Dr Ben Sutcliffe
MRC Career Development Fellow
In the Drosophila olfactory system around 1300 olfactory receptor neurons transmit sensory information to the antennal lobe where neurons of the same class converge on distinct glomeruli. Projection neuron dendrites innervate these glomeruli in a glomerular specific manner and send their axonal projections to the higher brain centres of the mushroom body and the lateral horn. In the mushroom body the projection neurons converge on the Kenyon cells with roughly a 10:1 ratio. In the lateral horn the projections neurons converge on a yet unknown number of cells. The lateral horn is thought to be anatomically subdivided into distinct region, one for processing of pheromone information and another for processing of food odour information. My aim is to use the chemical labelling techniques recently developed in our lab to map the neurons of the lateral horn, classifying them based on neuroblast lineage and assigning neurotransmitter profiles.
Associated News Items
Diaper DC, Adachi Y, Sutcliffe B, Humphrey DM, Elliott CJ, Stepto A, Ludlow ZN, Vanden Broeck L, Callaerts P, Dermaut B, Al-Chalabi A, Shaw CE, Robinson IM, Hirth F (2013), “Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes.” Hum Mol Genet 22(8):1539-57 Details
Sutcliffe B, Forero MG, Zhu B, Robinson IM, Hidalgo A (2013), “Neuron-Type Specific Functions of DNT1, DNT2 and Spz at the Drosophila Neuromuscular Junction.” PLoS One 8(10):e75902 Details
Hidalgo A, Kato K, Sutcliffe B, McIlroy G, Bishop S, Alahmed S (2011), “Trophic neuron-glia interactions and cell number adjustments in the fruit fly.” Glia 59(9):1296-303 Details
Zhu B, Pennack JA, McQuilton P, Forero MG, Mizuguchi K, Sutcliffe B, Gu CJ, Fenton JC, Hidalgo A (2008), “Drosophila neurotrophins reveal a common mechanism for nervous system formation.” PLoS Biol 6(11):e284 Details