Dr Simon Stott


I am interested in the development, maintenance and functioning of subsets of midbrain dopamine neurons, with a particular interest in Parkinson's disease.

My current lab work involves examining gene expression in dopamine neurons in the human midbrain as part of an EU-wide consortium (DDPDgenes - funded by FP7). This work is determining if developmentally expressed genes have any function in Parkinson’s disease.

I am also conducting a clinical study funded by BIRAX and Parkinson's UK investigating breath sampling in Parkinson's disease, as part of a collaboration with Prof Hossam Haick (Technion, Israel).

Research Focus







Clinical conditions

Parkinson's disease


Behavioural analysis

Cell culture

Confocal microscopy


Laser capture microdissection


Recombinant protein expression



Roger Barker

Jeff Dalley

Heike Laman

Emmanouil Metzakopian

United Kingdom

Siew-Lan Ang Web: http://www.nimr.mrc.ac.uk/researc...


Anders Bjorklund Web: http://www.med.lu.se/expmed/...

Hossam Haick Web: http://lnbd.technion.ac.il/team/pr...

Deniz Kirik Web: http://www.med.lu.se/expmed/...

Associated News Items



Khan S, Stott S, Chabrat A, Truckenbrodt AM, Spencer-Dene B, Nave KA, Guillemot F, Levesque M, Ang SL. (2017), “Survival of a novel subset of midbrain dopaminergic neurons projecting to the lateral septum is dependent on NeuroD proteins.” Journal of Neuroscience

Lakshminarayana R, Wang D, Burn D, Barker RA, Chaudhuri KR, Galtrey C, van Guzman N, Hellman B, Pal S, Stamford J, Steiger M, Stott SRW, Teo J, Bloem B, van der Eijk M, Wang E, Williams A. (2017), “Using a smartphone based self-management platform to support medication adherence and clinical consultation in Parkinson’s disease: Results from the SMART-PD Randomised Controlled Trial v4” npj Parkinson's Disease

Stott SR, Hayat S, Carnwath T, Garas S, Sleeman JP, Barker RA. (2017), “CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease.” PLOS ONE 12(2):e0171748


La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A, Borm L, Stott SRW, Toledo E, Villaescusa C, Lönnerberg P, Ryge J, Barker RA, Arenas E, Linnarsson S. (2016), “Molecular Anatomy of Midbrain and Dopaminergic Neuron Development in Mouse, Human and Stem Cells. ” Cell 167 (2), 566 – 580

Miller SR, Perera SN, Benito C, Stott SR, Baker CV (2016), “Evidence for a Notch1-mediated transition during olfactory ensheathing cell development” Journal of Anatomy, 229(3):369-83

Raha AA, Henderson JW, Stott SRW, Vuono R, Foscarin S, Friedland RP, Zaman SH, Raha-Chowdhury R (2016), “Neuroprotective effect of TREM-2 in ageing and Alzheimer’s disease model ” Journal of Alzheimer's Disease

Villaescusa JC, Li B, Toledo EM, Rivetti di Val Cervo P, Yang S, Stott SR, Kaiser K, Islam S, Gyllborg D, Laguna-Goya R, Landreh M, Lönnerberg P, Falk A, Bergman T, Barker RA, Linnarsson S, Selleri L, Arenas E (2016), “A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease ” EMBO 35(18):1963-78


Raha-Chowdhury R, Raha AA, Forostyak S, Zhao JW, Stott SR, Bomford A (2015), “Expression and cellular localization of hepcidin mRNA and protein in normal rat brain.” BMC Neurosci 16(1):24 Details

Roybon L, Mastracci TL, Li J, Stott SR, Leiter AB, Sussel L, Brundin P, Li JY (2015), “The Origin, Development and Molecular Diversity of Rodent Olfactory Bulb Glutamatergic Neurons Distinguished by Expression of Transcription Factor NeuroD1.” PLoS One 10(6):e0128035 Details

Schwab LC, Garas SN, Drouin-Ouellet J, Mason SL, Stott SR, Barker RA (2015), “Dopamine and Huntington's disease.” Expert Rev Neurother 15(4):445-58 Details

Stott SR (2015), “The wrong James Parkinson.” Pract Neurol Details


Stott SR, Barker RA (2014), “Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson's disease.” Eur J Neurosci 39(6):1042-56 Details


Ali F, Stott SR, Barker RA (2013), “Stem cells and the treatment of Parkinson's disease.” Exp Neurol Details

Stott SR, Metzakopian E, Lin W, Kaestner KH, Hen R, Ang SL (2013), “Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.” J Neurosci 33(18):8022-34 Details


Kornum BR, Stott SR, Mattsson B, Wisman L, Ettrup A, Hermening S, Knudsen GM, Kirik D (2010), “Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain.” Exp Neurol 222(1):70-85 Details


Hebsgaard JB, Nelander J, Sabelström H, Jönsson ME, Stott S, Parmar M (2009), “Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics.” Glia 57(15):1648-58 Details

Liuba K, Pronk CJ, Stott SR, Jacobsen SE (2009), “Polyclonal T-cell reconstitution of X-SCID recipients after in utero transplantation of lymphoid-primed multipotent progenitors.” Blood 113(19):4790-8 Details

Roybon L, Hjalt T, Stott S, Guillemot F, Li JY, Brundin P (2009), “Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis.” PLoS One 4(3):e4779 Details


Nygren JM, Liuba K, Breitbach M, Stott S, Thorén L, Roell W, Geisen C, Sasse P, Kirik D, Björklund A, Nerlov C, Fleischmann BK, Jovinge S, Jacobsen SE (2008), “Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.” Nat Cell Biol 10(5):584-92 Details


Barraud P, Stott S, Møllgård K, Parmar M, Björklund A (2007), “In vitro characterization of a human neural progenitor cell coexpressing SSEA4 and CD133.” J Neurosci Res 85(2):250-9 Details


Stott SR, Kirik D (2006), “Targeted in utero delivery of a retroviral vector for gene transfer in the rodent brain.” Eur J Neurosci 24(7):1897-906 Details


Krishnamurthi R, Stott S, Maingay M, Faull RL, McCarthy D, Gluckman P, Guan J (2004), “N-terminal tripeptide of IGF-1 improves functional deficits after 6-OHDA lesion in rats.” Neuroreport 15(10):1601-4 Details