Dr Susan Jones

Susan Jones

University position


Dr Susan Jones is pleased to consider applications from prospective PhD students.


Department of Physiology, Development and Neuroscience



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Research Theme

Cellular and Molecular Neuroscience


The primary focus of our research is the function of AMPA and NMDA glutamate receptors at excitatory synapses in the brain. We study the properties of glutamate receptors, glutamatergic synaptic transmission, and synaptic plasticity. We are interested in changes in glutamatergic function during behavioural adaptation and during neuronal dysfunction.

Research Focus



dopamine neurons

NMDA receptors

synaptic plasticity

neural circuits

Clinical conditions

No direct clinical relevance


Electrophysiological recording techniques


Whole cell patch clamp


No collaborators listed

Associated News Items



Wild AR, Bollands M, Morris PG and Jones S (2015), “Mechanisms regulating spill-over of synaptic glutamate to extrasynaptic NMDA receptors in substantia nigra dopaminergic neurons. ” Eur J Neurosci 42: 2633-2643


Wild AR, Jones S, Gibb AJ (2014), “Activity dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones” J Physiol 592: 653-668


Wild AR, Akyol E, Brothwell SL, Kimkool P, Skepper JN, Gibb AJ, Jones S (2013), “Memantine block depends on agonist presentation at the NMDA receptor in substantia nigra pars compacta dopamine neurones.” Neuropharmacology 73:138-46 Details

Xu W, Jones S, Edgley SA (2013), “Event time representation in cerebellar mossy fibres arising from the lateral reticular nucleus.” J Physiol 591(Pt 4):1045-62 Details


Glynn D, Gibson HE, Harte MK, Reim K, Jones S, Reynolds GP, Morton AJ (2010), “Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse.” Hum Mol Genet 19(17):3402-12 Details

Su├írez F, Zhao Q, Monaghan DT, Jane DE, Jones S, Gibb AJ (2010), “Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones.” Eur J Neurosci 32(3):359-67 Details


Brothwell SL, Barber JL, Monaghan DT, Jane DE, Gibb AJ, Jones S (2008), “NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones.” J Physiol 586(3):739-50 Details

Poisik OV, Shen JX, Jones S, Yakel JL (2008), “Functional alpha7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulata.” J Physiol 586(5):1365-78 Details


Kung VW, Hassam R, Morton AJ, Jones S (2007), “Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease.” Neuroscience 146(4):1571-80 Details


Gibson HE, Reim K, Brose N, Morton AJ, Jones S (2005), “A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse.” Eur J Neurosci 22(7):1701-12 Details

Jones S, Bonci A (2005), “Synaptic plasticity and drug addiction.” Curr Opin Pharmacol 5(1):20-5 Details

Jones S, Gibb AJ (2005), “Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones.” J Physiol 569(Pt 1):209-21 Details


Faleiro LJ, Jones S, Kauer JA (2004), “Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection.” Neuropsychopharmacology 29(12):2115-25 Details


Jones S, Yakel JL (2003), “Casein kinase ii (protein kinase ck2) regulates serotonin 5-ht(3) receptor channel function in ng108-15 cells.” Neuroscience 119(3):629-34 Details


Jones S, Kornblum JL, Kauer JA (2000), “Amphetamine blocks long-term synaptic depression in the ventral tegmental area.” J Neurosci 20(15):5575-80 Details


Jones S, Kauer JA (1999), “Amphetamine depresses excitatory synaptic transmission via serotonin receptors in the ventral tegmental area.” J Neurosci 19(22):9780-7 Details

Jones S, Sudweeks S, Yakel JL (1999), “Nicotinic receptors in the brain: correlating physiology with function.” Trends Neurosci 22(12):555-61 Details

Jones S, Yakel JL (1999), “Inhibitory interneurons in hippocampus.” Cell Biochem Biophys 31(2):207-18 Details

Jones S, Yakel JL (1999), “Functional study of glutamate receptor channels in brain slices.” Methods Mol Med 22:247-56 Details


Jones S, Yakel JL (1998), “Ca2+ influx through voltage-gated Ca2+ channels regulates 5-HT3 receptor channel desensitization in rat glioma x mouse neuroblastoma hybrid NG108-15 cells.” J Physiol 510 ( Pt 2):361-70 Details


Jones S, Yakel JL (1997), “Functional nicotinic ACh receptors on interneurones in the rat hippocampus.” J Physiol 504 ( Pt 3):603-10 Details


Jones S, Brown DA, Milligan G, Willer E, Buckley NJ, Caulfield MP (1995), “Bradykinin excites rat sympathetic neurons by inhibition of M current through a mechanism involving B2 receptors and G alpha q/11.” Neuron 14(2):399-405 Details


Caulfield MP, Jones S, Vallis Y, Buckley NJ, Kim GD, Milligan G, Brown DA (1994), “Muscarinic M-current inhibition via G alpha q/11 and alpha-adrenoceptor inhibition of Ca2+ current via G alpha o in rat sympathetic neurones.” J Physiol 477 ( Pt 3):415-22 Details


Cloues R, Jones S, Brown DA (1993), “Zn2+ potentiates ATP-activated currents in rat sympathetic neurons.” Pflugers Arch 424(2):152-8 Details


Jones S, Robbins J, Brown DA (1992), “Neurotransmitter modulation of calcium channels is dependent on the charge carrier used in the recording of currents.” Neurosci Lett 145(2):153-6 Details