Professor Robin Franklin FMedSci, FRS

Collaborators

Associated News Items

• The Biology of Regenerative Medicines - 22-24 April 2015 - Hinxton, Cambridge
• Calling for help: damaged nerve cells communicate with stem cells
• Vitamin D could repair nerve damage in multiple sclerosis
• Election of 3 neuroscientists to The Academy of Medical Sciences
• Robin Franklin Wins Innovation Prize for Multiple Sclerosis Research
• Selected Awards and Honours to Cambridge Neuroscience members in 2017
• Congratulations to Professor Robin Franklin!

Key publications

McMurran CE, Guzman de la Fuente A, Penalva R, Ben Menachem-Zidon O, Dombrowski Y, Falconer J, Gonzalez GA, Zhao C, Krause FN, Young AMH, Griffin JL, Jones CA, Hollins C, Heimesaat MM, Fitzgerald DC, Franklin RJM (2019), “The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination” Proceedings of the National Academy of Sciences USA 15: 201905787

Neumann B, Baror R, Zhao C, Segel M, Dietmann S, Rawji KS, Foerster S, McClain C, Chalut KC, van Wijngaarden P, Franklin RJM (2019), “Metformin restores the potential of aged stem cells for remyelination of the central nervous system” Cell Stem Cell 25: 473-485

Segel M, Neumann B, Hill MFE, Weber I, Viscomi C, Zhao C, Young A, Agley CC, Thompson AJ, Gonzalez G, Sharma A, Holmqvist S, Rowitch DH, Franze K, Franklin RJM*, Chalut KC* (2019), “Niche stiffness underlies the aging of central nervous system progenitor cells” Nature 573: 130-134

Dombrowski Y, O’HaganT, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PA, Evergren E, Perbal B, Williams AC8, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC (2017), “Regulatory T cells promote myelin regeneration in the central nervous system” Nature Neuroscience 20: 674-680

Guzman de la Fuente A, Errea A, van Wijngaarden P, Gonzalez GA, Kerninon C, Jarjour AA, Lewis HJ, Jones CA, Nait-Oumesmar B, Zhao C, Huang JK, ffrench-Constant C, Franklin RJM (2015), “Vitamin D receptor - retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation” Journal of Cell Biology 211: 975-985

Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, van Wijngaarden P, Wagers AJ, Williams A, Franklin RJ, ffrench-Constant C (2013), “M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination.” Nat Neurosci 16(9):1211-8 Details

Ruckh JM, Zhao JW, Shadrach JL, van Wijngaarden P, Rao TN, Wagers AJ, Franklin RJ (2012), “Rejuvenation of regeneration in the aging central nervous system.” Cell Stem Cell 10(1):96-103 Details

Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH (2011), “Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination.” Nat Neurosci 14(8):1009-16 Details

Huang JK, Jarjour AA, Nait Oumesmar B, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Baron-Van Evercooren A, Chambon P, Ffrench-Constant C, Franklin RJ (2011), “Retinoid X receptor gamma signaling accelerates CNS remyelination.” Nat Neurosci 14(1):45-53 Details

Zawadzka M, Rivers LE, Fancy SP, Zhao C, Tripathi R, Jamen F, Young K, Goncharevich A, Pohl H, Rizzi M, Rowitch DH, Kessaris N, Suter U, Richardson WD, Franklin RJ (2010), “CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.” Cell Stem Cell 6(6):578-90 Details

Fancy SP, Baranzini SE, Zhao C, Yuk DI, Irvine KA, Kaing S, Sanai N, Franklin RJ, Rowitch DH (2009), “Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS.” Genes Dev 23(13):1571-85 Details

Franklin RJ, Ffrench-Constant C (2008), “Remyelination in the CNS: from biology to therapy.” Nat Rev Neurosci 9(11):839-55 Details

Publications

2019

Nobuta H, Yang N, Ng Y-H, Marro S, Sabeur K, Chavali M, Stockley J, Killilea DW, Walter P, Zhao C, Huie CP, Goldman SA, Kriegstein A, Franklin RJM, Rowitch D, M, Wernig M (2019), “Oligodendrocyte death in Pelizaeus-Merzbacher disease is rescued by iron chelation” Cell Stem Cell 25: 531-541

Raror R, Neumann B, Segel M, Chalut KC, Fancy SPJ, Schafer DP, Franklin RJM (2019), “Transforming growth factor-beta renders ageing microglia inhibitory to oligodendrocyte generation by CNS progenitors” Glia 67: 1374-1384

Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kreigstein AR, Rowitch DH (2019), “Neuronal vulnerability and multilineage diversity in multiple sclerosis” Nature 388(4), 1545–8

Silva ME, Lange S, Hinrichsen B, Philip A, Reyes CR, Halabi D, Rotheneichner R, Guzman de la Fuente A, Couilliard-Despres S, Batiz LF, Franklin RJM, Aigner L, Rivera FJ (2019), “Pericytes favour oligodendrocyte fate choice in adult neural stem cells” Frontiers in Cellular Neuroscience 35: 85

2018

Hammond TR, Dufort C, Dissing-Olesen, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll S, Stevens B (2018), “Single-Cell RNA Sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes” Immunity 50: 1-19

Ma D, Wang B, Zadwadzka M, Gonzalez G, Wu Z, Yu B, Rawlins EL, Franklin RJM*, Zhao C* (* joint senior authors) (2018), “A sub-population of Foxj1 expressing, non-myelinating Schwann cells of the peripheral nervous system contribute to Schwann cell remyelination in the central nervous system” Journal of Neuroscience 38:9228 –9239

Schirmer L, Cruz Herranz A, Ben Haim L, Zhao C, Cordano C, Pröbstel AK, Shiow LR, Kelley KW, Moebius W, Timmons G, Sin JH, Wright J, Morrison D, Chang S, Sabeur K, Nave KA, R. Franklin RJM, Green AJ, Rowitch DH (2018), “Oligodendrocyte Kir4.1 is essential for axon integrity and a therapeutic target in multiple sclerosis” eLife e36428

Ulanska-Poutanen J, Mieczkowski J, Zhao C, Konarzewska K, Kaza B, Pohl HBF, Bugajski L, Kaminska B, Franklin RJM*, Zawadzka M* (* joint senior authors) (2018), “Injury-induced perivascular niche supports alternative differentiation of adult CNS progenitor cells” eLife e30325

2017

Kazanis I, Evans KA, Andreopoulou E, Dimitriou C, Koutsakis C, Karadottir RT, Franklin RJM (2017), “Subependymal zone derived oligodendroblasts respond in a fast and transient mode to focal demyelination but fail to generate myelin in young and aged mice” Stem Cell Reports 8, 685-70

Moyon S, Ma D, Huynh JL, Coutts DJC, Zhao C, Casaccia P, Franklin RJM (2017), “Efficient remyelination requires DNA methylation” eNeuro : 0336-16

