Dr Sofia Papadia


I am interested in the neuronal control of obesity, investigating the molecular mechanisms and signalling pathways by which genes in the brain are regulating energy homeostasis.

I have been a member of Prof. I.S. Farooqi's team from 2010-2014 at the Institute of Metabolic Science.

Research Focus



melanocortin pathway



Clinical conditions



Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy





Frank Reimann

Maria Grazia Spillantini

Associated News Items



    Deighton RF, Márkus NM, Al-Mubarak B, Bell KF, Papadia S, Meakin PJ, Chowdhry S, Hayes JD, Hardingham GE (2014), “Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes.” Proc Natl Acad Sci U S A 111(18):E1818-20 Details


    McMahon AC, Barnett MW, O'Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC (2012), “SynGAP isoforms exert opposing effects on synaptic strength.” Nat Commun 3:900 Details


    Soriano FX, Léveillé F, Papadia S, Bell KF, Puddifoot C, Hardingham GE (2011), “Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses.” Antioxid Redox Signal 14(8):1425-36 Details


    Fricker M, Papadia S, Hardingham GE, Tolkovsky AM (2010), “Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons.” J Neurochem 114(3):772-83 Details

    Léveillé F, Papadia S, Fricker M, Bell KF, Soriano FX, Martel MA, Puddifoot C, Habel M, Wyllie DJ, Ikonomidou C, Tolkovsky AM, Hardingham GE (2010), “Suppression of the intrinsic apoptosis pathway by synaptic activity.” J Neurosci 30(7):2623-35 Details


    Léveillé F, Soriano FX, Papadia S, Hardingham GE (2009), “Excitotoxic insults lead to peroxiredoxin hyperoxidation.” Oxid Med Cell Longev 2(2):110-3 Details

    Soriano FX, Papadia S, Bell KF, Hardingham GE (2009), “Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2.” Epigenetics 4(3):152-8 Details


    Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE (2008), “Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.” Nat Neurosci 11(4):476-87 Details

    Soriano FX, Léveillé F, Papadia S, Higgins LG, Varley J, Baxter P, Hayes JD, Hardingham GE (2008), “Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.” J Neurochem 107(2):533-43 Details

    Soriano FX, Martel MA, Papadia S, Vaslin A, Baxter P, Rickman C, Forder J, Tymianski M, Duncan R, Aarts M, Clarke P, Wyllie DJ, Hardingham GE (2008), “Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.” J Neurosci 28(42):10696-710 Details


    Papadia S, Hardingham GE (2007), “The dichotomy of NMDA receptor signaling.” Neuroscientist 13(6):572-9 Details


    McKenzie G, Ward G, Stallwood Y, Briend E, Papadia S, Lennard A, Turner M, Champion B, Hardingham GE (2006), “Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals.” BMC Cell Biol 7:10 Details

    Soriano FX, Papadia S, Hofmann F, Hardingham NR, Bading H, Hardingham GE (2006), “Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability.” J Neurosci 26(17):4509-18 Details


    McKenzie GJ, Stevenson P, Ward G, Papadia S, Bading H, Chawla S, Privalsky M, Hardingham GE (2005), “Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.” J Neurochem 93(1):171-85 Details

    Papadia S, Stevenson P, Hardingham NR, Bading H, Hardingham GE (2005), “Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection.” J Neurosci 25(17):4279-87 Details

    Papadia S, Tzolovsky G, Zhao D, Leaper K, Clyde D, Taylor P, Asscher E, Kirk G, Bownes M (2005), “emc has a role in dorsal appendage fate formation in Drosophila oogenesis.” Mech Dev 122(9):961-74 Details