Professor Peter Hutchinson University positionProfessor Professor Peter Hutchinson is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Clinical Neurosciences InstitutesHome pagehttp://www.neurosurg.cam.ac.uk/ Research ThemeInterestsI am a NIHR Research Professor at the Department of Clinical Neurosciences, University of Cambridge and Honorary Consultant Neurosurgeon at Addenbrooke's Hospital, Cambridge. I have a general neurosurgical practice with a subspecialist interest in the management of patients with neurological trauma. My research interests include traumatic brain injury (Chief Investigator of the MRC/NIHR-funded RESCUEicp decompressive study), multimodality monitoring in neurocritical care, and functional brain imaging. I was the previous Chair of the European Association of Neurological Societies (EANS) Research Committee and am now a Vice President of the EANS. I am also the Neurosurgical Specialty Lead at the Royal College of Surgeons of England; Chair of the Society of British Neurological Surgeons (SBNS) Neurotrauma Group; a member of the SBNS Council; Director of Clinical Studies and Fellow at Robinson College, Cambridge; and Chief Medical Officer for the Formula 1 British Grand Prix. Research Focus
EquipmentComputerised tomography Cross-sectional and cohort studies Gene therapy Intracerebral microdialysis Magnetic resonance imaging (MRI) Positron Emission Tomography (PET) Randomised control trials CollaboratorsNo collaborators listed Associated News Items
Publications2014Dyson EW, Kolias AG, Burnstein RM, Hutchinson PJ, Garnett MR, Menon DK, Trivedi RA (2014), “Neuro-critical care: A valuable placement during foundation and early neurosurgical training.” Br J Neurosurg Details Helmy A, Guilfoyle MR, Carpenter KL, Pickard JD, Menon DK, Hutchinson PJ (2014), “Recombinant human interleukin-1 receptor antagonist in severe traumatic brain injury: a phase II randomized control trial.” J Cereb Blood Flow Metab Details Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK (2014), “Amyloid imaging with carbon 11-labeled Pittsburgh Compound B for traumatic brain injury.” JAMA Neurol 71(1):23-31 Details Kolias AG, Coulter IC, Marcus HJ, Gray WP, Brennan PM, Hutchinson PJ, British Neurosurgical Trainee Research Collaborative (2014), “Chronic subdural haematoma: How can we improve patient care and outcomes?” Br J Neurosurg 28(1):136-7 Details Singh N, Hopkins SJ, Hulme S, Galea JP, Hoadley M, Vail A, Hutchinson PJ, Grainger S, Rothwell NJ, King AT, Tyrrell PJ (2014), “The effect of intravenous interleukin-1 receptor antagonist on inflammatory mediators in cerebrospinal fluid after subarachnoid haemorrhage: a phase II randomised controlled trial.” J Neuroinflammation 11:1 Details Wilson MH, Kolias AG, Hutchinson PJ (2014), “Neurotrauma - a multidisciplinary disease.” Int J Clin Pract 68(1):5-7 Details 2013Carpenter KL, Jalloh I, Gallagher CN, Grice P, Howe DJ, Mason A, Timofeev I, Helmy A, Murphy MP, Menon DK, Kirkpatrick PJ, Carpenter TA, Sutherland GR, Pickard JD, Hutchinson PJ (2013), “13C-labelled microdialysis studies of cerebral metabolism in TBI patients.” Eur J Pharm Sci Details Clark DJ, Kolias AG, Corteen EA, Ingham SC, Piercy J, Crick SJ, Menon DK, Hutchinson PJ, RESCUE-ASDH Collaborative Group (2013), “Community consultation in emergency neurotrauma research: results from a pre-protocol survey.” Acta Neurochir (Wien) 155(7):1329-34; discussion 1334 Details Coulter IC, Kolias AG, Marcus HJ, Ahmed AI, Alli S, Al-Mahfoudh R, Borg A, Cowie CJ, Hill CS, Joannides AJ, Jones TL, Kailaya-Vasan A, Livermore JL, Narayanamurthy H, Ngoga D, Shapey J, Tarnaris A, Gregson BA, Gray WP, Nelson RJ, Hutchinson PJ, Brennan PM, UK Neurosurgical Research Network, British Neurosurgical Trainee Research Collaborative (2013), “Proposal for a prospective multi-centre audit of chronic subdural haematoma management in the United Kingdom and Ireland.” Br J Neurosurg Details Guilfoyle MR, Helmy A, Duane D, Hutchinson PJ (2013), “Regional scalp block for postcraniotomy analgesia: a systematic review and meta-analysis.” Anesth Analg 116(5):1093-102 Details Harrison DA, Prabhu G, Grieve R, Harvey SE, Sadique MZ, Gomes M, Griggs KA, Walmsley E, Smith M, Yeoman P, Lecky FE, Hutchinson PJ, Menon DK, Rowan KM (2013), “Risk Adjustment In Neurocritical care (RAIN)--prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study.” Health Technol Assess 17(23):vii-viii, 1-350 Details Helmy A, Agarwal M, Hutchinson PJ (2013), “Concussion and sport.” BMJ 347:f5748 Details Hutchinson PJ, Kolias AG, Czosnyka M, Kirkpatrick PJ, Pickard JD, Menon DK (2013), “Intracranial pressure monitoring in severe traumatic brain injury.” BMJ 346:f1000 Details Jalloh I, Helmy A, Shannon RJ, Gallagher CN, Menon DK, Carpenter KL, Hutchinson PJ (2013), “Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study.” J Neurotrauma 30(24):2031-7 Details Kolias AG, Bulters DO, Cowie CJ, Wilson MH, Afshari FT, Helmy A, Broughton E, Joannides AJ, Zebian B, Harrisson SE, Hill CS, Ahmed AI, Barone DG, Thakur B, McMahon CJ, Adlam DM, Bentley RP, Tolias CM, Mitchell PM, Whitfield PC, Critchley GR, Belli A, Brennan PM, Hutchinson PJ, British Neurosurgical Trainee Research Collaborative, British Neurotrauma Group, UKCRR Collaborative Group (2013), “Proposal for establishment of the UK Cranial Reconstruction Registry (UKCRR).” Br J Neurosurg Details Kolias AG, Cowie CJ, Tarnaris A, Hutchinson PJ, Brennan PM, British Neurosurgical Trainee Research Collaborative (2013), “Ensuring a bright future for clinical research in surgery with trainee led research networks.” BMJ 347:f5225 Details Kolias AG, Guilfoyle MR, Helmy A, Allanson J, Hutchinson PJ (2013), “Traumatic brain injury in adults.” Pract Neurol 13(4):228-35 Details Kolias AG, Jones TL, Cowie CJ, Coulter IC, Afshari FT, Tarnaris A, Nelson RJ, Gray WP, Hutchinson PJ, Brennan PM, UK Neurosurgical Research Network, British Neurosurgical Trainee Research Collaborative (2013), “A report from the inaugural meeting of the British Neurosurgical Trainee Research Collaborative held in the Royal College of Surgeons of England, 19 October 2012.” Br J Neurosurg 27(3):307-10 Details Kolias AG, Kirkpatrick PJ, Hutchinson PJ (2013), “Decompressive craniectomy: past, present and future.” Nat Rev Neurol 9(7):405-15 Details Kolias AG, Li LM, Guilfoyle MR, Timofeev I, Corteen EA, Pickard JD, Kirkpatrick PJ, Menon DK, Hutchinson PJ (2013), “Decompressive craniectomy for acute subdural hematomas: time for a randomized trial.” Acta Neurochir (Wien) 155(1):187-8 Details Kolias AG, Scotton WJ, Belli A, King AT, Brennan PM, Bulters DO, Eljamel MS, Wilson MH, Papadopoulos MC, Mendelow AD, Menon DK, Hutchinson PJ, UK Neurosurgical Research Network, RESCUE-ASDH collaborative group (2013), “Surgical management of acute subdural haematomas: current practice patterns in the United Kingdom and the Republic of Ireland.” Br J Neurosurg 27(3):330-3 Details Kolias AG, Sinha R, Park H, Santarius T, Hutchinson PJ (2013), “Surgical management of chronic subdural hematomas: in need of better evidence.” Acta Neurochir (Wien) 155(1):183-4 Details Newcombe VF, Williams GB, Outtrim JG, Chatfield D, Gulia Abate M, Geeraerts T, Manktelow A, Room H, Mariappen L, Hutchinson PJ, Coles JP, Menon DK (2013), “Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.” J Cereb Blood Flow Metab 33(6):855-62 Details Scotton WJ, Kolias AG, Ban VS, Crick SJ, Sinha R, Gardner A, Massey K, Minett T, Santarius T, Hutchinson PJ (2013), “Community consultation in emergency neurosurgical research: lessons from a proposed trial for patients with chronic subdural haematomas.” Br J Neurosurg 27(5):590-4 Details Shannon RJ, Carpenter KL, Guilfoyle MR, Helmy A, Hutchinson PJ (2013), “Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications.” J Pharmacokinet Pharmacodyn 40(3):343-58 Details Timofeev I, Nortje J, Al-Rawi PG, Hutchinson PJ, Gupta AK (2013), “Extracellular brain pH with or without hypoxia is a marker of profound metabolic derangement and increased mortality after traumatic brain injury.” J Cereb Blood Flow Metab 33(3):422-7 Details 2012Aries MJ, Czosnyka M, Budohoski KP, Steiner LA, Lavinio A, Kolias AG, Hutchinson PJ, Brady KM, Menon DK, Pickard JD, Smielewski P (2012), “Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury.” Crit Care Med 40(8):2456-63 Details Carpenter KL, Timofeev I, Nortje J, Czosnyka M, Pickard JD, Hutchinson PJ (2012), “A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring.” Acta Neurochir Suppl 114:271-6 Details Hart MG, Trivedi RA, Hutchinson PJ (2012), “Boxing sparring complicated by an acute subdural haematoma and brainstem haemorrhage.” Br J Neurosurg 26(5):776-8 Details Helmy A, Antoniades CA, Guilfoyle MR, Carpenter KL, Hutchinson PJ (2012), “Principal component analysis of the cytokine and chemokine response to human traumatic brain injury.” PLoS One 7(6):e39677 Details Helmy A, Kirkpatrick PJ, Seeley HM, Corteen E, Menon DK, Hutchinson PJ (2012), “Fixed, dilated pupils following traumatic brain injury: historical perspectives, causes and ophthalmological sequelae.” Acta Neurochir Suppl 114:295-9 Details Hutchinson PJ, Kirkpatrick PJ (2012), “Headache. Diagnosing subarachnoid hemorrhage: are CT scans enough?” Nat Rev Neurol 8(3):126-7 Details Keong NC, Bulters DO, Richards HK, Farrington M, Sparrow OC, Pickard JD, Hutchinson PJ, Kirkpatrick PJ (2012), “The SILVER (Silver Impregnated Line Versus EVD Randomized trial): a double-blind, prospective, randomized, controlled trial of an intervention to reduce the rate of