Schilling F, Ros S, Hu D, D'Santos P, McGuire S, Mair R, Wright A, Mannion E, Neves AA, Franklin RJM, Brindle KM (2017), “The urea transporter – a novel substrate-free MRI gene reporter detected using transmembrane water exchange imaging” Nature Biotechnology 35: 75-80

2016

Bielecki B, Mattern C, Ghoumari AM, Javaid S, Smietanka K, Abi Ghanem C, Mhaouty-Kodja S, Ghandour S, Baulieu E-E, Franklin RJM, Schumacher M, Traiffort E (2016), “Unexpected central role of the androgen receptor in the spontaneous regeneration of myelin” PNAS 113:14829-14834

Crawford AH, Tripathi RB, Richardson WD, Franklin RJM (2016), “The developmental origin of oligodendrocyte lineage cells determines their response to demyelination and susceptibility to age-associated functional decline” Cell Reports 15: 761-773

Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, Yoo S, Lawrence R, Wegner M, John GR, Emery B, Lubetzki C, Franklin RJM, Fan G, Zhu J, Dupree JL, Casaccia P (2016), “Functional characterization of DNA methylation in the oligodendrocyte lineage” Cell Reports 15: 761-773

Ossola B, Zhao C, Compston A, Pluchino S, Franklin RJM, Spillantini MG (2016), “Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation” Glia 64: 457-471

Syed YA, Zhao C, Mahad D, Möbius W, Altmann F, Foss F, Acker-Palmer A, Lubec G, Lilley K, Franklin RJM, Nave KA, Kotter MRN (2016), “Antibody mediated neutralization of myelin associated EphrinB3 accelerates CNS remyelination” Acta Neuropathologica 131: 281-98

2015

Brennan FH, Gordon R, Lao HW, Biggins PJ, Taylor SM, Franklin RJ, Woodruff TM, Ruitenberg MJ (2015), “The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury.” J Neurosci 35(16):6517-31 Details

Crawford AH, Tripathi RB, Foerster S, McKenzie I, Kouioumtzidou E, Grist M, Richardson WD, Franklin RJM (2015), “Pre-existing mature oligodendrocytes do not contribute to remyelination following toxin-induced spinal cord demyelination” American Journal of Pathology 186: 511-516

Franklin RJM ( (2015), “Regenerative medicines for remyelination: from aspiration to reality” Cell Stem Cell 16: 576-577

Furusho M, Roulois AJ, Franklin RJ, Bansal R (2015), “Fibroblast growth factor signaling in oligodendrocyte-lineage cells facilitates recovery of chronically demyelinated lesions but is redundant in acute lesions.” Glia Details

Gautier HO, Evans KA, Volbracht K, James R, Sitnikov S, Lundgaard I, James F, Lao-Peregrin C, Reynolds R, Franklin RJM, Káradóttir RT (2015), “Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors” Nature Communications 6: 8518

Kazanis I, Feichtner M, Lange S, Rotheneichner P, Hainzl S, Öller M, Schallmoser K, Rohde E, Reitsamer HA, Couillard-Despres S, Bauer HC, Franklin RJ, Aigner L, Rivera FJ (2015), “Lesion-Induced Accumulation of Platelets Promotes Survival of Adult Neural Stem / Progenitor Cells.” Exp Neurol 269:75-89 Details

Monteiro de Castro G, Deja NA Ma D, Zhao C, Franklin RJM (2015), “Astrocyte activation via Stat3 signalling determines the balance of oligodendrocyte versus Schwann cell remyelinationAmerican Journal of Pathology” American Journal of Pathology 185: 2431-2440

Moyon S, Dubessy AL, Aigrot MS, Trotter M, Huang JK, Dauphinot L, Potier MC, Kerninon C, Melik Parsadaniantz S, Franklin RJ, Lubetzki C (2015), “Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.” J Neurosci 35(1):4-20 Details

Natrajan MS, Guzman de la Fuente A, Crawford AH, Linehan E, Nuñez V, Johnson KR, Wu T, Fitzgerald DC, Ricote M, Bielekova B, Franklin RJM (2015), “Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination” Brain 138: 3581-3597

Natrajan MS, Komori M, Kosa P, Johnson KR, Wu T, Franklin RJM, Bielekova B (2015), “Pioglitazone enhances myelin phagocytosis and regulates multiple sclerosis monocytes” Annals of Clinical and Translational Neurology 2: 1071-1084

Stoffels JM, Hoekstra D, Franklin RJ, Baron W, Zhao C (2015), “The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination.” Glia 63(2):242-56 Details

Zhao C, Ma D, Zawadzka M, Fancy SPJ, Elis-Williams L, Bouvier G, Stockley JH, Monteiro de Castro G, Wang B, Jacobs S, Casaccia P, Franklin RJM (2015), “Sox2 sustains recruitment of oligodendrocyte progenitor cells following CNS demyelination and primes them for differentiation during CNS remyelination” Journal of Neuroscience 35: 11482-11499

2014

Crawford AH, Stockley JH, Tripathi RB, Richardson WD, Franklin RJ (2014), “Oligodendrocyte progenitors: Adult stem cells of the central nervous system?” Exp Neurol Details

Franklin RJ, Gallo V (2014), “The translational biology of remyelination: Past, present, and future.” Glia Details

Franklin RJ, Snyder EY (2014), “Special Issue on Stem Cells: "The End of the Beginning"” Exp Neurol Details

Granger N, Franklin RJ, Jeffery ND (2014), “Cell Therapy for Spinal Cord Injuries: What Is Really Going on?” Neuroscientist Details

Mei F, Fancy SP, Shen YA, Niu J, Zhao C, Presley B, Miao E, Lee S, Mayoral SR, Redmond SA, Etxeberria A, Xiao L, Franklin RJ, Green A, Hauser SL, Chan JR (2014), “Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis.” Nat Med Details

Miron VE, Franklin RJ (2014), “Macrophages and CNS Remyelination.” J Neurochem Details

Montani L, Buerki-Thurnherr T, de Faria JP, Pereira JA, Dias NG, Fernandes R, Gonçalves AF, Braun A, Benninger Y, Böttcher RT, Costell M, Nave KA, Franklin RJ, Meijer D, Suter U, Relvas JB (2014), “Profilin 1 is required for peripheral nervous system myelination.” Development 141(7):1553-61 Details

Pagliara S, Franze K, McClain CR, Wylde GW, Fisher CL, Franklin RJ, Kabla AJ, Keyser UF, Chalut KJ (2014), “Auxetic nuclei in embryonic stem cells exiting pluripotency.” Nat Mater 13(6):638-44 Details

Sawcer S, Franklin RJ, Ban M (2014), “Multiple sclerosis genetics.” Lancet Neurol 13(7):700-709 Details

