Dr Patrick Yu-Wai-Man PhD, FRCPath, FRCOphth

University position

Senior Lecturer and Honorary Consultant Ophthalmologist

Dr Patrick Yu-Wai-Man PhD, FRCPath, FRCOphth is pleased to consider applications from prospective PhD students.


Department of Clinical Neurosciences


Mitochondrial Biology Unit, MRC and Cambridge Centre for Brain Repair



Research Themes

Clinical and Veterinary Neuroscience

Cellular and Molecular Neuroscience


I am an academic neuro-ophthalmologist with a major research interest in mitochondrial eye diseases.

My research programme is currently focused on dissecting the molecular genetic basis and the disease mechanisms leading to progressive retinal ganglion cell loss in mitochondrial optic neuropathies.

With funding from the NIHR and the MRC as part of a Clinician Scientist Fellowship, I have built a national referral network for the investigation and management of patients with mitochondrial eye diseases. We are capitalising on this unique resource to explore disease biomarkers and the clinical applicability of high-resolution structural and functional ocular imaging.

We are currently entering an exciting translational phase for mitochondrial eye diseases. I am actively collaborating with an international network of academic and industrial partners in an effort to fast track the development of effective therapies for this group of patients, in particular novel gene therapy approaches.

Research Focus



Optic Neuropathies


Gene Therapy


Clinical conditions

Inherited optic neuropathies

Mitochondrial eye diseases

Multiple sclerosis


Applied Genomics

Cell culture

Clinical trials

Cohort studies

Deep phenotyping

Ocular imaging


No collaborators listed

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