Professor Patrick Yu-Wai-Man PhD, FRCPath, FRCOphth

University position


Professor Patrick Yu-Wai-Man PhD, FRCPath, FRCOphth is pleased to consider applications from prospective PhD students.


Department of Clinical Neurosciences


Mitochondrial Biology Unit, MRC and Cambridge Centre for Brain Repair


Home page (personal home page)

Research Themes

Clinical and Veterinary Neuroscience

Cellular and Molecular Neuroscience


I am an academic neuro-ophthalmologist with a major research interest in optic neuropathies, neurogenetics and mitochondrial eye diseases. I hold joint clinical appointments at Addenbrooke’s Hospital in Cambridge and Moorfields Eye Hospital in London as an Honorary Consultant.

My research programme is currently focused on dissecting the disease mechanisms leading to progressive retinal ganglion cell loss in inherited optic neuropathies by using a combination of patient tissues, induced pluripotent stem cells and animal models. I was awarded an NIHR Advanced Fellowship (2021-2026) to evaluate patient outcomes and fast track the development of effective therapies for this group of disorders, in particular novel gene therapy approaches.

I am the Director of the Cambridge Clinical Vision Laboratory (CCVL) that was set up as a cross-cutting facility to support advanced therapeutics on the Cambridge Biomedical Campus.

Research Focus



Optic Neuropathies


Gene Therapy


Clinical conditions

Inherited optic neuropathies

Mitochondrial eye diseases

Multiple sclerosis


Applied Genomics

Cell culture

Clinical trials

Cohort studies

Deep phenotyping

Ocular imaging