Dr Sybil StacpooleUniversity positionClinical Fellow in Neurology DepartmentsDepartment of Clinical Neurosciences InstitutesHome pageResearch ThemesInterestsI am currently a neurology registrar, having completed a PhD working with neural precursor cells derived from human embryonic stem cells. I studied the pathways involved in directing neural precursor cells into oligodendrocytes, and investigated some of the biuological properties of human OPCs and oligodendrocytes in vitro. I have also developed an interest in the role of low, physiological oxygen levels in cell culture. Research Focus
EquipmentCell culture Confocal microscopy Fluorescence microscopy Immunohistochemistry Microscopy CollaboratorsNo collaborators listed Associated News ItemsPublications2013Stacpoole SR, Spitzer S, Bilican B, Compston A, Karadottir R, Chandran S, Franklin RJ (2013), “High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.” Stem Cell Reports 1(5):437-50 Details Stacpoole SR, Webber DJ, Bilican B, Compston A, Chandran S, Franklin RJ (2013), “Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.” Stem Cells Transl Med 2(6):464-72 Details 2011Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S (2011), “Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.” Nat Protoc 6(8):1229-40 Details Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S (2011), “Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation.” Cell Death Differ 18(6):1016-23 Details |