Dr Sarah Mason University positionResearch Associate DepartmentsDepartment of Clinical Neurosciences InstitutesCambridge Centre for Brain Repair Home pagehttp://thebarkerlab.co.uk/hunting... Research ThemeInterestsMy research interests are: 1) Better defining the neuropsychological profile of presymptomatic and early Huntington's disease using fMRI scanning and behavioural testing. With a particular interest in determining the factors which underpin the cognitive heterogeneity of the disease. 2) Understanding the role of apathy in Huntington's disease, how it evolves with advancing disease and its relationship to cognitive processes such as reward processing, decision making and emotional. 3) Exploring social cognition in Huntington's disease. Research Focus
EquipmentfMRI Neuropsychological testing Collaborators
Associated News ItemsKey publicationsAlpar S Lazar, Francesca Panin, Anna O G Goodman, Stanley E Lazic, Zsolt I Lazar, Sarah L Mason, Lorraine Rogers, Peter R Murgatroyd, Laura P E Watson, Priya Singh, Beth Borowsky, John M Shneerson, Roger A Barker (2015), “Sleep Deficits but No Metabolic Deficits in Premanifest Huntington's Disease” Annals of Neurology 78 (4), 630-48 Publications2019Christopher J Heath, Claire O'Callaghan, Sarah L Mason, Benjamin U Phillips, Lisa M Saksida, Trevor W Robbins, Roger A Barker, Timothy J Bussey, Barbara J Sahakian (2019), “A Touchscreen Motivation Assessment Evaluated in Huntington's Disease Patients and R6/1 Model Mice” Frontiers in Neurology 10, 858 2014Barker RA, Mason SL (2014), “Neurodegenerative disease: Mapping the natural history of Huntington disease.” Nat Rev Neurol 10(1):12-3 Details 2013Barker RA, Barrett J, Mason SL, Björklund A (2013), “Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease.” Lancet Neurol 12(1):84-91 Details Barker RA, Mason SL, Harrower TP, Swain RA, Ho AK, Sahakian BJ, Mathur R, Elneil S, Thornton S, Hurrelbrink C, Armstrong RJ, Tyers P, Smith E, Carpenter A, Piccini P, Tai YF, Brooks DJ, Pavese N, Watts C, Pickard JD, Rosser AE, Dunnett SB, NEST-UK collaboration (2013), “The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease.” J Neurol Neurosurg Psychiatry 84(6):657-65 Details Begeti F, Tan AY, Cummins GA, Collins LM, Guzman NV, Mason SL, Barker RA (2013), “The Addenbrooke's Cognitive Examination-Revised accurately detects cognitive decline in Huntington's disease.” J Neurol 260(11):2777-85 Details Breen DP, Williams-Gray CH, Mason SL, Foltynie T, Barker RA (2013), “Excessive daytime sleepiness and its risk factors in incident Parkinson's disease.” J Neurol Neurosurg Psychiatry 84(2):233-4 Details Williams-Gray CH, Mason SL, Evans JR, Foltynie T, Brayne C, Robbins TW, Barker RA (2013), “The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort.” J Neurol Neurosurg Psychiatry 84(11):1258-64 Details Winder-Rhodes SE, Evans JR, Ban M, Mason SL, Williams-Gray CH, Foltynie T, Duran R, Mencacci NE, Sawcer SJ, Barker RA (2013), “Glucocerebrosidase mutations influence the natural history of Parkinson's disease in a community-based incident cohort.” Brain 136(Pt 2):392-9 Details 2012Evans JR, Mason SL, Barker RA (2012), “Current status of clinical trials of neural transplantation in Parkinson's disease.” Prog Brain Res 200:169-98 Details McColgan P, Evans JR, Breen DP, Mason SL, Barker RA, Williams-Gray CH (2012), “Addenbrooke's Cognitive Examination-Revised for mild cognitive impairment in Parkinson's disease.” Mov Disord 27(9):1173-7 Details 2011Barker RA, Mason SL (2011), “Neurodegenerative disease: Tracking disease progress in Huntington disease.” Nat Rev Neurol 7(4):192-3 Details Evans JR, Mason SL, Williams-Gray CH, Foltynie T, Brayne C, Robbins TW, Barker RA (2011), “The natural history of treated Parkinson's disease in an incident, community based cohort.” J Neurol Neurosurg Psychiatry Details Evans JR, Mason SL, Williams-Gray CH, Foltynie T, Trotter M, Barker RA (2011), “The factor structure of the UPDRS as an index of disease progression in Parkinson's disease.” J Parkinsons Dis 1(1):75-82 Details Politis M, Pavese N, Tai YF, Kiferle L, Mason SL, Brooks DJ, Tabrizi SJ, Barker RA, Piccini P (2011), “Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study.” Hum Brain Mapp 32(2):258-70 Details 2010Antoniades CA, Xu Z, Mason SL, Carpenter RH, Barker RA (2010), “Huntington's disease: changes in saccades and hand-tapping over 3 years.” J Neurol 257(11):1890-8 Details Calder AJ, Keane J, Young AW, Lawrence AD, Mason S, Barker RA (2010), “The relation between anger and different forms of disgust: implications for emotion recognition impairments in Huntington's disease.” Neuropsychologia 48(9):2719-29 Details Mason SL, Wijeyekoon R, Swain R, Ho AK, Smith EL, Sahakian B, Barker RA (2010), “Cognitive follow up of a small cohort of Huntington's disease patients over a 5 year period.” PLoS Curr 2 Details Pavese N, Politis M, Tai YF, Barker RA, Tabrizi SJ, Mason SL, Brooks DJ, Piccini P (2010), “Cortical dopamine dysfunction in symptomatic and premanifest Huntington's disease gene carriers.” Neurobiol Dis 37(2):356-61 Details 2009Lazic SE, Mason SL, Michell AW, Barker RA (2009), “Visualising disease progression on multiple variables with vector plots and path plots.” BMC Med Res Methodol 9:32 Details Mason SL, Barker RA (2009), “Emerging drug therapies in Huntington's disease.” Expert Opin Emerg Drugs 14(2):273-97 Details 2008Reuter I, Tai YF, Pavese N, Chaudhuri KR, Mason S, Polkey CE, Clough C, Brooks DJ, Barker RA, Piccini P (2008), “Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease.” J Neurol Neurosurg Psychiatry 79(8):948-51 Details Wedderburn C, Wear H, Brown J, Mason SJ, Barker RA, Hodges J, Williams-Gray C (2008), “The utility of the Cambridge Behavioural Inventory in neurodegenerative disease.” J Neurol Neurosurg Psychiatry 79(5):500-3 Details 2007Antoniades CA, Altham PM, Mason SL, Barker RA, Carpenter R (2007), “Saccadometry: a new tool for evaluating presymptomatic Huntington patients.” Neuroreport 18(11):1133-6 Details |