Professor Robert TaskerUniversity positionProfessor of Neurology and Anaesthesia, Harvard Medical School DepartmentsInstitutesHarvard Medical School Research ThemesInterests1. Multicenter clinical studies: In the USA I am a co-investigator and Executive Committee member for the recently funded NIH ‘Multiple Medical Therapies for Pediatric Traumatic Brain Injury – A Comparative Effectiveness Approach’ that will recruit 1000 patients from 30 centers in North America and Europe (UO1). I am also a co-investigator and member in the American Epilepsy Society funded Pediatric Status Epilepticus Research Group (pSERG), a consortium examining refractory status epilepticus in children. 2. Computational physiology in collaboration with MIT: Computational Physiology and the problem of raised intracranial pressure (NIH R21), brain perfusion and vascular resistance; Magnetic resonance imaging measures of brain water content and functional imaging of brain networks and language processing in the critically ill; and Near-Infra-Red spectroscopy measures of functional brain networks in the critically ill. Research Focus
EquipmentMagnetic resonance imaging (MRI) MRI Collaborators
Associated News ItemsPublications2014Beardsall K, Vanhaesebrouck S, Frystyk J, Ogilvy-Stuart AL, Vanhole C, van Weissenbruch M, Midgley P, Thio M, Cornette L, Gill B, Ossuetta I, Iglesias I, Theyskens C, de Jong M, Ahluwalia JS, de Zegher F, Dunger DB, NIRTURE Study Group (2014), “Relationship between insulin-like growth factor I levels, early insulin treatment, and clinical outcomes of very low birth weight infants.” J Pediatr 164(5):1038-1044.e1 Details Macrae D, Grieve R, Allen E, Sadique Z, Betts H, Morris K, Pappachan VJ, Parslow R, Tasker RC, Baines P, Broadhead M, Duthie ML, Fortune PM, Inwald D, McMaster P, Peters MJ, Schindler M, Guerriero C, Piercy D, Slavik Z, Snowdon C, Van Dyck L, Elbourne D (2014), “A clinical and economic evaluation of Control of Hyperglycaemia in Paediatric intensive care (CHiP): a randomised controlled trial.” Health Technol Assess 18(26):1-210 Details Macrae D, Grieve R, Allen E, Sadique Z, Morris K, Pappachan J, Parslow R, Tasker RC, Elbourne D, CHiP Investigators (2014), “A randomized trial of hyperglycemic control in pediatric intensive care.” N Engl J Med 370(2):107-18 Details Macrae D, Tasker RC, Elbourne D (2014), “A trial of hyperglycemic control in pediatric intensive care.” N Engl J Med 370(14):1355-6 Details McCann ME, Schouten AN, Dobija N, Munoz C, Stephenson L, Poussaint TY, Kalkman CJ, Hickey PR, de Vries LS, Tasker RC (2014), “Infantile postoperative encephalopathy: perioperative factors as a cause for concern.” Pediatrics 133(3):e751-7 Details Mehta NM, Smallwood CD, Joosten KF, Hulst JM, Tasker RC, Duggan CP (2014), “Accuracy of a simplified equation for energy expenditure based on bedside volumetric carbon dioxide elimination measurement - A two-center study.” Clin Nutr Details Rahiman S, Sadasivam K, Ridout DA, Tasker RC, Ramnarayan P (2014), “Comparison of three different timeframes for pediatric index of mortality data collection in transported intensive care admissions*.” Pediatr Crit Care Med 15(3):e120-7 Details Sánchez Fernández I, Abend NS, Agadi S, An S, Arya R, Carpenter JL, Chapman KE, Gaillard WD, Glauser TA, Goldstein DB, Goldstein JL, Goodkin HP, Hahn CD, Heinzen EL, Mikati MA, Peariso K, Pestian JP, Ream M, Riviello JJ Jr, Tasker RC, Williams K, Loddenkemper T, Pediatric Status Epilepticus Research Group (pSERG) (2014), “Gaps and opportunities in refractory status epilepticus research in children: a multi-center approach by the Pediatric Status Epilepticus Research Group (pSERG).” Seizure 23(2):87-97 Details Tasker RC (2014), “Update on pediatric neurocritical care.” Paediatr Anaesth Details Tasker RC (2014), “Hypothermia did not improve mortality or disability in severe traumatic brain injury.” Arch Dis Child Educ Pract Ed 99(3):119 Details Tasker RC, Acerini CL (2014), “Cerebral edema in children with diabetic ketoacidosis: vasogenic rather than cellular?” Pediatr Diabetes 15(4):261-70 Details Tasker RC, Burns J (2014), “Hypertonic saline therapy for cerebral edema in diabetic ketoacidosis: no change yet, please.” Pediatr Crit Care Med 15(3):284-5 Details Wilkes R, Tasker RC (2014), “Intensive Care Treatment of Uncontrolled Status Epilepticus in Children: Systematic Literature Search of Midazolam and Anesthetic Therapies.” Pediatr Crit Care Med Details 2013Bell MJ, Adelson PD, Hutchison JS, Kochanek PM, Tasker RC, Vavilala MS, Beers SR, Fabio A, Kelsey SF, Wisniewski SR, Multiple Medical Therapies for Pediatric Traumatic Brain Injury Workgroup (2013), “Differences in medical therapy goals for children with severe traumatic brain injury-an international study.” Pediatr Crit Care Med 14(8):811-8 Details Branco RG, Acerini CL, Tasker RC (2013), “Glycaemic threshold for activation of the stress response in children.” Acta Paediatr Details Branco RG, Garcia PC, Tasker RC (2013), “Inhaled adrenaline in acute bronchiolitis.” N Engl J Med 369(11):1075-6 Details Branco RG, Tasker RC (2013), “Engineering a control system for hypoglycemia prevention, detection, and intervention in critical care*.” Pediatr Crit Care Med 14(8):819-20 Details Driessen C, Joosten KF, Florisson JM, Lequin M, van Veelen ML, Dammers R, Bredero-Boelhouwer H, Tasker RC, Mathijssen IM (2013), “Sleep apnoea in syndromic craniosynostosis occurs independent of hindbrain herniation.” Childs Nerv Syst 29(2):289-96 Details LaRovere KL, Graham RJ, Tasker RC, Pediatric Critical Nervous System Program (pCNSp) (2013), “Pediatric neurocritical care: a neurology consultation model and implication for education and training.” Pediatr Neurol 48(3):206-11 Details Livingston-Thomas JM, Tasker RA (2013), “Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations.” Exp Transl Stroke Med 5(1):2 Details Tasker RC (2013), “Brain vascular and hydrodynamic physiology.” Semin Pediatr Surg 22(4):168-73 Details Tasker RC (2013), “Tight glucose control (with frequent episodes of hypoglycemia) among children admitted to the pediatric intensive care unit, does not affect neurocognitive development.” J Pediatr 162(3):649 Details Tasker RC (2013), “Electroencephalographic seizure activity in the comatose critically ill child: getting closer to knowing what to do.” Crit Care Med 41(1):362-3 Details Tasker RC, Darras BT (2013), “Neuromuscular disorders: from diagnosis to translational research, drug development and clinical trials.” Curr Opin Pediatr 25(6):674-5 Details Wilkes R, Tasker RC (2013), “Pediatric intensive care treatment of uncontrolled status epilepticus.” Crit Care Clin 29(2):239-57 Details 2012Goldstein B, Tasker RC, Wakeland W (2012), “From Lundberg to SIM-ICP: computational physiology and modeling intracranial pressure.” Sci Transl Med 4(129):129fs6 Details Kirkham FJ, Wade AM, McElduff F, Boyd SG, Tasker RC, Edwards M, Neville BG, Peshu N, Newton CR (2012), “Seizures in 204 comatose children: incidence and outcome.” Intensive Care Med 38(5):853-62 Details Kochanek PM, Carney N, Adelson PD, Ashwal S, Bell MJ, Bratton S, Carson S, Chesnut RM, Ghajar J, Goldstein B, Grant GA, Kissoon N, Peterson K, Selden NR, Tasker RC, Tong KA, Vavilala MS, Wainwright MS, Warden CR, American Academy of Pediatrics-Section on Neurological Surgery, American Association of Neurological Surgeons/Congress of Neurological Surgeons, Child Neurology Society, European Society of Pediatric and Neonatal Intensive Care, Neurocritical Care Society, Pediatric Neurocritical Care Research Group, Society of Critical Care Medicine, Paediatric Intensive Care Society UK, Society for Neuroscience in Anesthesiology and Critical Care, World Federation of Pediatric Intensive and Critical Care Societies (2012), “Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition.” Pediatr Crit Care Med 13 Suppl 1:S1-82 Details LaRovere KL, Brett MS, Tasker RC, Strauss KJ, Burns JP, Pediatric Critical Nervous System Program (2012), “Head computed tomography scanning during pediatric neurocritical care: diagnostic yield and the utility of portable studies.” Neurocrit Care 16(2):251-7 Details Tasker RC (2012), “Pediatric critical care, glycemic control, and hypoglycemia: what is the real target?” JAMA 308(16):1687-8 Details Tasker RC (2012), “Spreading depolarisations and traumatic brain injury: time course and mechanisms.” Lancet Neurol 11(5):389; author reply 389-90 Details Tasker RC (2012), “Intracranial pressure: influence of head-of-bed elevation, and beyond.” Pediatr Crit Care Med 13(1):116-7 Details Tasker RC, Pomeroy SL (2012), “Sport-related concussion: time to take notice.” Curr Opin Pediatr 24(6):687-8 Details 2011Branco RG, Xavier L, Garcia PC, Piva JP, Fiori HH, Baldisserotto M, Fiori RM, Tasker RC (2011), “Prospective operationalization and feasibility of a glycemic control protocol in critically ill children.” Pediatr Crit Care Med 12(3):265-70 Details Devictor DJ, Latour JM, EURYDICE II study group (2011), “Forgoing life support: how the decision is made in European pediatric intensive care units.” Intensive Care Med 37(11):1881-7 Details Fraser LK, Miller M, Draper ES, McKinney PA, Parslow RC, Paediatric Intensive Care Audit Network (2011), “Place of death and palliative care following discharge from paediatric intensive care units.” Arch Dis Child 96(12):1195-8 Details Harron K, Ramachandra G, Mok Q, Gilbert R, CATCH team (2011), “Consistency between guidelines and reported practice for reducing the risk of catheter-related infection in British paediatric intensive care units.” Intensive Care Med 37(10):1641-7 Details Spence SJ, Tasker RC, Pomeroy SL (2011), “Recent advances in autism spectrum disorders.” Curr Opin Pediatr 23(6):607-8 Details Tasker RC (2011), “Paediatric