external ventricular drain infection.” Neurosurgery 71(2):394-403; discussion 403-4 Details Kolias AG, Belli A, Li LM, Timofeev I, Corteen EA, Santarius T, Menon DK, Pickard JD, Kirkpatrick PJ, Hutchinson PJ (2012), “Primary decompressive craniectomy for acute subdural haematomas: results of an international survey.” Acta Neurochir (Wien) 154(9):1563-5 Details Kolias AG, Cowie CJ, Tarnaris A, Hutchinson PJ, Brennan PM (2012), “Proposal for a British neurosurgical trainee research collaborative.” Br J Neurosurg 26(3):434-5 Details Kolias AG, Li LM, Corteen EA, Timofeev I, Kirkpatrick PJ, Hutchinson PJ (2012), “Decompressive craniectomy versus craniotomy for head-injured patients with acute subdural hematoma.” J Trauma Acute Care Surg 72(5):1451 Details Li LM, Kolias AG, Guilfoyle MR, Timofeev I, Corteen EA, Pickard JD, Menon DK, Kirkpatrick PJ, Hutchinson PJ (2012), “Outcome following evacuation of acute subdural haematomas: a comparison of craniotomy with decompressive craniectomy.” Acta Neurochir (Wien) 154(9):1555-61 Details Sorrentino E, Diedler J, Kasprowicz M, Budohoski KP, Haubrich C, Smielewski P, Outtrim JG, Manktelow A, Hutchinson PJ, Pickard JD, Menon DK, Czosnyka M (2012), “Critical thresholds for cerebrovascular reactivity after traumatic brain injury.” Neurocrit Care 16(2):258-66 Details Timofeev I, Santarius T, Kolias AG, Hutchinson PJ (2012), “Decompressive craniectomy - operative technique and perioperative care.” Adv Tech Stand Neurosurg 38:115-36 Details 2011Fuller G, Bouamra O, Woodford M, Jenks T, Patel H, Coats TJ, Oakley P, Mendelow AD, Pigott T, Hutchinson PJ, Lecky F (2011), “The effect of specialist neurosciences care on outcome in adult severe head injury: a cohort study.” J Neurosurg Anesthesiol 23(3):198-205 Details Fuller G, Bouamra O, Woodford M, Jenks T, Patel H, Coats TJ, Oakley P, Mendelow AD, Pigott T, Hutchinson PJ, Lecky F (2011), “Temporal trends in head injury outcomes from 2003 to 2009 in England and Wales.” Br J Neurosurg 25(3):414-21 Details Helmy A, Antoun N, Hutchinson P (2011), “Cerebral tuberculoma and magnetic resonance imaging.” J R Soc Med 104(7):299-301 Details Helmy A, Carpenter KL, Menon DK, Pickard JD, Hutchinson PJ (2011), “The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production.” J Cereb Blood Flow Metab 31(2):658-70 Details Helmy A, De Simoni MG, Guilfoyle MR, Carpenter KL, Hutchinson PJ (2011), “Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury.” Prog Neurobiol 95(3):352-72 Details Helmy A, Guilfoyle MR, Carpenter KL, Hutchinson PJ (2011), “Sex and the cytokines: are there fundamental differences in response to brain injury?” Neurosurgery 69(4):E1029-30 Details Hutchinson PJ, Kirkpatrick PJ, RESCUEicp Central Study Team (2011), “Craniectomy in diffuse traumatic brain injury.” N Engl J Med 365(4):375; author reply 376 Details Hutchinson PJ, Timofeev I, Kolias AG, Corteen EA, Czosnyka M, Menon DK, Pickard JD, Kirkpatrick PJ (2011), “Decompressive craniectomy for traumatic brain injury: the jury is still out.” Br J Neurosurg 25(3):441-2 Details Newcombe VF, Outtrim JG, Chatfield DA, Manktelow A, Hutchinson PJ, Coles JP, Williams GB, Sahakian BJ, Menon DK (2011), “Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury.” Brain 134(Pt 3):759-68 Details Price SJ, Green HA, Dean AF, Joseph J, Hutchinson PJ, Gillard JH (2011), “Correlation of MR relative cerebral blood volume measurements with cellular density and proliferation in high-grade gliomas: an image-guided biopsy study.” AJNR Am J Neuroradiol 32(3):501-6 Details Timofeev I, Carpenter KL, Nortje J, Al-Rawi PG, O'Connell MT, Czosnyka M, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ (2011), “Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients.” Brain 134(Pt 2):484-94 Details Timofeev I, Czosnyka M, Carpenter KL, Nortje J, Kirkpatrick PJ, Al-Rawi PG, Menon DK, Pickard JD, Gupta AK, Hutchinson PJ (2011), “Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location.” J Neurotrauma 28(6):849-60 Details 2010Al-Rawi PG, Tseng MY, Richards HK, Nortje J, Timofeev I, Matta BF, Hutchinson PJ, Kirkpatrick PJ (2010), “Hypertonic saline in patients with poor-grade subarachnoid hemorrhage improves cerebral blood flow, brain tissue oxygen, and pH.” Stroke 41(1):122-8 Details Guilfoyle MR, Seeley HM, Corteen E, Harkin C, Richards H, Menon DK, Hutchinson PJ (2010), “Assessing quality of life after traumatic brain injury: examination of the short form 36 health survey.” J Neurotrauma 27(12):2173-81 Details Helmy A, Timofeev I, Palmer CR, Gore A, Menon DK, Hutchinson PJ (2010), “Hierarchical log linear analysis of admission blood parameters and clinical outcome following traumatic brain injury.” Acta Neurochir (Wien) 152(6):953-7 Details Li LM, Timofeev I, Czosnyka M, Hutchinson PJ (2010), “Review article: the surgical approach to the management of increased intracranial pressure after traumatic brain injury.” Anesth Analg 111(3):736-48 Details Marcus HJ, Carpenter KL, Price SJ, Hutchinson PJ (2010), “In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines.” J Neurooncol 97(1):11-23 Details Santarius T, Kirkpatrick PJ, Kolias AG, Hutchinson PJ (2010), “Working toward rational and evidence-based treatment of chronic subdural hematoma.” Clin Neurosurg 57:112-22 Details Santarius T, Qureshi HU, Sivakumaran R, Kirkpatrick PJ, Kirollos RW, Hutchinson PJ (2010), “The role of external drains and peritoneal conduits in the treatment of recurrent chronic subdural hematoma.” World Neurosurg 73(6):747-50 Details Tseng MY, Hutchinson PJ, Kirkpatrick PJ (2010), “Interaction of neurovascular protection of erythropoietin with age, sepsis, and statin therapy following aneurysmal subarachnoid hemorrhage.” J Neurosurg 112(6):1235-9 Details Zweifel C, Castellani G, Czosnyka M, Helmy A, Manktelow A, Carrera E, Brady KM, Hutchinson PJ, Menon DK, Pickard JD, Smielewski P (2010), “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients.” J Neurotrauma 27(11):1951-8 Details 2009Castellani G, Zweifel C, Kim DJ, Carrera E, Radolovich DK, Smielewski P, Hutchinson PJ, Pickard JD, Czosnyka M (2009), “Plateau waves in head injured patients requiring neurocritical care.” Neurocrit Care 11(2):143-50 Details Gallagher CN, Carpenter KL, Grice P, Howe DJ, Mason A, Timofeev I, Menon DK, Kirkpatrick PJ, Pickard JD, Sutherland GR, Hutchinson PJ (2009), “The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study.” Brain 132(Pt 10):2839-49 Details Helmy A, Carpenter KL, Skepper JN, Kirkpatrick PJ, Pickard JD, Hutchinson PJ (2009), “Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.” J Neurotrauma 26(4):549-61 Details Hutchinson PJ, O'Connell MT, Seal A, Nortje J, Timofeev I, Al-Rawi PG, Coles JP, Fryer TD, Menon DK, Pickard JD, Carpenter KL (2009), “A combined microdialysis and FDG-PET study of glucose metabolism in head injury.” Acta Neurochir (Wien) 151(1):51-61; discussion 61 Details Price SJ, Fryer TD, Cleij MC, Dean AF, Joseph J, Salvador R, Wang DD, Hutchinson PJ, Clark JC, Burnet NG, Pickard JD, Aigbirhio FI, Gillard JH (2009), “Imaging regional variation of cellular proliferation in gliomas using 3'-deoxy-3'-[18F]fluorothymidine positron-emission tomography: an image-guided biopsy study.” Clin Radiol 64(1):52-63 Details Santarius T, Kirkpatrick PJ, Ganesan D, Chia HL, Jalloh I, Smielewski P, Richards HK, Marcus H, Parker RA, Price SJ, Kirollos RW, Pickard JD, Hutchinson PJ (2009), “Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial.” Lancet 374(9695):1067-73 Details Seeley HM, Kirker S, Harkin C, Dias C, Richards H, Pickard JD, Hutchinson PJ (2009), “Head injury rehabilitation: the role of a neurotrauma clinic.” Br J Neurosurg 23(5):530-7 Details Tseng MY, Hutchinson PJ, Richards HK, Czosnyka M, Pickard JD, Erber WN, Brown S, Kirkpatrick PJ (2009), “Acute systemic erythropoietin therapy to reduce delayed ischemic deficits following aneurysmal subarachnoid hemorrhage: a Phase II randomized, double-blind, placebo-controlled trial. Clinical article.” J Neurosurg 111(1):171-80 Details Wijesurendra RS, Bernard F, Outtrim J, Maiya B, Joshi S, Hutchinson PJ, Halsall DJ, Menon DK (2009), “Low-dose and high-dose synacthen tests and the hemodynamic response to hydrocortisone in acute traumatic brain injury.” Neurocrit Care 11(2):158-64 Details Zygun DA, Nortje J, Hutchinson PJ, Timofeev I, Menon DK, Gupta AK (2009), “The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury.” Crit Care Med 37(3):1074-8 Details 2008Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD, Hutchinson PJ (2008), “Nitric oxide in acute brain injury: a pilot study of NO(x) concentrations in human brain microdialysates and their relationship with energy metabolism.” Acta Neurochir Suppl 102:207-13 Details Geeraerts T, Newcombe VF, Coles JP, Abate MG, Perkes IE, Hutchinson PJ, Outtrim JG, Chatfield DA, Menon DK (2008), “Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure.” Crit Care 12(5):R114 Details Kirkpatrick PJ, Tseng MY, Hutchinson PJ (2008), “How SAFE is albumin for fluid resuscitation in critically ill patients with traumatic brain injury?” Nat Clin Pract Neurol 4(5):248-9 Details Mendelow AD, Timothy J, Steers JW, Lecky F, Yates D, Bouamra O, Woodford M, Hutchinson PJ (2008), “Management of patients with head injury.” Lancet 372(9639):685-7 Details Newcombe VF, Hawkes RC, Harding SG, Willcox R, Brock S, Hutchinson PJ, Menon DK, Carpenter TA, Coles JP (2008), “Potential heating caused by intraparenchymal intracranial pressure transducers in a 3-tesla magnetic resonance imaging system using a body radiofrequency