Dr Shaline Fazal
Research into the role of peripheral immune cells in Huntington's disease. A particular focus is on the possible influence that these peripheral immune cells may have on the seeding and propagation of mutant Huntingtin between cells. A patient and disease specific in vitro modelling platform is used, where dermal fibroblasts from patients are directly reprogrammed into neurons (induced neurons).
Another aspect of my research focuses on developing in vitro modelling platforms to study Parkinson's disease.
Recombinant protein expression