neurointensive care and decompressive craniectomy for malignant middle cerebral artery infarction.” Dev Med Child Neurol 53(1):5-6 Details Tasker RC, Fleming TJ, Young AE, Morris KP, Parslow RC (2011), “Severe head injury in children: intensive care unit activity and mortality in England and Wales.” Br J Neurosurg 25(1):68-77 Details Top AP, Tasker RC, Ince C (2011), “The microcirculation of the critically ill pediatric patient.” Crit Care 15(2):213 Details 2010Branco RG, Chavan A, Tasker RC (2010), “Pilot evaluation of continuous subcutaneous glucose monitoring in children with multiple organ dysfunction syndrome.” Pediatr Crit Care Med 11(3):415-9 Details Branco RG, Tasker RC (2010), “Outside the limits of normal blood glucose during critical illness: failed homeostasis and quantifying allostatic load.” Pediatr Crit Care Med 11(6):755-7 Details Branco RG, Tasker RC (2010), “Meningococcal meningitis.” Curr Treat Options Neurol 12(5):464-74 Details Fraser LK, Fleming T, Miller M, Draper ES, McKinney PA, Parslow RC, Paediatric Intensive Care Audit Network (2010), “Palliative care discharge from paediatric intensive care units in Great Britain.” Palliat Med 24(6):608-15 Details Garcia PC, Eulmesekian P, Branco RG, Perez A, Sffogia A, Olivero L, Piva JP, Tasker RC (2010), “External validation of the paediatric logistic organ dysfunction score.” Intensive Care Med 36(1):116-22 Details Gorman MP, Tasker RC, Pomeroy SL (2010), “Growing spectrum and relevance of pediatric neuro-immunology.” Curr Opin Pediatr 22(6):717 Details Macrae D, Pappachan J, Grieve R, Parslow R, Nadel S, Schindler M, Baines P, Fortune PM, Slavik Z, Goldman A, Truesdale A, Betts H, Allen E, Snowdon C, Percy D, Broadhead M, Quick T, Peters M, Morris K, Tasker R, Elbourne D (2010), “Control of hyperglycaemia in paediatric intensive care (CHiP): study protocol.” BMC Pediatr 10:5 Details Santschi M, Jouvet P, Leclerc F, Gauvin F, Newth CJ, Carroll CL, Flori H, Tasker RC, Rimensberger PC, Randolph AG, PALIVE Investigators, Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI), European Society of Pediatric and Neonatal Intensive Care (ESPNIC) (2010), “Acute lung injury in children: therapeutic practice and feasibility of international clinical trials.” Pediatr Crit Care Med 11(6):681-9 Details Snowdon C, Harvey SE, Brocklehurst P, Tasker RC, Platt MP, Allen E, Elbourne D (2010), “The BRACELET Study: surveys of mortality in UK neonatal and paediatric intensive care trials.” Trials 11:65 Details Tasker RC (2010), “Influenza-associated encephalopathy and neurolgic features of novel influenza A (H1N1) virus infection.” Pediatr Crit Care Med 11(2):297-9 Details Tasker RC, Westland AG, White DK, Williams GB (2010), “Corpus callosum and inferior forebrain white matter microstructure are related to functional outcome from raised intracranial pressure in child traumatic brain injury.” Dev Neurosci 32(5-6):374-84 Details 2009Baldasso E, Garcia PC, Piva JP, Branco RG, Tasker RC (2009), “Pilot safety study of low-dose vasopressin in non-septic critically ill children.” Intensive Care Med 35(2):355-9 Details Inwald DP, Tasker RC, Peters MJ, Nadel S, Paediatric Intensive Care Society Study Group (PICS-SG) (2009), “Emergency management of children with severe sepsis in the United Kingdom: the results of the Paediatric Intensive Care Society sepsis audit.” Arch Dis Child 94(5):348-53 Details Kochanek PM, Tasker RC (2009), “Pediatric neurointensive care: 2008 update for the Rogers' Textbook of Pediatric Intensive Care.” Pediatr Crit Care Med 10(4):517-23 Details Parslow RC, Tasker RC, Draper ES, Parry GJ, Jones S, Chater T, Thiru K, McKinney PA, Paediatric Intensive Care Audit Network (2009), “Epidemiology of critically ill children in England and Wales: incidence, mortality, deprivation and ethnicity.” Arch Dis Child 94(3):210-5 Details Slawik H, Salmond CH, Taylor-Tavares JV, Williams GB, Sahakian BJ, Tasker RC (2009), “Frontal cerebral vulnerability and executive deficits from raised intracranial pressure in child traumatic brain injury.” J Neurotrauma 26(11):1891-903 Details Tasker RC (2009), “Pediatric neurocritical care: is it time to come of age?” Curr Opin Pediatr 21(6):724-30 Details Tasker RC (2009), “Validating serologic biomarkers of brain injury for cardiac arrest research.” Pediatr Crit Care Med 10(4):529-30 Details Tasker RC (2009), “Extracorporeal cardiopulmonary resuscitation for in-hospital cardiac arrest: lessons from acute neurotoxicity.” Pediatr Crit Care Med 10(4):525-7 Details Tasker RC (2009), “Blood oxygen on Mount Everest.” N Engl J Med 360(18):1909; author reply 1910 Details Tasker RC (2009), “Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injury.” Crit Care Med 37(1):378-9; author reply 379-80 Details Tasker RC (2009), “Oxygen and living at altitude.” Arch Dis Child 94(1):1-2 Details 2008Acerini CL, Tasker RC (2008), “Neuroendocrine