Dr Julie Qiaojin Lin

Interests

Neurons connect to their remote targets via axons, which usually survive for the lifetime of an organism. Spatiotemporal regulation of the axonal proteome by local protein synthesis plays a critical role in neuronal wiring and axon survival, raising the intriguing possibility that some neurological disorders involve local protein synthesis dysfunction. My research uses various imaging techniques, including widefield fluorescence microscopy, confocal microscopy and super-resolution microscopy, to investigate RNA localisation and local translation in axons. I sought to understand how aberrant translational activity in axons leads to prominent axonopathy, which recapitulates features of early stages of neurological diseases.

Research Focus

Keywords

Axonal protein synthesis

RNA localisation

Axon guidance

Axon survival

Amyotrophic lateral sclerosis

Clinical conditions

Amyotrophic lateral sclerosis

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Molecular biology

Super-resolution microscopy

Collaborators

No collaborators listed

Associated News Items