Dis 19(4):239-46 Details Mukherjee B, Preece M, Houston GC, Papadakis NG, Carpenter TA, Hall LD, Huang CL (2005), “Mapping of the cerebral response to acetazolamide using graded asymmetric spin echo EPI.” Magn Reson Imaging 23(9):907-20 Details Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details Salvador R, Peña A, Menon DK, Carpenter TA, Pickard JD, Bullmore ET (2005), “Formal characterization and extension of the linearized diffusion tensor model.” Hum Brain Mapp 24(2):144-55 Details 2004Coles JP, Fryer TD, Smielewski P, Chatfield DA, Steiner LA, Johnston AJ, Downey SP, Williams GB, Aigbirhio F, Hutchinson PJ, Rice K, Carpenter TA, Clark JC, Pickard JD, Menon DK (2004), “Incidence and mechanisms of cerebral ischemia in early clinical head injury.” J Cereb Blood Flow Metab 24(2):202-11 Details Guadagno JV, Warburton EA, Aigbirhio FI, Smielewski P, Fryer TD, Harding S, Price CJ, Gillard JH, Carpenter TA, Baron JC (2004), “Does the acute diffusion-weighted imaging lesion represent penumbra as well as core? A combined quantitative PET/MRI voxel-based study.” J Cereb Blood Flow Metab 24(11):1249-54 Details Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD (2004), “Diffusion limited oxygen delivery following head injury.” Crit Care Med 32(6):1384-90 Details Price SJ, Peña A, Burnet NG, Jena R, Green HA, Carpenter TA, Pickard JD, Gillard JH (2004), “Tissue signature characterisation of diffusion tensor abnormalities in cerebral gliomas.” Eur Radiol 14(10):1909-17 Details 2003Coles JP, Steiner LA, Martin J, Donovan T, Hutchinson PJ, Carpenter TA, Menon DK (2003), “Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner.” Anaesthesia 58(2):143-8 Details Donovan T, Fryer TD, Peña A, Watts C, Carpenter TA, Pickard JD (2003), “Stereotactic MR imaging for planning neural transplantation: a reliable technique at 3 Tesla?” Br J Neurosurg 17(5):443-9 Details Fletcher PC, Stephenson CM, Carpenter TA, Donovan T, Bullmorel ET (2003), “Regional brain activations predicting subsequent memory success: an event-related fMRI study of the influence of encoding tasks.” Cortex 39(4-5):1009-26 Details Gustard S, Williams EJ, Hall LD, Pickard JD, Carpenter TA (2003), “Influence of baseline hematocrit on between-subject BOLD signal change using gradient echo and asymmetric spin echo EPI.” Magn Reson Imaging 21(6):599-607 Details Marshall JW, Ridley RM, Baker HF, Hall LD, Carpenter TA, Wood NI (2003), “Serial MRI, functional recovery, and long-term infarct maturation in a non-human primate model of stroke.” Brain Res Bull 61(6):577-85 Details Price SJ, Burnet NG, Donovan T, Green HA, Peña A, Antoun NM, Pickard JD, Carpenter TA, Gillard JH (2003), “Diffusion tensor imaging of brain tumours at 3T: a potential tool for assessing white matter tract invasion?” Clin Radiol 58(6):455-62 Details Watts C, Donovan T, Gillard JH, Antoun NM, Burnstein R, Menon DK, Carpenter TA, Fryer T, Thomas DG, Pickard JD (2003), “Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease.” Cell Transplant 12(7):697-704 Details |