Dr Sabine Rühle University positionResearch Associate InstitutesMedical Research Council Laboratory of Molecular Biology Home pagehttp://www2.mrc-lmb.cam.ac.uk/group-l... Research ThemesInterestsBy combining behavioural, genetic, electrophysiological and optical techniques, I aim to investigate how sensory inputs and motivational states are integrated to produce behavioural outputs. Research Focus
EquipmentBehavioural analysis Calcium imaging Confocal microscopy Electrophysiological recording techniques Fluorescence microscopy Immunohistochemistry Optogenetics Viral vectors CollaboratorsNo collaborators listed Associated News ItemsKey publicationsRosa JM*, Ruehle S*, Ding H, Lagnado L. *Co-first author (2016), “Crossover-inhibition generates sustained visual responses in the inner retina” Neuron 90(2):308-19 Soria-Gómez E, Bellocchio L, Reguero L, Lepousez G, Martin C, Bendahmane M, Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B, Guzmán M, Gurden H, Ferreira G, Lledo PM, Grandes P, Marsicano G (2014), “The endocannabinoid system controls food intake via olfactory processes.” Nat Neurosci 17(3):407-15 Details Ruehle S, Remmers F, Romo-Parra H, Massa F, Wickert M, Wörtge S, Häring M, Kaiser N, Marsicano G, Pape HC, Lutz B (2013), “Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions.” J Neurosci 33(25):10264-77 Details Publications2016Gutiérrez-Rodríguez A, Puente N, Elezgarai I, Ruehle S, Lutz B, Reguero L, Gerrikagoitia I, Marsicano G, Grandes P (2016), “Anatomical characterization of the cannabinoid CB1 receptor in cell type-specific mutant mouse rescue models” J Comp Neurol Jun 23. doi: 10.1002/cne.24066 2014Kohl J, Ng J, Cachero S, Ciabatti E, Dolan MJ, Sutcliffe B, Tozer A, Ruehle S, Krueger D, Frechter S, Branco T, Tripodi M, Jefferis GS. (2014), “Ultrafast tissue staining with chemical tags” Proc Natl Acad Sci U S A 111(36):E3805-14 2013Steindel F, Lerner R, Häring M, Ruehle S, Marsicano G, Lutz B, Monory K (2013), “Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus.” J Neurochem 124(6):795-807 Details 2012Ruehle S, Rey AA, Remmers F, Lutz B (2012), “The endocannabinoid system in anxiety, fear memory and habituation.” J Psychopharmacol 26(1):23-39 Details 2011Mersmann N, Tkachev D, Jelinek R, Röth PT, Möbius W, Ruhwedel T, Rühle S, Weber-Fahr W, Sartorius A, Klugmann M (2011), “Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.” PLoS One 6(5):e20336 Details |