Dr Sabine Rühle


By combining behavioural, genetic, electrophysiological and optical techniques, I aim to investigate how sensory inputs and motivational states are integrated to produce behavioural outputs.

Research Focus


defensive behaviour

synaptic integration



Clinical conditions

No direct clinical relevance


Behavioural analysis

Calcium imaging

Confocal microscopy

Electrophysiological recording techniques

Fluorescence microscopy



Viral vectors


No collaborators listed

Associated News Items

    Key publications

    Rosa JM*, Ruehle S*, Ding H, Lagnado L. *Co-first author (2016), “Crossover-inhibition generates sustained visual responses in the inner retina” Neuron 90(2):308-19

    Soria-Gómez E, Bellocchio L, Reguero L, Lepousez G, Martin C, Bendahmane M, Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B, Guzmán M, Gurden H, Ferreira G, Lledo PM, Grandes P, Marsicano G (2014), “The endocannabinoid system controls food intake via olfactory processes.” Nat Neurosci 17(3):407-15 Details

    Ruehle S, Remmers F, Romo-Parra H, Massa F, Wickert M, Wörtge S, Häring M, Kaiser N, Marsicano G, Pape HC, Lutz B (2013), “Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions.” J Neurosci 33(25):10264-77 Details



    Gutiérrez-Rodríguez A, Puente N, Elezgarai I, Ruehle S, Lutz B, Reguero L, Gerrikagoitia I, Marsicano G, Grandes P (2016), “Anatomical characterization of the cannabinoid CB1 receptor in cell type-specific mutant mouse rescue models” J Comp Neurol Jun 23. doi: 10.1002/cne.24066


    Kohl J, Ng J, Cachero S, Ciabatti E, Dolan MJ, Sutcliffe B, Tozer A, Ruehle S, Krueger D, Frechter S, Branco T, Tripodi M, Jefferis GS. (2014), “Ultrafast tissue staining with chemical tags” Proc Natl Acad Sci U S A 111(36):E3805-14


    Steindel F, Lerner R, Häring M, Ruehle S, Marsicano G, Lutz B, Monory K (2013), “Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus.” J Neurochem 124(6):795-807 Details


    Ruehle S, Rey AA, Remmers F, Lutz B (2012), “The endocannabinoid system in anxiety, fear memory and habituation.” J Psychopharmacol 26(1):23-39 Details


    Mersmann N, Tkachev D, Jelinek R, Röth PT, Möbius W, Ruhwedel T, Rühle S, Weber-Fahr W, Sartorius A, Klugmann M (2011), “Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.” PLoS One 6(5):e20336 Details