Tanaka M, Izawa T, Yamate J, Franklin RJ, Kuramoto T, Serikawa T, Kuwamura M (2014), “The VF rat with abnormal myelinogenesis has a mutation in Dopey1.” Glia 62(9):1530-42 Details

Tyzack GE, Sitnikov S, Barson D, Adams-Carr KL, Lau NK, Kwok JC, Zhao C, Franklin RJ, Karadottir RT, Fawcett JW, Lakatos A (2014), “Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression.” Nat Commun 5:4294 Details

Zhu B, Zhao C, Young FI, Franklin RJ, Song B (2014), “Isolation and long-term expansion of functional, myelinating oligodendrocyte progenitor cells from neonatal rat brain.” Curr Protoc Stem Cell Biol 31:2D.17.1-2D.17.15 Details

2013

Camacho A, Huang JK, Delint-Ramirez I, Yew Tan C, Fuller M, Lelliott CJ, Vidal-Puig A, Franklin RJ (2013), “Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis.” Eur J Neurosci 38(5):2672-83 Details

Crawford AH, Chambers C, Franklin RJ (2013), “Remyelination: the true regeneration of the central nervous system.” J Comp Pathol 149(2-3):242-54 Details

Franklin RJ, Bussey TJ (2013), “Do your glial cells make you clever?” Cell Stem Cell 12(3):265-6 Details

Hampton DW, Serio A, Pryce G, Al-Izki S, Franklin RJ, Giovannoni G, Baker D, Chandran S (2013), “Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis.” Acta Neuropathol Commun 1(1):84 Details

Kazanis I, Gorenkova N, Zhao JW, Franklin RJ, Modo M, Ffrench-Constant C (2013), “The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.” Exp Neurol 248:387-97 Details

Lange S, Trost A, Tempfer H, Bauer HC, Bauer H, Rohde E, Reitsamer HA, Franklin RJ, Aigner L, Rivera FJ (2013), “Brain pericyte plasticity as a potential drug target in CNS repair.” Drug Discov Today 18(9-10):456-63 Details

Lundgaard I, Luzhynskaya A, Stockley JH, Wang Z, Evans KA, Swire M, Volbracht K, Gautier HO, Franklin RJ, Charles Ffrench-Constant, Attwell D, Káradóttir RT (2013), “Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.” PLoS Biol 11(12):e1001743 Details

Stacpoole SR, Spitzer S, Bilican B, Compston A, Karadottir R, Chandran S, Franklin RJ (2013), “High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology.” Stem Cell Reports 1(5):437-50 Details

Stacpoole SR, Webber DJ, Bilican B, Compston A, Chandran S, Franklin RJ (2013), “Neural precursor cells cultured at physiologically relevant oxygen tensions have a survival advantage following transplantation.” Stem Cells Transl Med 2(6):464-72 Details

Stoffels JM, de Jonge JC, Stancic M, Nomden A, van Strien ME, Ma D, Sisková Z, Maier O, Ffrench-Constant C, Franklin RJ, Hoekstra D, Zhao C, Baron W (2013), “Fibronectin aggregation in multiple sclerosis lesions impairs remyelination.” Brain 136(Pt 1):116-31 Details

Syed YA, Baer A, Hofer MP, González GA, Rundle J, Myrta S, Huang JK, Zhao C, Rossner MJ, Trotter MW, Lubec G, Franklin RJ, Kotter MR (2013), “Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination.” EMBO Mol Med 5(12):1918-34 Details

van Wijngaarden P, Franklin RJ (2013), “Ageing stem and progenitor cells: implications for rejuvenation of the central nervous system.” Development 140(12):2562-75 Details

Vanhaesebrouck AE, Bhatti SF, Franklin RJ, Van Ham L (2013), “Myokymia and neuromyotonia in veterinary medicine: a comparison with peripheral nerve hyperexcitability syndrome in humans.” Vet J 197(2):153-62 Details

Yuen TJ, Johnson KR, Miron VE, Zhao C, Quandt J, Harrisingh MC, Swire M, Williams A, McFarland HF, Franklin RJ, Ffrench-Constant C (2013), “Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination.” Brain 136(Pt 4):1035-47 Details

2012

Chong SY, Rosenberg SS, Fancy SP, Zhao C, Shen YA, Hahn AT, McGee AW, Xu X, Zheng B, Zhang LI, Rowitch DH, Franklin RJ, Lu QR, Chan JR (2012), “Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination.” Proc Natl Acad Sci U S A 109(4):1299-304 Details

Coutts DJ, Humphries CE, Zhao C, Plant GW, Franklin RJ (2012), “Embryonic-derived olfactory ensheathing cells remyelinate focal areas of spinal cord demyelination more efficiently than neonatal or adult derived cells.” Cell Transplant Details

Franklin RJ, ffrench-Constant C, Edgar JM, Smith KJ (2012), “Neuroprotection and repair in multiple sclerosis.” Nat Rev Neurol 8(11):624-34 Details

Granger N, Blamires H, Franklin RJ, Jeffery ND (2012), “Autologous olfactory mucosal cell transplants in clinical spinal cord injury: a randomized double-blinded trial in a canine translational model.” Brain 135(Pt 11):3227-37 Details

Hampton DW, Innes N, Merkler D, Zhao C, Franklin RJ, Chandran S (2012), “Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency.” Am J Pathol 180(5):1897-905 Details

Holdsworth G, Slocombe P, Doyle C, Sweeney B, Veverka V, Le Riche K, Franklin RJ, Compson J, Brookings D, Turner J, Kennedy J, Garlish R, Shi J, Newnham L, McMillan D, Muzylak M, Carr MD, Henry AJ, Ceska T, Robinson MK (2012), “Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.” J Biol Chem 287(32):26464-77 Details

Huang JK, Ferrari CC, Monteiro de Castro G, Lafont D, Zhao C, Zaratin P, Pouly S, Greco B, Franklin RJ (2012), “Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z.” Am J Pathol 181(5):1518-23 Details

Huang JK, Franklin RJ (2012), “Current status of myelin replacement therapies in multiple sclerosis.” Prog Brain Res 201:219-31 Details

Jagielska A, Norman AL, Whyte G, Vliet KJ, Guck J, Franklin RJ (2012), “Mechanical environment modulates biological properties of oligodendrocyte progenitor cells.” Stem Cells Dev 21(16):2905-14 Details

Kipp M, Victor M, Martino G, Franklin RJ (2012), “Endogeneous Remyelination: Findings in Human Studies.” CNS Neurol Disord Drug Targets Details

Tanaka M, Soma K, Izawa T, Yamate J, Franklin RJ, Kuramoto T, Serikawa T, Kuwamura M (2012), “Abnormal myelinogenesis in the central nervous system of the VF mutant rat with recoverable tremor.” Brain Res 1488:104-12 Details