consequences of traumatic brain injury.” J Pediatr Endocrinol Metab 21(7):611-9 Details Bannink N, Joosten KF, van Veelen ML, Bartels MC, Tasker RC, van Adrichem LN, van der Meulen JJ, Vaandrager JM, de Jong TH, Mathijssen IM (2008), “Papilledema in patients with Apert, Crouzon, and Pfeiffer syndrome: prevalence, efficacy of treatment, and risk factors.” J Craniofac Surg 19(1):121-7 Details Forsyth RJ, Parslow RC, Tasker RC, Hawley CA, Morris KP, UK Paediatric Traumatic Brain Injury Study Group, Paediatric Intensive Care Society Study Group (PICSSG) (2008), “Prediction of raised intracranial pressure complicating severe traumatic brain injury in children: implications for trial design.” Pediatr Crit Care Med 9(1):8-14 Details Tasker RC (2008), “CPAP and HFOV: different guises of the same underlying intensive care strategy for supporting RSV bronchiolitis.” Intensive Care Med 34(9):1560-1 Details 2007Acerini CL, Tasker RC (2007), “Endocrine sequelae of traumatic brain injury in childhood.” Horm Res 68 Suppl 5:14-7 Details Acerini CL, Tasker RC (2007), “Traumatic brain injury induced hypothalamic-pituitary dysfunction: a paediatric perspective.” Pituitary 10(4):373-80 Details Amoretti CF, Tasker RC (2007), “Year in review 2006: Critical Care--Paediatrics.” Crit Care 11(4):222 Details Branco RG, Amoretti CF, Tasker RC (2007), “Meningococcal disease and meningitis.” J Pediatr (Rio J) 83(2 Suppl):S46-53 Details Branco RG, Tasker RC (2007), “Glycemic level in mechanically ventilated children with bronchiolitis.” Pediatr Crit Care Med 8(6):546-50 Details Casartelli CH, Garcia PC, Branco RG, Piva JP, Einloft PR, Tasker RC (2007), “Adrenal response in children with septic shock.” Intensive Care Med 33(9):1609-13 Details Garcia Branco R, Tasker RC, Ramos Garcia PC, Piva JP, Dias Xavier L (2007), “Glycemic control and insulin therapy in sepsis and critical illness.” J Pediatr (Rio J) 83(5 Suppl):S128-36 Details Garcia PC, Longhi F, Branco RG, Piva JP, Lacks D, Tasker RC (2007), “Ferritin levels in children with severe sepsis and septic shock.” Acta Paediatr 96(12):1829-31 Details 2006Acerini CL, Tasker RC, Bellone S, Bona G, Thompson CJ, Savage MO (2006), “Hypopituitarism in childhood and adolescence following traumatic brain injury: the case for prospective endocrine investigation.” Eur J Endocrinol 155(5):663-9 Details Andrews P, Azoulay E, Antonelli M, Brochard L, Brun-Buisson C, de Backer D, Dobb G, Fagon JY, Gerlach H, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pugin J, Pinsky M, Radermacher P, Richard C, Tasker R (2006), “Year in review in intensive care medicine. 2005. I. Acute respiratory failure and acute lung injury, ventilation, hemodynamics, education, renal failure.” Intensive Care Med 32(2):207-16 Details Andrews P, Azoulay E, Antonelli M, Brochard L, Brun-Buisson C, Dobb G, Fagon JY, Gerlach H, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pugin J, Pinsky M, Radermacher P, Richard C, Tasker R (2006), “Year in review in intensive care medicine, 2005. III. Nutrition, pediatric and neonatal critical care, and experimental.” Intensive Care Med 32(4):490-500 Details Andrews P, Azoulay E, Antonelli M, Brochard L, Brun-Buisson C, Dobb G, Fagon JY, Gerlach H, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pugin J, Pinsky M, Radermacher P, Richard C, Tasker R (2006), “Year in review in intensive care medicine, 2005. II. Infection and sepsis, ventilator-associated pneumonia, ethics, haematology and haemostasis, ICU organisation and scoring, brain injury.” Intensive Care Med 32(3):380-90 Details Carcillo JA, Tasker RC (2006), “Fluid resuscitation of hypovolemic shock: acute medicine's great triumph for children.” Intensive Care Med 32(7):958-61 Details Garcia PC, Eulmesekian P, Sffogia A, Perez A, Branco RG, Piva JP, Tasker RC (2006), “Limitation in paediatric logistic organ dysfunction score.” Lancet 368(9542):1151; author reply 1151-2 Details Morris K, Tasker R, Parslow R, Forsyth R, Hawley C (2006), “Organ donation in paediatric traumatic brain injury.” Intensive Care Med 32(9):1458; author reply 1448 Details Morris KP, Forsyth RJ, Parslow RC, Tasker RC, Hawley CA, UK Paediatric Traumatic Brain Injury Study Group, Paediatric Intensive Care Society Study Group (2006), “Intracranial pressure complicating severe traumatic brain injury in children: monitoring and management.” Intensive Care Med 32(10):1606-12 Details Seeley HM, Hutchinson P, Maimaris C, Carroll G, Kirker S, Tasker R, Haynes K, Pickard JD (2006), “A decade of change in regional head injury care: a retrospective review.” Br J Neurosurg 20(1):9-21 Details Seeley HM, Maimaris C, Hutchinson PJ, Carroll G, White B, Kirker S, Tasker RC, Steward C, Haynes K, Hardy D, Pickard JD (2006), “Standards for head injury management in acute hospitals: evidence from the six million population of the Eastern region.” Emerg Med J 23(2):128-32 Details