Mr Stephen Price University positionSenior Research Associate Mr Stephen Price is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Clinical Neurosciences InstitutesNeurosurgery Unit and Wolfson Brain Imaging Centre Research ThemeInterestsMy group uses advanced multimodal MR and PET imaging to understand the heterogeneity of gliomas (high and low grade) in individual patients. We know that gliomas are among the most heterogeneous tumours but still do not have a method of detecting this heterogeneity. Tissue markers cannot impact surgically based therapies. Imaging provides a non-invasive method of assessing tumour pathology. My work focuses on two areas: 1. Intertumoural heterogeneity (i.e. differences between individuals). Especially heterogeneity of tumour invasion. Post-mortem studies show there is variation in tumour invasion with 20-25% of GBMs extend <1cm from the edge of the tumour mass, with another 20% extending >3 centimetres. 2. Intratumoural heterogeneity (i.e. differences within a tumour in an individual patient). Our work studies variation of response to chemotherapy/radiotherapy and drug uptake. We are developing [3-N-11C-methyl]-temozolomide a PET tracer to correlate response with drug uptake.  Diffusion tensor imaging can identify tumour invasion of normal brain in regions that appear normal on conventional imaging. Follow up imaging shows these abnormalities can predict the pattern of progression. View image full-size (1396x687 pixels) Research Focus
EquipmentMagnetic resonance imaging (MRI) Microdialysis Positron Emission Tomography (PET) Collaborators
Associated News Items
Key publicationsMohsen LA, Shi V, Jena R, Gillard JH, Price SJ (2013), “Diffusion tensor invasive phenotypes can predict progression-free survival in glioblastomas.” Br J Neurosurg Details Price SJ, Jena R, Burnet NG, Carpenter TA, Pickard JD, Gillard JH (2007), “Predicting patterns of glioma recurrence using diffusion tensor imaging.” Eur Radiol 17(7):1675-84 PDF Details Price SJ, Jena R, Burnet NG, Hutchinson PJ, Dean AF, Peņa A, Pickard JD, Carpenter TA, Gillard JH (2006), “Improved delineation of glioma margins and regions of infiltration with the use of diffusion tensor imaging: an image-guided biopsy study.” AJNR Am J Neuroradiol 27(9):1969-74 PDF Details Price SJ, Peņa A, Burnet NG, Jena R, Green HA, Carpenter TA, Pickard JD, Gillard JH (2004), “Tissue signature characterisation of diffusion tensor abnormalities in cerebral gliomas.” Eur Radiol 14(10):1909-17 Details Publications2014Watts C, Price SJ, Santarius T (2014), “Current concepts in the surgical management of glioma patients.” Clin Oncol (R Coll Radiol) 26(7):385-94 Details 2013Elmahdi A, Frary AJ, Scotton WJ, O'Donovan DG, Price SJ (2013), “Glioblastomas with oligodendroglial component have the same clinical phenotype as classical glioblastomas.” Br J Neurosurg Details Jefferies SJ, Harris FP, Price SJ, Collins VP, Watts C (2013), “High grade glioma--the arrival of the molecular diagnostic era for patients over the age of 65 years in the UK.” Clin Oncol (R Coll Radiol) 25(7):391-3 Details Jefferies SJ, Harris FP, Price SJ, Collins VP, Watts C (2013), “High Grade Glioma - The Arrival of the Molecular Diagnostic Era for Patients over the Age of 65 Years in the UK.” Clinical Oncology 25(7): 391-3 PDF 2012Annamalai AK, Powlson AS, Kandasamy N, Lodge K, Graggaber J, Halsall DJ, Antoun NM, Cheow HK, Buttery PC, George E, Griffiths M, Price SJ, Pickard JD, Sivasothy P, Gurnell M (2012), “Hypopituitarism, pulmonary infiltration and a spontaneously resolving occipital mass.” QJM Details McLean MA, Sun A, Bradstreet TE, Schaeffer AK, Liu H, Iannone R, Herman G, Railkar RA, Joubert I, Gillard JH, Price SJ, Griffiths JR (2012), “Repeatability of edited lactate and other metabolites in astrocytoma at 3T.” J Magn Reson Imaging 36(2):468-75 Details Piccirillo SG, Dietz S, Madhu B, Griffiths J, Price SJ, Collins VP, Watts C (2012), “Fluorescence-guided surgical sampling of glioblastoma identifies phenotypically distinct tumour-initiating cell populations in the tumour mass and margin.” Br J Cancer 107(3):462-8 Details Price SJ, Whittle IR, Ashkan K, Grundy P, Cruickshank G, UK-HGG Study Group (2012), “NICE guidance on the use of carmustine wafers in high grade gliomas: a national study on variation in practice.” Br J Neurosurg 26(3):331-5 PDF Details Ryan