2011

Fancy SP, Chan JR, Baranzini SE, Franklin RJ, Rowitch DH (2011), “Myelin regeneration: a recapitulation of development?” Annu Rev Neurosci 34:21-43 Details

Huang JK, Fancy SP, Zhao C, Rowitch DH, Ffrench-Constant C, Franklin RJ (2011), “Myelin regeneration in multiple sclerosis: targeting endogenous stem cells.” Neurotherapeutics 8(4):650-8 Details

Huang JK, Franklin RJ (2011), “Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation.” Neurochem Int Details

Huang JK, Jarjour AA, Ffrench-Constant C, Franklin RJ (2011), “Retinoid X receptors as a potential avenue for regenerative medicine in multiple sclerosis.” Expert Rev Neurother 11(4):467-8 Details

Kuwamura M, Inumaki K, Tanaka M, Shirai M, Izawa T, Yamate J, Franklin RJ, Kuramoto T, Serikawa T (2011), “Oligodendroglial pathology in the development of myelin breakdown in the dmy mutant rat.” Brain Res 1389:161-8 Details

Pohl HB, Porcheri C, Mueggler T, Bachmann LC, Martino G, Riethmacher D, Franklin RJ, Rudin M, Suter U (2011), “Genetically induced adult oligodendrocyte cell death is associated with poor myelin clearance, reduced remyelination, and axonal damage.” J Neurosci 31(3):1069-80 Details

Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S (2011), “Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation.” Cell Death Differ 18(6):1016-23 Details

Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S (2011), “Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.” Nat Protoc 6(8):1229-40 Details

Zambonin JL, Zhao C, Ohno N, Campbell GR, Engeham S, Ziabreva I, Schwarz N, Lee SE, Frischer JM, Turnbull DM, Trapp BD, Lassmann H, Franklin RJ, Mahad DJ (2011), “Increased mitochondrial content in remyelinated axons: implications for multiple sclerosis.” Brain 134(Pt 7):1901-13 Details

2010

Barraud P, He X, Zhao C, Caldwell MA, Franklin RJ (2010), “FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures.” Exp Cell Res 316(9):1489-99 Details

Buckley CE, Marguerie A, Alderton WK, Franklin RJ (2010), “Temporal dynamics of myelination in the zebrafish spinal cord.” Glia 58(7):802-12 Details

Buckley CE, Marguerie A, Roach AG, Goldsmith P, Fleming A, Alderton WK, Franklin RJ (2010), “Drug reprofiling using zebrafish identifies novel compounds with potential pro-myelination effects.” Neuropharmacology Details

Christ AF, Franze K, Gautier H, Moshayedi P, Fawcett J, Franklin RJ, Karadottir RT, Guck J (2010), “Mechanical difference between white and gray matter in the rat cerebellum measured by scanning force microscopy.” J Biomech Details

Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJ (2010), “Overcoming remyelination failure in multiple sclerosis and other myelin disorders.” Exp Neurol 225(1):18-23 Details

Franklin RJ, Ffrench-Constant C (2010), “Stem cell treatments and multiple sclerosis.” BMJ 340:c1387 Details

Harrington EP, Zhao C, Fancy SP, Kaing S, Franklin RJ, Rowitch DH (2010), “Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination.” Ann Neurol 68(5):703-16 Details

Izawa T, Yamate J, Franklin RJ, Kuwamura M (2010), “Abnormal iron accumulation is involved in the pathogenesis of the demyelinating dmy rat but not in the hypomyelinating mv rat.” Brain Res 1349:105-14 Details

Izawa T, Yamate J, Franklin RJ, Kuwamura M (2010), “Abnormal myelinogenesis both in the white and gray matter of the attractin-deficient mv rat.” Brain Res 1312:145-55 Details

Martino G, Franklin RJ, Van Evercooren AB, Kerr DA, Stem Cells in Multiple Sclerosis (STEMS) Consensus Group (2010), “Stem cell transplantation in multiple sclerosis: current status and future prospects.” Nat Rev Neurol 6(5):247-55 Details

Ziabreva I, Campbell G, Rist J, Zambonin J, Rorbach J, Wydro MM, Lassmann H, Franklin RJ, Mahad D (2010), “Injury and differentiation following inhibition of mitochondrial respiratory chain complex IV in rat oligodendrocytes.” Glia Details

2009

Baer AS, Syed YA, Kang SU, Mitteregger D, Vig R, Ffrench-Constant C, Franklin RJ, Altmann F, Lubec G, Kotter MR (2009), “Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling.” Brain 132(Pt 2):465-81 Details

Bruce CC, Zhao C, Franklin RJ (2009), “Remyelination - An effective means of neuroprotection.” Horm Behav Details

Bull ND, Irvine KA, Franklin RJ, Martin KR (2009), “Transplanted oligodendrocyte precursor cells reduce neurodegeneration in a model of glaucoma.” Invest Ophthalmol Vis Sci 50(9):4244-53 Details

Mi S, Miller RH, Tang W, Lee X, Hu B, Wu W, Zhang Y, Shields CB, Zhang Y, Miklasz S, Shea D, Mason J, Franklin RJ, Ji B, Shao Z, Chédotal A, Bernard F, Roulois A, Xu J, Jung V, Pepinsky B (2009), “Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells.” Ann Neurol 65(3):304-15 Details

Porter J, Lumb S, Franklin RJ, Gascon-Simorte JM, Calmiano M, Riche KL, Lallemand B, Keyaerts J, Edwards H, Maloney A, Delgado J, King L, Foley A, Lecomte F, Reuberson J, Meier C, Batchelor M (2009), “Discovery of 4-azaindoles as novel inhibitors of c-Met kinase.” Bioorg Med Chem Lett 19(10):2780-4 Details

Zhao C, Fancy SP, Franklin RJ, ffrench-Constant C (2009), “Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination.” J Neurosci Res 87(15):3447-55 Details

2008

Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S (2008), “Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis.” Brain 131(Pt 7):1736-48 Details

Barraud P, He X, Caldwell MA, Franklin RJ (2008), “Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures.” BMC Neurosci 9:24 Details

Brinkmann BG, Agarwal A, Sereda MW, Garratt AN, Müller T, Wende H, Stassart RM, Nawaz S, Humml C, Velanac V, Radyushkin K, Goebbels S, Fischer TM, Franklin RJ, Lai C, Ehrenreich H, Birchmeier C, Schwab MH, Nave KA (2008), “Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.” Neuron 59(4):581-95 Details

Brinkmann, B. G., Agarwal, A., Serada, M. W., Garratt, A. N., Mueller, T., Wende, H., Stassart, R. M., Nawaz, S., Humml, C., Velanac, V., Radyuschkin, K., Goebbels, S., Fischer, T. M., Franklin, R. J. M., Lai, C., Ehrenreich, H., Birchmeier, C., Schwab, M. H., Nave, K. A. (2008), “Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system” Neuron 59 581-594

