Dr Svetlana Khoronenkova


University position

Wellcome Trust Sir Henry Dale fellow/PI

Dr Svetlana Khoronenkova is pleased to consider applications from prospective PhD students.

Departments

Department of Biochemistry

Email

sk870@cam.ac.uk

Home page

https://www.bioc.cam.ac.uk/researc...

Research Theme

Cellular and Molecular Neuroscience

Interests

Human cells repair thousands of DNA lesions daily. The majority of lesions arise from the intrinsic chemical instability of DNA and include single-strand breaks and base modifications. Unrepaired lesions can obstruct DNA replication, leading to mutations and toxic DNA double-strand breaks. In non-proliferating cells (for example, post-mitotic neurons) damaged DNA bases and single-strand breaks can block transcription, leading to cell death and disease. Although defects in DNA repair are often linked to progressive neurological disorders, their precise roles in the neurological phenotypes remain elusive.

Our research objectives are to:

- Unravel molecular mechanisms by which mutations in DNA damage response proteins lead to progressive neurodegeneration.

- Determine how DNA damage and repair contributes to disease progression in the brain.

- Identify novel DNA damage response proteins required for the maintenance of homeostasis in the brain.

Research Focus

Keywords

DNA damage

DNA repair

neurodegeneration

Clinical conditions

Cerebellar ataxias

Childhood disorders

Cognitive impairment

Genetic disorders

Learning disabilities

Spinocerebellar ataxia

Equipment

Calcium imaging

Cell culture

Confocal microscopy

Enzyme assays

Fluorescence microscopy

Immunohistochemistry

Microscopy

Protein purification

Recombinant protein expression

Collaborators

Cambridge

Florian Hollfelder​

Ragnhildur Thóra Káradóttir

International

Alice Lee Web: https://compgen.hms.harvard.edu

Mike Lodato Web: https://www.lodatolab.org

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