resonator: assessment of the Codman MicroSensor Transducer.” J Neurosurg 109(1):159-64 Details Newcombe VF, Williams GB, Nortje J, Bradley PG, Chatfield DA, Outtrim JG, Harding SG, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2008), “Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma.” Acta Neurochir Suppl 102:247-51 Details Nortje J, Coles JP, Timofeev I, Fryer TD, Aigbirhio FI, Smielewski P, Outtrim JG, Chatfield DA, Pickard JD, Hutchinson PJ, Gupta AK, Menon DK (2008), “Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.” Crit Care Med 36(1):273-81 Details Santarius T, Lawton R, Kirkpatrick PJ, Hutchinson PJ (2008), “The management of primary chronic subdural haematoma: a questionnaire survey of practice in the United Kingdom and the Republic of Ireland.” Br J Neurosurg 22(4):529-34 Details Timofeev I, Czosnyka M, Nortje J, Smielewski P, Kirkpatrick P, Gupta A, Hutchinson P (2008), “Effect of decompressive craniectomy on intracranial pressure and cerebrospinal compensation following traumatic brain injury.” J Neurosurg 108(1):66-73 Details Timofeev I, Dahyot-Fizelier C, Keong N, Nortje J, Al-Rawi PG, Czosnyka M, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ (2008), “Ventriculostomy for control of raised ICP in acute traumatic brain injury.” Acta Neurochir Suppl 102:99-104 Details Tseng MY, Hutchinson PJ, Kirkpatrick PJ (2008), “Effects of fluid therapy following aneurysmal subarachnoid haemorrhage: a prospective clinical study.” Br J Neurosurg 22(2):257-68 Details Tseng MY, Hutchinson PJ, Turner CL, Czosnyka M, Richards HK, Pickard JD, Kirkpatrick PJ (2008), “Statin use was not associated with less vasospasm or improved outcome after subarachnoid hemorrhage.” Neurosurgery 63(6):E1209; author reply E1209 Details 2007Bodkin PA, Al-Rawi PG, Canal AC, Hutchinson PJ (2007), “Microdialysis to monitor scalp flap viability.” J Reconstr Microsurg 23(1):57 Details Gallagher CN, Hutchinson PJ, Pickard JD (2007), “Neuroimaging in trauma.” Curr Opin Neurol 20(4):403-9 Details Helmy A, Carpenter KL, Hutchinson PJ (2007), “Microdialysis in the human brain and its potential role in the development and clinical assessment of drugs.” Curr Med Chem 14(14):1525-37 Details Hutchinson PJ, O'Connell MT, Rothwell NJ, Hopkins SJ, Nortje J, Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD (2007), “Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra.” J Neurotrauma 24(10):1545-57 Details Lavinio A, Timofeev I, Nortje J, Outtrim J, Smielewski P, Gupta A, Hutchinson PJ, Matta BF, Pickard JD, Menon D, Czosnyka M (2007), “Cerebrovascular reactivity during hypothermia and rewarming.” Br J Anaesth 99(2):237-44 Details Mannion RJ, Cross J, Bradley P, Coles JP, Chatfield D, Carpenter A, Pickard JD, Menon DK, Hutchinson PJ (2007), “Mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome.” J Neurotrauma 24(1):128-35 Details Newcombe VF, Williams GB, Nortje J, Bradley PG, Harding SG, Smielewski P, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2007), “Analysis of acute traumatic axonal injury using diffusion tensor imaging.” Br J Neurosurg 21(4):340-8 Details Tseng MY, Al-Rawi PG, Czosnyka M, Hutchinson PJ, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Enhancement of cerebral blood flow using systemic hypertonic saline therapy improves outcome in patients with poor-grade spontaneous subarachnoid hemorrhage.” J Neurosurg 107(2):274-82 Details Tseng MY, Hutchinson PJ, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Effects of acute pravastatin treatment on intensity of rescue therapy, length of inpatient stay, and 6-month outcome in patients after aneurysmal subarachnoid hemorrhage.” Stroke 38(5):1545-50 Details Tseng MY, Hutchinson PJ, Turner CL, Czosnyka M, Richards H, Pickard JD, Kirkpatrick PJ (2007), “Biological effects of acute pravastatin treatment in patients after aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled trial.” J Neurosurg 107(6):1092-100 Details 2006Bradley LJ, Kirker SG, Corteen E, Seeley HM, Pickard JD, Hutchinson PJ (2006), “Inappropriate acute neurosurgical bed occupancy and short falls in rehabilitation: implications for the National Service Framework.” Br J Neurosurg 20(1):36-9 Details Czosnyka M, Hutchinson PJ, Balestreri M, Hiler M, Smielewski P, Pickard JD (2006), “Monitoring and interpretation of intracranial pressure after head injury.” Acta Neurochir Suppl 96:114-8 Details Guendling K, Smielewski P, Czosnyka M, Lewis P, Nortje J, Timofeev I, Hutchinson PJ, Pickard JD (2006), “Use of ICM+ software for on-line analysis of intracranial and arterial pressures in head-injured patients.” Acta Neurochir Suppl 96:108-13 Details Hutchinson PJ, Corteen E, Czosnyka M, Mendelow AD, Menon DK, Mitchell P, Murray G, Pickard JD, Rickels E, Sahuquillo J, Servadei