Tasker RC (2006), “Biochemical markers of brain injury: Can they point to a diagnosis?” Pediatr Crit Care Med 7(6):608-10 Details Tasker RC (2006), “Midazolam for refractory status epilepticus in children: higher dosing and more rapid and effective control.” Intensive Care Med 32(12):1935-6 Details Tasker RC (2006), “Changes in white matter late after severe traumatic brain injury in childhood.” Dev Neurosci 28(4-5):302-8 Details UK Paediatric Brain Injury Study Group and the Paediatric Intensive Care Society Study Group, Tasker RC, Morris KP, Forsyth RJ, Hawley CA, Parslow RC (2006), “Severe head injury in children: emergency access to neurosurgery in the United Kingdom.” Emerg Med J 23(7):519-22 Details 2005Andrews P, Azoulay E, Antonelli M, Brochard L, Brun-Buisson C, Dobb G, Fagon JY, Gerlach H, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pugin J, Pinsky M, Radermacher P, Richard C, Tasker R, Vallet B (2005), “Year in review in intensive care medicine, 2004. III. Outcome, ICU organisation, scoring, quality of life, ethics, psychological problems and communication in the ICU, immunity and hemodynamics during sepsis, pediatric and neonatal critical care, experimental studies.” Intensive Care Med 31(3):356-72 Details Andrews P, Azoulay E, Antonelli M, Brochard L, Brun-Buisson C, Dobb G, Fagon JY, Gerlach H, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pugin J, Pinsky M, Radermacher P, Richard C, Tasker R, Vallet B (2005), “Year in review in intensive care medicine, 2004. II. Brain injury, hemodynamic monitoring and treatment, pulmonary embolism, gastrointestinal tract, and renal failure.” Intensive Care Med 31(2):177-88 Details Andrews P, Azoulay E, Antonelli M, Brochard L, Brun-Buisson C, Dobb G, Fagon JY, Gerlach H, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pugin J, Pinsky M, Radermacher P, Richard C, Tasker R, Vallet B (2005), “Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis.” Intensive Care Med 31(1):28-40 Details Branco RG, Garcia PC, Piva JP, Casartelli CH, Seibel V, Tasker RC (2005), “Glucose level and risk of mortality in pediatric septic shock.” Pediatr Crit Care Med 6(4):470-2 Details Branco RG, Tasker R (2005), “Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats.” Crit Care Med 33(11):2719; author reply 2719-20 Details Branco RG, Tasker RC (2005), “Staphylococcal sepsis in children.” N Engl J Med 353(26):2820; author reply 2820 Details Chambers IR, Jones PA, Minns RA, Stobbart L, Mendelow AD, Tasker RC, Kirkham F (2005), “Which paediatric head injured patients might benefit from decompression? Thresholds of ICP and CPP in the first six hours.” Acta Neurochir Suppl 95:21-3 Details Chambers IR, Stobbart L, Jones PA, Kirkham FJ, Marsh M, Mendelow AD, Minns RA, Struthers S, Tasker RC (2005), “Age-related differences in intracranial pressure and cerebral perfusion pressure in the first 6 hours of monitoring after children's head injury: association with outcome.” Childs Nerv Syst 21(3):195-9 Details Parslow RC, Morris KP, Tasker RC, Forsyth RJ, Hawley CA, UK Paediatric Traumatic Brain Injury Study Steering Group, Paediatric Intensive Care Society Study Group (2005), “Epidemiology of traumatic brain injury in children receiving intensive care in the UK.” Arch Dis Child 90(11):1182-7 Details Tasker RC (2005), “Inter-hospital transport for children and their parent(s).” Arch Dis Child 90(12):1217-8 Details Tasker RC (2005), “Paediatric cardiac resuscitation: can we do better?” Arch Dis Child 90(11):1102-3 Details Tasker RC (2005), “Skull x rays, CT scans, and making a decision in head injury.” Arch Dis Child 90(8):774-5 Details Tasker RC, Lutman D, Peters MJ (2005), “Hyperventilation in severe diabetic ketoacidosis.” Pediatr Crit Care Med 6(4):405-11 Details Tasker RC, Salmond CH, Westland AG, Pena A, Gillard JH, Sahakian BJ, Pickard JD (2005), “Head circumference and brain and hippocampal volume after severe traumatic brain injury in childhood.” Pediatr Res 58(2):302-8 Details 2004Abraham E, Andrews P, Antonelli M, Brochard L, Brun-Buisson C, Dobb G, Fagon JY, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pinsky M, Radermacher P, Ranieri M, Richard C, Tasker R, Vallet B (2004), “Year in review in intensive care medicine-2003. Part 3: intensive care unit organization, scoring, quality of life, ethics, neonatal and pediatrics, and experimental.” Intensive Care Med 30(8):1514-25 Details Abraham E, Andrews P, Antonelli M, Brochard L, Brun-Buisson C, Dobb G, Fagon JY, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pinsky M, Radermacher P, Ranieri M, Richard C, Tasker R, Vallet B (2004), “Year in review in intensive care medicine: 2003. II. Brain injury, hemodynamics, gastrointestinal tract, renal failure, metabolism, trauma, and postoperative.” Intensive Care Med 30(7):1266-75 Details Abraham E, Andrews P, Antonelli M, Brochard L, Brun-Buisson C, Dobb G, Fagon