Dr Richard Adams University positionLecturer Dr Richard Adams is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Physiology, Development and Neuroscience Research ThemeInterestsMy group is interested in the mechanisms of morphogenesis that shape the early central nervous system. Using zebrafish as a developmental model, we image the movements of many hundreds of cells using time-lapse micoscopy. Applying methods of image analysis was are able to trace the movements that take place during gastrulation and neurulation to tranform the CNS into its 3D form.  Dynamic fate map of the zebrafish forebrain generated by tracing the paths of hundreds of individual cells. Click image to view full-size Research Focus
EquipmentComputational modelling Confocal microscopy Fluorescence microscopy Microscopy CollaboratorsNo collaborators listed Associated News ItemsKey publicationsBlanchard GB, Kabla AJ, Schultz NL, Butler LC, Sanson B, Gorfinkiel N, Mahadevan L, Adams RJ (2009), “Tissue tectonics: morphogenetic strain rates, cell shape change and intercalation.” Nat Methods 6(6):458-64 Details England SJ, Blanchard GB, Mahadevan L, Adams RJ (2006), “A dynamic fate map of the forebrain shows how vertebrate eyes form and explains two causes of cyclopia.” Development 133(23):4613-7 Details Rembold M, Loosli F, Adams RJ, Wittbrodt J (2006), “Individual cell migration serves as the driving force for optic vesicle evagination” Science 313:1130-4 Details Publications2014Booth AJ, Blanchard GB, Adams RJ, Röper K (2014), “A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation.” Dev Cell 29(5):562-76 Details Fischer SC, Blanchard GB, Duque J, Adams RJ, Arias AM, Guest SD, Gorfinkiel N (2014), “Contractile and mechanical properties of epithelia with perturbed actomyosin dynamics.” PLoS One 9(4):e95695 Details 2011Blanchard GB, Adams RJ (2011), “Measuring the multi-scale integration of mechanical forces during morphogenesis.” Curr Opin Genet Dev 21(5):653-63 Details England SJ, Adams RJ (2011), “Blastomere injection of cleavage-stage zebrafish embryos and imaging of labeled cells.” Cold Spring Harb Protoc 2011(8):958-66 Details 2010Blanchard GB, Murugesu S, Adams RJ, Martinez-Arias A, Gorfinkiel N (2010), “Cytoskeletal dynamics and supracellular organisation of cell shape fluctuations during dorsal closure.” Development 137(16):2743-52 Details 2009Butler LC, Blanchard GB, Kabla AJ, Lawrence NJ, Welchman DP, Mahadevan L, Adams RJ, Sanson B (2009), “Cell shape changes indicate a role for extrinsic tensile forces in Drosophila germ-band extension.” Nat Cell Biol 11(7):859-64 Details Gorfinkiel N, Blanchard GB, Adams RJ, Martinez Arias A (2009), “Mechanical control of global cell behaviour during dorsal closure in Drosophila.” Development 136(11):1889-98 Details Meilhac SM, Adams RJ, Morris SA, Danckaert A, Le Garrec JF, Zernicka-Goetz M (2009), “Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst.” Dev Biol 331(2):210-21 Details 2007England SJ, Adams RJ (2007), “Building a dynamic fate map.” Biotechniques 43(1 Suppl):20-4 Details Svetic V, Hollway GE, Elworthy S, Chipperfield TR, Davison C, Adams RJ, Eisen JS, Ingham PW, Currie PD, Kelsh RN (2007), “Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants.” Development 134(5):1011-22 Details 2006Strauss B, Adams RJ, Papalopulu N (2006), “A default mechanism of spindle orientation based on cell shape is sufficient to generate cell fate diversity in polarised Xenopus blastomeres.” Development 133(19):3883-93 Details 2003Glickman NS, Kimmel CB, Jones MA, Adams RJ (2003), “Shaping the zebrafish notochord.” Development 130(5):873-87 Details Ulrich F, Concha ML, Heid PJ, Voss E, Witzel S, Roehl H, Tada M, Wilson SW, Adams RJ, Soll DR, Heisenberg CP (2003), “Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset of zebrafish gastrulation.” Development 130(22):5375-84 Details 2002Feldman B, Concha ML, Saúde L, Parsons MJ, Adams RJ, Wilson SW, Stemple DL (2002), “Lefty antagonism of Squint is essential for normal gastrulation.” Curr Biol 12(24):2129-35 Details 2000Skaliora I, Adams R, Blakemore C (2000), “Morphology and growth patterns of developing thalamocortical axons.” J Neurosci 20(10):3650-62 Details 1998Concha ML, Adams RJ (1998), “Oriented cell divisions and cellular morphogenesis in the zebrafish gastrula and neurula: a time-lapse analysis.” Development 125(6):983-94 Details Molnár Z, Adams R, Blakemore C (1998), “Mechanisms underlying the early establishment of thalamocortical connections in the rat.” J Neurosci 18(15):5723-45 Details Molnár Z, Adams R, Goffinet AM, Blakemore C (1998), “The role of the first postmitotic cortical cells in the development of thalamocortical innervation in the reeler mouse.” J Neurosci 18(15):5746-65 Details 1996Adams RJ (1996), “Metaphase spindles rotate in the neuroepithelium of rat cerebral cortex.” J Neurosci 16(23):7610-8 Details 1991Holliday J, Adams RJ, Sejnowski TJ, Spitzer NC (1991), “Calcium-induced release of calcium regulates differentiation of cultured spinal neurons.” Neuron 7(5):787-96 Details 1989Adams RJ, Pollard TD (1989), “Binding of myosin I to membrane lipids.” Nature 340(6234):565-8 Details Adams RJ, Pollard TD (1989), “Membrane-bound myosin-I provides new mechanisms in cell motility.” Cell Motil Cytoskeleton 14(2):178-82 Details 1986Adams RJ, Pollard TD (1986), “Propulsion of organelles isolated from Acanthamoeba along actin filaments by myosin-I.” Nature 322(6081):754-6 Details 1983Adams RJ, Bray D (1983), “Rapid transport of foreign particles microinjected into crab axons.” Nature 303(5919):718-20 Details 1982Adams RJ (1982), “Organelle movement in axons depends on ATP.” Nature 297(5864):327-9 Details |