Dr Steve Edgley University positionReader Dr Steve Edgley is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Physiology, Development and Neuroscience Home pagehttp://www.pdn.cam.ac.uk/groups/... (personal home page) Research ThemesInterestsI’m interested in how movements are controlled. Our everyday movements are performed with little conscious thought and are remarkably precise. Despite what the textbooks tell you, the way in which this is accomplished is poorly understood. I work at several levels, the main ones being at the level of spinal circuits, and at the level of the cerebellar information processing. My spinal cord work has involved interneurone circuits, recently commissural neurones that connect the two sides of the cord. My cerebellar work has used electrophysiological approaches to examine what inputs influence cerebellar neurones and how information is processed in the circuit. This work has examined how the climbing fibre system behaves, and more recently, how Golgi cells are activated in relation to the local granule and Purkinje cells.  Juxtacellularly labelled Golgi cell Click image to view full-size Research Focus
EquipmentBehavioural analysis Electrophysiological recording techniques Extracellular recording Intracellular recording Ionophoresis Neuroanatomical tracing Collaborators
Associated News Items
Key publicationsSoteropoulos DS, Edgley SA, Baker SN (2013), “Spinal commissural connections to motoneurons controlling the primate hand and wrist.” J Neurosci 33(23):9614-25 Details Xu W, Jones S, Edgley SA (2013), “Event time representation in cerebellar mossy fibres arising from the lateral reticular nucleus.” J Physiol 591(Pt 4):1045-62 Details Zaaimi B, Edgley SA, Soteropoulos DS, Baker SN (2012), “Changes in descending motor pathway connectivity after corticospinal tract lesion in macaque monkey.” Brain 135(Pt 7):2277-89 Details Jankowska E, Edgley SA (2010), “Functional subdivision of feline spinal interneurons in reflex pathways from group Ib and II muscle afferents; an update.” Eur J Neurosci 32(6):881-93 Details Publications2013Edgley SA, Gandevia SC (2013), “Batteries and the brain.” J Physiol 591(Pt 13):3105 Details Van Dijck G, Van Hulle MM, Heiney SA, Blazquez PM, Meng H, Angelaki DE, Arenz A, Margrie TW, Mostofi A, Edgley S, Bengtsson F, Ekerot CF, Jörntell H, Dalley JW, Holtzman T (2013), “Probabilistic identification of cerebellar cortical neurones across species.” PLoS One 8(3):e57669 Details 2011Holtzman T, Sivam V, Zhao T, Frey O, van der Wal PD, de Rooij NF, Dalley JW, Edgley SA (2011), “Multiple extra-synaptic spillover mechanisms regulate prolonged activity in cerebellar Golgi cell-granule cell loops.” J Physiol 589(Pt 15):3837-54 Details Soteropoulos DS, Edgley SA, Baker SN (2011), “Lack of evidence for direct corticospinal contributions to control of the ipsilateral forelimb in monkey.” J Neurosci 31(31):11208-19 Details 2010Lemon RN, Edgley SA (2010), “Life without a cerebellum.” Brain 133(Pt 3):652-4 Details Mostofi A, Holtzman T, Grout AS, Yeo CH, Edgley SA (2010), “Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex.” J Neurosci 30(26):8920-34 Details Xu W, Edgley SA (2010), “Cerebellar Golgi cells in the rat receive convergent peripheral inputs via a lateral reticular nucleus relay.” Eur J Neurosci 32(4):591-7 Details 2009Holtzman T, Cerminara NL, Edgley SA, Apps R (2009), “Characterization in vivo of bilaterally branching pontocerebellar mossy fibre to Golgi cell inputs in the rat cerebellum.” Eur J Neurosci 29(2):328-39 Details Riddle CN, Edgley SA, Baker SN (2009), “Direct and indirect connections with upper limb motoneurons from the primate reticulospinal tract.” J Neurosci 29(15):4993-9 Details 2008Aggelopoulos NC, Chakrabarty S, Edgley SA (2008), “Presynaptic control of transmission through group II muscle afferents in the midlumbar and sacral segments of the spinal cord is independent of corticospinal control.” Exp Brain Res 187(1):61-70 Details Xu W, Edgley SA (2008), “Climbing fibre-dependent changes in Golgi cell responses to peripheral stimulation.” J Physiol 586(Pt 20):4951-9 Details 2006Baker MR, Edgley SA (2006), “Non-uniform olivocerebellar conduction time in the vermis of the rat cerebellum.” J Physiol 570(Pt 3):501-6 Details Bannatyne BA, Edgley SA, Hammar