Dr Shigekazu OdaUniversity positionResearch Associate InstitutesMedical Research Council Laboratory of Molecular Biology Home pagehttp://www2.mrc-lmb.cam.ac.uk/groups/... Research ThemesInterestsMy long-term goal is to discover a general principle of information process in a neural circuit. The main subject is that 'how biological system behave as a system?' To answer this question, I am using a simple model organism, C. elegans by using highly quantitative methods, information coding analysis and genetic tools. I am analysing a neural circuit both locally and globally. I have been studying the molecular and neural dynamics in C. elegans by using and developing in vivo imaging techniques. And I discovered neuronal dynamics in learning & memory, information coding of MAPK-ERK and signal transduction of cGMP. Now I am working on molecular mechanism underlying aggregation behaviour of C. elegans. And I am also working on modulation of frequency coding properties by neuroglobin in a neural circuit. Research Focus
EquipmentBehavioural analysis Calcium imaging Computational modelling Confocal microscopy Fluorescence microscopy Immunohistochemistry in vivo imaging (Calcium, ERK-MAPK, release of synaptic vesicles and cGMP), MATLAB, IgorPro, microfluidic device Microscopy Collaborators
Associated News ItemsKey publicationsCouto A, Oda S, Nikolaev VO, Soltesz Z, de Bono M (2013), “In vivo genetic dissection of O2-evoked cGMP dynamics in a Caenorhabditis elegans gas sensor.” Proc Natl Acad Sci U S A Details Tomida* T, Oda* S, Takekawa M, Iino Y, Saito H (*Co-first authors) (2012), “The temporal pattern of stimulation determines the extent and duration of MAPK activation in a Caenorhabditis elegans sensory neuron.” Sci Signal 5(246):ra76 Oda S, Tomioka M, Iino Y (2011), “Neuronal plasticity regulated by the insulin-like signaling pathway underlies salt chemotaxis learning in Caenorhabditis elegans.” J Neurophysiol 106(1):301-8 Details Publications2014Gross E, Soltesz Z, Oda S, Zelmanovich V, Abergel Z, de Bono M (2014), “GLOBIN-5-Dependent O2 Responses Are Regulated by PDL-1/PrBP That Targets Prenylated Soluble Guanylate Cyclases to Dendritic Endings.” J Neurosci 34(50):16726-38 Details 2012Yoshida K, Hirotsu T, Tagawa T, Oda S, Wakabayashi T, Iino Y, Ishihara T (2012), “Odour concentration-dependent olfactory preference change in C. elegans.” Nat Commun 3:739 Details 2011Iwata R, Oda S, Kunitomo H, Iino Y (2011), “Roles for class IIA phosphatidylinositol transfer protein in neurotransmission and behavioral plasticity at the sensory neuron synapses of Caenorhabditis elegans.” Proc Natl Acad Sci U S A 108(18):7589-94 Details |