Mr Robert Horne


University position

PhD student
Supervised by Michele Vendruscolo

Departments

Department of Chemistry

Institutes

Centre for Misfolding Diseases

Home page

https://www.cmd.ch.cam.ac.uk/person/...

Research Themes

Cellular and Molecular Neuroscience

Systems and Computational Neuroscience

Interests

The high attrition rate of drug discovery is a pressing issue for neurodegenerative diseases where very few disease-modifying drugs have been approved. Numerous trials targeted at the suspected pathological species, misfolded protein aggregates, have failed due to the differential toxicity of aggregate species and the complex kinetics that govern their formation. To address this problem, I have developed a machine learning approach to identify small molecule inhibitors of the proliferation of misfolded ?-synuclein aggregates through secondary nucleation, a process that has been implicated in Parkinsonís disease and related synucleinopathies. Secondary nucleation results in soluble oligomer proliferation, the suspected cause of pathology. These oligomers are heterogeneous, transient and challenging to measure via bulk techniques. We integrate single molecule approaches into the pipeline to characterise oligomers formed during the aggregation and validate the identified inhibitors.

Research Focus

Keywords

Biophysics

Protein Misfolding

Neurodegeneration

Oligomeric Toxicity

Machine Learning

Clinical conditions

Alzheimer's disease

Dementia

Multiple system atrophy

Parkinson's disease

Prion diseases

Equipment

Computational modelling

Fluorescence microscopy

Machine Learning

Single molecule analysis

Collaborators

Cambridge

Ewa Andrzejewska

Z. Faidon Brotzakis

International

Parvez Alam Web: https://loop.frontiersin.org/people/...

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