Buckley CE, Goldsmith P, Franklin RJ (2008), “Zebrafish myelination: a transparent model for remyelination?” Dis Model Mech 1(4-5):221-8 Details

Chandran S, Hunt D, Joannides A, Zhao C, Compston A, Franklin RJ (2008), “Myelin repair: the role of stem and precursor cells in multiple sclerosis.” Philos Trans R Soc Lond B Biol Sci 363(1489):171-83 Details

Franklin RJ, Kotter MR (2008), “The biology of CNS remyelination: the key to therapeutic advances.” J Neurol 255 Suppl 1:19-25 Details

Hamilton L, Franklin RJ, Jeffery ND (2008), “Quantification of deficits in lateral paw positioning after spinal cord injury in dogs.” BMC Vet Res 4:47 Details

Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJ, Baker D, Chandran S (2008), “An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss.” J Neuroimmunol 201-202:200-11 Details

Ito D, Fujita N, Ibanez C, Sasaki N, Franklin RJ, Jeffery ND (2008), “Serum-free medium provides a clinically relevant method to increase olfactory ensheathing cell numbers in olfactory mucosa cell culture.” Cell Transplant 16(10):1021-7 Details

Neumann H, Kotter MR, Franklin RJ (2008), “Debris clearance by microglia: an essential link between degeneration and regeneration.” Brain Details

Rist JM, Franklin RJ (2008), “Taking ageing into account in remyelination-based therapies for multiple sclerosis.” J Neurol Sci 274(1-2):64-7 Details

Shen S, Sandoval J, Swiss VA, Li J, Dupree J, Franklin RJ, Casaccia-Bonnefil P (2008), “Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency.” Nat Neurosci 11(9):1024-34 Details

Zhao C, Fancy SP, ffrench-Constant C, Franklin RJ (2008), “Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination.” Neurobiol Dis 31(2):209-17 Details

Zhao C, Zawadzka M, Roulois AJ, Bruce CC, Franklin RJ (2008), “Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells: defining cellular targets.” J Neurol Sci 265(1-2):12-6 Details

2007

Barraud P, He X, Zhao C, Ibanez C, Raha-Chowdhury R, Caldwell MA, Franklin RJ (2007), “Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells.” Eur J Neurosci 26(12):3345-57 Details

Benninger Y, Thurnherr T, Pereira JA, Krause S, Wu X, Chrostek-Grashoff A, Herzog D, Nave KA, Franklin RJ, Meijer D, Brakebusch C, Suter U, Relvas JB (2007), “Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development.” J Cell Biol 177(6):1051-61 Details

Bowen S, Ateh DD, Deinhardt K, Bird MM, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, El-Tawil T, Roos J, Hoyle A, Nickols CD, Knowles CH, Pullen AH, Luthert PJ, Weller RO, Hafezparast M, Franklin RJ, Revesz T, King RH, Berninghausen O, Fisher EM, Schiavo G, Martin JE (2007), “The phagocytic capacity of neurones.” Eur J Neurosci 25(10):2947-55 Details

Hamilton L, Franklin RJ, Jeffery ND (2007), “Development of a universal measure of quadrupedal forelimb-hindlimb coordination using digital motion capture and computerised analysis.” BMC Neurosci 8:77 Details

Ibanez C, Ito D, Zawadzka M, Jeffery ND, Franklin RJ (2007), “Calponin is expressed by fibroblasts and meningeal cells but not olfactory ensheathing cells in the adult peripheral olfactory system.” Glia 55(2):144-51 Details

Skelly BJ, Franklin RJ (2007), “Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs.” Vet J 174(3):652-4 Details

Woodhoo A, Sahni V, Gilson J, Setzu A, Franklin RJ, Blakemore WF, Mirsky R, Jessen KR (2007), “Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System.” Brain 130(Pt 8):2175-85 Details

Zawadzka M, Franklin RJ (2007), “Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology.” Curr Opin Neurol 20(3):294-8 Details

2006

Benninger Y, Colognato H, Thurnherr T, Franklin RJ, Leone DP, Atanasoski S, Nave KA, Ffrench-Constant C, Suter U, Relvas JB (2006), “Beta1-integrin signaling mediates premyelinating oligodendrocyte survival but is not required for CNS myelination and remyelination.” J Neurosci 26(29):7665-73 Details

Dunning MD, Kettunen MI, Ffrench Constant C, Franklin RJ, Brindle KM (2006), “Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres.” Neuroimage 31(1):172-80 Details

Franklin RJ, Zhao C (2006), “Tyrosine kinases: maiming myelin in leprosy.” Nat Med 12(8):889-90 Details

Kotter MR, Li W-W, Chao Z, Franklin RJM (2006), “Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation” Journal of Neuroscience 26:328-332

Li WW, Penderis J, Zhao C, Schumacher M, Franklin RJ (2006), “Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS.” Exp Neurol 202(1):250-4 Details

Ligon KL, Fancy SP, Franklin RJ, Rowitch DH (2006), “Olig gene function in CNS development and disease.” Glia 54(1):1-10 Details

Setzu A, Lathia JD, Zhao C, Wells K, Rao MS, Ffrench-Constant C, Franklin RJ (2006), “Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells.” Glia 54(4):297-303 Details

Thurnherr T, Benninger Y, Wu X, Chrostek A, Krause SM, Nave KA, Franklin RJ, Brakebusch C, Suter U, Relvas JB (2006), “Cdc42 and Rac1 signaling are both required for and act synergistically in the correct formation of myelin sheaths in the CNS.” J Neurosci 26(40):10110-9 Details

Zhao C, Li WW, Franklin RJ (2006), “Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination.” Neurobiol Aging 27(9):1298-307 Details

2005

Bridge WL, Vandenberg CJ, Franklin RJ, Hiom K (2005), “The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair.” Nat Genet 37(9):953-7 Details

Kotter MR, Zhao C, van Rooijen N, Franklin RJ (2005), “Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression.” Neurobiol Dis 18(1):166-75 Details

Li WW, Setzu A, Zhao C, Franklin RJ (2005), “Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination.” J Neuroimmunol 158(1-2):58-66 Details

Skinner AP, Pachnicke S, Lakatos A, Franklin RJ, Jeffery ND (2005), “Nasal and frontal sinus mucosa of the adult dog contain numerous olfactory sensory neurons and ensheathing glia.” Res Vet Sci 78(1):9-15 Details

Zhao C, Fancy SP, Kotter MR, Li WW, Franklin RJ (2005), “Mechanisms of CNS remyelination--the key to therapeutic advances.” J Neurol Sci 233(1-2):87-91 Details

