Dr Susan Jones University positionLecturer Dr Susan Jones is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Physiology, Development and Neuroscience Home pagehttp://www.pdn.cam.ac.uk/staff/j... Research ThemeInterestsThe primary focus of our research is the function of AMPA and NMDA glutamate receptors at excitatory synapses in the brain. We study the properties of glutamate receptors, glutamatergic synaptic transmission, and synaptic plasticity. We are interested in changes in glutamatergic function during behavioural adaptation and during neuronal dysfunction. Research Focus
EquipmentElectrophysiological recording techniques Immunohistochemistry Whole cell patch clamp CollaboratorsNo collaborators listed Associated News ItemsPublications2015Wild AR, Bollands M, Morris PG and Jones S (2015), “Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in substantia nigra dopaminergic neurons. ” Eur J Neurosci 42: 2633-2643 2014Wild AR, Jones S, Gibb AJ (2014), “Activity dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones” J Physiol 592: 653-668 2013Wild AR, Akyol E, Brothwell SL, Kimkool P, Skepper JN, Gibb AJ, Jones S (2013), “Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones.” Neuropharmacology 73:138-46 Details Xu W, Jones S, Edgley SA (2013), “Event time representation in cerebellar mossy fibres arising from the lateral reticular nucleus.” J Physiol 591(Pt 4):1045-62 Details 2010Glynn D, Gibson HE, Harte MK, Reim K, Jones S, Reynolds GP, Morton AJ (2010), “Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse.” Hum Mol Genet 19(17):3402-12 Details Suárez F, Zhao Q, Monaghan DT, Jane DE, Jones S, Gibb AJ (2010), “Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones.” Eur J Neurosci 32(3):359-67 Details 2008Brothwell SL, Barber JL, Monaghan DT, Jane DE, Gibb AJ, Jones S (2008), “NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones.” J Physiol 586(3):739-50 Details Poisik OV, Shen JX, Jones S, Yakel JL (2008), “Functional alpha7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulata.” J Physiol 586(5):1365-78 Details 2007Kung VW, Hassam R, Morton AJ, Jones S (2007), “Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease.” Neuroscience 146(4):1571-80 Details 2005Gibson HE, Reim K, Brose N, Morton AJ, Jones S (2005), “A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse.” Eur J Neurosci 22(7):1701-12 Details Jones S, Bonci A (2005), “Synaptic plasticity and drug addiction.” Curr Opin Pharmacol 5(1):20-5 Details Jones S, Gibb AJ (2005), “Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones.” J Physiol 569(Pt 1):209-21 Details 2004Faleiro LJ, Jones S, Kauer JA (2004), “Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection.” Neuropsychopharmacology 29(12):2115-25 Details 2003Jones S, Yakel JL (2003), “Casein kinase ii (protein kinase ck2) regulates serotonin 5-ht(3) receptor channel function in ng108-15 cells.” Neuroscience 119(3):629-34 Details 2000Jones S, Kornblum JL, Kauer JA (2000), “Amphetamine blocks long-term synaptic depression in the ventral tegmental area.” J Neurosci 20(15):5575-80 Details 1999Jones S, Kauer JA (1999), “Amphetamine depresses excitatory synaptic transmission via serotonin receptors in the ventral tegmental area.” J Neurosci 19(22):9780-7 Details Jones S, Sudweeks S, Yakel JL (1999), “Nicotinic receptors in the brain: correlating physiology with function.” Trends Neurosci 22(12):555-61 Details Jones S, Yakel JL (1999), “Inhibitory interneurons in hippocampus.” Cell Biochem Biophys 31(2):207-18 Details Jones S, Yakel JL (1999), “Functional study of glutamate receptor channels in brain slices.” Methods Mol Med 22:247-56 Details 1998Jones S, Yakel JL (1998), “Ca2+ influx through voltage-gated Ca2+ channels regulates 5-HT3 receptor channel desensitization in rat glioma x mouse neuroblastoma hybrid NG108-15 cells.” J Physiol 510 ( Pt 2):361-70 Details 1997Jones S, Yakel JL (1997), “Functional nicotinic ACh receptors on interneurones in the rat hippocampus.” J Physiol 504 ( Pt 3):603-10 Details 1995Jones S, Brown DA, Milligan G, Willer E, Buckley NJ, Caulfield MP (1995), “Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11.” Neuron 14(2):399-405 Details 1994Caulfield MP, Jones S, Vallis Y, Buckley NJ, Kim GD, Milligan G, Brown DA (1994), “Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones.” J Physiol 477 ( Pt 3):415-22 Details 1993Cloues R, Jones S, Brown DA (1993), “Zn2+ potentiates ATP-activated currents in rat sympathetic neurons.” Pflugers Arch 424(2):152-8 Details 1992Jones S, Robbins J, Brown DA (1992), “Neurotransmitter modulation of calcium channels is dependent on the charge carrier used in the recording of currents.” Neurosci Lett 145(2):153-6 Details |