Dr RATNASEKHAR CH
Life is a cyclical chemical process from birth to death, which consists of developmental changes from single cell to adult and aging changes from adult to death. There are internal circannual cycles, circadian rhythms with in this birth to death cycle. Disruption of circadian rhythms might increase the risk of cancer, obesity. Mechanisms based on transcriptional and translational feedback loop (TTFL) is a current model for molecular circadian clocks in eukaryotic cells. Recent discovery of Red-Ox cycles of peroxiredoxin proteins in cells has prompted a reappraisal of TTFL model.
Our research work is focused on the temporal compartmentalization of metabolism that takes place during such circadian cycles. Studying cyclic changes in cell’s metabolic state, which may be a fundamental driving force for such biological oscillations. By using un-targeted & targeted metabolomics, we are trying to understand metabolic state of cells and different model organisms.
No collaborators listed
Associated News Items
Ratnasekhar Ch & Arvind Kumar Shukla & Prakash Pragya & Hitesh Singh Chaouhan & Devendra Kumar Patel & Debapratim Kar Chowdhuri & Mohana Krishna Reddy Mudiam (2015), “Metabolomic Analysis Provides Insights on Paraquat-Induced Parkinson-Like Symptoms in Drosophila melanogaster” Molecular Neurobiology
Ratnasekhar Ch, Amit Kumar Singh, Pathya Pandey, Prem Narain Saxena, Mohana Krishna Reddy Mudiam (2015), “Identifying the metabolic perturbations in earthworm induced by cypermethrin using gas chromatography-mass spectrometry based metabolomics” NPG Scientific Reports
Ratnasekhar Ch, Sonane M, Satish A, Mudiam MK, (2015), “Metabolomics reveals the perturbations in the metabolome of Caenorhabditis elegans exposed to titanium dioxide nanoparticles” Nanotoxicology