F, Teasdale GM, Timofeev I, Unterberg A, Kirkpatrick PJ (2006), “Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com).” Acta Neurochir Suppl 96:17-20 Details Hutchinson PJ, Gimson A, Al-Rawi PG, O'Connell MT, Czosnyka M, Menon DK (2006), “Microdialysis in the management of hepatic encephalopathy.” Neurocrit Care 5(3):202-5 Details Hutchinson PJ, Pickard JD (2006), “Deficiencies in rehabilitation after traumatic brain injury.” BMJ 332(7533):118 Details Keong NC, Gleave JR, Hutchinson PJ (2006), “Neurosurgical history: Comparing the management of penetrating head injury in 1969 with 2005.” Br J Neurosurg 20(4):227-32 Details Price SJ, Jena R, Burnet NG, Hutchinson PJ, Dean AF, Peña A, Pickard JD, Carpenter TA, Gillard JH (2006), “Improved delineation of glioma margins and regions of infiltration with the use of diffusion tensor imaging: an image-guided biopsy study.” AJNR Am J Neuroradiol 27(9):1969-74 Details Seeley HM, Maimaris C, Hutchinson PJ, Carroll G, White B, Kirker S, Tasker RC, Steward C, Haynes K, Hardy D, Pickard JD (2006), “Standards for head injury management in acute hospitals: evidence from the six million population of the Eastern region.” Emerg Med J 23(2):128-32 Details Sergides IG, Whiting G, Howarth S, Hutchinson PJ (2006), “Is the recommended target of 4 hours from head injury to emergency craniotomy achievable?” Br J Neurosurg 20(5):301-5 Details Timofeev I, Hutchinson PJ (2006), “Outcome after surgical decompression of severe traumatic brain injury.” Injury 37(12):1125-32 Details Timofeev I, Kirkpatrick PJ, Corteen E, Hiler M, Czosnyka M, Menon DK, Pickard JD, Hutchinson PJ (2006), “Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy.” Acta Neurochir Suppl 96:11-6 Details 2005Al-Rawi PG, Zygun D, Tseng MY, Hutchinson PJ, Matta BF, Kirkpatrick PJ (2005), “Cerebral blood flow augmentation in patients with severe subarachnoid haemorrhage.” Acta Neurochir Suppl 95:123-7 Details Czosnyka M, Balestreri M, Steiner L, Smielewski P, Hutchinson PJ, Matta B, Pickard JD (2005), “Age, intracranial pressure, autoregulation, and outcome after brain trauma.” J Neurosurg 102(3):450-4 Details Czosnyka M, Steiner L, Balestreri M, Schmidt E, Smielewski P, Hutchinson PJ, Pickard JD (2005), “Concept of "true ICP" in monitoring and prognostication in head trauma.” Acta Neurochir Suppl 95:341-4 Details Hutchinson PJ (2005), “Microdialysis in traumatic brain injury--methodology and pathophysiology.” Acta Neurochir Suppl 95:441-5 Details Hutchinson PJ, Menon DK, Kirkpatrick PJ (2005), “Decompressive craniectomy in traumatic brain injury--time for randomised trials?” Acta Neurochir (Wien) 147(1):1-3 Details Hutchinson PJ, O'Connell MT, Nortje J, Smith P, Al-Rawi PG, Gupta AK, Menon DK, Pickard JD (2005), “Cerebral microdialysis methodology--evaluation of 20 kDa and 100 kDa catheters.” Physiol Meas 26(4):423-8 Details Johnston AJ, Steiner LA, Coles JP, Chatfield DA, Fryer TD, Smielewski P, Hutchinson PJ, O'Connell MT, Al-Rawi PG, Aigbirihio FI, Clark JC, Pickard JD, Gupta AK, Menon DK (2005), “Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury.” Crit Care Med 33(1):189-95; discussion 255-7 Details Kett-White R, O'Connell MT, Hutchinson PJ, Al-Rawi PG, Gupta AK, Pickard JD, Kirkpatrick PJ (2005), “Extracellular amino acid changes in patients during reversible cerebral ischaemia.” Acta Neurochir Suppl 95:83-8 Details O'Connell MT, Seal A, Nortje J, Al-Rawi PG, Coles JP, Fryer TD, Menon DK, Pickard JD, Hutchinson PJ (2005), “Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study.” Acta Neurochir Suppl 95:165-8 Details Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details 2004Buczacki SJ, Kirkpatrick PJ, Seeley HM, Hutchinson PJ (2004), “Late epilepsy following open surgery for aneurysmal subarachnoid haemorrhage.” J Neurol Neurosurg Psychiatry 75(11):1620-2 Details Coles JP, Fryer TD, Smielewski P, Chatfield DA, Steiner LA, Johnston AJ, Downey SP, Williams GB, Aigbirhio F, Hutchinson PJ, Rice K, Carpenter TA, Clark JC, Pickard JD, Menon DK (2004), “Incidence and mechanisms of cerebral ischemia in early clinical head injury.” J Cereb Blood Flow Metab 24(2):202-11 Details Gupta AK, Zygun DA, Johnston AJ, Steiner LA, Al-Rawi PG, Chatfield D, Shepherd E, Kirkpatrick PJ, Hutchinson PJ, Menon DK (2004), “Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury.” J Neurotrauma 21(6):678-84 Details Hutchinson PJ (2004), “Large diameter twist drill craniostomy.” Br J Neurosurg 18(4):403 Details Hutchinson PJ (2004), “Post traumatic brain contusions and lacerations. An international focus meeting, September 19-20, 2003, Rimini, Italy.” Acta Neurochir (Wien) 146(5):535-6 Details Hutchinson PJ, Kirkpatrick PJ (2004), “Decompressive craniectomy in head injury.” Curr Opin Crit Care 10(2):101-4 Details