I, Jankowska E, Maxwell DJ (2006), “Differential projections of excitatory and inhibitory dorsal horn interneurons relaying information from group II muscle afferents in the cat spinal cord.” J Neurosci 26(11):2871-80 Details Edgley SA, Aggelopoulos NC (2006), “Short latency crossed inhibitory reflex actions evoked from cutaneous afferents.” Exp Brain Res 171(4):541-50 Details Holtzman T, Mostofi A, Phuah CL, Edgley SA (2006), “Cerebellar Golgi cells in the rat receive multimodal convergent peripheral inputs via the lateral funiculus of the spinal cord.” J Physiol 577(Pt 1):69-80 Details Holtzman T, Rajapaksa T, Mostofi A, Edgley SA (2006), “Different responses of rat cerebellar Purkinje cells and Golgi cells evoked by widespread convergent sensory inputs.” J Physiol 574(Pt 2):491-507 Details Jankowska E, Edgley SA (2006), “How can corticospinal tract neurons contribute to ipsilateral movements? A question with implications for recovery of motor functions.” Neuroscientist 12(1):67-79 Details Jankowska E, Stecina K, Cabaj A, Pettersson LG, Edgley SA (2006), “Neuronal relays in double crossed pathways between feline motor cortex and ipsilateral hindlimb motoneurones.” J Physiol 575(Pt 2):527-41 Details 2005Jankowska E, Edgley SA, Krutki P, Hammar I (2005), “Functional differentiation and organization of feline midlumbar commissural interneurones.” J Physiol 565(Pt 2):645-58 Details 2004Edgley SA, Jankowska E, Hammar I (2004), “Ipsilateral actions of feline corticospinal tract neurons on limb motoneurons.” J Neurosci 24(36):7804-13 Details Edgley SA, Winter AP (2004), “Different effects of fatiguing exercise on corticospinal and transcallosal excitability in human hand area motor cortex.” Exp Brain Res 159(4):530-6 Details Hammar I, Bannatyne BA, Maxwell DJ, Edgley SA, Jankowska E (2004), “The actions of monoamines and distribution of noradrenergic and serotoninergic contacts on different subpopulations of commissural interneurons in the cat spinal cord.” Eur J Neurosci 19(5):1305-16 Details Pardoe J, Edgley SA, Drew T, Apps R (2004), “Changes in excitability of ascending and descending inputs to cerebellar climbing fibers during locomotion.” J Neurosci 24(11):2656-66 Details 2003Bannatyne BA, Edgley SA, Hammar I, Jankowska E, Maxwell DJ (2003), “Networks of inhibitory and excitatory commissural interneurons mediating crossed reticulospinal actions.” Eur J Neurosci 18(8):2273-84 Details Edgley SA, Jankowska E, Krutki P, Hammar I (2003), “Both dorsal horn and lamina VIII interneurones contribute to crossed reflexes from feline group II muscle afferents.” J Physiol 552(Pt 3):961-74 Details Jankowska E, Hammar I, Slawinska U, Maleszak K, Edgley SA (2003), “Neuronal basis of crossed actions from the reticular formation on feline hindlimb motoneurons.” J Neurosci 23(5):1867-78 Details Krutki P, Jankowska E, Edgley SA (2003), “Are crossed actions of reticulospinal and vestibulospinal neurons on feline motoneurons mediated by the same or separate commissural neurons?” J Neurosci 23(22):8041-50 Details 2001Baker MR, Javid M, Edgley SA (2001), “Activation of cerebellar climbing fibres to rat cerebellar posterior lobe from motor cortical output pathways.” J Physiol 536(Pt 3):825-39 Details Edgley SA (2001), “Organisation of inputs to spinal interneurone populations.” J Physiol 533(Pt 1):51-6 Details 1999Edgley SA, Lemon RN (1999), “Experiments using transcranial magnetic brain stimulation in man could reveal important new mechanisms in motor control.” J Physiol 521 Pt 3:565 Details 1997Aggelopoulos NC, Chakrabarty S, Edgley SA (1997), “Evoked excitability changes at the terminals of midlumbar premotor interneurons in the cat spinal cord.” J Neurosci 17(4):1512-8 Details Armand J, Olivier E, Edgley SA, Lemon RN (1997), “Postnatal development of corticospinal projections from motor cortex to the cervical enlargement in the macaque monkey.” J Neurosci 17(1):251-66 Details Edgley SA, Eyre JA, Lemon RN, Miller S (1997), “Comparison of activation of corticospinal neurons and spinal motor neurons by magnetic and electrical transcranial stimulation in the lumbosacral cord of the anaesthetized monkey.” Brain 120 ( Pt 5):839-53 Details Olivier E, Edgley SA, Armand J, Lemon RN (1997), “An electrophysiological study of the postnatal development of the