Dr Julie Qiaojin Lin
Sir Henry Wellcome Postdoctoral Fellow
I am a Sir Henry Wellcome Postdoctoral Fellow based at the UK Dementia Research Institute at the University of Cambridge. I am interested in understanding how localised protein synthesis at distal neuronal compartments, particularly axons, contributes to neural development and maintenance. Due to long distances away from the soma, distal axons are prone to intra- and/or extra-neuronal disturbances, and pathological changes in axons are frequent early manifestations of neurodegenerative disorders. Localised mRNA translation enables precise spatiotemporal control of axonal proteomes in rapid response to intracellular and environmental stimuli. My research uses various imaging techniques, in combination with RNA-Seq and proteomics, to investigate RNA localisation and local translation in axons. I sought to understand how aberrant translational activity in axons leads to prominent axonopathy, which recapitulates features of early stages of neurological diseases.
Associated News Items
Cioni JM*, Lin JQ*, Holtermann AV, Koppers M, Jakobs MA, Azizi A, Turner-Bridger B, Shigeoka T, Franze K, Harris WA, Holt CE. (2019), “Late endosomes act as mRNA translation platforms and sustain mitochondria in axons” Cell, 176(1-2), 56-72.
Qamar S*, Wang G*, Randle SJ*, Ruggeri FS*, Varela JA*, Lin JQ*, Phillips EC*, Miyashita A, Williams D, Ströhl F, Meadows W, Ferry R, Dardov VJ, Tartaglia GG, Farrer LA, Kaminski-Schierle GS, Kaminski CF, Holt CE, Fraser PE, Schmitt-Ulms G, Klenerman D, Knowles T, Vendruscolo M, St George-Hyslop P. (2018), “FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-π interactions.” Cell, 173(3), 720-734.
Ströhl F*, Lin JQ*, Laine RF, Wong HH, Urbančič V, Cagnetta R, Holt CE, Kaminski CF. (2017), “Single molecule translation imaging visualizes the dynamics of local β-actin synthesis in retinal axons.” Scientific reports, 7(1), 709.
Murakami T*, Qamar S*, Lin JQ*, Schierle GS*, Rees E, Miyashita A, Costa AR, Dodd RB, Chan FT, Michel CH, Kronenberg-Versteeg D, Li Y, Yang S, Wakutani Y, Meadows W, Ferry RR, Dong L, Tartaglia GG, Favrin G, Lin W, Dickson DW, Zhen M, Ron D, Schmitt-Ulms G, Fraser PE, Shneider NA, Holt CE, Vendruscolo M, Kaminski CF, St George-Hyslop P. (2015), “ALS/FTD mutation-induced phase transition of FUS liquid droplets and reversible hydrogels into irreversible hydrogels impairs RNP granule function.” Neuron, 88(4), 678-690.
Koppers M, Cagnetta R, Shigeoka T, Wunderlich LC, Vallejo-Ramirez P, Lin JQ, Zhao S, Jakobs MA, Dwivedy A, Minett MS, Bellon A. (2019), “Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons.” eLife, 8, p.e48718.
Shigeoka, T, Koppers, M, Wong, HHW*, Lin, JQ*, Cagnetta, R*, Dwivedy, A, de Freitas Nascimento, J, van Tartwijk, FW, Ströhl, F, ... Holt, CE. (2019), “On-site ribosome remodeling by locally synthesized ribosomal proteins in axons.” Cell Reports, 29(11), pp.3605-3619
Leung K*, Lu B*, Wong HH*, Lin JQ, Turner-Bridger B, Holt CE. (2018), “Cue-Polarized Transport of β-actin mRNA Depends on 3′ UTR and Microtubules in Live Growth Cones.” Frontiers in cellular neuroscience, 12.
St George-Hyslop P, Lin JQ, Miyashita A, Phillips EC, Qamar S, Randle SJ, Wang G. (2018), “The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration.” Brain research, 1693, 11-23.
Wong HH, Lin JQ, Ströhl F, Roque CG, Cioni JM, Cagnetta R, Turner-Bridger B, Laine RF, Harris WA, Kaminski CF, Holt CE. (2017), “RNA docking and local translation regulate site-specific axon remodeling in vivo.” Neuron, 95(4), 852-868.
Roque CG, Wong HH, Lin JQ, Holt CE. (2016), “Tumor protein Tctp regulates axon development in the embryonic visual system. ” Development, 143(7), 1134-1148.
Shigeoka T, Jung H, Jung J, Turner-Bridger B, Ohk J, Lin JQ, Amieux PS, Holt CE. (2016), “Dynamic axonal translation in developing and mature visual circuits.” Cell, 166(1), 181-192.