2004

Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD (2004), “bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.” Science 306(5704):2111-5 Details

Dunning MD, Lakatos A, Loizou L, Kettunen M, ffrench-Constant C, Brindle KM, Franklin RJ (2004), “Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS.” J Neurosci 24(44):9799-810 Details

Dunning MD, Lakatos A, Loizou L, Kettunen M, ffrench-Constant C, Brindle KM, Franklin RJM (2004), “Superparamagnetic iron oxide (SPIO)-labelled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties following transplantation into the CNS” Journal of Neuroscience 24:9799-9810

Fancy SP, Zhao C, Franklin RJ (2004), “Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS.” Mol Cell Neurosci 27(3):247-54 Details

ffrench-Constant C, Colognato H, Franklin RJ (2004), “Neuroscience. The mysteries of myelin unwrapped.” Science 304(5671):688-9 Details

Hampton DW, Rhodes KE, Zhao C, Franklin RJ, Fawcett JW (2004), “The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain.” Neuroscience 127(4):813-20 Details

Ibanez C, Shields SA, El-Etr M, Baulieu EE, Schumacher M, Franklin RJ (2004), “Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats.” Neuropathol Appl Neurobiol 30(1):80-9 Details

Setzu A, Ffrench-Constant C, Franklin RJ (2004), “CNS axons retain their competence for myelination throughout life.” Glia 45(3):307-11 Details

Stidworthy MF, Genoud S, Li WW, Leone DP, Mantei N, Suter U, Franklin RJ (2004), “Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination.” Brain 127(Pt 9):1928-41 Details

Williams SK, Franklin RJ, Barnett SC (2004), “Response of olfactory ensheathing cells to the degeneration and regeneration of the peripheral olfactory system and the involvement of the neuregulins.” J Comp Neurol 470(1):50-62 Details

Woodruff RH, Fruttiger M, Richardson WD, Franklin RJ (2004), “Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination.” Mol Cell Neurosci 25(2):252-62 Details

2003

Franklin RJ (2003), “Remyelination by transplanted olfactory ensheathing cells.” Anat Rec B New Anat 271(1):71-6 Details

Ibanez C, Shields SA, El-Etr M, Leonelli E, Magnaghi V, Li WW, Sim FJ, Baulieu EE, Melcangi RC, Schumacher M, Franklin RJ (2003), “Steroids and the reversal of age-associated changes in myelination and remyelination.” Prog Neurobiol 71(1):49-56 Details

Lakatos A, Barnett SC, Franklin RJ (2003), “Olfactory ensheathing cells induce less host astrocyte response and chondroitin sulphate proteoglycan expression than Schwann cells following transplantation into adult CNS white matter.” Exp Neurol 184(1):237-46 Details

Lakatos A, Smith PM, Barnett SC, Franklin RJ (2003), “Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells.” Brain 126(Pt 3):598-609 Details

Penderis J, Shields SA, Franklin RJ (2003), “Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system.” Brain 126(Pt 6):1382-91 Details

Penderis J, Woodruff RH, Lakatos A, Li WW, Dunning MD, Zhao C, Marchionni M, Franklin RJ (2003), “Increasing local levels of neuregulin (glial growth factor-2) by direct infusion into areas of demyelination does not alter remyelination in the rat CNS.” Eur J Neurosci 18(8):2253-64 Details

Schumacher M, Weill-Engerer S, Liere P, Robert F, Franklin RJ, Garcia-Segura LM, Lambert JJ, Mayo W, Melcangi RC, Parducz A, Suter U, Carelli C, Baulieu EE, Akwa Y (2003), “Steroid hormones and neurosteroids in normal and pathological aging of the nervous system.” Prog Neurobiol 71(1):3-29 Details

Stidworthy MF, Genoud S, Suter U, Mantei N, Franklin RJ (2003), “Quantifying the early stages of remyelination following cuprizone-induced demyelination.” Brain Pathol 13(3):329-39 Details

Zhao C, Strappe PM, Lever AM, Franklin RJ (2003), “Lentiviral vectors for gene delivery to normal and demyelinated white matter.” Glia 42(1):59-67 Details

2002

Franklin RJ (2002), “Obtaining olfactory ensheathing cells from extra-cranial sources a step closer to clinical transplant-mediated repair of the CNS?” Brain 125(Pt 1):2-3 Details

Franklin RJ (2002), “Why does remyelination fail in multiple sclerosis?” Nat Rev Neurosci 3(9):705-14 Details

Franklin RJ (2002), “Remyelination of the demyelinated CNS: the case for and against transplantation of central, peripheral and olfactory glia.” Brain Res Bull 57(6):827-32 Details

Franklin RJ, Zhao C, Sim FJ (2002), “Ageing and CNS remyelination.” Neuroreport 13(7):923-8 Details

Lakatos A, Franklin RJ (2002), “Transplant mediated repair of the central nervous system: an imminent solution?” Curr Opin Neurol 15(6):701-5 Details

O'Leary MT, Hinks GL, Charlton HM, Franklin RJ (2002), “Increasing local levels of IGF-I mRNA expression using adenoviral vectors does not alter oligodendrocyte remyelination in the CNS of aged rats.” Mol Cell Neurosci 19(1):32-42 Details

Sim FJ, Zhao C, Li WW, Lakatos A, Franklin RJ (2002), “Expression of the POU-domain transcription factors SCIP/Oct-6 and Brn-2 is associated with Schwann cell but not oligodendrocyte remyelination of the CNS.” Mol Cell Neurosci 20(4):669-82 Details

Sim FJ, Zhao C, Penderis J, Franklin RJ (2002), “The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation.” J Neurosci 22(7):2451-9 Details

Skelly BJ, Franklin RJ (2002), “Recognition and diagnosis of lysosomal storage diseases in the cat and dog.” J Vet Intern Med 16(2):133-41 Details

Smith PM, Lakatos A, Barnett SC, Jeffery ND, Franklin RJ (2002), “Cryopreserved cells isolated from the adult canine olfactory bulb are capable of extensive remyelination following transplantation into the adult rat CNS.” Exp Neurol 176(2):402-6 Details

2001

Franklin RJ, Hinks GL, Woodruff RH, O'Leary MT (2001), “What roles do growth factors play in CNS remyelination?” Prog Brain Res 132:185-93 Details

Hinks GL, Chari DM, O'Leary MT, Zhao C, Keirstead HS, Blakemore WF, Franklin RJ (2001), “Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X-irradiated compared to normal CNS.” Neuropathol Appl Neurobiol 27(1):59-67 Details

Jeffery ND, Penderis J, Smith PM, Franklin RJ (2001), “Bridging the divide: spinal cord repair by cellular transplantation--from research laboratory to therapeutic application.” J Small Anim Pract 42(9):428-32 Details

