Mr Patrick Flagmeier
My main research interests focus on contributing to our understanding of protein misfolding and aggregation associated with neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.
One aspect of my work is the development of small molecules and antibodies that inhibit protein aggregation to enable disease treatment.
A second aspect of the research is the identification of the species of the protein that is neurotoxic and therefore directly linked to disease onset. The goal of the research is to develop methodologies that will enable not only the identification of damaging species but also to screen potential therapeutical agents.
No equipment indicated
No collaborators listed
Associated News Items
Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D (2018), “Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with high affinity” ACS Chemical Biology 13(3):636-646.
Varela JA, Rodrigues M, De S, Flagmeier P, Gandhi S, Dobson CM, Klenerman D, Lee SF (2018), “Optical Structural Analysis of Individual α-Synuclein Oligomers.” Angew Chem Int Ed Engl. 57, 4886-4890.
Whiten DR, Cox D, Horrocks MH, Taylor CG, De S, Flagmeier P, Tosatto L, Kumita JR, Heath Ecroyd H, Dobson CM, Klenerman D, Wilson MR (2018), “Single molecule characterisation of the interactions between extracellular chaperones and toxic α-synuclein oligomers” Cell Reports
Anna Drews*, Suman De*, Patrick Flagmeier*, David C. Wirthensohn*, Wei-Hsin Chen, Daniel R. Whiten, Margarida Rodrigues, Cécile Vincke, Serge Muyldermans, Ross W. Paterson, Catherine F. Slattery, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Christopher M. Dobson, Sonia Gandhi, David Klenerman (2017), “Inhibiting the Ca2+ Influx Induced by Human CSF” Cell Reports 21(11):3310-3316.
Chia S*, Flagmeier P*, Habchi J*, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M. (2017), “Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.” Proc Natl Acad Sci U S A 114(30):8005-8010.
Flagmeier P*, De S*, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D (2017), “Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates” Angew Chem Int Ed Engl 56(27): 7750-7754.
Michele Perni, Céline Galvagnion, Alexander Maltsev, Georg Meisl, Martin B. D. Müller, Pavan K. Challa, Julius B. Kirkegaard, Patrick Flagmeier, Samuel I. A. Cohen, Roberta Cascella, Serene W. Chen, Ryan Limbocker, Pietro Sormanni, Gabriella T. Heller, Francesco A. Aprile, Nunilo Cremades, Cristina Cecchi, Fabrizio Chiti, Ellen A. A. Nollen, Tuomas P. J. Knowles, Michele Vendruscolo, Adriaan Bax, Michael Zasloff, and Christopher M. Dobson (2017), “A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity” Proc Natl Acad Sci U S A 114(6):E1009-E1017.
Brown JW, Buell AK, Michaels TC, Meisl G, Carozza J, Flagmeier P, Vendruscolo M, Knowles TP, Dobson CM, Galvagnion C. (2016), “β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.” Scientific Reports 6:36010.
Flagmeier P, Meisl G, Vendruscolo M, Knowles TP, Dobson CM, Buell AK, Galvagnion C (2016), “Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation.” Proc Natl Acad Sci U S A. 113(37):10328-33.
Galvagnion C, Brown JW, Ouberai MM, Flagmeier P, Vendruscolo M, Buell AK, Sparr E, Dobson CM (2016), “Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein.” Proc Natl Acad Sci U S A. 113(26):7065-70.
Shimanovich U, Efimov I, Mason TO, Flagmeier P, Buell AK, Gedanken A, Linse S, Åkerfeldt KS, Dobson CM, Weitz DA, Knowles TP (2015), “Protein microgels from amyloid fibril networks.” ACS Nano 27;9(1):43-51.