Dr Shaline Fazal

Interests

Research into the role of peripheral immune cells in Huntington's disease. A particular focus is on the possible influence that these peripheral immune cells may have on the seeding and propagation of mutant Huntingtin between cells. A patient and disease specific in vitro modelling platform is used, where dermal fibroblasts from patients are directly reprogrammed into neurons (induced neurons).

Another aspect of my research focuses on developing in vitro modelling platforms to study Parkinson's disease.

Research Focus

Keywords

Huntington's disease

Cell therapies

Disease propagation

Neurodgeneration

Parkinson's disease

Clinical conditions

Huntington's disease

Parkinson's disease

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Microscopy

Recombinant protein expression

Collaborators

Cambridge

Peter Arthur-Farraj

United Kingdom

Graham Fraser Web: https://www.astrazeneca.com/our-sci...

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