JY, Groeneveld J, Mancebo J, Metnitz P, Nava S, Pinsky M, Radermacher P, Ranieri M, Richard C, Tasker R, Vallet B (2004), “Year in review in Intensive Care Medicine-2003. Part 1: Respiratory failure, infection and sepsis.” Intensive Care Med 30(6):1017-31 Details Bunn F, Roberts I, Tasker R, Akpa E (2004), “Hypertonic versus near isotonic crystalloid for fluid resuscitation in critically ill patients.” Cochrane Database Syst Rev (3):CD002045 Details Dunger DB, Sperling MA, Acerini CL, Bohn DJ, Daneman D, Danne TP, Glaser NS, Hanas R, Hintz RL, Levitsky LL, Savage MO, Tasker RC, Wolfsdorf JI, ESPE, LWPES (2004), “ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents.” Arch Dis Child 89(2):188-94 Details Dunger DB, Sperling MA, Acerini CL, Bohn DJ, Daneman D, Danne TP, Glaser NS, Hanas R, Hintz RL, Levitsky LL, Savage MO, Tasker RC, Wolfsdorf JI, European Society for Paediatric Endocrinology, Lawson Wilkins Pediatric Endocrine Society (2004), “European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents.” Pediatrics 113(2):e133-40 Details Geddes JF, Tasker RC, Adams GG, Whitwell HL (2004), “Violence is not necessary to produce subdural and retinal haemorrhage: a reply to Punt et al.” Pediatr Rehabil 7(4):261-5 Details Roe MF, Bloxham DM, White DK, Ross-Russell RI, Tasker RT, O'Donnell DR (2004), “Lymphocyte apoptosis in acute respiratory syncytial virus bronchiolitis.” Clin Exp Immunol 137(1):139-45 Details Tasker RC (2004), “Non-traumatic coma.” Hosp Med 65(1):48-51 Details Tasker RC, Gupta S, White DK (2004), “Severe head injury in children: geographical range of an emergency neurosurgical practice.” Emerg Med J 21(4):433-7 Details Tasker RC, Roe MF, Bloxham DM, White DK, Ross-Russell RI, O'Donnell DR (2004), “The neuroendocrine stress response and severity of acute respiratory syncytial virus bronchiolitis in infancy.” Intensive Care Med 30(12):2257-62 Details 2003Geddes JF, Tasker RC, Hackshaw AK, Nickols CD, Adams GG, Whitwell HL, Scheimberg I (2003), “Dural haemorrhage in non-traumatic infant deaths: does it explain the bleeding in 'shaken baby syndrome'?” Neuropathol Appl Neurobiol 29(1):14-22 Details Geddes JF, Whitwell HL, Tasker RC (2003), “Shaken baby syndrome.” Br J Neurosurg 17(1):18 Details McDouall SF, Campbell RC, Tasker RC (2003), “Clinical alert: failure in face of mask seal as a consequence of incorrect face mask assembly.” Br J Anaesth 91(6):924-5 Details O'Donnell R, Tasker RC, Roe MF (2003), “SARS: understanding the coronavirus: apoptosis may explain lymphopenia of SARS.” BMJ 327(7415):620 Details Roe M, O'Donnell DR, Tasker RC (2003), “Acute laryngotracheobronchitis.” Paediatr Respir Rev 4(3):267, 269 Details Roe M, O'Donnell DR, Tasker RC (2003), “Respiratory viruses in the intensive care unit.” Paediatr Respir Rev 4(3):166-71 Details 2002Bunn F, Roberts I, Tasker R, Akpa E (2002), “Hypertonic versus isotonic crystalloid for fluid resuscitation in critically ill patients.” Cochrane Database Syst Rev (1):CD002045 Details Dobyns EL, Anas NG, Fortenberry JD, Deshpande J, Cornfield DN, Tasker RC, Liu P, Eells PL, Griebel J, Kinsella JP, Abman SH (2002), “Interactive effects of high-frequency oscillatory ventilation and inhaled nitric oxide in acute hypoxemic respiratory failure in pediatrics.” Crit Care Med 30(11):2425-9 Details Gupta S, Tasker RC (2002), “Does giving albumin infusion in hypoalbuminaeimic children with oncological disease affect colloid osmotic pressure and outcome?” Arch Dis Child 86(5):380-1 Details 2001Buck JJ, Debenham P, Tasker RC (2001), “Prophylaxis for respiratory syncytial virus infection: missing the target.” Arch Dis Child 84(4):375 Details Eriksson KJ, Boyd SG, Tasker RC (2001), “Acute neurology and neurophysiology of haemolytic-uraemic syndrome.” Arch Dis Child 84(5):434-5 Details Peters MJ, Ross-Russell RI, White D, Kerr SJ, Eaton FE, Keengwe IN, Tasker RC, Wade AM, Klein NJ (2001), “Early severe neutropenia and thrombocytopenia identifies the highest risk cases of severe meningococcal disease.” Pediatr Crit Care Med 2(3):225-231 Details Tasker RC (2001), “Neurocritical care and traumatic brain injury.” Indian J Pediatr 68(3):257-66 Details Tasker RC (2001), “Hippocampal selective regional vulnerability and development.” Dev Med Child Neurol Suppl 86:6-7 Details 2000Bunn F, Roberts I, Tasker R, Akpa E (2000), “Hypertonic versus isotonic crystalloid for fluid resuscitation in critically ill patients.” Cochrane Database Syst Rev (4):CD002045 Details Peters M, Tasker RC (2000), “Reply” Intensive Care Med 26(1):149 Details Tasker RC (2000), “Training and dealing with errors or mistakes in medical practical procedures.” Arch Dis Child 83(2):95-8 Details Tasker RC (2000), “Gender differences and critical medical illness.” Acta Paediatr 89(5):621-3 Details Tasker RC (2000), “Neurological critical care.” Curr Opin Pediatr 12(3):222-6 Details Tasker RC, Gordon