Jolly RD, Ehrlich PC, Franklin RJ, Macdougall DF, Palmer AC (2001), “Histological diagnosis of mucopolysaccharidosis IIIA in a wire-haired dachshund.” Vet Rec 148(18):564-7 Details

Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJ (2001), “Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination.” Glia 35(3):204-12 Details

Lobsiger CS, Smith PM, Buchstaller J, Schweitzer B, Franklin RJ, Suter U, Taylor V (2001), “SpL201: a conditionally immortalized Schwann cell precursor line that generates myelin.” Glia 36(1):31-47 Details

Palmer AC, Callanan JJ, Guerin LA, Sheahan BJ, Stronach N, Franklin RJ (2001), “Progressive encephalomyelopathy and cerebellar degeneration in 10 captive-bred cheetahs.” Vet Rec 149(2):49-54 Details

Penderis J, Franklin RJ (2001), “Dyskinesia in an adult bichon frise.” J Small Anim Pract 42(1):24-5 Details

Relvas JB, Setzu A, Baron W, Buttery PC, LaFlamme SE, Franklin RJ, ffrench-Constant C (2001), “Expression of dominant-negative and chimeric subunits reveals an essential role for beta1 integrin during myelination.” Curr Biol 11(13):1039-43 Details

Smith PM, Franklin RJ (2001), “The effect of immunosuppressive protocols on spontaneous CNS remyelination following toxin-induced demyelination.” J Neuroimmunol 119(2):261-8 Details

Smith PM, Sim FJ, Barnett SC, Franklin RJ (2001), “SCIP/Oct-6, Krox-20, and desert hedgehog mRNA expression during CNS remyelination by transplanted olfactory ensheathing cells.” Glia 36(3):342-53 Details

2000

Barnett SC, Alexander CL, Iwashita Y, Gilson JM, Crowther J, Clark L, Dunn LT, Papanastassiou V, Kennedy PG, Franklin RJ (2000), “Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons.” Brain 123 ( Pt 8):1581-8 Details

Blakemore WF, Franklin RJ (2000), “Transplantation options for therapeutic central nervous system remyelination.” Cell Transplant 9(2):289-94 Details

Blakemore WF, Smith PM, Franklin RJ (2000), “Remyelinating the demyelinated CNS.” Novartis Found Symp 231:289-98; discussion 298-306 Details

Franklin RJ (2000), “The Brown Animal Sanatory Institution--historical lessons for the present?” Vet J 159(3):231-7 Details

Franklin RJ, Barnett SC (2000), “Olfactory ensheathing cells and CNS regeneration: the sweet smell of success?” Neuron 28(1):15-8 Details

Hinks GL, Franklin RJ (2000), “Delayed changes in growth factor gene expression during slow remyelination in the CNS of aged rats.” Mol Cell Neurosci 16(5):542-56 Details

Iwashita Y, Fawcett JW, Crang AJ, Franklin RJ, Blakemore WF (2000), “Schwann cells transplanted into normal and X-irradiated adult white matter do not migrate extensively and show poor long-term survival.” Exp Neurol 164(2):292-302 Details

Lakatos A, Franklin RJ, Barnett SC (2000), “Olfactory ensheathing cells and Schwann cells differ in their in vitro interactions with astrocytes.” Glia 32(3):214-25 Details

Moon LD, Brecknell JE, Franklin RJ, Dunnett SB, Fawcett JW (2000), “Robust regeneration of CNS axons through a track depleted of CNS glia.” Exp Neurol 161(1):49-66 Details

Shields SA, Blakemore WF, Franklin RJ (2000), “Schwann cell remyelination is restricted to astrocyte-deficient areas after transplantation into demyelinated adult rat brain.” J Neurosci Res 60(5):571-8 Details

Sim FJ, Hinks GL, Franklin RJ (2000), “The re-expression of the homeodomain transcription factor Gtx during remyelination of experimentally induced demyelinating lesions in young and old rat brain.” Neuroscience 100(1):131-9 Details

Whitfield P, Johnson AW, Dunn KA, Delauche AJ, Winchester BG, Franklin RJ (2000), “GM1-gangliosidosis in a cross-bred dog confirmed by detection of GM1-ganglioside using electrospray ionisation-tandem mass spectrometry.” Acta Neuropathol 100(4):409-14 Details

1999

Franklin RJ, Blaschuk KL, Bearchell MC, Prestoz LL, Setzu A, Brindle KM, ffrench-Constant C (1999), “Magnetic resonance imaging of transplanted oligodendrocyte precursors in the rat brain.” Neuroreport 10(18):3961-5 Details

Franklin RJ, Hinks GL (1999), “Understanding CNS remyelination: clues from developmental and regeneration biology.” J Neurosci Res 58(2):207-13 Details

Franklin RJ, Ramsey IK (1999), “Neurological and urological condition in young boxer dogs.” Vet Rec 145(15):440 Details

Hinks GL, Franklin RJ (1999), “Distinctive patterns of PDGF-A, FGF-2, IGF-I, and TGF-beta1 gene expression during remyelination of experimentally-induced spinal cord demyelination.” Mol Cell Neurosci 14(2):153-68 Details

Kiernan BW, Garcion E, Ferguson J, Frost EE, Torres EM, Dunnett SB, Saga Y, Aizawa S, Faissner A, Kaur R, Franklin RJ, ffrench-Constant C (1999), “Myelination and behaviour of tenascin-C null transgenic mice.” Eur J Neurosci 11(9):3082-92 Details

Ramsey IK, Chandler KE, Franklin RJ (1999), “A movement disorder in boxer pups.” Vet Rec 144(7):179-80 Details

Shields SA, Gilson JM, Blakemore WF, Franklin RJ (1999), “Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination.” Glia 28(1):77-83 Details

Woodruff RH, Franklin RJ (1999), “The expression of myelin protein mRNAs during remyelination of lysolecithin-induced demyelination.” Neuropathol Appl Neurobiol 25(3):226-35 Details

Woodruff RH, Franklin RJ (1999), “Demyelination and remyelination of the caudal cerebellar peduncle of adult rats following stereotaxic injections of lysolecithin, ethidium bromide, and complement/anti-galactocerebroside: a comparative study.” Glia 25(3):216-28 Details

1998

Franklin RJ, Blakemore WF (1998), “Transplanting myelin-forming cells into the central nervous system: principles and practice.” Methods 16(3):311-9 Details

McKay JS, Blakemore WF, Franklin RJ (1998), “Trapidil-mediated inhibition of CNS remyelination results from reduced numbers and impaired differentiation of oligodendrocytes.” Neuropathol Appl Neurobiol 24(6):498-506 Details

Palmer AC, Blakemore WF, Franklin RJ, Frost LM, Gough RE, Lewis JC, Macdougall DF, O'Leary MT, Stocker LR (1998), “Paralysis in hedgehogs (Erinaceus europaeus) associated with demyelination.” Vet Rec 143(20):550-2 Details

