Dr Ru Tian

University position

PhD student

Departments

Department of Chemistry

Research Theme

Cellular and Molecular Neuroscience

Interests

IMAGING ALPHA-SYNUCLEIN OLIGOMERS IN PARKINSON’S DISEASE BRAINS

To date, the molecular origins of PD are not fully understood and no disease-modifying treatments are available. Although Lewy bodies are relatively inert, smaller soluble assemblies of α-synuclein, referred to as oligomers, are likely to be actively neurotoxic. Therefore, investigating the role of α-synuclein oligomers in PD is a matter of urgency. Given their heterogeneous and transient nature, exploring them at the single-molecule level is important to define their properties and mechanisms of toxicity for diagnostic and therapeutic interventions. To address this problem, we are using super-resolution microscopy to analyze α-synuclein oligomers in PD brain tissues. Our aim is to generate the first oligomer PD brain map. It will enable us to develop new hypotheses, explore disease mechanisms and identify new therapeutic targets for treating PD.

Research Focus

Keywords

Parkinson's disease

alpha synuclein

human brain tissue

oligomers

imaging

Clinical conditions

Parkinson's disease

Equipment

Confocal microscopy

Immunohistochemistry

Microscopy

Collaborators

No collaborators listed

Associated News Items