I, Kiff K (2000), “Time course of severe respiratory syncytial virus infection in mechanically ventilated infants.” Acta Paediatr 89(8):938-41 Details Tasker RC, Sahota SK, Williams SR (2000), “Hypercarbia and mild hypothermia, only when not combined, improve postischemic bioenergetic recovery in neonatal rat brain slices.” J Cereb Blood Flow Metab 20(3):612-9 Details Watkins SJ, Peters MJ, Tasker RC (2000), “One hundred courses of high frequency oscillatory ventilation: what have we learned?” Eur J Pediatr 159(1-2):134 Details 1999Dobyns EL, Cornfield DN, Anas NG, Fortenberry JD, Tasker RC, Lynch A, Liu P, Eells PL, Griebel J, Baier M, Kinsella JP, Abman SH (1999), “Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure.” J Pediatr 134(4):406-12 Details McFadzean J, Tasker RC, Petros AJ (1999), “Nitric oxide ABO blood group difference in children.” Lancet 353(9162):1414-5 Details Mok Q, Yates R, Tasker RC (1999), “Persistent pulmonary hypertension of the term neonate: a strategy for management.” Eur J Pediatr 158(10):825-7 Details Petros AJ, Heys R, Tasker RC, Fortune PM, Roberts I, Kiely E (1999), “Near infrared spectroscopy can detect changes in splanchnic oxygen delivery in neonates during apnoeic episodes.” Eur J Pediatr 158(2):173-4 Details Ranganathan S, Tasker R, Booy R, Habibi P, Nadel S, Britto J (1999), “Pertussis is increasing in unimmunized infants: is a change in policy needed?” Arch Dis Child 80(3):297-9 Details Tasker RC (1999), “Pharmacological advance in the treatment of acute brain injury.” Arch Dis Child 81(1):90-5 Details 1998Chisakuta A, Tasker RC (1998), “Respiratory failure in myasthenia gravis and negative pressure support.” Pediatr Neurol 19(3):225-6 Details Fraser J, Henrichsen T, Mok Q, Tasker RC (1998), “Prolonged mechanical ventilation as a consequence of acute illness.” Arch Dis Child 78(3):253-6 Details Gemke RJ, Tasker RC (1998), “Clinical assessment of acute coma in children.” Lancet 351(9107):926-7 Details Golder ND, Lane R, Tasker RC (1998), “Timing of recovery of lung function after severe hypoxemic respiratory failure in children.” Intensive Care Med 24(5):530-3 Details Peters MJ, Tasker RC, Kiff KM, Yates R, Hatch DJ (1998), “Acute hypoxemic respiratory failure in children: case mix and the utility of respiratory severity indices.” Intensive Care Med 24(7):699-705 Details Tasker RC (1998), “Emergency treatment of acute seizures and status epilepticus.” Arch Dis Child 79(1):78-83 Details Tasker RC, Dundas I, Laverty A, Fletcher M, Lane R, Stocks J (1998), “Distinct patterns of respiratory difficulty in young children with achondroplasia: a clinical, sleep, and lung function study.” Arch Dis Child 79(2):99-108 Details Tasker RC, Peters MJ (1998), “Combined lung injury, meningitis and cerebral edema: how permissive can hypercapnia be?” Intensive Care Med 24(6):616-9 Details Tasker RC, Sahota SK, Cotter FE, Williams SR (1998), “Early postischemic dantrolene-induced amelioration of poly(ADP-ribose) polymerase-related bioenergetic failure in neonatal rat brain slices.” J Cereb Blood Flow Metab 18(12):1346-56 Details 1997Bodamer OA, Leonard JV, Tasker RC, Hoffmann GF, Halliday D (1997), “Protein turnover in critically ill children.” Eur J Pediatr 156 Suppl 1:S59-61 Details Cameron FJ, Hawkins KC, Khadilkar VV, Tasker RC, Preece MA (1997), “Insulin-dependent diabetes mellitus presenting with ketoalkalosis in Rett syndrome.” Diabet Med 14(10):884-5 Details Doull IJ, Mok Q, Tasker RC (1997), “Tracheobronchomalacia in preterm infants with chronic lung disease.” Arch Dis Child Fetal Neonatal Ed 76(3):F203-5 Details Fraser J, Mok Q, Tasker R (1997), “Survey of occupancy of paediatric intensive care units by children who are dependent on ventilators.” BMJ 315(7104):347-8 Details Goldman AP, Kerr SJ, Butt W, Marsh MJ, Murdoch IA, Paul T, Firmin RK, Tasker RC, Macrae DJ (1997), “Extracorporeal support for intractable cardiorespiratory failure due to meningococcal disease.” Lancet 349(9050):466-9 Details Goldman AP, Tasker RC, Hosiasson S, Henrichsen T, Macrae DJ (1997), “Early response to inhaled nitric oxide and its relationship to outcome in children with severe hypoxemic respiratory failure.” Chest 112(3):752-8 Details Tasker RC (1997), “Should paediatric intensive care be centralised.” Lancet 350(9070):66; author reply 67-8 Details 1996Balfour-Lynn IM, Tasker RC (1996), “At the coalface--medical ethics in practice. Futility and death in paediatric medical intensive care.” J Med Ethics 22(5):279-81 Details Davenport M, Hosie GP, Tasker RC, Gordon I, Kiely EM, Spitz L (1996), “Long-term effects of gastric transposition in children: a physiological study.” J Pediatr Surg 31(4):588-93 Details Goldman A, Tyszczuk L, Drake D, Tasker R, Macrae D (1996), “Nitric oxide avoids the need for a second course of ECMO in congenital diaphragmatic hernia.” Pediatr Surg Int 11(4):272-3 Details