Dr Stephen Sawiak University positionResearch Associate DepartmentsDepartment of Clinical Neurosciences and Department of Psychology InstitutesBehavioural and Clinical Neuroscience Institute and Wolfson Brain Imaging Centre Home pagehttp://www.wbic.cam.ac.uk/~sjs80/ (personal home page) Research ThemesInterestsI am a physicist working with MRI. My primary research interest has been in morphometry, with structural imaging, diffusion tensor imaging and spectroscopy. I am particularly focussed on preclinical applications.  Map of cortical thickness of a rat brain derived from MRI images Click image to view full-size Research Focus
EquipmentMagnetic resonance imaging (MRI) Positron Emission Tomography (PET) Collaborators
Associated News Items
Key publicationsSawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry.” Neurobiol Dis 33(1):20-7 Details Publications2014Buonincontri G, Hu CH, Sawiak S, Krieg T (2014), “P516Diastolic dysfunction in diabetic mice revealed by MRI.” Cardiovasc Res 103 Suppl 1:S94-5 Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Functional assessment of the mouse heart by MRI with a 1-min acquisition.” NMR Biomed Details Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2014), “Trajectory correction for free-breathing radial cine MRI.” Magn Reson Imaging Details Buonincontri G, Wood NI, Puttick SG, Ward AO, Carpenter TA, Sawiak SJ, Morton AJ (2014), “Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine.” J Huntingtons Dis 3(1):25-32 Details Chouchani ET, Methner C, Buonincontri G, Hu CH, Logan A, Sawiak SJ, Murphy MP, Krieg T (2014), “Complex I deficiency due to selective loss of ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.” PLoS One 9(4):e94157 Details Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC (2014), “Orbitofrontal Dopamine Depletion Upregulates Caudate Dopamine and Alters Behavior via Changes in Reinforcement Sensitivity.” J Neurosci 34(22):7663-76 Details Hayes DJ, Jupp B, Sawiak SJ, Merlo E, Caprioli D, Dalley JW (2014), “Brain ?-aminobutyric acid: a neglected role in impulsivity.” Eur J Neurosci Details Izquierdo-Garcia D, Sawiak SJ, Knesaurek K, Narula J, Fuster V, Machac J, Fayad ZA (2014), “Comparison of MR-based attenuation correction and CT-based attenuation correction of whole-body PET/MR imaging.” Eur J Nucl Med Mol Imaging Details Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T (2014), “Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.” Eur J Heart Fail Details Morton AJ, Rudiger SR, Wood NI, Sawiak SJ, Brown GC, McLaughlan CJ, Kuchel TR, Snell RG, Faull RL, Bawden CS (2014), “Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment.” Hum Mol Genet Details Sawiak SJ, Picq JL, Dhenain M (2014), “Voxel-based morphometry analyses of in vivo MRI in the aging mouse lemur primate.” Front Aging Neurosci 6:82 Details 2013Buonincontri G, Methner C, Carpenter TA, Hawkes RC, Sawiak SJ, Krieg T (2013), “MRI and PET in mouse models of myocardial infarction.” J Vis Exp (82):e50806 Details Buonincontri G, Methner C, Krieg T, Carpenter TA, Sawiak SJ (2013), “A fast protocol for infarct quantification in mice.” J Magn Reson Imaging Details Buonincontri G, Sawiak SJ, Methner C, Krieg T, Hawkes RC, Carpenter TA (2013), “PET/MRI in the infarcted mouse heart with the Cambridge split magnet.” Nucl Instrum Methods Phys Res A 702 Details Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW (2013), “Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls.” Curr Opin Neurobiol 23(4):597-606 Details Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW (2013), “Baseline-dependent effects of cocaine pre-exposure on impulsivity and D(2/3) receptor availability in the rat striatum: Possible relevance to the attention-deficit hyperactivity syndrome.” Neuropsychopharmacology Details Caprioli D, Sawiak SJ, Merlo E, Theobald DE, Spoelder M, Jupp B, Voon V, Carpenter TA, Everitt BJ, Robbins TW, Dalley JW (2013), “Gamma Aminobutyric Acidergic and Neuronal Structural Markers in the Nucleus Accumbens Core Underlie Trait-like Impulsive Behavior.” Biol Psychiatry Details Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Baron JC (2013), “Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.” Neurobiol Dis 51:120-32 Details Methner C, Buonincontri G, Hu CH, Vujic A, Kretschmer A, Sawiak S, Carpenter A, Stasch JP, Krieg T (2013), “Riociguat reduces infarct size and post-infarct heart failure in mouse hearts: insights from MRI/PET imaging.” PLoS One 8(12):e83910 Details Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2013), “Voxel-based morphometry with templates and validation in a mouse model of Huntington's disease.” Magn Reson Imaging 31(9):1522-31 Details Williamson DJ, Ejaz S, Sitnikov S, Fryer TD, Sawiak SJ, Burke P, Baron JC, Aigbirhio FI (2013), “A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke.” Nucl Med Biol 40(3):338-44 Details 2012Kielar C, Sawiak SJ, Navarro Negredo P, Tse DH, Morton AJ (2012), “Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse.” PLoS One 7(2):e32636 Details Sawiak SJ, Wood NI, Carpenter TA, Morton AJ (2012), “Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy.” PLoS One 7(12):e53361 Details Wood NI, Sawiak SJ, Buonincontri G, Niu Y, Kane AD, Carpenter TA, Giussani DA, Morton AJ (2012), “Direct evidence of progressive cardiac dysfunction in a transgenic mouse model of Huntington's disease.” J Huntingtons Dis 1(1) Details 2011Riss PJ, Hong YT, Williamson D, Caprioli D, Sitnikov S, Ferrari V, Sawiak SJ, Baron JC, Dalley JW, Fryer TD, Aigbirhio FI (2011), “Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.” J Cereb Blood Flow Metab 31(12):2334-42 Details 2009Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease.” Neurobiol Dis 33(1):12-9 Details |