Johnston AJ, Steiner LA, Chatfield DA, Coles JP, Hutchinson PJ, Al-Rawi PG, Menon DK, Gupta AK (2004), “Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury.” Intensive Care Med 30(5):791-7 Details Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD (2004), “Diffusion limited oxygen delivery following head injury.” Crit Care Med 32(6):1384-90 Details Pickard JD, Seeley HM, Kirker S, Maimaris C, McGlashan K, Roels E, Greenwood R, Steward C, Hutchinson PJ, Carroll G (2004), “Mapping rehabilitation resources for head injury.” J R Soc Med 97(8):384-9 Details Santarius T, Hutchinson PJ (2004), “Chronic subdural haematoma: time to rationalize treatment?” Br J Neurosurg 18(4):328-32 Details Wilby MJ, Hutchinson PJ (2004), “The pharmacology of chlormethiazole: a potential neuroprotective agent?” CNS Drug Rev 10(4):281-94 Details Zygun DA, Steiner LA, Johnston AJ, Hutchinson PJ, Al-Rawi PG, Chatfield D, Kirkpatrick PJ, Menon DK, Gupta AK (2004), “Hyperglycemia and brain tissue pH after traumatic brain injury.” Neurosurgery 55(4):877-81; discussion 882 Details 2003Coles JP, Steiner LA, Martin J, Donovan T, Hutchinson PJ, Carpenter TA, Menon DK (2003), “Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner.” Anaesthesia 58(2):143-8 Details Hutchinson PJ, Eastern Region Head Injury Study Group (2003), “Future perspectives in the acute management of head injury.” Br J Surg 90(7):769-71 Details Wilby MJ, Sharp M, Whitfield PC, Hutchinson PJ, Menon DK, Kirkpatrick PJ (2003), “Cost-effective outcome for treating poor-grade subarachnoid hemorrhage.” Stroke 34(10):2508-11 Details 2002Gupta AK, Al-Rawi PG, Hutchinson PJ, Kirkpatrick PJ (2002), “Effect of hypothermia on brain tissue oxygenation in patients with severe head injury.” Br J Anaesth 88(2):188-92 Details Gupta AK, Hutchinson PJ, Fryer T, Al-Rawi PG, Parry DA, Minhas PS, Kett-White R, Kirkpatrick PJ, Mathews JC, Downey S, Aigbirhio F, Clark J, Pickard JD, Menon DK (2002), “Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method.” J Neurosurg 96(2):263-8 Details Hutchinson PJ, Gupta AK, Fryer TF, Al-Rawi PG, Chatfield DA, Coles JP, O'Connell MT, Kett-White R, Minhas PS, Aigbirhio FI, Clark JC, Kirkpatrick PJ, Menon DK, Pickard JD (2002), “Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.” J Cereb Blood Flow Metab 22(6):735-45 Details Hutchinson PJ, Kirkpatrick PJ (2002), “Acute head injury for the neurologist.” J Neurol Neurosurg Psychiatry 73 Suppl 1:i3-7 Details Hutchinson PJ, O'Connell MT, Al-Rawi PG, Kett-White CR, Gupta AK, Maskell LB, Pickard JD, Kirkpatrick PJ (2002), “Increases in GABA concentrations during cerebral ischaemia: a microdialysis study of extracellular amino acids.” J Neurol Neurosurg Psychiatry 72(1):99-105 Details Hutchinson PJ, O'Connell MT, al-Rawi PG, Kett-White R, Gupta AK, Kirkpatrick PJ, Pickard JD (2002), “Clinical cerebral microdialysis--determining the true extracellular concentration.” Acta Neurochir Suppl 81:359-62 Details Hutchinson PJ, O'Connell MT, Coles JP, Chatfield DA, Coleman MR, Al-Rawi PG, Kett-White CR, Gupta AK, Menon DK, Boniface SJ, Heazell M, Kirkpatrick PJ, Pickard JD (2002), “Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent.” Br J Clin Pharmacol 53(3):275-83 Details Hutchinson PJ, O'Connell MT, Kirkpatrick PJ, Pickard JD (2002), “How can we measure substrate, metabolite and neurotransmitter concentrations in the human brain?” Physiol Meas 23(2):R75-109 Details Kett-White R, Hutchinson PJ, Al-Rawi PG, Czosnyka M, Gupta AK, Pickard JD, Kirkpatrick PJ (2002), “Cerebral oxygen and microdialysis monitoring during aneurysm surgery: effects of blood pressure, cerebrospinal fluid drainage, and temporary clipping on infarction.” J Neurosurg 96(6):1013-9 Details Kett-White R, Hutchinson PJ, al-Rawi PG, Gupta AK, O'Connell MT, Pickard JD, Kirkpatrick PJ (2002), “Extracellular lactate/pyruvate and glutamate changes in patients during per-operative episodes of cerebral ischaemia.” Acta Neurochir Suppl 81:363-5 Details Kett-White R, Hutchinson PJ, Al-Rawi PG, Gupta AK, Pickard JD, Kirkpatrick PJ (2002), “Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes.” Neurosurgery 50(6):1213-21; discussion 1221-2 Details Kett-White R, Hutchinson PJ, Czosnyka M, al-Rawi P, Gupta A, Pickard JD, Kirkpatrick PJ (2002), “Effects of variation in cerebral haemodynamics during aneurysm surgery on brain tissue oxygen and metabolism.” Acta Neurochir Suppl 81:327-9 Details Kett-White R, Hutchinson PJ, Czosnyka M, Boniface S, Pickard JD, Kirkpatrick PJ (2002), “Multi-modal monitoring of acute brain injury.” Adv Tech Stand Neurosurg 27:87-134 Details Patel HC, Menon DK, Tebbs S, Hawker R, Hutchinson PJ, Kirkpatrick PJ (2002), “Specialist neurocritical care and outcome from head injury.” Intensive Care Med 28(5):547-53 