R, Booth S, Price S (2012), “Corticosteroid-use in primary and secondary brain tumour patients: a review.” J Neurooncol 106(3):449-59 Details Zikic D, Glocker B, Konukoglu E, Criminisi A, Demiralp C, Shotton J, Thomas OM, Das T, Jena R, Price SJ (2012), “Decision forests for tissue-specific segmentation of high-grade gliomas in multi-channel MR.” Med Image Comput Comput Assist Interv 15(Pt 3):369-76 Details 2011Guilfoyle MR, Weerakkody RA, Oswal A, Oberg I, Jeffery C, Haynes K, Kullar PJ, Greenberg D, Jefferies SJ, Harris F, Price SJ, Thomson S, Watts C (2011), “Implementation of neuro-oncology service reconfiguration in accordance with NICE guidance provides enhanced clinical care for patients with glioblastoma multiforme.” Br J Cancer 104(12):1810-5 Details Price SJ, Gillard JH (2011), “Imaging biomarkers of brain tumour margin and tumour invasion.” Br J Radiol 84 Spec No 2:S159-67 Details Price SJ, Green HA, Dean AF, Joseph J, Hutchinson PJ, Gillard JH (2011), “Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study.” AJNR Am J Neuroradiol 32(3):501-6 Details 2010Marcus HJ, Carpenter KL, Price SJ, Hutchinson PJ (2010), “In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines.” J Neurooncol 97(1):11-23 Details Price SJ (2010), “Advances in imaging low-grade gliomas.” Adv Tech Stand Neurosurg 35:1-34 Details 2009Al-Tamimi YZ, Helmy A, Bavetta S, Price SJ (2009), “Assessment of zero drift in the Codman intracranial pressure monitor: a study from 2 neurointensive care units.” Neurosurgery 64(1):94-8; discussion 98-9 Details Price SJ, Fryer TD, Cleij MC, Dean AF, Joseph J, Salvador R, Wang DD, Hutchinson PJ, Clark JC, Burnet NG, Pickard JD, Aigbirhio FI, Gillard JH (2009), “Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study.” Clin Radiol 64(1):52-63 Details Santarius T, Kirkpatrick PJ, Ganesan D, Chia HL, Jalloh I, Smielewski P, Richards HK, Marcus H, Parker RA, Price SJ, Kirollos RW, Pickard JD, Hutchinson PJ (2009), “Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial.” Lancet 374(9695):1067-73 Details 2008Marcus HJ, Price SJ, Wilby M, Santarius T, Kirollos RW (2008), “Radiotherapy as an adjuvant in the management of intracranial meningiomas: are we practising evidence-based medicine?” Br J Neurosurg 22(4):520-8 Details 2007Burnet NG, Lynch AG, Jefferies SJ, Price SJ, Jones PH, Antoun NM, Xuereb JH, Pohl U (2007), “High grade glioma: imaging combined with pathological grade defines management and predicts prognosis.” Radiother Oncol 85(3):371-8 Details Jena R, Price SJ, Romeo A, Gillard JH, Kingsbury N, Burnet NG (2007), “Automated feature extraction from diffusion tensor image data for radiotherapy planning of gliomas.” Clin Oncol (R Coll Radiol) 19(3 Suppl):S34 Price SJ (2007), “The role of advanced MR imaging in understanding brain tumour pathology.” Br J Neurosurg 21(6):562-75 Details Price SJ, Jena R, Green HA, Kirkby NF, Lynch AG, Coles CE, Pickard JD, Gillard JH, Burnet NG (2007), “Early radiotherapy dose response and lack of hypersensitivity effect in normal brain tissue: a sequential dynamic susceptibility imaging study of cerebral perfusion.” Clin Oncol (R Coll Radiol) 19(8):577-87 Details 2006Peņa A, Green HA, Carpenter TA, Price SJ, Pickard JD, Gillard JH (2006), “Enhanced visualization and quantification of magnetic resonance diffusion tensor imaging using the p:q tensor decomposition.” Br J Radiol 79(938):101-9 Details 2005Jena R, Price SJ, Baker C, Jefferies SJ, Pickard JD, Gillard JH, Burnet NG (2005), “Diffusion tensor imaging: possible implications for radiotherapy treatment planning of patients with high-grade glioma.” Clin Oncol (R Coll Radiol) 17(8):581-90 Details Tipper G, U-King-Im JM, Price SJ, Trivedi RA, Cross JJ, Higgins NJ, Farmer R, Wat J, Kirollos R, Kirkpatrick PJ, Antoun NM, Gillard JH (2005), “Detection and evaluation of intracranial aneurysms with 16-row multislice CT angiography.” Clin Radiol 60(5):565-72 Details 2004Price SJ, Peņa A, Burnet NG, Pickard JD, Gillard JH (2004), “Detecting glioma invasion of the corpus callosum using diffusion tensor imaging.” Br J Neurosurg 18(4):391-5 Details 2003Price SJ, Burnet NG, Donovan T, Green HA, Peņa A, Antoun NM, Pickard JD, Carpenter TA, Gillard JH (2003), “Diffusion tensor imaging of brain tumours at 3T: a potential tool for assessing white matter tract invasion?” Clin Radiol 58(6):455-62 PDF Details |