corticospinal system in the macaque monkey.” J Neurosci 17(1):267-76 Details 1996Aggelopoulos NC, Bawa P, Edgley SA (1996), “Activation of midlumbar neurones by afferents from anterior hindlimb muscles in the cat.” J Physiol 497 ( Pt 3):795-802 Details Aggelopoulos NC, Burton MJ, Clarke RW, Edgley SA (1996), “Characterization of a descending system that enables crossed group II inhibitory reflex pathways in the cat spinal cord.” J Neurosci 16(2):723-9 Details 1995Aggelopoulos NC, Duke C, Edgley SA (1995), “Non-uniform conduction time in the olivocerebellar pathway in the anaesthetized cat.” J Physiol 486 ( Pt 3):763-8 Details Aggelopoulos NC, Edgley SA (1995), “Segmental localisation of the relays mediating crossed inhibition of hindlimb motoneurones from group II afferents in the anaesthetized cat spinal cord.” Neurosci Lett 185(1):60-4 Details 1994Armand J, Edgley SA, Lemon RN, Olivier E (1994), “Protracted postnatal development of corticospinal projections from the primary motor cortex to hand motoneurones in the macaque monkey.” Exp Brain Res 101(1):178-82 Details Davies HE, Edgley SA (1994), “Inputs to group II-activated midlumbar interneurones from descending motor pathways in the cat.” J Physiol 479 ( Pt 3):463-73 Details 1992Asif M, Edgley SA (1992), “Projections of group II-activated midlumbar spinocerebellar tract neurones to the region of nucleus Z in the cat.” J Physiol 448:565-78 Details Bajwa S, Edgley SA, Harrison PJ (1992), “Crossed actions on group II-activated interneurones in the midlumbar segments of the cat spinal cord.” J Physiol 455:205-17 Details 1991Arya T, Bajwa S, Edgley SA (1991), “Crossed reflex actions from group II muscle afferents in the lumbar spinal cord of the anaesthetized cat.” J Physiol 444:117-31 Details Edgley SA, Grant GM (1991), “Inputs to spinocerebellar tract neurones located in stilling's nucleus in the sacral segments of the rat spinal cord.” J Comp Neurol 305(1):130-8 Details 1990Edgley SA, Eyre JA, Lemon RN, Miller S (1990), “Excitation of the corticospinal tract by electromagnetic and electrical stimulation of the scalp in the macaque monkey.” J Physiol 425:301-20 Details 1989Edgley SA, Wallace NA (1989), “A short-latency crossed pathway from cutaneous afferents to rat hindlimb motoneurones.” J Physiol 411:469-80 Details 1988Armstrong DM, Edgley SA (1988), “Discharges of interpositus and Purkinje cells of the cat cerebellum during locomotion under different conditions.” J Physiol 400:425-45 Details Armstrong DM, Edgley SA, Lidierth M (1988), “Complex spikes in Purkinje cells of the paravermal part of the anterior lobe of the cat cerebellum during locomotion.” J Physiol 400:405-14 Details Edgley SA, Gallimore CM (1988), “The morphology and projections of dorsal horn spinocerebellar tract neurones in the cat.” J Physiol 397:99-111 Details Edgley SA, Jankowska E (1988), “Information processed by dorsal horn spinocerebellar tract neurones in the cat.” J Physiol 397:81-97 Details Edgley SA, Jankowska E, Shefchyk S (1988), “Evidence that mid-lumbar neurones in reflex pathways from group II afferents are involved in locomotion in the cat.” J Physiol 403:57-71 Details Edgley SA, Lidierth M (1988), “Step-related discharges of Purkinje cells in the paravermal cortex of the cerebellar anterior lobe in the cat.” J Physiol 401:399-415 Details 1987Cavallari P, Edgley SA, Jankowska E (1987), “Post-synaptic actions of midlumbar interneurones on motoneurones of hind-limb muscles in the cat.” J Physiol 389:675-89 Details Edgley SA, Jankowska E (1987), “An interneuronal relay for group I and II muscle afferents in the midlumbar segments of the cat spinal cord.” J Physiol 389:647-74 Details Edgley SA, Jankowska E (1987), “Field potentials generated by group II muscle afferents in the middle lumbar segments of the cat spinal cord.” J Physiol 385:393-413 Details Edgley SA, Lidierth M (1987), “The discharges of cerebellar Golgi cells during locomotion in the cat.” J Physiol 392:315-32 Details 1984Armstrong DM, Edgley SA (1984), “Discharges of Purkinje cells in the paravermal part of the cerebellar anterior lobe during locomotion in the cat.” J Physiol 352:403-24 Details Armstrong DM, Edgley SA (1984), “Discharges of nucleus interpositus neurones during locomotion in the cat.” J Physiol 351:411-32 Details |