Details Ross N, Hutchinson PJ, Seeley H, Kirkpatrick PJ (2002), “Timing of surgery for supratentorial aneurysmal subarachnoid haemorrhage: report of a prospective study.” J Neurol Neurosurg Psychiatry 72(4):480-4 Details 2001Hutchinson PJ (2001), “Twist-drill skull placement of bolts and drains.” Br J Neurosurg 15(3):285-6 Details Hutchinson PJ, Kirkpatrick PJ (2001), “What is the most sensitive non-invasive strategy for the diagnosis of intracranial aneurysms?” J Neurol Neurosurg Psychiatry 71(3):289 Details Laing RJ, Ng I, Seeley HM, Hutchinson PJ (2001), “Prospective study of clinical and radiological outcome after anterior cervical discectomy.” Br J Neurosurg 15(4):319-23 Details Whitfield PC, Patel H, Hutchinson PJ, Czosnyka M, Parry D, Menon D, Pickard JD, Kirkpatrick PJ (2001), “Bifrontal decompressive craniectomy in the management of posttraumatic intracranial hypertension.” Br J Neurosurg 15(6):500-7 Details 2000al-Rawi PG, Hutchinson PJ, Gupta AK, Piechnik SK, Pickard JD, Kirkpatrick PJ (2000), “Multiparameter brain tissue monitoring--correlation between parameters and identification of CPP thresholds.” Zentralbl Neurochir 61(2):74-9 Details Hutchinson PJ, al-Rawi PG, O'Connell MT, Gupta AK, Maskell LB, Hutchinson DB, Pickard JD, Kirkpatrick PJ (2000), “On-line monitoring of substrate delivery and brain metabolism in head injury.” Acta Neurochir Suppl 76:431-5 Details Hutchinson PJ, al-Rawi PG, O'Connell MT, Gupta AK, Maskell LB, Hutchinson DB, Pickard JD, Kirkpatrick PJ (2000), “Head injury monitoring using cerebral microdialysis and Paratrend multiparameter sensors.” Zentralbl Neurochir 61(2):88-94 Details Hutchinson PJ, Al-Rawi PG, O'Connell MT, Gupta AK, Pickard JD, Kirkpatrick PJ (2000), “Biochemical changes related to hypoxia during cerebral aneurysm surgery: combined microdialysis and tissue oxygen monitoring: case report.” Neurosurgery 46(1):201-5; discussion 205-6 Details Hutchinson PJ, Hutchinson DB, Barr RH, Burgess F, Kirkpatrick PJ, Pickard JD (2000), “A new cranial access device for cerebral monitoring.” Br J Neurosurg 14(1):46-8 Details Hutchinson PJ, Laing RJ, Waran V, Hutchinson E, Hollingworth W (2000), “Assessing outcome in lumbar disc surgery using patient completed measures.” Br J Neurosurg 14(3):195-9 Details Hutchinson PJ, O'Connell MT, Al-Rawi PG, Maskell LB, Kett-White R, Gupta AK, Richards HK, Hutchinson DB, Kirkpatrick PJ, Pickard JD (2000), “Clinical cerebral microdialysis: a methodological study.” J Neurosurg 93(1):37-43 Details Hutchinson PJ, Pickard JD, Higgins JN (2000), “Neurological picture. Vertebral artery dissection presenting as cerebellar infarction.” J Neurol Neurosurg Psychiatry 68(1):98-9 Details Hutchinson PJ, Power DM, Tripathi P, Kirkpatrick PJ (2000), “Outcome from poor grade aneurysmal subarachnoid haemorrhage--which poor grade subarachnoid haemorrhage patients benefit from aneurysm clipping?” Br J Neurosurg 14(2):105-9 Details Pickard JD, Kirkpatrick PJ, Melsen T, Andreasen RB, Gelling L, Fryer T, Matthews J, Minhas P, Hutchinson PJ, Menon D, Downey SP, Kendall I, Clark J, Carpenter TA, Williams E, Persson L (2000), “Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage.” Blood Coagul Fibrinolysis 11 Suppl 1:S117-20 Details 1999Gupta AK, Hutchinson PJ, Al-Rawi P, Gupta S, Swart M, Kirkpatrick PJ, Menon DK, Datta AK (1999), “Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury.” Anesth Analg 88(3):549-53 Details Hutchinson PJ, Al-Rawi PG, O'Connell MT, Gupta AK, Maskell LB, Hutchinson DB, Pickard JD, Kirkpatrick PJ (1999), “Monitoring of brain metabolism during aneurysm surgery using microdialysis and brain multiparameter sensors.” Neurol Res 21(4):352-8 Details Hutchinson PJ, O'Connell MT, Al-Rawi PG, Maskell LB, Gupta AK, Hutchinson DB, Pickard JD, Kirkpatrick PJ, Wharton SB (1999), “Neuropathological findings after intracerebral implantation of microdialysis catheters in sheep forebrain.” Neuroreport 10(3):i Details Hutchinson PJ, O'Connell MT, Maskell LB, Pickard JD (1999), “Monitoring by subcutaneous microdialysis in neurosurgical intensive care.” Acta Neurochir Suppl 75:57-9 Details Mavaddat N, Sahakian BJ, Hutchinson PJ, Kirkpatrick PJ (1999), “Cognition following subarachnoid hemorrhage from anterior communicating artery aneurysm: relation to timing of surgery.” J Neurosurg 91(3):402-7 Details Patel HC, Hutchinson PJ, Pickard JD (1999), “Traumatic subarachnoid haemorrhage.” Hosp Med 60(7):497-9 Details 1998Hutchinson PJ, Kirkpatrick PJ, Addison J, Jackson S, Pickard JD (1998), “The management of minor traumatic brain injury.” J Accid Emerg Med 15(2):84-8 Details Hutchinson PJ, Seeley HM, Kirkpatrick PJ (1998), “Factors implicated in deaths from subarachnoid haemorrhage: are they avoidable?” Br J Neurosurg 12(1):37-40 Details |