Goldman AP, Macrae DJ, Tasker RC, Edberg KE, Mellgren G, Herberhold C, Jacobs JP, Delius RE, Elliott MJ (1996), “Extracorporeal membrane oxygenation as a bridge to definitive tracheal surgery in children.” J Pediatr 128(3):386-8 Details Goldman AP, Tasker RC, Haworth SG, Sigston PE, Macrae DJ (1996), “Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn.” Pediatrics 98(4 Pt 1):706-13 Details Kiff KM, Mok Q, Dunne J, Tasker RC (1996), “Steroids for intubated croup masking airway haemangioma.” Arch Dis Child 74(1):66-7 Details Mok Q, Tasker R, Macrae D, James I (1996), “Impact of specialised paediatric retrieval teams. A regionally based retrieval service is warranted.” BMJ 312(7023):119; author reply 121 Details Tasker RC, Sahota SK, Williams SR (1996), “Bioenergetic recovery following ischemia in brain slices studied by 31P-NMR spectroscopy: differential age effect of depolarization mediated by endogenous nitric oxide.” J Cereb Blood Flow Metab 16(1):125-33 Details 1995Clark JR, Smith LJ, Kendall BE, Tasker RC, Wilkinson KA (1995), “Unexpected brainstem compression following routine surgery in a child with oto-palato-digital syndrome.” Anaesthesia 50(7):641-3 Details Goldman AP, Tasker RC, Cook P, Macrae DJ (1995), “Transfer of critically ill patients with inhaled nitric oxide.” Arch Dis Child 73(5):480 Details Slater AJ, Nichani SH, Macrae D, Wilkinson KA, Novelli V, Tasker RC (1995), “Surfactant adjunctive therapy for Pneumocystis carinii pneumonitis in an infant with acute lymphoblastic leukaemia.” Intensive Care Med 21(3):261-3 Details Tatman A, Mok Q, James I, Tasker RC (1995), “Rapid control of severe hypercapnia with high frequency oscillatory ventilation.” Paediatr Anaesth 5(4):269-71 Details Vornov JJ, Tasker RC, Park J (1995), “Neurotoxicity of acute glutamate transport blockade depends on coactivation of both NMDA and AMPA/Kainate receptors in organotypic hippocampal cultures.” Exp Neurol 133(1):7-17 Details 1994Novelli V, al-Ansari H, Mok Q, Tasker R (1994), “Pertussis vaccination: is there a need for a booster dose?” Lancet 344(8931):1225-6 Details Tasker RC, Wilkinson K, Slater TJ, Novelli V (1994), “Unsuspected Pneumocystis carinii pneumonia and vertically acquired HIV infection in infants requiring intensive care.” BMJ 308(6926):462-3 Details Vornov JJ, Tasker RC, Coyle JT (1994), “Delayed protection by MK-801 and tetrodotoxin in a rat organotypic hippocampal culture model of ischemia.” Stroke 25(2):457-64; discussion 464-5 Details 1993Miller OI, Gaynor JW, Macrae DJ, Tasker RC (1993), “Inhaled nitric oxide for pulmonary hypertension after repair of exomphalos.” Arch Dis Child 69(5 Spec No):518-20 Details 1992Tasker RC (1992), “Excitatory amino acid neurotoxicity--a broader horizon for cerebral protection?” Arch Dis Child 67(11):1327-9 Details Tasker RC, Coyle JT, Vornov JJ (1992), “The regional vulnerability to hypoglycemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801.” J Neurosci 12(11):4298-308 Details 1991Tasker RC, Boyd SG, Harden A, Kendall B, Harding BN, Matthew DJ (1991), “The clinical significance of seizures in critically ill young infants requiring intensive care.” Neuropediatrics 22(3):129-38 Details Tasker RC, Matthew DJ (1991), “Cerebral intraparenchymal pressure monitoring in non-traumatic coma: clinical evaluation of a new fibreoptic device.” Neuropediatrics 22(1):47-9 Details Vornov JJ, Tasker RC, Coyle JT (1991), “Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures.” Exp Neurol 114(1):11-22 Details 1990Tasker RC, Boyd SG, Harden A, Matthew DJ (1990), “The cerebral function analysing monitor in paediatric medical intensive care: applications and limitations.” Intensive Care Med 16(1):60-8 Details Tasker RC, Matthew DJ, Kendall B (1990), “Computed tomography in the assessment of raised intracranial pressure in non-traumatic coma.” Neuropediatrics 21(2):91-4 Details 1989Tasker RC, Boyd SG, Harden A, Matthew DJ (1989), “Intracranial pressure monitoring following hypoxic-ischaemic cerebral insults.” Childs Nerv Syst 5(5):280 Details Tasker RC, Boyd SG, Harden A, Matthew DJ (1989), “EEG monitoring of prolonged thiopentone administration for intractable seizures and status epilepticus in infants and young children.” Neuropediatrics 20(3):147-53 Details 1988Tasker RC, Boyd S, Harden A, Matthew DJ (1988), “Monitoring in non-traumatic coma. Part II: Electroencephalography.” Arch Dis Child 63(8):895-9 Details Tasker RC, Matthew DJ, Helms P, Dinwiddie R, Boyd S (1988), “Monitoring in non-traumatic coma. Part I: Invasive intracranial measurements.” Arch Dis Child 63(8):888-94 Details 1986Rossi MB, Ho SY, Tasker RC (1986), “Absent aortic valve leaflets.” Int J Cardiol 11(2):235-7 Details Sweatman MC, Tasker R, Warner JO, Ferguson MM, Mitchell DN (1986), “Oro-facial granulomatosis. Response to elemental diet and provocation by food additives.” Clin Allergy 16(4):331-8 Details |