Woodruff RH, Franklin RJ (1998), “The expression of myelin basic protein exon 1 and exon 2 containing transcripts during myelination of the neonatal rat spinal cord--an in situ hybridization study.” J Neurocytol 27(9):683-93 Details

1997

Franklin RJ (1997), “Charles Dickens, The Royal Veterinary College and the veterinary profession.” Vet Hist 9(4):107-13 Details

Franklin RJ, Barnett SC (1997), “Do olfactory glia have advantages over Schwann cells for CNS repair?” J Neurosci Res 50(5):665-72 Details

Franklin RJ, Blakemore WF (1997), “Transplanting oligodendrocyte progenitors into the adult CNS.” J Anat 190 ( Pt 1):23-33 Details

Franklin RJ, Blakemore WF (1997), “To what extent is oligodendrocyte progenitor migration a limiting factor in the remyelination of multiple sclerosis lesions?” Mult Scler 3(2):84-7 Details

Franklin RJ, Gilson JM, Blakemore WF (1997), “Local recruitment of remyelinating cells in the repair of demyelination in the central nervous system.” J Neurosci Res 50(2):337-44 Details

Franklin RJ, Ramsey IK, McKerrell RE (1997), “An inherited neurological disorder of the St Bernard dog characterised by unusual cerebellar cortical dysplasia.” Vet Rec 140(25):656-7 Details

McKay JS, Blakemore WF, Franklin RJ (1997), “The effects of the growth factor-antagonist, trapidil, on remyelination in the CNS.” Neuropathol Appl Neurobiol 23(1):50-8 Details

Milner R, Anderson HJ, Rippon RF, McKay JS, Franklin RJ, Marchionni MA, Reynolds R, Ffrench-Constant C (1997), “Contrasting effects of mitogenic growth factors on oligodendrocyte precursor cell migration.” Glia 19(1):85-90 Details

Scolding NJ, Franklin RJ (1997), “Remyelination in demyelinating disease.” Baillieres Clin Neurol 6(3):525-48 Details

Woodruff RH, Franklin RJ (1997), “Growth factors and remyelination in the CNS.” Histol Histopathol 12(2):459-66 Details

1996

Franklin RJ, Bayley SA, Blakemore WF (1996), “Transplanted CG4 cells (an oligodendrocyte progenitor cell line) survive, migrate, and contribute to repair of areas of demyelination in X-irradiated and damaged spinal cord but not in normal spinal cord.” Exp Neurol 137(2):263-76 Details

Franklin RJ, Gilson JM (1996), “Remyelination in the CNS of the hypothyroid rat.” Neuroreport 7(9):1526-30 Details

Franklin RJ, Gilson JM, Franceschini IA, Barnett SC (1996), “Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathing cell line into areas of demyelination in the adult CNS.” Glia 17(3):217-24 Details

1995

Blakemore WF, Crang AJ, Franklin RJ, Tang K, Ryder S (1995), “Glial cell transplants that are subsequently rejected can be used to influence regeneration of glial cell environments in the CNS.” Glia 13(2):79-91 Details

Blakemore WF, Olby NJ, Franklin RJ (1995), “The use of transplanted glial cells to reconstruct glial environments in the CNS.” Brain Pathol 5(4):443-50 Details

Franklin RJ, Bayley SA, Milner R, Ffrench-Constant C, Blakemore WF (1995), “Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter.” Glia 13(1):39-44 Details

Franklin RJ, Blakemore WF (1995), “Glial-cell transplantation and plasticity in the O-2A lineage--implications for CNS repair.” Trends Neurosci 18(3):151-6 Details

Franklin RJ, Blakemore WF (1995), “Reconstruction of the glia limitans by sub-arachnoid transplantation of astrocyte-enriched cultures.” Microsc Res Tech 32(4):295-301 Details

1994

Blakemore WF, Franklin RJ, Crang AJ (1994), “Repair of demyelinated lesions by glial cell transplantation.” J Neurol 242(1 Suppl 1):S61-3 Details

1993

Barnett SC, Franklin RJ, Blakemore WF (1993), “In vitro and in vivo analysis of a rat bipotential O-2A progenitor cell line containing the temperature-sensitive mutant gene of the SV40 large T antigen.” Eur J Neurosci 5(10):1247-60 Details

Franklin RJ, Blakemore WF (1993), “Requirements for Schwann cell migration within CNS environments: a viewpoint.” Int J Dev Neurosci 11(5):641-9 Details

Franklin RJ, Crang AJ, Blakemore WF (1993), “The role of astrocytes in the remyelination of glia-free areas of demyelination.” Adv Neurol 59:125-33 Details

Franklin RJ, Crang AJ, Blakemore WF (1993), “The reconstruction of an astrocytic environment in glia-deficient areas of white matter.” J Neurocytol 22(5):382-96 Details

Groves AK, Barnett SC, Franklin RJ, Crang AJ, Mayer M, Blakemore WF, Noble M (1993), “Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells.” Nature 362(6419):453-5 Details

1992

Crang AJ, Franklin RJ, Blakemore WF, Noble M, Barnett SC, Groves A, Trotter J, Schachner M (1992), “The differentiation of glial cell progenitor populations following transplantation into non-repairing central nervous system glial lesions in adult animals.” J Neuroimmunol 40(2-3):243-53 Details

Franklin RJ, Crang AJ, Blakemore WF (1992), “The behaviour of meningeal cells following glial cell transplantation into chemically-induced areas of demyelination in the CNS.” Neuropathol Appl Neurobiol 18(2):189-200 Details

Franklin RJ, Crang AJ, Blakemore WF (1992), “Type 1 astrocytes fail to inhibit Schwann cell remyelination of CNS axons in the absence of cells of the O-2A lineage.” Dev Neurosci 14(2):85-92 Details

1991

Blakemore WF, Franklin RJ (1991), “Transplantation of glial cells into the CNS.” Trends Neurosci 14(8):323-7 Details

Crang AJ, Franklin RJ, Blakemore WF, Trotter J, Schachner M, Barnett SC, Noble M (1991), “Transplantation of normal and genetically engineered glia into areas of demyelination.” Ann N Y Acad Sci 633:563-5 Details

Franklin RJ, Crang AJ, Blakemore WF (1991), “Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord.” J Neurocytol 20(5):420-30 Details

1990

Blakemore WF, Crang AJ, Franklin RJ (1990), “Transplantation of glial cell cultures into areas of demyelination in the adult CNS.” Prog Brain Res 82:225-32 Details

Franklin RJ, Blakemore WF (1990), “The peripheral nervous system--central nervous system regeneration dichotomy: a role for glial cell transplantation.” J Cell Sci 95 ( Pt 2):185-90 Details