Dr Shahid Zaman


The main theme of our research is to understand the role of amyloid, tau, inflammation and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down's syndrome.

Research Focus


Down's syndrom

Alzheimer's disease

cognitive impairment



Clinical conditions

Alzheimer's disease

Cognitive impairment

Down's syndrome

Learning disabilities


Cell culture

Confocal microscopy

Enzyme assays


Magnetic resonance imaging (MRI)


Neuropsychological testing

Positron Emission Tomography (PET)



Franklin Aigbirhio

Tim Fryer

Tony Holland

Young Hong

David Menon

Peter Nestor

Ruma Raha-Chowdhury

Rob Smith

Guy Williams

Associated News Items



    Annus T, Wilson LR, Acosta-Cabronero J, Cardenas-Blanco A, Hong, YT, Fryer TD, Coles JP, Menon DK, Zaman SH, Holland AJ, Nestor PJ (2017), “The Down syndrome brain in the presence and absence of fibrillar ?-amyloidosis” Neurobiology of Aging 53(May): 11-19

    Castro P, Zaman SH & Holland AJ (2017), “Alzheimer’s disease in people with Down’s syndrome: the prospects for and the challenges of developing preventative treatments” Journal of Neurology 264(4): 804–813

    Lautarescu BA, Holland AJ & Zaman SH (2017), “The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies” Neuropsychology Review 27(1): 31-45

    Raha AA, Henderson JW, Stott SR, Vuono R, Foscarin S, Friedland RP, Zaman SH, Raha-Chowdhury R (2017), “Neuroprotective Effect of TREM-2 in Aging and Alzheimer’s Disease Model” Journal of Alzheimer's Disease 55(1): 199-217


    d'Abrera JC, Holland AJ, Landt J, Stocks-Gee G, Zaman SH (2013), “A neuroimaging proof of principle study of Down's syndrome and dementia: ethical and methodological challenges in intrusive research.” J Intellect Disabil Res 57(2):105-18 Details


    S H Zaman (2012), “'The impact of studies of memory mechanisms for psychiatry'” Chapter in, 'The Memory Mechanism' Edited by KP Giese published by World Scientific Publishing pp 397-430


    Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar ?-amyloid in adults with down syndrome: safety, acceptability, and feasibility.” Arch Neurol 68(7):890-6 Details


    Malinow R, Hayashi Y, Maletic-Savatic M, Zaman SH, Poncer JC, Shi SH, Esteban JA, Osten P, Seidenman K (2010), “Introduction of green fluorescent protein (GFP) into hippocampal neurons through viral infection.” Cold Spring Harb Protoc 2010(4):pdb.prot5406 Details


    Craig MC, Zaman SH, Daly EM, Cutter WJ, Robertson DM, Hallahan B, Toal F, Reed S, Ambikapathy A, Brammer M, Murphy CM, Murphy DG (2007), “Women with autistic-spectrum disorder: magnetic resonance imaging study of brain anatomy.” Br J Psychiatry 191:224-8 Details


    Terashima A, Cotton L, Dev KK, Meyer G, Zaman S, Duprat F, Henley JM, Collingridge GL, Isaac JT (2004), “Regulation of synaptic strength and AMPA receptor subunit composition by PICK1.” J Neurosci 24(23):5381-90 Details


    Daw MI, Bortolotto ZA, Saulle E, Zaman S, Collingridge GL, Isaac JT (2002), “Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression.” Nat Neurosci 5(9):835-6 Details

    Greenfield LJ Jr, Zaman SH, Sutherland ML, Lummis SC, Niemeyer MI, Barnard EA, Macdonald RL (2002), “Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement.” Neuropharmacology 42(4):502-21 Details


    Zaman SH, Parent A, Laskey A, Lee MK, Borchelt DR, Sisodia SS, Malinow R (2000), “Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine.” Neurobiol Dis 7(1):54-63 Details


    Shi SH, Hayashi Y, Petralia RS, Zaman SH, Wenthold RJ, Svoboda K, Malinow R (1999), “Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation.” Science 284(5421):1811-6 Details


    Barnard EA, Sutherland M, Zaman S, Matsumoto M, Nayeem N, Green T, Darlison MG, Bateson AN (1993), “Multiplicity, structure, and function in GABAA receptors.” Ann N Y Acad Sci 707:116-25 Details


    Zaman SH, Harvey RJ, Barnard EA, Darlison MG (1992), “Unusual effects of benzodiazepines and cyclodiene insecticides on an expressed invertebrate GABAA receptor.” FEBS Lett 307(3):351-4 Details

    Zaman SH, Shingai R, Harvey RJ, Darlison MG, Barnard EA (1992), “Effects of subunit types of the recombinant GABAA receptor on the response to a neurosteroid.” Eur J Pharmacol 225(4):321-30 Details


    Harvey RJ, Vreugdenhil E, Zaman SH, Bhandal NS, Usherwood PN, Barnard EA, Darlison MG (1991), “Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate alpha subunit.” EMBO J 10(11):3239-45 Details


    Zaman SH (1990), “Endogenous steroids and pathogenesis of hepatic encephalopathy.” Lancet 336(8714):573-4 Details